The Chhasra Formation(CF)of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds.The CF is subdivided into two members:th...The Chhasra Formation(CF)of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds.The CF is subdivided into two members:the lower Claystone(CM)and the upper Siltstone(SM)member.Three CM outcrops(P1-P3)comprising buried palaeosols that formed under a specific environmental set-up involving imperfectly to poorly drained conditions,are exposed along the Berwali River.The biostromal carbonate beds,alternating with the palaeosols,contain invertebrate bioclasts(bivalves,gastropods,echinoids,etc.)and are characterized by a paucispecific firmground Thalassinoides ichnofabric.At section P1,below the contact between the underlying palaeosol and overlying carbonate,Thalassinoides transforms into firmground Gyrolithes inside the palaeosol forming a compound ichnotaxon.The palaeosol intervals of sections P1 and P2 consist of a Vondrichnus-Termitichnus-root trace ichnofabric defining the Termitichnus ichnofacies.At section P3,lenses of fully bioturbated siltstones with a monospecific firmground Thalassinoides ichnofabric can be observed within an overall silty palaeosol horizon,thereby,locally cross-cutting the pedogenic features.The ichnofabrics of section P3 indicate polyphase pedogenesis with three stages:(1)initial stage:pedogenesis in siltstone of undefined depositional affinity which was obscured by pedogenic processes,(2)transient stage:recurring marine incursions and colonization by crustaceans within the lens-shaped palaeotopographic depressions overprinting the palaeosol,and(3)final stage:subaerial exposure and another preserved phase of pedogenesis.The CM shows an apparent low-order T-R(transgressive-regressive)cyclicity within a 3rd-order TST(transgressive systems tract)that is supported by pedogenic intensity,ichnofabrics,and reciprocal sedimentation near the Miocene basin margin,though the cyclicity can be the result of both autogenic and/or lowerorder allogenic changes.展开更多
Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic character...Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored yet.This study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W cycles.The uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W cycles.The potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W cycles.The proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W cycles.The micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and branched.The gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W cycles.Overall,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions.展开更多
Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induce...Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induced by the large radius of K+ions.Here,we explore high-performance K-ion half/full batteries with high rate capability,high specific capacity,and extremely durable cycle stability based on carbon nanosheets with tailored N dopants,which can alleviate the change of volume,increase electronic conductivity,and enhance the K+ion adsorption.The as-assembled K-ion half-batteries show an excellent rate capability of 468 mA h g^(−1) at 100 mA g^(−1),which is superior to those of most carbon materials reported to date.Moreover,the as-assembled half-cells have an outstanding life span,running 40,000 cycles over 8 months with a specific capacity retention of 100%at a high current density of 2000 mA g^(−1),and the target full cells deliver a high reversible specific capacity of 146 mA h g^(−1) after 2000 cycles over 2 months,with a specific capacity retention of 113%at a high current density of 500 mA g^(−1),both of which are state of the art in the field of K-ion batteries.This study might provide some insights into and potential avenues for exploration of advanced K-ion batteries with durable stability for practical applications.展开更多
The use of carbon dioxide as a working fluid has been the subject of extensive studies in recent years, particularly in the field of refrigeration where it is at the heart of research to replace CFC and HCFC. Its ther...The use of carbon dioxide as a working fluid has been the subject of extensive studies in recent years, particularly in the field of refrigeration where it is at the heart of research to replace CFC and HCFC. Its thermodynamic properties make it a fluid of choice in the efficient use of energy at low and medium temperatures in engine cycles. However, the performance of transcritical CO2 cycles weakens under high temperature and pressure conditions, especially in refrigeration systems;On the other hand, this disadvantage becomes rather interesting in engine cycles where CO2 can be used as an alternative to the organic working fluid in small and medium-sized electrical systems for low quality or waste heat sources. In order to improve the performance of systems operating with CO2 in the field of refrigeration and electricity production, research has made it possible to develop several concepts, of which this article deals with a review of the state of the art, followed by analyzes in-depth and critical of the various developments to the most recent modifications in these fields. Detailed discussions on the performance and technical characteristics of the different evolutions are also highlighted as well as the factors affecting the overall performance of the systems studied. Finally, perspectives on the future development of the use of CO2 in these different cycles are presented.展开更多
Due to climatic factors and rapid urbanization,the soil in the Loess Plateau,China,experiences the coupled effects of dry-wet cycles and chemical contamination.Understanding the mechanical behavior and corresponding m...Due to climatic factors and rapid urbanization,the soil in the Loess Plateau,China,experiences the coupled effects of dry-wet cycles and chemical contamination.Understanding the mechanical behavior and corresponding microstructural evolution of contaminated loess subjected to dry-wet cycles is essential to elucidate the soil degradation mechanism.Therefore,direct shear and consolidation tests were performed to investigate the variations in mechanical properties of compacted loess contaminated with acetic acid,sodium hydroxide,and sodium sulfate during dry-wet cycles.The mechanical response mechanisms were investigated using zeta potential,mineral chemical composition,and scanning electron microscopy(SEM)tests.The results indicate that the mechanical deterioration of sodium hydroxidecontaminated loess during dry-wet cycles decreases with increasing contaminant concentration,which is mainly attributed to the thickening of the electrical double layer(EDL)by Nat and the precipitation of calcite,as well as the formation of colloidal flocs induced by OH,thus inhibiting the development of large pores during the dry-wet process.In contrast,the attenuation of mechanical properties of both acetic acid-and sodium sulfate-contaminated loess becomes more severe with increasing contaminant concentration,with the latter being more particularly significant.This is primarily due to the reduction of the EDL thickness and the erosion of cement in the acidic environment,which facilitates the connectivity of pores during dry-wet cycles.Furthermore,the salt expansion generated by the drying process of saline loess further intensifies the structural disturbance.Consequently,the mechanical performance of compacted loess is sensitive to both pollutant type and concentration,exhibiting different response patterns in the dry-wet cycling condition.展开更多
The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to ...The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037.展开更多
Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of differe...Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of different low-temperaturecycles (20°C, –80°C, and −160°C) and concrete specimen crack widths (0, 0.3, and 0.6 mm) on the Cl−ion diffusion performance through rapid erosion tests conducted on pre-cracked concrete. The results show thatthe minimum temperature and crack width of freeze-thaw cycles enhance the erosive effect of chloride ions. TheCl− ion concentration and growth rate increased with the increasing crack width. Based on the experimental modeland in accordance with Fick’s second law of diffusion, the Cl− ion diffusion equation was modified by introducingcorrection factors in consideration of the freeze-thaw temperature, crack width, and their coupling effect.The experimental and fitting results obtained from this model can provide excellent reference for practical engineeringapplications.展开更多
Sandstone is the fundamental material in various engineering and construction projects.However,the mechanical integrity of sandstone can be compromised by initial unloading damage resulting from activities such as eng...Sandstone is the fundamental material in various engineering and construction projects.However,the mechanical integrity of sandstone can be compromised by initial unloading damage resulting from activities such as engineering excavations.Furthermore,this degradation is further exacerbated under periodic dry-wet environmental conditions.This study investigated the effects of dry-wet cycles and unloading on the mechanical properties of jointed fine sandstone using uniaxial and triaxial compression tests.These tests were performed on rock samples subjected to varying unloading degrees and different numbers of dry-wet cycles.The results demonstrate that with an increase in the unloading degree from 0%to 70%,there is a corresponding decrease in peak stress ranging from 10%to 33%.Additionally,the cohesion exhibits a reduction of approximately 20%to 25%,while the internal friction angle experiences a decline of about 3.5%to 6%.These findings emphasize a significant unloading effect.Moreover,the degree of peak stress degradation in unloading jointed fine sandstone diminishes with an increase in confining pressure,suggesting that confining pressure mitigates the deterioration caused by dry-wet cycles.Additionally,as the number of dry-wet cycles increases,there is a notable decline in the mechanical properties of the sandstone,evidencing significant dry-wet degradation.Utilizing the Drucker Prager criterion,this study establishes a strength criterion and fracture criterion,denoted as σ_(1)(m,n) and K_(T)^(Ⅱ)(m, n), to quantify the combined impacts of dry-wet cycles and unloading on jointed fine sandstone,which provides a comprehensive understanding of its mechanical behavior under such conditions.展开更多
To investigate the freeze-thaw(F-T)damages and failure characteristics of rock mass with arc-shaped joints in cold regions,three types of cement mortar specimens with different central angles and prefabricated arc-sha...To investigate the freeze-thaw(F-T)damages and failure characteristics of rock mass with arc-shaped joints in cold regions,three types of cement mortar specimens with different central angles and prefabricated arc-shaped flaws are subjected to uniaxial compressive tests under different F-T cycles.Experimental observations show that the uniaxial compressive strength of specimens are significantly influenced by F-T cycles and their failure modes are mainly affected by the central angleαof the prefabricated flaws.Unlike the specimens with a central angle of 60°,the specimens with a central angle of 120°and 180°have greater curvature of flaws,so tensile cracks occur in the arc-top area of their prefabricated flaws.According to experimental images observed by environmental scanning electron microscope(ESEM),as the number of F-T cycles increases,the deterioration effect of the specimen becomes more obvious,which is specifically reflected in the increase of the mass loss,peak stress loss,and damage variables as a power function,and the peak strain decreases as a quadratic polynomial.According to numerical results using two-dimensional particle flow code(PFC2D),it is found that F-T cycles cause more damage to the specimen in the early stages than in the later ones.The area of the concentrated compressive stress zone in the middle is decreased due to the increased number of F-T cycles,while the area of the surrounding tensile-shear stress zone is increased.The models appear different failure modes due to the release of concentrated stress in different tensile-shear zones.展开更多
Soil aggregate is the basic structural unit of soil,which is the foundation for supporting ecosystem functions,while its composition and stability is significantly affected by the external environment.This study was c...Soil aggregate is the basic structural unit of soil,which is the foundation for supporting ecosystem functions,while its composition and stability is significantly affected by the external environment.This study was conducted to explore the effect of external environment(wetting-drying cycles and acidic conditions)on the soil aggregate distribution and stability and identify the key soil physicochemical factors that affect the soil aggregate stability.The yellow‒brown soil from the Three Gorges Reservoir area(TGRA)was used,and 8 wetting-drying conditions(0,1,2,3,4,5,10 and 15 cycles)were simulated under 4 acidic conditions(pH=3,4,5 and 7).The particle size distribution and soil aggregate stability were determined by wet sieving method,the contribution of environmental factors(acid condition,wetting-drying cycle and their combined action)to the soil aggregate stability was clarified and the key soil physicochemical factors that affect the soil aggregate stability under wetting-drying cycles and acidic conditions were determined by using the Pearson’s correlation analysis,Partial least squares path modeling(PLS‒PM)and multiple linear regression analysis.The results indicate that wetting-drying cycles and acidic conditions have significant effects on the stability of soil aggregates,the soil aggregate stability gradually decreases with increasing number of wetting-drying cycles and it obviously decreases with the increase of acidity.Moreover,the combination of wetting-drying cycles and acidic conditions aggravate the reduction in the soil aggregate stability.The wetting-drying cycles,acidic conditions and their combined effect imposes significant impact on the soil aggregate stability,and the wetting-drying cycles exert the greatest influence.The soil aggregate stability is significantly correlated with the pH,Ca^(2+),Mg^(2+),maximum disintegration index(MDI)and soil bulk density(SBD).The PLS‒PM and multiple linear regression analysis further reveal that the soil aggregate stability is primarily influenced by SBD,Ca^(2+),and MDI.These results offer a scientific basis for understanding the soil aggregate breakdown mechanism and are helpful for clarifying the coupled effect of wetting-drying cycles and acid rain on terrestrial ecosystems in the TGRA.展开更多
The rotation of the Earth and the related length of the day (LOD) are predominantly affected by tidal dissipation through the Moon and the growth of the Earth’s core. Due to the increased concentration of mass around...The rotation of the Earth and the related length of the day (LOD) are predominantly affected by tidal dissipation through the Moon and the growth of the Earth’s core. Due to the increased concentration of mass around the rotation axis of the spinning Earth during the growth of the core the rotation should have been accelerated. Controversially the tidal dissipation by the Moon, which is mainly dependent on the availability of open shallow seas and the kind of Moon escape from a nearby position, acts towards a deceleration of the rotating Earth. Measurements of LOD for Phanerozoic and Precambrian times open ways to solve questions concerning the geodynamical history of the Earth. These measurements encompass investigations of growth patterns in fossils and depositional patterns in sediments (Cyclostratigraphy, Tidalites, Stromatolites, Rhythmites). These patterns contain information on the LOD and on the changing distance between Earth and Moon and can be used as well for a discussion about the growth of the Earth’s core. By updating an older paper with its simple approach as well as incorporating newly published results provided by the geoscientific community, a moderate to fast growth of the core in a hot early Earth will be favored controversially to the assumption of a delayed development of the core in an originally cold Earth. Core development with acceleration of Earth’s rotation and the contemporaneous slowing down due to tidal dissipation during the filling of the ocean may significantly interrelate.展开更多
Zinc(Zn),a widespread metal in the Earth’s crust,serves as a crucial nutrient in the Southern Ocean’s primary production.Studies on Zn in Antarctic snow and ice offer insights into the origins of this metal and its ...Zinc(Zn),a widespread metal in the Earth’s crust,serves as a crucial nutrient in the Southern Ocean’s primary production.Studies on Zn in Antarctic snow and ice offer insights into the origins of this metal and its transport routes,as well as its impact on the biogeochemical processes within the Antarctic atmosphere–land–ocean system.This review examines research on the spatial and temporal distribution of Zn in Antarctic snow and ice,as well as in Southern Ocean waters.It includes an overview of advanced methods for sampling and analyzing Zn,along with explanations for the observed variations.The review also discusses various sources of Zn as a nutrient to the Southern Ocean.Finally,it addresses prospective issues related to the use of Zn isotopes in identifying atmospheric sources and their biogeochemical effects on the development of the Southern Ocean ecosystem.展开更多
Underground pumped storage power plant(UPSP)is an innovative concept for space recycling of abandoned mines.Its realization requires better understanding of the dynamic performance and durability of reservoir rock.Thi...Underground pumped storage power plant(UPSP)is an innovative concept for space recycling of abandoned mines.Its realization requires better understanding of the dynamic performance and durability of reservoir rock.This paper conducted ultrasonic detection,split Hopkinson pressure bar(SHPB)impact,mercury intrusion porosimetry(MIP),and backscatter electron observation(BSE)tests to investigate the dynamical behaviour and microstructure of sandstone with cyclical dry-wet damage.A coupling FEM-DEM model was constructed for reappearing mesoscopic structure damage.The results show that dry-wet cycles decrease the dynamic compressive strength(DCS)with a maximum reduction of 39.40%,the elastic limit strength is reduced from 41.75 to 25.62 MPa.The sieved fragments obtain the highest crack growth rate during the 23rd dry-wet cycle with a predictable life of 25 cycles for each rock particle.The pore fractal features of the macropores and micro-meso pores show great differences between the early and late cycles,which verifies the computational statistics analysis of particle deterioration.The numerical results show that the failure patterns are governed by the strain in pre-peak stage and the shear cracks are dominant.The dry-wet cycles reduce the energy transfer efficiency and lead to the discretization of force chain and crack fields.展开更多
This paper explores the existence of heteroclinic cycles and corresponding chaotic dynamics in a class of 3-dimensional two-zone piecewise affine systems. Moreover, the heteroclinic cycles connect two saddle foci and ...This paper explores the existence of heteroclinic cycles and corresponding chaotic dynamics in a class of 3-dimensional two-zone piecewise affine systems. Moreover, the heteroclinic cycles connect two saddle foci and intersect the switching manifold at two points and the switching manifold is composed of two perpendicular planes.展开更多
By analysing a long series of data (1996-2019), we show that solar cycle 23 was more marked by violent solar flares and coronal mass ejections (CMEs) compared to solar cycle 24. In particular, the halo coronal mass ej...By analysing a long series of data (1996-2019), we show that solar cycle 23 was more marked by violent solar flares and coronal mass ejections (CMEs) compared to solar cycle 24. In particular, the halo coronal mass ejections associated with X-class flares appear to be among the most energetic events in solar activity given the size of the flares, the speed of the CMEs and the intense geomagnetic storms they produce. Out of eighty-six (86) X-class halo CMEs, thirty-seven (37) or 43% are highly geoeffective;twenty-four (24) or approximately 28% are moderately geoeffective and twenty-five (25) or 29% are not geoeffective. Over the two solar cycles (1996 to 2019), 71% of storms were geoeffective and 29% were not. For solar cycle 23, about 78% of storms were geoeffective, while for solar cycle 24, about 56% were geoeffective. For the statistical study based on speed, 85 halo CMEs associated with X-class flares were selected because the CME of 6 December 2006 has no recorded speed value. For both solar cycles, 75.29% of the halo CMEs associated with X-class flares have a speed greater than 1000 km/s. The study showed that 42.18% of halo (X) CMEs with speeds above 1000 km/s could cause intense geomagnetic disturbances. These results show the contribution (in terms of speed) of each class of halo (X) CMEs to the perturbation of the Earth’s magnetic field. Coronal mass ejections then become one of the key indicators of solar activity, especially as they affect the Earth.展开更多
Economic cycles are not economic evils but rather healing agents for returning to equilibrium,just as inflation and deflation are not economic misfortunes but the sign of bad governance and a bitter medicine for retur...Economic cycles are not economic evils but rather healing agents for returning to equilibrium,just as inflation and deflation are not economic misfortunes but the sign of bad governance and a bitter medicine for returning to calm monetary.Unfortunately,signs of poor governance are mistaken for unfortunate events,but are instead tools offered to restore economic systems.Politics seeks consensus and does not accept the bitter cure of recession.Monetary policy is therefore called into question even if monetary anomalies also depend on errors in the management of the economy;the result is the gradual increase in interest rates.Is the idea that we can achieve the goal of complete neutrality with nature acceptable in a global economic framework pervaded by inflation and denunciation?Can we similarly argue that economic problems can coexist once the goal of neutrality has been achieved?The answer is negative.We must correct these anomalies and dysfunctions of the economy,which cannot coexist in the new context of complete and indefinite equilibrium of tomorrow.And not even the idea that conflicts can be resolved with war seems to find a place in the renewed scenario of neutrality.In this regard we can remember that,when we have reached the economic optimum of complete neutrality,or at least we are close to it,the most socially and economically advanced territories and continents will benefit from an acceleration of productivity and development.Scarcity itself will give way to the new,long-awaited reality.A condition that approaches the state of abundance and which will produce surpluses to be allocated to countries and territories that are struggling towards the condition of neutrality.The acceleration of lagging continents and the recovery of altered economic systems are therefore preconditions that can allow us to access the state of global neutrality.As we get closer to the great objective,it is to be believed that the pretense of regulating conflicts through war will also disappear.With the new reality of abundance,the economic reason for war disappears,while the aspiration of peoples-inscribed in their DNA-for solidarity and peaceful aggregation towards substantial unity becomes clear.展开更多
The Total Coloring Conjecture (TCC) proposes that every simple graph G is (Δ + 2)-totally-colorable, where Δ is the maximum degree of G. For planar graph, TCC is open only in case Δ = 6. In this paper, we prove tha...The Total Coloring Conjecture (TCC) proposes that every simple graph G is (Δ + 2)-totally-colorable, where Δ is the maximum degree of G. For planar graph, TCC is open only in case Δ = 6. In this paper, we prove that TCC holds for planar graph with Δ = 6 and every 7-cycle contains at most two chords.展开更多
objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but n...objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively.展开更多
As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying tem...As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying temperature. A series of dynamic cyclic triaxial experiments were conducted through a cryogenic triaxial apparatus for exploring the influences of F-T cycles on the dynamic mechanical properties of frozen subgrade clay.According to the experimental results of frozen clay at the temperature of-10℃, the dynamic responses and microstructure variation at different times of F-T cycles(0, 1, 5, and 20 cycles) were explored in detail.It is experimentally demonstrated that the dynamic stress-strain curves and dynamic volumetric strain curves of frozen clay are significantly sparse after 20F-T cycles. Meanwhile, the cyclic number at failure(Nf) of the frozen specimen reduces by 89% after 20freeze-thaw cycles at a low ratio of the dynamic stress amplitude. In addition, with the increasing F-T cycles,the axial accumulative strain, residual deformation,and the value of damage variable of frozen clay increase, while the dynamic resilient modulus and dynamic strength decrease. Finally, the influence of the F-T cycles on the failure mechanisms of frozen clay was discussed in terms of the microstructure variation. These studies contribute to a better understanding of the fundamental changes in the dynamic mechanical of frozen soils exposed to F-T cycles in cold and seismic regions.展开更多
基金the following funding agencies for the research grants:Science and Engineering Research Board (SERB)Government ofIndia (grant#CRG/2018/000259 to SDG)+2 种基金Industrial Research and Consultancy Centre (IRCC)IIT Bombay (seed grant#RD/0517-IRCCSH0-035 to SDG)Council of Scientific&Industrial Research (CSIR) (doctoral scholarship for AS)。
文摘The Chhasra Formation(CF)of Kutch Basin exemplifies a typical mixed siliciclastic-carbonate system with alternations of biostromal carbonate and fine-grained siliciclastic beds.The CF is subdivided into two members:the lower Claystone(CM)and the upper Siltstone(SM)member.Three CM outcrops(P1-P3)comprising buried palaeosols that formed under a specific environmental set-up involving imperfectly to poorly drained conditions,are exposed along the Berwali River.The biostromal carbonate beds,alternating with the palaeosols,contain invertebrate bioclasts(bivalves,gastropods,echinoids,etc.)and are characterized by a paucispecific firmground Thalassinoides ichnofabric.At section P1,below the contact between the underlying palaeosol and overlying carbonate,Thalassinoides transforms into firmground Gyrolithes inside the palaeosol forming a compound ichnotaxon.The palaeosol intervals of sections P1 and P2 consist of a Vondrichnus-Termitichnus-root trace ichnofabric defining the Termitichnus ichnofacies.At section P3,lenses of fully bioturbated siltstones with a monospecific firmground Thalassinoides ichnofabric can be observed within an overall silty palaeosol horizon,thereby,locally cross-cutting the pedogenic features.The ichnofabrics of section P3 indicate polyphase pedogenesis with three stages:(1)initial stage:pedogenesis in siltstone of undefined depositional affinity which was obscured by pedogenic processes,(2)transient stage:recurring marine incursions and colonization by crustaceans within the lens-shaped palaeotopographic depressions overprinting the palaeosol,and(3)final stage:subaerial exposure and another preserved phase of pedogenesis.The CM shows an apparent low-order T-R(transgressive-regressive)cyclicity within a 3rd-order TST(transgressive systems tract)that is supported by pedogenic intensity,ichnofabrics,and reciprocal sedimentation near the Miocene basin margin,though the cyclicity can be the result of both autogenic and/or lowerorder allogenic changes.
基金The authors gratefully acknowledge the financial support of National NaturalScience Foundation of China(Grant No.41972276)Natural Science Foundation of Fujian Province,China(Grant No.2020J06013)"Foal Eagle Program"Youth Top-notch Talent Project of Fujian Province,China(Grant No.00387088).
文摘Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored yet.This study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W cycles.The uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W cycles.The potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W cycles.The proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W cycles.The micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and branched.The gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W cycles.Overall,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions.
基金National Natural Science Foundation of China,Grant/Award Numbers:51972178,52202061Hunan Provincial Nature Science Foundation,Grant/Award Number:2022JJ40068。
文摘Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induced by the large radius of K+ions.Here,we explore high-performance K-ion half/full batteries with high rate capability,high specific capacity,and extremely durable cycle stability based on carbon nanosheets with tailored N dopants,which can alleviate the change of volume,increase electronic conductivity,and enhance the K+ion adsorption.The as-assembled K-ion half-batteries show an excellent rate capability of 468 mA h g^(−1) at 100 mA g^(−1),which is superior to those of most carbon materials reported to date.Moreover,the as-assembled half-cells have an outstanding life span,running 40,000 cycles over 8 months with a specific capacity retention of 100%at a high current density of 2000 mA g^(−1),and the target full cells deliver a high reversible specific capacity of 146 mA h g^(−1) after 2000 cycles over 2 months,with a specific capacity retention of 113%at a high current density of 500 mA g^(−1),both of which are state of the art in the field of K-ion batteries.This study might provide some insights into and potential avenues for exploration of advanced K-ion batteries with durable stability for practical applications.
文摘The use of carbon dioxide as a working fluid has been the subject of extensive studies in recent years, particularly in the field of refrigeration where it is at the heart of research to replace CFC and HCFC. Its thermodynamic properties make it a fluid of choice in the efficient use of energy at low and medium temperatures in engine cycles. However, the performance of transcritical CO2 cycles weakens under high temperature and pressure conditions, especially in refrigeration systems;On the other hand, this disadvantage becomes rather interesting in engine cycles where CO2 can be used as an alternative to the organic working fluid in small and medium-sized electrical systems for low quality or waste heat sources. In order to improve the performance of systems operating with CO2 in the field of refrigeration and electricity production, research has made it possible to develop several concepts, of which this article deals with a review of the state of the art, followed by analyzes in-depth and critical of the various developments to the most recent modifications in these fields. Detailed discussions on the performance and technical characteristics of the different evolutions are also highlighted as well as the factors affecting the overall performance of the systems studied. Finally, perspectives on the future development of the use of CO2 in these different cycles are presented.
基金supported by the Second Tibet Plateau Scientific Expedition and Research Program(Grant No.2019QZKK0905)the Key Program of the National Natural Science Foundation of China(Grant No.41931285)the Key Research and Development Program of Shaanxi Province(Grant No.2019ZDLSF05-07).
文摘Due to climatic factors and rapid urbanization,the soil in the Loess Plateau,China,experiences the coupled effects of dry-wet cycles and chemical contamination.Understanding the mechanical behavior and corresponding microstructural evolution of contaminated loess subjected to dry-wet cycles is essential to elucidate the soil degradation mechanism.Therefore,direct shear and consolidation tests were performed to investigate the variations in mechanical properties of compacted loess contaminated with acetic acid,sodium hydroxide,and sodium sulfate during dry-wet cycles.The mechanical response mechanisms were investigated using zeta potential,mineral chemical composition,and scanning electron microscopy(SEM)tests.The results indicate that the mechanical deterioration of sodium hydroxidecontaminated loess during dry-wet cycles decreases with increasing contaminant concentration,which is mainly attributed to the thickening of the electrical double layer(EDL)by Nat and the precipitation of calcite,as well as the formation of colloidal flocs induced by OH,thus inhibiting the development of large pores during the dry-wet process.In contrast,the attenuation of mechanical properties of both acetic acid-and sodium sulfate-contaminated loess becomes more severe with increasing contaminant concentration,with the latter being more particularly significant.This is primarily due to the reduction of the EDL thickness and the erosion of cement in the acidic environment,which facilitates the connectivity of pores during dry-wet cycles.Furthermore,the salt expansion generated by the drying process of saline loess further intensifies the structural disturbance.Consequently,the mechanical performance of compacted loess is sensitive to both pollutant type and concentration,exhibiting different response patterns in the dry-wet cycling condition.
文摘The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037.
基金the Key Laboratory of Intelligent Health Perception and Lakes,Ministry of Education,Hubei University of Technology(No.2020EJB004)National Natural Science Foundation of China(No.51508171)Natural Science Foundation of Hubei Province(No.2020CFB860).
文摘Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of different low-temperaturecycles (20°C, –80°C, and −160°C) and concrete specimen crack widths (0, 0.3, and 0.6 mm) on the Cl−ion diffusion performance through rapid erosion tests conducted on pre-cracked concrete. The results show thatthe minimum temperature and crack width of freeze-thaw cycles enhance the erosive effect of chloride ions. TheCl− ion concentration and growth rate increased with the increasing crack width. Based on the experimental modeland in accordance with Fick’s second law of diffusion, the Cl− ion diffusion equation was modified by introducingcorrection factors in consideration of the freeze-thaw temperature, crack width, and their coupling effect.The experimental and fitting results obtained from this model can provide excellent reference for practical engineeringapplications.
基金financially supported by the National Natural Science Foundation of China(42177166).
文摘Sandstone is the fundamental material in various engineering and construction projects.However,the mechanical integrity of sandstone can be compromised by initial unloading damage resulting from activities such as engineering excavations.Furthermore,this degradation is further exacerbated under periodic dry-wet environmental conditions.This study investigated the effects of dry-wet cycles and unloading on the mechanical properties of jointed fine sandstone using uniaxial and triaxial compression tests.These tests were performed on rock samples subjected to varying unloading degrees and different numbers of dry-wet cycles.The results demonstrate that with an increase in the unloading degree from 0%to 70%,there is a corresponding decrease in peak stress ranging from 10%to 33%.Additionally,the cohesion exhibits a reduction of approximately 20%to 25%,while the internal friction angle experiences a decline of about 3.5%to 6%.These findings emphasize a significant unloading effect.Moreover,the degree of peak stress degradation in unloading jointed fine sandstone diminishes with an increase in confining pressure,suggesting that confining pressure mitigates the deterioration caused by dry-wet cycles.Additionally,as the number of dry-wet cycles increases,there is a notable decline in the mechanical properties of the sandstone,evidencing significant dry-wet degradation.Utilizing the Drucker Prager criterion,this study establishes a strength criterion and fracture criterion,denoted as σ_(1)(m,n) and K_(T)^(Ⅱ)(m, n), to quantify the combined impacts of dry-wet cycles and unloading on jointed fine sandstone,which provides a comprehensive understanding of its mechanical behavior under such conditions.
基金Funded by the National Key Research and Development Program of China(No.2023YFB260012602)the Shandong Provincial Natural Science Foundation(No.ZR2023ME208)。
文摘To investigate the freeze-thaw(F-T)damages and failure characteristics of rock mass with arc-shaped joints in cold regions,three types of cement mortar specimens with different central angles and prefabricated arc-shaped flaws are subjected to uniaxial compressive tests under different F-T cycles.Experimental observations show that the uniaxial compressive strength of specimens are significantly influenced by F-T cycles and their failure modes are mainly affected by the central angleαof the prefabricated flaws.Unlike the specimens with a central angle of 60°,the specimens with a central angle of 120°and 180°have greater curvature of flaws,so tensile cracks occur in the arc-top area of their prefabricated flaws.According to experimental images observed by environmental scanning electron microscope(ESEM),as the number of F-T cycles increases,the deterioration effect of the specimen becomes more obvious,which is specifically reflected in the increase of the mass loss,peak stress loss,and damage variables as a power function,and the peak strain decreases as a quadratic polynomial.According to numerical results using two-dimensional particle flow code(PFC2D),it is found that F-T cycles cause more damage to the specimen in the early stages than in the later ones.The area of the concentrated compressive stress zone in the middle is decreased due to the increased number of F-T cycles,while the area of the surrounding tensile-shear stress zone is increased.The models appear different failure modes due to the release of concentrated stress in different tensile-shear zones.
基金co-funded by the National Natural Science Foundation of China(U204020742277323)+2 种基金the 111 Project of Hubei Province(2021EJD026)the open fund of Key Laboratory of Geological Hazards on Three Gorges Reservoir Area(China Three Gorges University)Ministry of Education(2022KDZ24).
文摘Soil aggregate is the basic structural unit of soil,which is the foundation for supporting ecosystem functions,while its composition and stability is significantly affected by the external environment.This study was conducted to explore the effect of external environment(wetting-drying cycles and acidic conditions)on the soil aggregate distribution and stability and identify the key soil physicochemical factors that affect the soil aggregate stability.The yellow‒brown soil from the Three Gorges Reservoir area(TGRA)was used,and 8 wetting-drying conditions(0,1,2,3,4,5,10 and 15 cycles)were simulated under 4 acidic conditions(pH=3,4,5 and 7).The particle size distribution and soil aggregate stability were determined by wet sieving method,the contribution of environmental factors(acid condition,wetting-drying cycle and their combined action)to the soil aggregate stability was clarified and the key soil physicochemical factors that affect the soil aggregate stability under wetting-drying cycles and acidic conditions were determined by using the Pearson’s correlation analysis,Partial least squares path modeling(PLS‒PM)and multiple linear regression analysis.The results indicate that wetting-drying cycles and acidic conditions have significant effects on the stability of soil aggregates,the soil aggregate stability gradually decreases with increasing number of wetting-drying cycles and it obviously decreases with the increase of acidity.Moreover,the combination of wetting-drying cycles and acidic conditions aggravate the reduction in the soil aggregate stability.The wetting-drying cycles,acidic conditions and their combined effect imposes significant impact on the soil aggregate stability,and the wetting-drying cycles exert the greatest influence.The soil aggregate stability is significantly correlated with the pH,Ca^(2+),Mg^(2+),maximum disintegration index(MDI)and soil bulk density(SBD).The PLS‒PM and multiple linear regression analysis further reveal that the soil aggregate stability is primarily influenced by SBD,Ca^(2+),and MDI.These results offer a scientific basis for understanding the soil aggregate breakdown mechanism and are helpful for clarifying the coupled effect of wetting-drying cycles and acid rain on terrestrial ecosystems in the TGRA.
文摘The rotation of the Earth and the related length of the day (LOD) are predominantly affected by tidal dissipation through the Moon and the growth of the Earth’s core. Due to the increased concentration of mass around the rotation axis of the spinning Earth during the growth of the core the rotation should have been accelerated. Controversially the tidal dissipation by the Moon, which is mainly dependent on the availability of open shallow seas and the kind of Moon escape from a nearby position, acts towards a deceleration of the rotating Earth. Measurements of LOD for Phanerozoic and Precambrian times open ways to solve questions concerning the geodynamical history of the Earth. These measurements encompass investigations of growth patterns in fossils and depositional patterns in sediments (Cyclostratigraphy, Tidalites, Stromatolites, Rhythmites). These patterns contain information on the LOD and on the changing distance between Earth and Moon and can be used as well for a discussion about the growth of the Earth’s core. By updating an older paper with its simple approach as well as incorporating newly published results provided by the geoscientific community, a moderate to fast growth of the core in a hot early Earth will be favored controversially to the assumption of a delayed development of the core in an originally cold Earth. Core development with acceleration of Earth’s rotation and the contemporaneous slowing down due to tidal dissipation during the filling of the ocean may significantly interrelate.
基金supported by the National Natural Science Foundation of China(Grant nos.42176240 and 42101142).
文摘Zinc(Zn),a widespread metal in the Earth’s crust,serves as a crucial nutrient in the Southern Ocean’s primary production.Studies on Zn in Antarctic snow and ice offer insights into the origins of this metal and its transport routes,as well as its impact on the biogeochemical processes within the Antarctic atmosphere–land–ocean system.This review examines research on the spatial and temporal distribution of Zn in Antarctic snow and ice,as well as in Southern Ocean waters.It includes an overview of advanced methods for sampling and analyzing Zn,along with explanations for the observed variations.The review also discusses various sources of Zn as a nutrient to the Southern Ocean.Finally,it addresses prospective issues related to the use of Zn isotopes in identifying atmospheric sources and their biogeochemical effects on the development of the Southern Ocean ecosystem.
基金the National Natural Science Foundation of China(Nos.52374147,42372328,and U23B2091)National Key Research and Development Program of China(No.2023YFC3804200)Xinjiang Uygur Autonomous Region Science and Technology Major Program(No.2023A01002).
文摘Underground pumped storage power plant(UPSP)is an innovative concept for space recycling of abandoned mines.Its realization requires better understanding of the dynamic performance and durability of reservoir rock.This paper conducted ultrasonic detection,split Hopkinson pressure bar(SHPB)impact,mercury intrusion porosimetry(MIP),and backscatter electron observation(BSE)tests to investigate the dynamical behaviour and microstructure of sandstone with cyclical dry-wet damage.A coupling FEM-DEM model was constructed for reappearing mesoscopic structure damage.The results show that dry-wet cycles decrease the dynamic compressive strength(DCS)with a maximum reduction of 39.40%,the elastic limit strength is reduced from 41.75 to 25.62 MPa.The sieved fragments obtain the highest crack growth rate during the 23rd dry-wet cycle with a predictable life of 25 cycles for each rock particle.The pore fractal features of the macropores and micro-meso pores show great differences between the early and late cycles,which verifies the computational statistics analysis of particle deterioration.The numerical results show that the failure patterns are governed by the strain in pre-peak stage and the shear cracks are dominant.The dry-wet cycles reduce the energy transfer efficiency and lead to the discretization of force chain and crack fields.
文摘This paper explores the existence of heteroclinic cycles and corresponding chaotic dynamics in a class of 3-dimensional two-zone piecewise affine systems. Moreover, the heteroclinic cycles connect two saddle foci and intersect the switching manifold at two points and the switching manifold is composed of two perpendicular planes.
文摘By analysing a long series of data (1996-2019), we show that solar cycle 23 was more marked by violent solar flares and coronal mass ejections (CMEs) compared to solar cycle 24. In particular, the halo coronal mass ejections associated with X-class flares appear to be among the most energetic events in solar activity given the size of the flares, the speed of the CMEs and the intense geomagnetic storms they produce. Out of eighty-six (86) X-class halo CMEs, thirty-seven (37) or 43% are highly geoeffective;twenty-four (24) or approximately 28% are moderately geoeffective and twenty-five (25) or 29% are not geoeffective. Over the two solar cycles (1996 to 2019), 71% of storms were geoeffective and 29% were not. For solar cycle 23, about 78% of storms were geoeffective, while for solar cycle 24, about 56% were geoeffective. For the statistical study based on speed, 85 halo CMEs associated with X-class flares were selected because the CME of 6 December 2006 has no recorded speed value. For both solar cycles, 75.29% of the halo CMEs associated with X-class flares have a speed greater than 1000 km/s. The study showed that 42.18% of halo (X) CMEs with speeds above 1000 km/s could cause intense geomagnetic disturbances. These results show the contribution (in terms of speed) of each class of halo (X) CMEs to the perturbation of the Earth’s magnetic field. Coronal mass ejections then become one of the key indicators of solar activity, especially as they affect the Earth.
文摘Economic cycles are not economic evils but rather healing agents for returning to equilibrium,just as inflation and deflation are not economic misfortunes but the sign of bad governance and a bitter medicine for returning to calm monetary.Unfortunately,signs of poor governance are mistaken for unfortunate events,but are instead tools offered to restore economic systems.Politics seeks consensus and does not accept the bitter cure of recession.Monetary policy is therefore called into question even if monetary anomalies also depend on errors in the management of the economy;the result is the gradual increase in interest rates.Is the idea that we can achieve the goal of complete neutrality with nature acceptable in a global economic framework pervaded by inflation and denunciation?Can we similarly argue that economic problems can coexist once the goal of neutrality has been achieved?The answer is negative.We must correct these anomalies and dysfunctions of the economy,which cannot coexist in the new context of complete and indefinite equilibrium of tomorrow.And not even the idea that conflicts can be resolved with war seems to find a place in the renewed scenario of neutrality.In this regard we can remember that,when we have reached the economic optimum of complete neutrality,or at least we are close to it,the most socially and economically advanced territories and continents will benefit from an acceleration of productivity and development.Scarcity itself will give way to the new,long-awaited reality.A condition that approaches the state of abundance and which will produce surpluses to be allocated to countries and territories that are struggling towards the condition of neutrality.The acceleration of lagging continents and the recovery of altered economic systems are therefore preconditions that can allow us to access the state of global neutrality.As we get closer to the great objective,it is to be believed that the pretense of regulating conflicts through war will also disappear.With the new reality of abundance,the economic reason for war disappears,while the aspiration of peoples-inscribed in their DNA-for solidarity and peaceful aggregation towards substantial unity becomes clear.
文摘The Total Coloring Conjecture (TCC) proposes that every simple graph G is (Δ + 2)-totally-colorable, where Δ is the maximum degree of G. For planar graph, TCC is open only in case Δ = 6. In this paper, we prove that TCC holds for planar graph with Δ = 6 and every 7-cycle contains at most two chords.
基金supported by grants from the National Natural Science Foundation of China(No.81872375 and 82172863)the Natural Science Foundation of Guangdong Province(No.2021A1515010118).
文摘objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively.
基金the National Natural Science Foundation of China (NSFC)(Grant Nos.U22A20596 and 41771066)the Science and Technology Project of Qinghai-Tibet Railway Company (QZ2021-G03)。
文摘As a widely-applied engineering material in cold regions, the frozen subgrade soils are usually subjected to seismic loading, which are also dramatically influenced by the freeze-thaw(F-T)cycles due to the varying temperature. A series of dynamic cyclic triaxial experiments were conducted through a cryogenic triaxial apparatus for exploring the influences of F-T cycles on the dynamic mechanical properties of frozen subgrade clay.According to the experimental results of frozen clay at the temperature of-10℃, the dynamic responses and microstructure variation at different times of F-T cycles(0, 1, 5, and 20 cycles) were explored in detail.It is experimentally demonstrated that the dynamic stress-strain curves and dynamic volumetric strain curves of frozen clay are significantly sparse after 20F-T cycles. Meanwhile, the cyclic number at failure(Nf) of the frozen specimen reduces by 89% after 20freeze-thaw cycles at a low ratio of the dynamic stress amplitude. In addition, with the increasing F-T cycles,the axial accumulative strain, residual deformation,and the value of damage variable of frozen clay increase, while the dynamic resilient modulus and dynamic strength decrease. Finally, the influence of the F-T cycles on the failure mechanisms of frozen clay was discussed in terms of the microstructure variation. These studies contribute to a better understanding of the fundamental changes in the dynamic mechanical of frozen soils exposed to F-T cycles in cold and seismic regions.