In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic sys...In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic system that fulfills the requisite specifications should be designed.The AMESim software model is employed to construct a closed hydraulic transmission system,and the simulation analysis is then performed according to the data of hydraulic components.According to analysis results,the prototype can be optimized and upgraded,and a verification test is further carried out.The test results demonstrate that the designed closed hydraulic transmission system meets the actual working requirements of the high-clearance wheeled sprayer and provides a stable experimental platform for intelligent control of agricultural machinery.展开更多
Background Childhood absence epilepsy (CAE) is one of the most frequently recognized syndromes among the idiopathic generalized epilepsies (IGEs). CAE is considered to be a genetic disease, with a possible polygenic ...Background Childhood absence epilepsy (CAE) is one of the most frequently recognized syndromes among the idiopathic generalized epilepsies (IGEs). CAE is considered to be a genetic disease, with a possible polygenic inheritance pattern. The genes responsible for CAE have not been identified yet. The object of this study was to investigate whether or not CAE is associated with the gene encoding the gamma-aminobutyric acid (GABA) type-A receptor subunits α5 (GABRA5) and β3 (GABRB3) in a Chinese population. Methods Five microsatellite DNA repeats, 69CA, 85CA, 155CA1, 155CA2, and A55CA1, adjoining chromosome 15q11-q13, were used as genetic markers. Both case-control study and transmission/disequilibrium tests (TDTs), as well as fluorescence-based semi-automated genotyping techniques, were used in 90 CAE patient-mother-father trios and 100 normal controls of Han ethnicity to conduct association analysis. Results The frequencies of allele 5 of 69CA, alleles 2 and 8 of 85CA, alleles 6 and 7 of 155CA1, allele 2 of 155CA2, and alleles 1 and 11 of A55CA1 were significantly higher in CAE patients than in normal controls. To prevent spurious associations arising from population admixture, we further conducted TDT tests in the 90 CAE trios. The results of TDT analysis further suggested that microsatellite DNA repeats 85CA, 155CA1, and 155CA2 were associated with CAE.Conclusions GABA type-A receptor subunit genes GABRA5 and GABRB3 may be either directly involved in the etiology of CAE in the Chinese population or in linkage disequilibrium with disease-predisposing sites.展开更多
To realize automatic control of automobile transmission performance test stand Methods The automatic control technique of the lubricant temperature,the program- controll- edautomaticshifting of the transmission,the c...To realize automatic control of automobile transmission performance test stand Methods The automatic control technique of the lubricant temperature,the program- controll- edautomaticshifting of the transmission,the continuous adjusting of revolution speed and load, data-acquisition and data real-time processing were adopted.Results The lubricant temperature was controlled at the set temperature ±2℃.The automatic shifting of the trans- mission is simple,reliable and accurate.The automatic adjusting of load and rotation speed is rapidandaccurate,the torque divergence is ±1N·m,the rotation speed divergence is ±5r/min Conclusion The four kinds of techniques are applied into the automobile transmission perfor- mance test stand successfully. mancetest stand successfully.展开更多
With a transmission system suitable for a medium or large self-propelled cotton picker as the object of the study,the following work focuses on the influence law of an independently designed hydro-mechanical continuou...With a transmission system suitable for a medium or large self-propelled cotton picker as the object of the study,the following work focuses on the influence law of an independently designed hydro-mechanical continuously variable transmission(HMCVT)in the process of changing sections.An HMCVT simulation model was established using the multibody dynamics Simulation X software.The accuracy of the simulation model was verified by comparing the numerical values of the output speed of the HMCVT with model predictions.The HMCVT test bench was built independently using a John Deere 4045HYC11 diesel engine as power input.The engine speed,load torque,oil pressure,and flow of speed regulating valve were considered the influencing factors.The sliding friction power was the response index for the segment change process test.We analysed the reasons for the decrease in output speed during the shifting process,and proposed to effectively reduce the stable speed difference before and after the output shaft shifting by shifting the stage ahead(with displacement ratio of-0.96).This study provides a reference value for the smoothness of the HMCVT of the self-propelled cotton picker,and is relevant in promoting the use of the cotton picker.展开更多
Transmission disequilibrium test (TDT) is a popular family based genetic association method. Under multiplicative assumption, a conditional logistic regression for matched pair, affected offspring with allele transmit...Transmission disequilibrium test (TDT) is a popular family based genetic association method. Under multiplicative assumption, a conditional logistic regression for matched pair, affected offspring with allele transmitted from parents and pseudo-offspring (control) with allele non-transmitted from parents, was built to detect the <span style="font-family:Verdana;">main </span><span style="font-family:Verdana;">effects of genes and gene-covariate interaction</span><span style="font-family:Verdana;">s</span><span style="font-family:;" "=""><span style="font-family:Verdana;">. When there exist genotype uncertainties, expectation-maximization (EM) algorithm was adopted to estimate the coefficients. The transmission model was applied to detect the association between M235T polymorphism in AGT gene and essential hypertension (ESH). Most of parents are not available in the 126 families from HongKong Chinese population. The results </span><span style="font-family:Verdana;">showed M235T is associat</span></span><span style="font-family:Verdana;">ed</span><span style="font-family:Verdana;"> with hypertension and there is interaction between M235T and the case’s sex. The allele T is higher risk for male than female</span><span style="font-family:Verdana;">.</span>展开更多
Based on the experience of environmental acceptance tests for power transmission projects, the problems found in acceptance tests and the system shortcomings of acceptance test itself are analyzed. Recommendations are...Based on the experience of environmental acceptance tests for power transmission projects, the problems found in acceptance tests and the system shortcomings of acceptance test itself are analyzed. Recommendations are provided to improve the future work.展开更多
Holding the greatest power transmission capacity in China, Three Gorges power transmission and substation (T&S) project is an important landmark in the
In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perfor...In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perforated thin Plexiglas plates of various porosities. The plate is placed perpendicular to the flume with the height from the flume bottom to the position above water surface. With this thin wall in the flume wave overtopping is prohibited and incident waves are able to transmit. The porosities of the walls are achieved by perforating the plates with circular holes. Model settings with double perforated walls parallel to each other forming so called chamber system, have been also examined. Several parameters have been used for correlating the laboratory tests’ results. Experimental data are also compared with results from the numerical model by applying the multi-domain boundary element method (MDBEM) with linear wave theory. Wave energy dissipation due to the perforations of the thin wall has been represented by a simple yet effective porosity parameter in the model. The numerical model with the MDBEM has been further validated against the previously published data.展开更多
For the purpose of engineering development for a new 8-step speed automatic transmission,a simplified dynamic model for this gearbox was established and key parameters which affected the shift quality were analyzed.Ai...For the purpose of engineering development for a new 8-step speed automatic transmission,a simplified dynamic model for this gearbox was established and key parameters which affected the shift quality were analyzed.Aiming at four different shift types,the ideal characteristics of shift clutch and engine control were set up.By using torque estimation method,PI slip control algorithm and engine coordinated control principle,the control model and transmission controller were well developed for three shift phases which included rapid-fill phase,torque phase and inertia phase.The testing environment on the rig and prototype vehicle level was built and the testing results obtained in ultimate condition could verify the accuracy and feasibility of this shift control strategy.The peak jerk during shift process was controlled within ±2 g/s where the smooth gearshift was obtained.The development proposal and algorithm have a high value for engineering application.展开更多
Application of weathering and cold-formed steel in transmission lines can reduce steel consumption and environmental pollution. Some advances in the studies on the weathering and cold-formed steel in transmission towe...Application of weathering and cold-formed steel in transmission lines can reduce steel consumption and environmental pollution. Some advances in the studies on the weathering and cold-formed steel in transmission tower are introduced. Firstly, corrosion-resistant tests of weathering steel samples under different simulating technical atmospheres were carried out separately for 240 hours. It shows that the corrosion degree of joint samples is higher than that of single chip samples, and the corrosion-resistant performance of weathering steel is superior to common carbon steel. The corrosion-resistance of weathering steel meets with the requirement of transmission tower. Secondly, experiments and finite element analysis for cold-formed angles and a 220kV prototype tower were completed, and the stability coeffi-cient fitting curves as well as the modification formulas of slenderness ratio for cold-formed members were determined. According to the structural characteristics of transmission towers, four sections of cold-formed angles with different sections and slenderness ratios were selected in this study. The finite element model well predicted the buckling behav-iour of the cold-formed members. Ultimate loads calculating by the fitting curve were well agreed to the experimental values, especially for the members with small slenderness ratios. Weight of the cold-formed steel tower can be reduced by more than 5 percent after considering the strength enhancement. Cost of the weathering and cold-formed steel transmission tower is nearly equivalent to that of hot-rolled steel tower with hot galvanizing.展开更多
To evaluate maternal hepatitis B virus (HBV) DNA as risk for perinatal HBV infection among infants of HBV-infected women in California. METHODSRetrospective analysis among infants born to hepatitis B surface antigen (...To evaluate maternal hepatitis B virus (HBV) DNA as risk for perinatal HBV infection among infants of HBV-infected women in California. METHODSRetrospective analysis among infants born to hepatitis B surface antigen (HBsAg)-positive mothers who received post vaccination serologic testing (PVST) between 2005 and 2011 in California. Demographic information was collected from the California Department of Public Health Perinatal Hepatitis B Program databaseand matched to birth certificate records. HBV DNA level and hepatitis B e antigen (HBeAg) status were obtained from three large commercial laboratories in California and provider records if available and matched to mother infant pairs. Univariate analysis compared infected and uninfected infants. Multivariate analysis was restricted to infected infants and controls with complete maternal HBV DNA results using a predefined high HBV DNA level of > 2 × 10<sup>7</sup> IU/mL, a 5:1 ratio of cases to controls and a two-sided confidence level of 95%. RESULTSA total of 17687 infants were born to HBsAg positive mothers in California between Jan 1 2005 and Dec 31, 2011. Among 11473 infants with PVST, only 125 (1.1%) were found to be HBV infected. Among these infected infants, lapses in Advisory Committee on Immunization Practices recommended post exposure prophylaxis (PEP) occurred in only 9 infants. However, PEP errors were not significantly different between infected and uninfected infants. Among the 347 uninfected and infected infants who had maternal HBeAg and HBV DNA level, case-control analysis found HBeAg positivity (70.4% vs 28.9%, OR = 46.76, 95%CI: 6.05-361.32, P < 0.001) and a maternal HBV DNA level ≥ 2 × 10<sup>7</sup> IU/mL (92.6% vs 18.5%, OR = 54.5, 95%CI: 12.22-247.55, P < 0.001) were associated with perinatal HBV infection. In multivariate logistic regression, maternal HBV DNA level ≥ 2 × 10<sup>7</sup> IU/mL was the only significant independent predictor of perinatal HBV infection. CONCLUSIONIn California, transmission is low and most infected infants receive appropriate PEP and vaccination. Maternal HBV DNA ≥ 2 × 10<sup>7</sup> IU/mL is associated with high risk of perinatal infection.展开更多
BACKGROUND: Increasing evidence suggests overlapped genetic susceptibility across traditional classification systems that divided psychotic disorders into schizophrenia or affective disorder. OBJECTIVE: This study a...BACKGROUND: Increasing evidence suggests overlapped genetic susceptibility across traditional classification systems that divided psychotic disorders into schizophrenia or affective disorder. OBJECTIVE: This study aimed to explore whether schizophrenia and affective disorder share genetic susceptibility in NOTCH4 and GRIK2 loci in a population of Han Chinese. DESIGN: Repetitive measurements. SETTING: The experiment was carried out at Shanghai Mental Health Center and Hongkou Mental Health Center of Shanghai between January 2001 and June 2004. PARTICIPANTS: Sixty-five mixed pedigrees (suffering from various diseases, in combination with schizophrenia and affective disorder), composed of 45 completed trios and 20 single-parent families, were selected from Shanghai Mental Health Center and Hongkou Mental Health Center of Shanghai between January 2001 and June 2004. Probands received clinical diagnosis according to ICD-10; an independent clinician used identical criteria to review all diagnoses. All subjects were Han Chinese in origin and provided informed consent. There were 65 probands and 110 parents among the subjects. The probands comprised 30 males and 35 females: 33 with schizophrenia, 32 with affective disorder, mean age of (30.9 ± 9.8) years, mean age of onset (24.3 ± 8.8) years, mean duration (6.6 ± 7.0) years, and mean age of parents (58.8 ±10.9) years. METHODS: DNA samples from probands and their biological parents were extracted from peripheral blood according to standard methods. Four polymorphisms, -1725T/G and -25T/C in NOTCH4, rs6922753T/C and rs2227283G/A in GRIK2, were amplified and genotyped with PCR-RFLP techniques. MAIN OUTCOME MEASURES: Association between NOTCH4, GRIK2 polymorphism, and schizophrenia was analyzed by transmission disequilibrium test (TDT). RESULTS: Sixty-five probands and 110 parents were included in the result analysis, with no dropouts. The results showed that the -25T/C polymorphism of NOTCH4 associated significantly with affective disorder and -1725G/-25T haplotype with schizophrenia. SNP rs6922753 of GRIK2 did not associate with the two diseases; SNP rs2227283 and haplotypes, TG and CA, were significantly associated with both diseases. CONCLUSION: Schizophrenia and affective disorder might share genetic susceptibility among mixed pedigrees of the Han Chinese population. NOTCH4 and GRIK2 might be two of the most common susceptibility genes for these psychoses.展开更多
Exact simulation of the acoustic performance is essential to the engineering application for a vehicle intake system. The rectangular-pulse method based on the computational fluid dynamics approach was employed for ca...Exact simulation of the acoustic performance is essential to the engineering application for a vehicle intake system. The rectangular-pulse method based on the computational fluid dynamics approach was employed for calculating the transmission loss. Firstly, the transmission loss of the single-cavity element was simulated without any airflow, and the effects of different structural parameters on the acoustic performance were investigated comprehensively. Secondly, the static transmission loss of the perforated intake pipe was obtained by the rectangular-pulse method, which is proved to be accurate enough compared with the result by finite element method. Thirdly, under the different conditions of the mean airflow and the operating temperature, the specific transmission loss was acquired respectively. In general, the peaks of the transmission loss are shifted to the lower frequency range because of the reverse airflow, but the amplitudes are irregularly changed. Besides, when the operating temperature increases, the peaks are shifted to the higher frequencies. Finally, with the designed perforated pipe installed to the intake system, the road tests were proceeded to evaluate the actual acoustic performance, and the result indicates that the intake sound pressure level is greatly attenuated. Typically in the range of 600–1500 Hz, the insertion loss of the intake noise at the decelerating moment is almost 20 d B(A), and the overall noise is reduced more than 14.2 d B(A). In conclusion, the perforated intake pipe has been proved excellent in improving the acoustic performance of intake system and could provide the guidance for the automotive engineering application.展开更多
The transmission ratio along the radian direction normal to the joints was studied in the Universal Distinct Element Code (UDEC). The variation of the transmission ratio with the ratio of joint spacing to wavelength...The transmission ratio along the radian direction normal to the joints was studied in the Universal Distinct Element Code (UDEC). The variation of the transmission ratio with the ratio of joint spacing to wavelength was generalized into a general curve, which was determined by two critical points. The relationship between the two critical points and the affecting factors, quantity of joints and the normalized normal stiffness of joints, were obtained. A prediction model of the transmission ratio in the radian direction normal to the joints was proposed. The proposed model was applied to a field explosion test. The estimated values of the peak particle velocity from the prediction model were compared with the field records. The comparisons showed that the prediction model of the transmission ratio in the direction normal to the joints in the process of 2-D compressional wave propagation through multiple parallel joints is reliable.展开更多
In this article, using the likelihood score theory extended to nuisance parameters we derive a new homogeneity score test for comparing linkage disequilibrium across several strata. Power and sample size formulae are...In this article, using the likelihood score theory extended to nuisance parameters we derive a new homogeneity score test for comparing linkage disequilibrium across several strata. Power and sample size formulae are also obtained.展开更多
During the last few decades, photothermal radiometry(PTR) has been greatly developed and widely applied in the field of nondestructive testing. However, the traditional PTR system employs an expensive lock-in amplif...During the last few decades, photothermal radiometry(PTR) has been greatly developed and widely applied in the field of nondestructive testing. However, the traditional PTR system employs an expensive lock-in amplifier to detect the weak photothermal signal, which leads to high cost and long test time. In this paper, a fast transmission PTR system based on sampling by using an internal computer sound card was developed to lower the system cost and shorter the test time. A piece of amorphous silicon(a:Si) thin film solar cells with artificial defects was prepared and tested by the system. The results show that the sharpened defects can be identified easily and quickly according to the significant peaks of the original infrared signal sampled by the internal computer sound card. Furthermore, more detailed defects can be investigated by processing the infrared signal. These validate the effectiveness of the proposed transmission PTR system as a low cost and efficient non-destructive test technique.展开更多
With an advanced foreign hydraulic automatic transmission as the objective,an analytical method for the gear-shifting schedule is proposed.First the demanded maximum gradient of test is estimated.Then a test scheme an...With an advanced foreign hydraulic automatic transmission as the objective,an analytical method for the gear-shifting schedule is proposed.First the demanded maximum gradient of test is estimated.Then a test scheme and analytical procedure is formulated by initial test and hypothetical shift parameters.Finally through gear-shifting tests under different road conditions,load,accelerator pedal position limitation,throttle opening and output shaft speed are found to be the gear-shifting parameters.Under a common road condition,the gear-shifting schedule is a double-parameter schedule.Based on the driver's demands on braking and dynamic performance,different shift schedules are made under downhill,uphill and quick releasing acceleration pedal conditions.The operation criteria of down-shift schedule on abrupt grade are proposed.展开更多
The UHVAC 1 000-kV transmission system is so far the one with the most advanced transmission technique applied and highest operation voltage.There are no guidelines or standards available for the design of 1 000-kV ov...The UHVAC 1 000-kV transmission system is so far the one with the most advanced transmission technique applied and highest operation voltage.There are no guidelines or standards available for the design of 1 000-kV overhead transmission line in China.Study on key technologies and design schemes shall be carried out to ascertain the technical principles and construction standards for project construction,which are presented in this paper based on the Southeast Shanxi-Nanyang-Jingmen test and demonstration transmission line.A comparison and analysis of technical data and economic indices between UHV line and other lines are also described.展开更多
In the present paper the main results of the pre-operational studies related to the energization maneuver of a Half-Wavelength Transmission Line (AC-Link), are presented. The simulations were performed in PSCAD with a...In the present paper the main results of the pre-operational studies related to the energization maneuver of a Half-Wavelength Transmission Line (AC-Link), are presented. The simulations were performed in PSCAD with actual Brazilian system data. Specifically the following studies were performed: electromagnetic transient studies of energization maneuver considering no fault and the occurrence of fault along the trunk;dynamic analysis of generator units that will energize the AC-Link;TRV on the circuit-breaker that will energize the trunk. The main conclusion is that the AC-Link energization experiment can be implemented without jeopardizing or causing time-life reduction of the equipment involved in the experiment, which comprises the generator unit that will energize the trunk, the step-up transformer, the arresters that will be kept during the experiments, as well as the circuit-breaker that will energize and then trip the AC-Link.展开更多
基金Supported by 2023 Xinjiang Uygur Autonomous Region R&D and Promotion and Application of Key Technologies of CNC Sprayer for Seed Corn(2023NC010).
文摘In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic system that fulfills the requisite specifications should be designed.The AMESim software model is employed to construct a closed hydraulic transmission system,and the simulation analysis is then performed according to the data of hydraulic components.According to analysis results,the prototype can be optimized and upgraded,and a verification test is further carried out.The test results demonstrate that the designed closed hydraulic transmission system meets the actual working requirements of the high-clearance wheeled sprayer and provides a stable experimental platform for intelligent control of agricultural machinery.
基金ThisresearchwassupportedbygrantsfromtheBeijingNaturalScienceFoundation (No 70 0 10 0 3 ) theHumanDiseaseGeneCenterofthePekingUniversityFoundation (No 2 0 0 0 A 8) theBeijingMunicipalCommissionforScience&Technology (No H0 10 2 10 2 3 0 119)
文摘Background Childhood absence epilepsy (CAE) is one of the most frequently recognized syndromes among the idiopathic generalized epilepsies (IGEs). CAE is considered to be a genetic disease, with a possible polygenic inheritance pattern. The genes responsible for CAE have not been identified yet. The object of this study was to investigate whether or not CAE is associated with the gene encoding the gamma-aminobutyric acid (GABA) type-A receptor subunits α5 (GABRA5) and β3 (GABRB3) in a Chinese population. Methods Five microsatellite DNA repeats, 69CA, 85CA, 155CA1, 155CA2, and A55CA1, adjoining chromosome 15q11-q13, were used as genetic markers. Both case-control study and transmission/disequilibrium tests (TDTs), as well as fluorescence-based semi-automated genotyping techniques, were used in 90 CAE patient-mother-father trios and 100 normal controls of Han ethnicity to conduct association analysis. Results The frequencies of allele 5 of 69CA, alleles 2 and 8 of 85CA, alleles 6 and 7 of 155CA1, allele 2 of 155CA2, and alleles 1 and 11 of A55CA1 were significantly higher in CAE patients than in normal controls. To prevent spurious associations arising from population admixture, we further conducted TDT tests in the 90 CAE trios. The results of TDT analysis further suggested that microsatellite DNA repeats 85CA, 155CA1, and 155CA2 were associated with CAE.Conclusions GABA type-A receptor subunit genes GABRA5 and GABRB3 may be either directly involved in the etiology of CAE in the Chinese population or in linkage disequilibrium with disease-predisposing sites.
文摘To realize automatic control of automobile transmission performance test stand Methods The automatic control technique of the lubricant temperature,the program- controll- edautomaticshifting of the transmission,the continuous adjusting of revolution speed and load, data-acquisition and data real-time processing were adopted.Results The lubricant temperature was controlled at the set temperature ±2℃.The automatic shifting of the trans- mission is simple,reliable and accurate.The automatic adjusting of load and rotation speed is rapidandaccurate,the torque divergence is ±1N·m,the rotation speed divergence is ±5r/min Conclusion The four kinds of techniques are applied into the automobile transmission perfor- mance test stand successfully. mancetest stand successfully.
基金Supported by the National Natural Science Foundation of China(51665051)the Autonomous Region Graduate Innovation Project of China(XJ2019G112)。
文摘With a transmission system suitable for a medium or large self-propelled cotton picker as the object of the study,the following work focuses on the influence law of an independently designed hydro-mechanical continuously variable transmission(HMCVT)in the process of changing sections.An HMCVT simulation model was established using the multibody dynamics Simulation X software.The accuracy of the simulation model was verified by comparing the numerical values of the output speed of the HMCVT with model predictions.The HMCVT test bench was built independently using a John Deere 4045HYC11 diesel engine as power input.The engine speed,load torque,oil pressure,and flow of speed regulating valve were considered the influencing factors.The sliding friction power was the response index for the segment change process test.We analysed the reasons for the decrease in output speed during the shifting process,and proposed to effectively reduce the stable speed difference before and after the output shaft shifting by shifting the stage ahead(with displacement ratio of-0.96).This study provides a reference value for the smoothness of the HMCVT of the self-propelled cotton picker,and is relevant in promoting the use of the cotton picker.
文摘Transmission disequilibrium test (TDT) is a popular family based genetic association method. Under multiplicative assumption, a conditional logistic regression for matched pair, affected offspring with allele transmitted from parents and pseudo-offspring (control) with allele non-transmitted from parents, was built to detect the <span style="font-family:Verdana;">main </span><span style="font-family:Verdana;">effects of genes and gene-covariate interaction</span><span style="font-family:Verdana;">s</span><span style="font-family:;" "=""><span style="font-family:Verdana;">. When there exist genotype uncertainties, expectation-maximization (EM) algorithm was adopted to estimate the coefficients. The transmission model was applied to detect the association between M235T polymorphism in AGT gene and essential hypertension (ESH). Most of parents are not available in the 126 families from HongKong Chinese population. The results </span><span style="font-family:Verdana;">showed M235T is associat</span></span><span style="font-family:Verdana;">ed</span><span style="font-family:Verdana;"> with hypertension and there is interaction between M235T and the case’s sex. The allele T is higher risk for male than female</span><span style="font-family:Verdana;">.</span>
文摘Based on the experience of environmental acceptance tests for power transmission projects, the problems found in acceptance tests and the system shortcomings of acceptance test itself are analyzed. Recommendations are provided to improve the future work.
文摘Holding the greatest power transmission capacity in China, Three Gorges power transmission and substation (T&S) project is an important landmark in the
基金the Yildiz Technical University Research Fund for financially supporting this work
文摘In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perforated thin Plexiglas plates of various porosities. The plate is placed perpendicular to the flume with the height from the flume bottom to the position above water surface. With this thin wall in the flume wave overtopping is prohibited and incident waves are able to transmit. The porosities of the walls are achieved by perforating the plates with circular holes. Model settings with double perforated walls parallel to each other forming so called chamber system, have been also examined. Several parameters have been used for correlating the laboratory tests’ results. Experimental data are also compared with results from the numerical model by applying the multi-domain boundary element method (MDBEM) with linear wave theory. Wave energy dissipation due to the perforations of the thin wall has been represented by a simple yet effective porosity parameter in the model. The numerical model with the MDBEM has been further validated against the previously published data.
基金Project(51105017) supported by the National Natural Science Foundation of ChinaProject(2011BAG09B00) supported by the National Science and Technology Support Program of ChinaProject(2010DFB80020) supported by the Technology Major Project of the Ministry of Science and Technology of China
文摘For the purpose of engineering development for a new 8-step speed automatic transmission,a simplified dynamic model for this gearbox was established and key parameters which affected the shift quality were analyzed.Aiming at four different shift types,the ideal characteristics of shift clutch and engine control were set up.By using torque estimation method,PI slip control algorithm and engine coordinated control principle,the control model and transmission controller were well developed for three shift phases which included rapid-fill phase,torque phase and inertia phase.The testing environment on the rig and prototype vehicle level was built and the testing results obtained in ultimate condition could verify the accuracy and feasibility of this shift control strategy.The peak jerk during shift process was controlled within ±2 g/s where the smooth gearshift was obtained.The development proposal and algorithm have a high value for engineering application.
文摘Application of weathering and cold-formed steel in transmission lines can reduce steel consumption and environmental pollution. Some advances in the studies on the weathering and cold-formed steel in transmission tower are introduced. Firstly, corrosion-resistant tests of weathering steel samples under different simulating technical atmospheres were carried out separately for 240 hours. It shows that the corrosion degree of joint samples is higher than that of single chip samples, and the corrosion-resistant performance of weathering steel is superior to common carbon steel. The corrosion-resistance of weathering steel meets with the requirement of transmission tower. Secondly, experiments and finite element analysis for cold-formed angles and a 220kV prototype tower were completed, and the stability coeffi-cient fitting curves as well as the modification formulas of slenderness ratio for cold-formed members were determined. According to the structural characteristics of transmission towers, four sections of cold-formed angles with different sections and slenderness ratios were selected in this study. The finite element model well predicted the buckling behav-iour of the cold-formed members. Ultimate loads calculating by the fitting curve were well agreed to the experimental values, especially for the members with small slenderness ratios. Weight of the cold-formed steel tower can be reduced by more than 5 percent after considering the strength enhancement. Cost of the weathering and cold-formed steel transmission tower is nearly equivalent to that of hot-rolled steel tower with hot galvanizing.
文摘To evaluate maternal hepatitis B virus (HBV) DNA as risk for perinatal HBV infection among infants of HBV-infected women in California. METHODSRetrospective analysis among infants born to hepatitis B surface antigen (HBsAg)-positive mothers who received post vaccination serologic testing (PVST) between 2005 and 2011 in California. Demographic information was collected from the California Department of Public Health Perinatal Hepatitis B Program databaseand matched to birth certificate records. HBV DNA level and hepatitis B e antigen (HBeAg) status were obtained from three large commercial laboratories in California and provider records if available and matched to mother infant pairs. Univariate analysis compared infected and uninfected infants. Multivariate analysis was restricted to infected infants and controls with complete maternal HBV DNA results using a predefined high HBV DNA level of > 2 × 10<sup>7</sup> IU/mL, a 5:1 ratio of cases to controls and a two-sided confidence level of 95%. RESULTSA total of 17687 infants were born to HBsAg positive mothers in California between Jan 1 2005 and Dec 31, 2011. Among 11473 infants with PVST, only 125 (1.1%) were found to be HBV infected. Among these infected infants, lapses in Advisory Committee on Immunization Practices recommended post exposure prophylaxis (PEP) occurred in only 9 infants. However, PEP errors were not significantly different between infected and uninfected infants. Among the 347 uninfected and infected infants who had maternal HBeAg and HBV DNA level, case-control analysis found HBeAg positivity (70.4% vs 28.9%, OR = 46.76, 95%CI: 6.05-361.32, P < 0.001) and a maternal HBV DNA level ≥ 2 × 10<sup>7</sup> IU/mL (92.6% vs 18.5%, OR = 54.5, 95%CI: 12.22-247.55, P < 0.001) were associated with perinatal HBV infection. In multivariate logistic regression, maternal HBV DNA level ≥ 2 × 10<sup>7</sup> IU/mL was the only significant independent predictor of perinatal HBV infection. CONCLUSIONIn California, transmission is low and most infected infants receive appropriate PEP and vaccination. Maternal HBV DNA ≥ 2 × 10<sup>7</sup> IU/mL is associated with high risk of perinatal infection.
基金the National Natural Science Foundationof China, No. 30270494
文摘BACKGROUND: Increasing evidence suggests overlapped genetic susceptibility across traditional classification systems that divided psychotic disorders into schizophrenia or affective disorder. OBJECTIVE: This study aimed to explore whether schizophrenia and affective disorder share genetic susceptibility in NOTCH4 and GRIK2 loci in a population of Han Chinese. DESIGN: Repetitive measurements. SETTING: The experiment was carried out at Shanghai Mental Health Center and Hongkou Mental Health Center of Shanghai between January 2001 and June 2004. PARTICIPANTS: Sixty-five mixed pedigrees (suffering from various diseases, in combination with schizophrenia and affective disorder), composed of 45 completed trios and 20 single-parent families, were selected from Shanghai Mental Health Center and Hongkou Mental Health Center of Shanghai between January 2001 and June 2004. Probands received clinical diagnosis according to ICD-10; an independent clinician used identical criteria to review all diagnoses. All subjects were Han Chinese in origin and provided informed consent. There were 65 probands and 110 parents among the subjects. The probands comprised 30 males and 35 females: 33 with schizophrenia, 32 with affective disorder, mean age of (30.9 ± 9.8) years, mean age of onset (24.3 ± 8.8) years, mean duration (6.6 ± 7.0) years, and mean age of parents (58.8 ±10.9) years. METHODS: DNA samples from probands and their biological parents were extracted from peripheral blood according to standard methods. Four polymorphisms, -1725T/G and -25T/C in NOTCH4, rs6922753T/C and rs2227283G/A in GRIK2, were amplified and genotyped with PCR-RFLP techniques. MAIN OUTCOME MEASURES: Association between NOTCH4, GRIK2 polymorphism, and schizophrenia was analyzed by transmission disequilibrium test (TDT). RESULTS: Sixty-five probands and 110 parents were included in the result analysis, with no dropouts. The results showed that the -25T/C polymorphism of NOTCH4 associated significantly with affective disorder and -1725G/-25T haplotype with schizophrenia. SNP rs6922753 of GRIK2 did not associate with the two diseases; SNP rs2227283 and haplotypes, TG and CA, were significantly associated with both diseases. CONCLUSION: Schizophrenia and affective disorder might share genetic susceptibility among mixed pedigrees of the Han Chinese population. NOTCH4 and GRIK2 might be two of the most common susceptibility genes for these psychoses.
基金Project(51705454)supported by the National Natural Science Foundation of China
文摘Exact simulation of the acoustic performance is essential to the engineering application for a vehicle intake system. The rectangular-pulse method based on the computational fluid dynamics approach was employed for calculating the transmission loss. Firstly, the transmission loss of the single-cavity element was simulated without any airflow, and the effects of different structural parameters on the acoustic performance were investigated comprehensively. Secondly, the static transmission loss of the perforated intake pipe was obtained by the rectangular-pulse method, which is proved to be accurate enough compared with the result by finite element method. Thirdly, under the different conditions of the mean airflow and the operating temperature, the specific transmission loss was acquired respectively. In general, the peaks of the transmission loss are shifted to the lower frequency range because of the reverse airflow, but the amplitudes are irregularly changed. Besides, when the operating temperature increases, the peaks are shifted to the higher frequencies. Finally, with the designed perforated pipe installed to the intake system, the road tests were proceeded to evaluate the actual acoustic performance, and the result indicates that the intake sound pressure level is greatly attenuated. Typically in the range of 600–1500 Hz, the insertion loss of the intake noise at the decelerating moment is almost 20 d B(A), and the overall noise is reduced more than 14.2 d B(A). In conclusion, the perforated intake pipe has been proved excellent in improving the acoustic performance of intake system and could provide the guidance for the automotive engineering application.
基金The work was partially supported by the Major State Basic Research Development Program of China (No. 2002CB412703).
文摘The transmission ratio along the radian direction normal to the joints was studied in the Universal Distinct Element Code (UDEC). The variation of the transmission ratio with the ratio of joint spacing to wavelength was generalized into a general curve, which was determined by two critical points. The relationship between the two critical points and the affecting factors, quantity of joints and the normalized normal stiffness of joints, were obtained. A prediction model of the transmission ratio in the radian direction normal to the joints was proposed. The proposed model was applied to a field explosion test. The estimated values of the peak particle velocity from the prediction model were compared with the field records. The comparisons showed that the prediction model of the transmission ratio in the direction normal to the joints in the process of 2-D compressional wave propagation through multiple parallel joints is reliable.
基金The NNSF (10371015, 10329102) of China, and the Science Foundation (20060101) for Young Teachers of Northeast Normal University.
文摘In this article, using the likelihood score theory extended to nuisance parameters we derive a new homogeneity score test for comparing linkage disequilibrium across several strata. Power and sample size formulae are also obtained.
基金supported by the National Natural Science Foundation of China under Grant No.61379013the Excellent Doctoral Academic Support Program under Grant No.YBXSZC2013021
文摘During the last few decades, photothermal radiometry(PTR) has been greatly developed and widely applied in the field of nondestructive testing. However, the traditional PTR system employs an expensive lock-in amplifier to detect the weak photothermal signal, which leads to high cost and long test time. In this paper, a fast transmission PTR system based on sampling by using an internal computer sound card was developed to lower the system cost and shorter the test time. A piece of amorphous silicon(a:Si) thin film solar cells with artificial defects was prepared and tested by the system. The results show that the sharpened defects can be identified easily and quickly according to the significant peaks of the original infrared signal sampled by the internal computer sound card. Furthermore, more detailed defects can be investigated by processing the infrared signal. These validate the effectiveness of the proposed transmission PTR system as a low cost and efficient non-destructive test technique.
基金Supported by the National High Technology Research and Development Program of China(863 Program)(2012AA112101)
文摘With an advanced foreign hydraulic automatic transmission as the objective,an analytical method for the gear-shifting schedule is proposed.First the demanded maximum gradient of test is estimated.Then a test scheme and analytical procedure is formulated by initial test and hypothetical shift parameters.Finally through gear-shifting tests under different road conditions,load,accelerator pedal position limitation,throttle opening and output shaft speed are found to be the gear-shifting parameters.Under a common road condition,the gear-shifting schedule is a double-parameter schedule.Based on the driver's demands on braking and dynamic performance,different shift schedules are made under downhill,uphill and quick releasing acceleration pedal conditions.The operation criteria of down-shift schedule on abrupt grade are proposed.
文摘The UHVAC 1 000-kV transmission system is so far the one with the most advanced transmission technique applied and highest operation voltage.There are no guidelines or standards available for the design of 1 000-kV overhead transmission line in China.Study on key technologies and design schemes shall be carried out to ascertain the technical principles and construction standards for project construction,which are presented in this paper based on the Southeast Shanxi-Nanyang-Jingmen test and demonstration transmission line.A comparison and analysis of technical data and economic indices between UHV line and other lines are also described.
基金supported CNPq,CAPES and FAPESP in Brazilthe project supported by ELETROBRAS/ELETRONORTE,ELETROBRAS/CHESF and ENTE as part of ANEEL(Brazilian Electrical Energy Regula-tory Agency)strategic project 2008(proc.4500072477).
文摘In the present paper the main results of the pre-operational studies related to the energization maneuver of a Half-Wavelength Transmission Line (AC-Link), are presented. The simulations were performed in PSCAD with actual Brazilian system data. Specifically the following studies were performed: electromagnetic transient studies of energization maneuver considering no fault and the occurrence of fault along the trunk;dynamic analysis of generator units that will energize the AC-Link;TRV on the circuit-breaker that will energize the trunk. The main conclusion is that the AC-Link energization experiment can be implemented without jeopardizing or causing time-life reduction of the equipment involved in the experiment, which comprises the generator unit that will energize the trunk, the step-up transformer, the arresters that will be kept during the experiments, as well as the circuit-breaker that will energize and then trip the AC-Link.