To reveal the sediment transporting mechanism between the abandoned Huanghe River (Yellow River) Delta and radial sand ridges, “End Member” Model and grain size trend analysis have been employed to separate the “...To reveal the sediment transporting mechanism between the abandoned Huanghe River (Yellow River) Delta and radial sand ridges, “End Member” Model and grain size trend analysis have been employed to separate the “dynamic populations” in the surficial sediment particle spectra and to determine the possible sediment transporting pathway. The results reveal four “dynamic subpopulations”(EM1 to EM4) and two reverse sediment transporting directions: a northward transport tend from the radial sand ridges to mud patch, and a southward transport trend in deep water area outside the mud patch. Combined with the published hydrodynamic information, the transporting mechanism of dynamic populations has been discussed, and the main conclusion is that the transporting of finer subpopulations EM1 and EM2 is controlled by the “anticlockwise residual current circulation” forming during tidal cycle, which favor a northward transporting trend and the forming of mud patch on the north of radial sand ridges, while the transporting of coarser EM3 is mainly controlled by wind driven drift in winter, which favors a southward transporting direction.展开更多
Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS)<span><span><span style="font-family:;" "=""> is one of the most interesting research topics in many...Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS)<span><span><span style="font-family:;" "=""> is one of the most interesting research topics in many fields of industries. It is an effective solution to reduce unexpected accidents that occur during transportation as well as increase productivity in manufacturing. The aim of this paper is to introduce the controller design for the MMTS which is built in our BK-Recme BioMech Lab at Ho Chi Minh City University of Technology (VNU-HCM), Viet Nam. Based on the design of this system, the control algorithms will be conducted to check the operation of the whole system. To evaluate the feasibility and effectiveness of this model, we design a series of random instances for different quantities of nodes as well as the different quantities of shuttles. Our system includes 4 stations and 6 shuttles which are assembled in the serial chain system. However, the number of stations and number of shuttles can be expanded to any desired ones which are based on the requirement of the industries. In this paper, we mainly focus on the controller design of this system to make it operate in an effective way that the goods will be transported and delivered to the target station as fast as possible. In order to solve the large</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">scale instances and realistic transport prob<span>lems, we propose three algorithms for three progresses as shuttles calling</span>, path reading and shuttles communicating. The shuttles calling is to decide which <span>shuttle should be called to the star</span></span></span></span><span><span><span style="font-family:;" "="">t</span></span></span><span><span><span style="font-family:;" "="">-node. Path reading to determine the shortest</span></span></span><span><span><span style="font-family:;" "=""> <span>way to go from start-node to end-node. Finally, shuttles communicating,</span> which allow one shuttle to interact with the next shuttles so we have a loop of orders (shuttle 1 to shuttle 2;shuttle 2 to shuttle 3;etc</span></span></span><span><span><span style="font-family:;" "="">.</span></span></span><span><span><span style="font-family:;" "="">;shuttle n-1 to shuttle n). This proposes solution can help us to solve the huge numbers of shuttles <span>and stations in the system. The specific result of this study is applying</span> Dijkstra’s algorithm to propose an algorithm that allows handling a transportation system without caring about the number of shuttles as well as the number of stations for the closed-loop path. Several test problems are carried out in order to check the feasibility and the effectiveness of our purposed control algorithm.</span></span></span>展开更多
目的通过建立胰岛素抵抗模型,探讨晚期糖基化终产物(AGEs)对SD大鼠乳鼠心肌细胞葡萄糖转运蛋白4(GLUT4)表达的影响,以及p38丝裂原活化蛋白激酶(MAPK)在此过程中的作用。方法采用酶消化法原代培养SD大鼠乳鼠心肌细胞,建立胰岛素抵抗模型...目的通过建立胰岛素抵抗模型,探讨晚期糖基化终产物(AGEs)对SD大鼠乳鼠心肌细胞葡萄糖转运蛋白4(GLUT4)表达的影响,以及p38丝裂原活化蛋白激酶(MAPK)在此过程中的作用。方法采用酶消化法原代培养SD大鼠乳鼠心肌细胞,建立胰岛素抵抗模型,给予不同干预,分为胰岛素抵抗对照组、牛血清白蛋白(BSA)组、糖化白蛋白(AGE-BSA)组,p38MAPK抑制剂SB203580+AGE-BSA组,用实时荧光定量聚合酶链反应(PCR)和蛋白质印迹法检测GLUT4和p38MAPK的蛋白及m RNA表达水平。结果胰岛素抵抗心肌细胞有GLUT4表达,其中对照组与BSA组比较差异无统计学意义(P>0.05),AGE-BSA可诱导GLUT4表达降低,且呈浓度依赖性,AGE-BSA组与对照组比较差异有统计学意义(P<0.05)。但在阻断p38MAPK途径后表达量明显上升(P<0.05),对照组与BSA组比较,p38MAPK磷酸化水平差异无统计学意义(P>0.05),AGE-BSA可导致p38MAPK磷酸化的增加,也呈浓度依赖性,AGE-BSA组与对照组比较差异有统计学意义(P<0.05)。结论 AGEs可诱导胰岛素抵抗心肌细胞GLUT4 m RNA和蛋白表达降低,此过程与p38-MAPK磷酸化增加有关。展开更多
文摘To reveal the sediment transporting mechanism between the abandoned Huanghe River (Yellow River) Delta and radial sand ridges, “End Member” Model and grain size trend analysis have been employed to separate the “dynamic populations” in the surficial sediment particle spectra and to determine the possible sediment transporting pathway. The results reveal four “dynamic subpopulations”(EM1 to EM4) and two reverse sediment transporting directions: a northward transport tend from the radial sand ridges to mud patch, and a southward transport trend in deep water area outside the mud patch. Combined with the published hydrodynamic information, the transporting mechanism of dynamic populations has been discussed, and the main conclusion is that the transporting of finer subpopulations EM1 and EM2 is controlled by the “anticlockwise residual current circulation” forming during tidal cycle, which favor a northward transporting trend and the forming of mud patch on the north of radial sand ridges, while the transporting of coarser EM3 is mainly controlled by wind driven drift in winter, which favors a southward transporting direction.
文摘Nowadays, the Multi-Shuttle and Multi-Station Transportation System (MMTS)<span><span><span style="font-family:;" "=""> is one of the most interesting research topics in many fields of industries. It is an effective solution to reduce unexpected accidents that occur during transportation as well as increase productivity in manufacturing. The aim of this paper is to introduce the controller design for the MMTS which is built in our BK-Recme BioMech Lab at Ho Chi Minh City University of Technology (VNU-HCM), Viet Nam. Based on the design of this system, the control algorithms will be conducted to check the operation of the whole system. To evaluate the feasibility and effectiveness of this model, we design a series of random instances for different quantities of nodes as well as the different quantities of shuttles. Our system includes 4 stations and 6 shuttles which are assembled in the serial chain system. However, the number of stations and number of shuttles can be expanded to any desired ones which are based on the requirement of the industries. In this paper, we mainly focus on the controller design of this system to make it operate in an effective way that the goods will be transported and delivered to the target station as fast as possible. In order to solve the large</span></span></span><span><span><span style="font-family:;" "="">-</span></span></span><span><span><span style="font-family:;" "="">scale instances and realistic transport prob<span>lems, we propose three algorithms for three progresses as shuttles calling</span>, path reading and shuttles communicating. The shuttles calling is to decide which <span>shuttle should be called to the star</span></span></span></span><span><span><span style="font-family:;" "="">t</span></span></span><span><span><span style="font-family:;" "="">-node. Path reading to determine the shortest</span></span></span><span><span><span style="font-family:;" "=""> <span>way to go from start-node to end-node. Finally, shuttles communicating,</span> which allow one shuttle to interact with the next shuttles so we have a loop of orders (shuttle 1 to shuttle 2;shuttle 2 to shuttle 3;etc</span></span></span><span><span><span style="font-family:;" "="">.</span></span></span><span><span><span style="font-family:;" "="">;shuttle n-1 to shuttle n). This proposes solution can help us to solve the huge numbers of shuttles <span>and stations in the system. The specific result of this study is applying</span> Dijkstra’s algorithm to propose an algorithm that allows handling a transportation system without caring about the number of shuttles as well as the number of stations for the closed-loop path. Several test problems are carried out in order to check the feasibility and the effectiveness of our purposed control algorithm.</span></span></span>
文摘目的通过建立胰岛素抵抗模型,探讨晚期糖基化终产物(AGEs)对SD大鼠乳鼠心肌细胞葡萄糖转运蛋白4(GLUT4)表达的影响,以及p38丝裂原活化蛋白激酶(MAPK)在此过程中的作用。方法采用酶消化法原代培养SD大鼠乳鼠心肌细胞,建立胰岛素抵抗模型,给予不同干预,分为胰岛素抵抗对照组、牛血清白蛋白(BSA)组、糖化白蛋白(AGE-BSA)组,p38MAPK抑制剂SB203580+AGE-BSA组,用实时荧光定量聚合酶链反应(PCR)和蛋白质印迹法检测GLUT4和p38MAPK的蛋白及m RNA表达水平。结果胰岛素抵抗心肌细胞有GLUT4表达,其中对照组与BSA组比较差异无统计学意义(P>0.05),AGE-BSA可诱导GLUT4表达降低,且呈浓度依赖性,AGE-BSA组与对照组比较差异有统计学意义(P<0.05)。但在阻断p38MAPK途径后表达量明显上升(P<0.05),对照组与BSA组比较,p38MAPK磷酸化水平差异无统计学意义(P>0.05),AGE-BSA可导致p38MAPK磷酸化的增加,也呈浓度依赖性,AGE-BSA组与对照组比较差异有统计学意义(P<0.05)。结论 AGEs可诱导胰岛素抵抗心肌细胞GLUT4 m RNA和蛋白表达降低,此过程与p38-MAPK磷酸化增加有关。