The molecular mechanisms underpinning temperature-dependent sex determination(TSD)in reptiles have attracted great biological interest for many years.However,which genetic factors are essential for TSD remain elusive,...The molecular mechanisms underpinning temperature-dependent sex determination(TSD)in reptiles have attracted great biological interest for many years.However,which genetic factors are essential for TSD remain elusive,especially regarding female sex determination.Cytochrome P450 family 19 subfamily A member 1(Cyp19a1)encodes the endoplasmic reticulum enzyme aromatase,which participates in the catalytic conversion of androgens to estrogens,and is implicated in sexual differentiation in many species.However,whether Cyp19a1 plays a critical role in determining gonadal sexual fate in TSD species remains to be elucidated.In the current study,Cyp19a1 exhibited a temperature-dependent and sexually dimorphic expression pattern,preceding gonadal sex differentiation in a TSD turtle species(Mauremys reevesii).Sexual phenotype of the turtles was successfully reversed by aromatase inhibitor treatment at the female-producing temperature(FPT).Furthermore,exogenous estradiol(E2)treatment led to complete male-to-female sex reversal at the male-producing temperature(MPT),accompanied by rapid up-regulation of Cyp19a1.Thus,Cyp19a1 appears to be essential for female sex determination in M.reevesii,suggesting a vital role in the female TSD pathway.展开更多
Aims: Diabetes is a major public health problem in low and middle-income countries. This study 1) estimated prevalence and factors associated with hyperglycemia in Benin, and 2) assessed the treatment quality of diabe...Aims: Diabetes is a major public health problem in low and middle-income countries. This study 1) estimated prevalence and factors associated with hyperglycemia in Benin, and 2) assessed the treatment quality of diabetes. Methodology: A cross-sectional research was conducted with two components. The First component has included 4954 subjects aged (18 - 69) randomly selected in Mono/Couffo and Donga regions. Data were collected according to WHO’s STEPS approach. Capillary blood glucose was measured using the automat Cardiocheck®PA. The Second component considered Public Health Centers (PHCs) within the study regions. Health system established for diabetes control, healthcare practices and the level of involvement of the Public Healthcare Providers and community actors in the management of diabetes have been explored. Findings: A total of 4775 subjects participated in the first component with a predominance of women (56.8%), rural residence and aged (Conclusion: Diabetes prevalence goes increasingly in Benin when its management is inadequate in PHCs. Prevention and control actions should be strengthened.展开更多
With observations and reflections on a series of phenomena,such as the ＂independent situation＂of China＇s FDI during the recent global financial risis and the increase of round tripped investment after the ＂tax rat...With observations and reflections on a series of phenomena,such as the ＂independent situation＂of China＇s FDI during the recent global financial risis and the increase of round tripped investment after the ＂tax rate unification,＂this paper examines a unique phenomenon in China＇s FDI-round tripped investment.It reveals its determinants from a micro-perspectiv ,and establishes a vector error correction mode（VECM）for emprirical testing.The results is that the determinants of China＇s round tripped investment are institutional factors such as ＂achievable differential treatment＂ and cpaital control.Tax ,exchange rate,housing price and capital control intensity all have an impact on the scale of round tripped FDI.However,judging from the extent of influence,the most important factor should be exchange rate ,followed by capital control intensity and housing price,and tax has a limited impact.展开更多
基金supported by the National Natural Science Foundation of China(32030013,31821001)。
文摘The molecular mechanisms underpinning temperature-dependent sex determination(TSD)in reptiles have attracted great biological interest for many years.However,which genetic factors are essential for TSD remain elusive,especially regarding female sex determination.Cytochrome P450 family 19 subfamily A member 1(Cyp19a1)encodes the endoplasmic reticulum enzyme aromatase,which participates in the catalytic conversion of androgens to estrogens,and is implicated in sexual differentiation in many species.However,whether Cyp19a1 plays a critical role in determining gonadal sexual fate in TSD species remains to be elucidated.In the current study,Cyp19a1 exhibited a temperature-dependent and sexually dimorphic expression pattern,preceding gonadal sex differentiation in a TSD turtle species(Mauremys reevesii).Sexual phenotype of the turtles was successfully reversed by aromatase inhibitor treatment at the female-producing temperature(FPT).Furthermore,exogenous estradiol(E2)treatment led to complete male-to-female sex reversal at the male-producing temperature(MPT),accompanied by rapid up-regulation of Cyp19a1.Thus,Cyp19a1 appears to be essential for female sex determination in M.reevesii,suggesting a vital role in the female TSD pathway.
文摘Aims: Diabetes is a major public health problem in low and middle-income countries. This study 1) estimated prevalence and factors associated with hyperglycemia in Benin, and 2) assessed the treatment quality of diabetes. Methodology: A cross-sectional research was conducted with two components. The First component has included 4954 subjects aged (18 - 69) randomly selected in Mono/Couffo and Donga regions. Data were collected according to WHO’s STEPS approach. Capillary blood glucose was measured using the automat Cardiocheck®PA. The Second component considered Public Health Centers (PHCs) within the study regions. Health system established for diabetes control, healthcare practices and the level of involvement of the Public Healthcare Providers and community actors in the management of diabetes have been explored. Findings: A total of 4775 subjects participated in the first component with a predominance of women (56.8%), rural residence and aged (Conclusion: Diabetes prevalence goes increasingly in Benin when its management is inadequate in PHCs. Prevention and control actions should be strengthened.
文摘With observations and reflections on a series of phenomena,such as the ＂independent situation＂of China＇s FDI during the recent global financial risis and the increase of round tripped investment after the ＂tax rate unification,＂this paper examines a unique phenomenon in China＇s FDI-round tripped investment.It reveals its determinants from a micro-perspectiv ,and establishes a vector error correction mode（VECM）for emprirical testing.The results is that the determinants of China＇s round tripped investment are institutional factors such as ＂achievable differential treatment＂ and cpaital control.Tax ,exchange rate,housing price and capital control intensity all have an impact on the scale of round tripped FDI.However,judging from the extent of influence,the most important factor should be exchange rate ,followed by capital control intensity and housing price,and tax has a limited impact.
