Preventive and therapeutic effect of long snake moxibustion on psoriasis with yang deficiency and external cold syndrome based on the theory of "treatment of winter disease in summer"

Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is refractory,recurrent and severe in winter and mild in summer,which has a great impact on patients'physical and mental health and quality of life.Traditional Chinese medicine has unique insights in the treatment of psoriasis,both curative effect and safety,have obvious advantages.Based on the concept of"winter disease and summer treatment",long-snake moxibustion gives full play to its functions of warming the kidney,invigorating the marrow,warming the meridians,activating blood circulation and removing blood stasis,so as to restore the deficiency of Yang in patients with psoriasis with external cold syndrome,enhance disease resistance,and prevent psoriasis recurrence or aggravation in winter.Therefore,based on the theory of"winter disease and summer treatment",this paper preliminarily discusses the mechanism of long-snake moxibustion in the prevention and treatment of psoriasis with external cold syndrome of Yang deficiency,and provides new ideas and directions for the prevention and treatment of psoriasis with traditional Chinese medicine.

Effect of Acupoint Liquid Nitrogen Cryotherapy on Neuro-Endocrine-Immune Network System in Patients with Lung Qi Deficiency Syndrome in Remission Stage of Bronchial Asthma

[Objectives]To observe the effect of acupoint liquid nitrogen cryotherapy on the neuro-endocrine-immune network system of lung qi deficiency syndrome during the remission period of bronchial asthma and explore its possible mechanism.[Methods]A total of 100 patients with bronchial asthma were randomly divided into control group and observation group,with 50 cases in each group.The control group was given budesonide spray inhalation treatment,combined with acupoint liquid nitrogen freezing treatment,twice a year for a course of treatment,followed up for 1 year.The other 50 healthy volunteers were included in the healthy group,and no treatment was given in the healthy group.Serum immunoglobulins A,G,E(IgA,IgG,IgE)were detected before and after treatment in each group,serum cytokines[interleukin-4(IL-4),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],plasma neurotransmitters[substance P(SP),vasoactive intestinal peptide(VIP)].[Results]Before treatment,compared with healthy group,the contents of IgA,IgG,IL-10,IFN-γand VIP in observation group and control group were decreased,while the contents of IgE,IL-4,TNF-αand SP were increased,with statistical significance(P<0.05).After treatment,compared with before treatment,IgA,IgG,IL-10,IFN-γand VIP contents in observation group and control group were increased(P<0.05),and observation group was higher than control group(P<0.05),IgE,IL-4 and SP contents in observation group and control group were decreased(P<0.05).The observation group was lower than the control group(P<0.05).[Conclusions]Acupoint liquid nitrogen cryotherapy may improve the immune function of the body,regulate the release of cytokines and regulate neuromediators,and thus play a role in the prevention and treatment of bronchial asthma.

Clinical research of acupoint application for "treatment of winterdisease in summer" used to prevent and treat bronchial asthma inchildren

OBJECTIVE:To preliminarily analyze key factors influencing curative effect through clinical observations of acupoint application for "treatment of win-ter disease in summer" used to prevent and treat bronchial asthma in children.METHODS:In an observational study and prospective cohort study,we observed children in remission of asthma at three class Ⅲ grade A TCM hospitals in Liaoning,Hubei,and Chengdu.RESULTS:A total of 609 children conformed to diagnostic and inclusive standards for remission of bronchial asthma.Through follow-up visits,we observed their skin reactions and the time and chance of treatment with different therapies in the three hospitals;we also compared and analyzed different drugs,acupoints,and preparations.We found that the key Chinese drugs were Bai Jie Zi(Semen Sinapis Albae) and Yian Hu Suo(Rhizoma Corydalis);the key acupoints were Feishu(BL 13),Gaohuang(BL 43),Dingchuan(EX-B1),Tiantu(CV 22),and Shanzhong(CV 17);and the best preparation was a mixture of drugs,ginger juice,and musk.Acupoint application was practiced on the hottest days of summer and the coldest days of winter for 0.5 to 2 h with the lowest rate of asthma relapse.CONCLUSIONS:The present data analysis shows that the curative effect of acupoint application for "treatment of winter disease in summer" may be influenced by recipes of Chinese drugs,preparations,prescriptions of acupoints,chance,time,and skin reactions.A curative effect is the result of the comprehensive action of these factors.

冬病夏治穴位贴敷、中药足浴及早期肺康复在COPD稳定期的应用进展

肺康复作为临床治疗慢性阻塞性肺疾病(COPD)的一个重要内容,最佳治疗时机是稳定期,应及早对患者呼吸肌功能开展评估,并进行锻炼,冬病夏治穴位贴敷、中药足浴可有效提高患者呼吸耐力,增加胸廓和肺的活动度,扩大胸腔容量,增加胸内负压,延缓肺功能下降。为此本研究综述了冬病夏治穴位贴敷、中药足浴及早期肺康复对COPD稳定期患者的研究,为我国COPD稳定期患者肺功能的临床护理实践提供较多的证据和支持,以降低患者的再住院率,进一步改善患者的生活质量。

冬病夏治三伏贴联合鼻三穴姜灸治疗变应性鼻炎临床观察

目的探讨冬病夏治三伏贴联合鼻三穴隔姜灸治疗变应性鼻炎的临床效果。方法选取2022年1月—2022年12月于江西中医药大学附属医院急诊科、耳鼻喉科就诊的120例变应性鼻炎患者,采用随机数字表法分为空白组(氯雷他定片)、对照组1(冬病夏治三伏贴)、对照组2(鼻三穴隔姜灸)、治疗组(冬病夏治三伏贴+鼻三穴隔姜灸),各30例。研究共4个疗程。比较四组患者治疗前后症状评分、体征评分及临床效果。结果空白组、对照组1、对照组2、治疗组总有效率分别为76.67%(23/30)、86.67%(26/30)、90.00%(27/30)、96.67%(29/30)。治疗后,四组临床症状评分、体征评分均较治疗前降低,且治疗组均低于对照组、空白组(P<0.05)。结论冬病夏治三伏贴联合鼻三穴隔姜灸能够有效改善变应性鼻炎患者的症状和体征,临床效果确切,值得借鉴和推广。

Efficacy comparison of different forms of dog-days acupoint application for prevention and treatment of chronic bronchitis

Objective: To analyze the clinical effect of traditionaldog-days acupoint application and Magic Acupuncture Patch (Manji) in the prevention and treatment of chronic bronchitis (CB) in remission stage in the past five years, and explore the principle of action and effective stimulation, to provide the evidence for treating CB by acupoint application. Methods: A retrospective study was conducted on 405 patients with CB who met the inclusion criteria. All patients were treated with dog-days acupoint application or Magic Acupuncture Patch between 2013 and 2017. The clinical data of 405 patients were statistically analyzed to compare the prevention and treatment effects of dog-days acupoint application and Magic Acupuncture Patch, and different degrees of stimulation of dog-days acupoint application. Results: Among the dog-days acupoint application groups, the total effective rate was 63.6% in the light stimulation group, 93.1% in the moderate stimulation group, and 94.8% in the strong stimulation group. The differences in the total effective rate between the light stimulation group and the moderate stimulation group, as well as the strong stimulation group, were statistically significant (both P<0.05). There was no significant difference in the total effective rate between the moderate stimulation group and the strong stimulation group (P>0.05). The total effective rate was 83.9% in the dog-days acupoint application group, versus 45.4% in the Magic Acupuncture Patch group, and there was a statistically significant difference between the two groups (P<0.05). Conclusion: The efficacy of dog-days acupoint application in the prevention and treatment of CB is better than that of Magic Acupuncture Patch;the degree of stimulation is the basis for the effect of dog-days acupoint application on prevention and treatment of CB, and the moderate and strong stimulations are more appropriate.

“冬病夏治法”对慢性阻塞性肺疾病作用的系统评价

目的:对“冬病夏治法”用于慢性阻塞性肺疾病(COPD)的临床疗效进行系统评价,以期为COPD的防治及冬病夏治的临床应用提供有价值的循证依据。方法:检索中国知网、万方数据库、维普数据库、PubMed、Web of Science、Embase(检索时间为建库至2023年8月),筛选较高质量的冬病夏治法用于COPD的临床随机对照试验研究(对照组采用常规疗法,如给予支气管舒张剂、吸入糖皮质激素、氧疗、戒烟等;研究组在对照组的基础上加用“冬病夏治法”或者单纯采用“冬病夏治法”),提取数据,应用RevMan 5.4.1软件进行Meta分析。结果:最终纳入65项随机对照试验研究,涉及5 736例受试者(研究组2 880例,对照组2 856例)。Meta分析结果表明,与常规疗法比较,“冬病夏治法”用于COPD的治疗可提高总有效率(OR=3.97,95%CI=3.32~4.74,P<0.000 01),提高第1秒用力呼气容积占用力肺活量百分比(MD=3.76,95%CI=2.66~4.85,P<0.000 01),降低圣乔治呼吸问卷评分(MD=-4.83,95%CI=-6.39~-3.27,P<0.000 01),差异均有统计学意义。结论:现有证据表明,对于COPD患者,在常规疗法的基础上加用中医“冬病夏治法”或单纯采用“冬病夏治法”,治疗效果更好。

冬病夏治穴位贴敷联合常规西药、康复锻炼治疗寒痹型膝骨关节炎的效果分析

目的:分析冬病夏治穴位贴敷联合常规西药、康复锻炼治疗寒痹型膝骨关节炎(KOA)的效果。方法:选取2010年1月—2017年12月华中师范大学校医院骨外科接诊的寒痹型KOA患者216例作为研究对象,依据随机数字表法分为对照组、观察组,各108例。对照组给予常规西药联合运动康复锻炼,观察组在对照组基础上给予冬病夏治穴位贴敷。比较两组疼痛情况、治疗效果。结果:治疗前,两组疼痛分级指数评定(PRI)、视觉模拟评分法(VAS)、现有疼痛强度评定(PPL)评分比较,差异无统计学意义(P>0.05);治疗后,两组PRI、VAS、PPL评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.025)。结论:冬病夏治穴位贴敷联合常规西药、康复锻炼治疗寒痹型KOA的效果显著,可减轻疼痛,提高治疗效果。

中药穴位贴敷对哮喘患者肺功能及血常规的影响

目的观察不同季节中药穴位贴敷治疗哮喘的疗效,以及对肺功能:一秒用力呼气容积(Forced Expiratory Volume in one second,FEV1),用力肺活量(Forced Vital Capacity,FVC),呼气峰流速(Peak Expiratory Flow,PEF),一秒用力呼气容积/用力肺活量(FEV1/FVC)与血常规的影响。方法将92例哮喘患儿,根据贴敷时间分为两组,夏季组50例,冬季组42例,对其进行肺功能测定与血常规测定。结果夏季组总有效率88%,高于冬季组的78.57%(P<0.05);两组血常规中嗜酸性粒细胞百分数治疗后较治疗前均明显下降(P<0.05),夏季组中血小板计数治疗后较治疗前升高(P<0.05),其他血常规指标治疗前后及组间比较差异均无统计学意义(P>0.05);肺功能各指标夏季组治疗后较治疗前均有提高(P<0.05);冬季组的肺功能治疗前后差异无统计学意义(P>0.05),两组治疗后组间各肺功能指标对比,夏季组高于冬季组(P<0.05)。结论从肺功能而言,夏季(伏天)贴敷,较冬季贴敷疗效好,从而证实了传统的中医"冬病夏治"理论是正确有效的,并揭示了中药贴敷防治哮喘的作用机理。

穴位贴敷防治支气管哮喘缓解期60例临床观察

目的:观察冬病夏治穴位贴敷防治支气管哮喘患者缓解期的临床疗效。方法:选择2019年6月—2019年10月就诊于由黑龙江中医药大学附属第一医院呼吸科符合诊断标准的支气管哮喘60例患者,随机分为治疗组和对照组,每组30例。治疗组于三伏天初、中、末伏的第1天在肺俞、定喘、大椎、中府的对照穴位上进行穴位贴敷治疗,对照组采用中药汤剂辨证论治,随访1年,1年后观察两组治疗前后哮喘发作次数、肺功能变化情况。结果:治疗后,穴位贴敷治疗支气管哮喘作用显著,可显著改善小气道功能,生活质量明显优于治疗组。两组治疗前肺功能(FEV1、FEV1/FVC、FEF25%)相比较,差异无统计学意义(P>0.05)。治疗1年后,治疗组与对照组肺功能(FEV1、FEV1/FVC、FEF25%)均有改善,而治疗组临床疗效明显优于对照组,差异具有统计学意义(P<0.05)。结论:采用穴位贴敷治疗支气管哮喘缓解期,疗效显著,改善患者活动受限,减少哮喘的发作次数,提高生存质量,在临床上具有较高的应用价值。

冬病夏治消喘膏贴敷与治未病

依据传统医学中的治未病思想,采用冬病夏治消喘膏贴敷背部俞穴,通过刺激体表的经络穴位等方式,达到对体内细胞因子、白细胞及T淋巴细胞的调节,用来防治支气管哮喘、慢性阻塞性肺病等呼吸系统疾患,这是既具有中国传统医学特点,又在实际应用中得到发展和不断创新的一种有效方法。

基于“冬病夏治”理念的中药穴位贴敷疗法对哮喘患儿肺功能、血清炎症因子及肺表面活性蛋白表达水平的影响

目的 探讨“冬病夏治”穴位贴敷对小儿哮喘患者肺功能、血清炎症因子及肺表面活性蛋白的影响。方法回顾性选取2018年7月至2020年至9月到唐山市妇幼保健院儿内科收治小儿哮喘患儿96例作为研究对象,按照治疗方法不同分为两组,每组48例。对照组采用常规雾化治疗法,观察组在对照组的治疗基础上采用“冬病夏治”穴位贴敷治疗。观察两组的临床疗效,并治疗前和治疗后1年测定两组患儿的肺功能指标[用力肺活量(FVC)、第一秒用力呼气容积(FEV1)]、炎症因子[肿瘤坏死因子α(TNF-α)、核转录因子κB(NF-κB)、白细胞介素(IL)-4、IL-8、IL-10]和肺表面活性蛋白[肺表面活性蛋白A(SP-A)、肺表面活性蛋白D(SP-D)]水平。结果 观察组患儿的总有效率为95.83%,高于对照组(79.17%),差异有统计学意义(P<0.05)。治疗前,两组FVC和FEV1水平比较,差异均无统计学意义(P> 0.05);治疗后,观察组FVC和FEV1为(90.13±2.24)%、(85.95±1.27)%,均高于对照组[(84.17±2.79)%、(81.17±1.63)%],差异均有统计学意义(P<0.05)。治疗前,两组TNF-α、NF-κB、IL-4、IL-8水平比较,差异均无统计学意义(P> 0.05);治疗后,观察组患者TNF-α、NF-κB、IL-4、IL-8水平为(10.33±1.82) pg/L、(88.39±13.18) ng/L、(124.41±20.38) ng/L、(118.32±15.68) ng/L,均低于对照组[(16.37±1.38) pg/L、(93.28±12.44) ng/L、(135.54±21.69) ng/L、(127.82±16.04) ng/L],IL-10水平为(88.29±8.95) ng/L,高于对照组[(84.45±5.42) ng/L],差异均有统计学意义(P<0.05)。治疗前,两组SP-A、SP-D水平比较,差异均无统计学意义(P>0.05);治疗后,观察组SP-A、SP-D水平为(48.31±14.12) mg/L、(49.29±13.05)μg/L,均低于对照组[(51.14±13.06) mg/L、(51.17±14.48)μg/L],差异均有统计学意义(P<0.05)。两组均未发生明显不良反应。结论 “冬病夏治”穴位贴敷疗法对改善支气管哮喘患儿肺功能疗效较佳,能调节儿童机体内TNF-α、NF-κB、IL-4、IL-8、IL-10等炎症因子水平,并降低血清SP-A和SP-D水平,具有临床应用价值。

冬病夏治穴位敷贴联合中药治疗儿童反复呼吸道感染的疗效研究

目的探究冬病夏治穴位贴敷联合中药治疗儿童反复呼吸道感染(RRTI)的疗效。方法选取新疆医科大学附属中医医院儿科2016年1月-2019年4月收治的115例反复呼吸道感染患儿为研究对象,随机分配法分为观察组(n=57)和对照组(n=58),对照组给予常规中药治疗,观察组在对照组基础上给予冬病夏治穴位敷贴治疗,连续治疗2个月,治疗后对所有患儿均定期随访3个月。比较两组患儿治疗后的临床疗效,体液免疫相关指标IgG、IgA、IgM及细胞免疫相关指标CD4^+、CD3^+、CD4^+/CD8^+水平的变化,统计随访期间患儿临床症状的情况。结果与对照组治疗后比较,观察组治疗后患儿血清中CD3^+、CD4^+水平和CD4^+/CD8^+值均升高,IgA、IgM和IgG水平均升高,IL-1β、IL-6水平均降低,患儿发热、咳嗽、扁桃体肿大和肺部啰音症状持续时间均缩短,治疗后总有效率升高,差异均有统计学意义(P<0.05)。结论冬病夏治穴位敷贴联合中药能够改善RRTI患儿细胞与体液免疫水平,减轻炎症反应程度,提升疗效,值得临床推广。

冬病夏治理论下中药穴位贴敷治疗老年哮喘作用机制及优缺点研究

老年哮喘是一种以嗜酸性粒细胞、肥大细胞反应为主的气道慢性炎症,且患者发病后常伴有不同程度、广泛的可逆性的气流阻塞症状。由于患者年龄较大、常伴有多种基础疾病,临床多表现为咳嗽、咳痰、呼气延长及胸闷等,影响患者健康、生活。冬病夏治理论下中药穴位贴敷是老年哮喘常用的中医外治疗法之一,具有安全有效、简便易行等优点。冬病夏治理论下中药穴位贴敷最早源于"天然相应""治末病"等理论,认为借助三伏时人体阳气最盛、气血充盈、阳气升发,导致气血浮于体表,经络通利,配合相应的穴位贴敷,能提高机体免疫,从而发挥扶正祛邪功效。但是,该治疗方法临床疗效受到的影响因素较多,包括:合理的贴敷时间、患者体质、贴敷次数等。因此,该研究以老年哮喘为起点,分析冬病夏治理论下中药穴位贴敷在老年哮喘患者中的作用机制,探讨冬病夏治理论下中药穴位贴敷临床治疗优缺点,为老年哮喘患者治疗提供新的方法。

伏九贴敷次数对儿童咳嗽变异性哮喘的影响

目的观察伏九贴贴敷次数对儿童咳嗽变异性哮喘（CVA）的影响。方法 120例患儿随机分为常规贴敷组和加强贴敷组各60例,2组均予芥子咳喘软膏贴敷,常规贴敷组三伏贴和三九贴均贴敷3次,加强贴敷组三伏贴和三九贴均贴敷9次,每次2~4 h。结果常规贴敷组完成研究57例,三九后1、3个月有效率分别为63.2%、50.8%,三伏后1、3个月有效率分别为73.7%、57.9%;加强贴敷组完成研究60例,三九后1、3个月有效率分别为66.7%、58.3%,三伏后1、3个月有效率分别为91.7%、70%。三伏后1个月2组有效率比较,差异有统计学意义（P〈0.01）,余观察时点差异无统计学意义（P〉0.05）。2组治疗前后在临床症状、患儿误课、家长误工及就诊费用方面差异有统计学意义（P〈0.05）。结论伏九穴位贴敷治疗儿童CVA疗效明显,伏九贴贴敷9次在三伏后1个月疗效明显优于贴敷3次。

中药敷贴、穴位注射预防支气管哮喘发作

目的 预防支气管哮喘的季节性发作。方法 根据祖国医学冬病夏治的原则 ,对 43例支气管哮喘患者 ,在夏季哮喘发作间歇期于定喘、肺俞、天突穴位进行中药敷贴 ,足三里穴位注射黄芪针剂 ,每疗程 3个月。统计用药前 1年和用药后 1年的发病率。结果 用药前的发病率为 10 0 %( 43 /4 3 ) ,其中发作 1次的发病率为 3 3 .49%( 2 3 /4 3 ) ,2次的发病率为 3 2 .5 6%( 14 /4 3 ) ,3次的发病率为 13 .95 %( 6/4 3 ) ;用药后的发病率分别为 2 7.91%( 12 /4 3 )、2 0 .93 %( 9/4 3 )、4.65 %( 2 /4 3 )、2 .3 3 %( 1/4 3 ) (P分别 <0 .0 0 5、0 .0 0 5、0 .0 0 5、>0 .0 5 ) ,且发作程度明显减轻。结论 中药敷贴。

冬病夏治对慢性支气管炎患者血清IgG、IgM、IgA水平的影响

目的:探讨冬病夏治穴位贴敷疗法对慢性支气管炎患者血清IgM、IgG、IgA水平的影响。方法:确诊慢性支气管炎缓解期的患者34例,随机均分为穴位贴敷治疗组和对照组,穴位贴敷治疗组给予"三伏贴"穴位贴敷疗法,对照组给予"安慰贴"穴位贴敷疗法,对比两组治疗前及治疗后的冬季血清IgM、IgG、IgA水平。结果:(1)与治疗前比较,治疗组治疗后血清中的IgM、IgG、IgA水平呈升高趋势,但差异无统计学意义(P>0.05);对照组血清IgM、IgG、IgA水平呈下降趋势,但差异无统计学意义(P>0.05);(2)治疗后两组比较在冬病夏治穴位贴敷治疗组血清IgM、IgG、IgA水平高于对照组,但血清IgM、IgG水平差异无统计学意义(P>0.05),IgA水平差异有统计学意义(P<0.05)。结论:冬病夏治穴位贴敷治疗能使慢性支气管炎患者血清IgM、IgG、IgA水平升高,以IgA最为明显。

冬病夏治之膏方新用治疗儿童反复呼吸道感染

儿童反复呼吸道感染在于肺脾肾不足,治疗的关键在于扶正祛邪,健脾益肺,提高儿童肺脾功能,从而达到提高儿童抗病能力的目的。通过中医治未病理论与临床实践,探讨夏日应用膏方治疗儿童反复呼吸道感染的可行性,为儿童反复呼吸道感染的诊疗提供新思路,提供更便捷、有效的方法。并为膏方应用提供更广阔的范围。

从“治未病”探讨儿童变态反应性疾病的防治

以"治未病"理论为指导思想,从未病先防、既病防变、疗后防复三个方面来讨论防治儿童变态反应性疾病的思路,指出过敏性体质儿童多属脾阴不足,不宜滥用清热泻火;应多用益气养阴,健脾除湿的药物改善体质;变态反应性疾病急性期重在祛邪,迁延期正邪兼顾,恢复期重在扶正;愈后当视患儿肺、脾、肾三脏虚损之不同,运用中成药、穴位敷贴、膏方等方法,达到扶正固本的目的。强调防治核心在于积极主动地改善过敏性体质,截断变态反应性疾病的进展,促进患儿的康复。

基于四季变化调理脾胃探析过敏性鼻炎防治

过敏性鼻炎常四季发病,严重影响病患的生活质量,故其防治有着极为重要的意义。脾胃者,寄治于四时,阴阳运动之中轴。脾胃旦病,则春生、夏长、秋收、冬藏皆为之不调,阴阳失和,鼻鼽遂生。笔者基于"春夏养阳,秋冬养阴"之法则,从理论依据、基四季调脾胃等方面详细探讨过敏性鼻炎之防治,提出春发陈,升运脾土为法、夏蕃秀,温补脾阳为治、秋容平,润脾降胃为法、冬闭藏,酸甘养阴为治,以应于临床,飨于同道。