Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is ...Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is refractory,recurrent and severe in winter and mild in summer,which has a great impact on patients'physical and mental health and quality of life.Traditional Chinese medicine has unique insights in the treatment of psoriasis,both curative effect and safety,have obvious advantages.Based on the concept of"winter disease and summer treatment",long-snake moxibustion gives full play to its functions of warming the kidney,invigorating the marrow,warming the meridians,activating blood circulation and removing blood stasis,so as to restore the deficiency of Yang in patients with psoriasis with external cold syndrome,enhance disease resistance,and prevent psoriasis recurrence or aggravation in winter.Therefore,based on the theory of"winter disease and summer treatment",this paper preliminarily discusses the mechanism of long-snake moxibustion in the prevention and treatment of psoriasis with external cold syndrome of Yang deficiency,and provides new ideas and directions for the prevention and treatment of psoriasis with traditional Chinese medicine.展开更多
Objective: To examine the variations in the prevalence of skin reactions and the association between skin reactions and efficacy of summer acupoint application treatment (SAAT) on chronic pulmonary disease (CPD)....Objective: To examine the variations in the prevalence of skin reactions and the association between skin reactions and efficacy of summer acupoint application treatment (SAAT) on chronic pulmonary disease (CPD). Methods: A total of 2,038 patients with CPD were enrolled at 3 independent hospitals (defined as Groups A, B and C, respectively) in China. All patients were treated by SAAT, as applying a herbal paste onto the acupoints of Fengmen (BL 12) and Feishu (BL 13) on the dog days of summer, according to the lunar calendar, in 2008. Ten days after treatment, skin reaction data (no reaction, itching, stinging, blistering, and infection) were obtained via face-to-face interviews. Patients were retreated in the same hospital one year later, thereby allowing doctors to assess treatment efficacy based on the patients' symptoms, the severity of the spirometric abnormalities, and the concomitant medications used. Results: A large number of patients (85.3%) displayed reactive symptoms; however, the marked associations between reactive symptoms and age or gender were not observed. An increased number of patients from Group B (99.3%) and Group C (76.5%) displayed reactive symptoms due to the increased mass of crude Semen Sinapis Albae. The effective rate of SPAT was as high as 90.4% for patients of Group B, which was followed by Group A (70.9%) and Group C (42.2%). Using stratified analyses, a convincing association between reactive symptoms and therapeutic efficacy was observed for patients with asthma [itching: odds ratio (OR)=2,17, 95% confidence interval (CI): 1.49 to 3.14; blistering: OR=0.43, 95% Ch 0.25 to 0.73; and no reaction: OR=0.56, 95% CI: 0.35 to 0.90]. However, the same tendency was not observed for patients with chronic bronchitis and chronic obstructive pulmonary disease. Conclusions: SAAT can induce very mild skin reactions for patients with CPD, among which patients with asthma displayed a strong association between skin reactions and therapeutic efficacy. The skin reactions may be induced by the crude Semen Sinapis Albae.展开更多
OBJECTIVE:To preliminarily analyze key factors influencing curative effect through clinical observations of acupoint application for "treatment of win-ter disease in summer" used to prevent and treat bronchi...OBJECTIVE:To preliminarily analyze key factors influencing curative effect through clinical observations of acupoint application for "treatment of win-ter disease in summer" used to prevent and treat bronchial asthma in children.METHODS:In an observational study and prospective cohort study,we observed children in remission of asthma at three class Ⅲ grade A TCM hospitals in Liaoning,Hubei,and Chengdu.RESULTS:A total of 609 children conformed to diagnostic and inclusive standards for remission of bronchial asthma.Through follow-up visits,we observed their skin reactions and the time and chance of treatment with different therapies in the three hospitals;we also compared and analyzed different drugs,acupoints,and preparations.We found that the key Chinese drugs were Bai Jie Zi(Semen Sinapis Albae) and Yian Hu Suo(Rhizoma Corydalis);the key acupoints were Feishu(BL 13),Gaohuang(BL 43),Dingchuan(EX-B1),Tiantu(CV 22),and Shanzhong(CV 17);and the best preparation was a mixture of drugs,ginger juice,and musk.Acupoint application was practiced on the hottest days of summer and the coldest days of winter for 0.5 to 2 h with the lowest rate of asthma relapse.CONCLUSIONS:The present data analysis shows that the curative effect of acupoint application for "treatment of winter disease in summer" may be influenced by recipes of Chinese drugs,preparations,prescriptions of acupoints,chance,time,and skin reactions.A curative effect is the result of the comprehensive action of these factors.展开更多
Objective: To analyze the clinical effect of traditionaldog-days acupoint application and Magic Acupuncture Patch (Manji) in the prevention and treatment of chronic bronchitis (CB) in remission stage in the past five ...Objective: To analyze the clinical effect of traditionaldog-days acupoint application and Magic Acupuncture Patch (Manji) in the prevention and treatment of chronic bronchitis (CB) in remission stage in the past five years, and explore the principle of action and effective stimulation, to provide the evidence for treating CB by acupoint application. Methods: A retrospective study was conducted on 405 patients with CB who met the inclusion criteria. All patients were treated with dog-days acupoint application or Magic Acupuncture Patch between 2013 and 2017. The clinical data of 405 patients were statistically analyzed to compare the prevention and treatment effects of dog-days acupoint application and Magic Acupuncture Patch, and different degrees of stimulation of dog-days acupoint application. Results: Among the dog-days acupoint application groups, the total effective rate was 63.6% in the light stimulation group, 93.1% in the moderate stimulation group, and 94.8% in the strong stimulation group. The differences in the total effective rate between the light stimulation group and the moderate stimulation group, as well as the strong stimulation group, were statistically significant (both P<0.05). There was no significant difference in the total effective rate between the moderate stimulation group and the strong stimulation group (P>0.05). The total effective rate was 83.9% in the dog-days acupoint application group, versus 45.4% in the Magic Acupuncture Patch group, and there was a statistically significant difference between the two groups (P<0.05). Conclusion: The efficacy of dog-days acupoint application in the prevention and treatment of CB is better than that of Magic Acupuncture Patch;the degree of stimulation is the basis for the effect of dog-days acupoint application on prevention and treatment of CB, and the moderate and strong stimulations are more appropriate.展开更多
目的 观察冬病夏治对雾霾暴露下支气管哮喘患者的临床疗效和炎性因子影响,为防治雾霾暴露下致哮喘急性发作提供思路。方法 选取2020年5月1日—2020年7月10日期间就诊于河北省中医院呼吸一科门诊的68例支气管哮喘患者,采用随机数字法分...目的 观察冬病夏治对雾霾暴露下支气管哮喘患者的临床疗效和炎性因子影响,为防治雾霾暴露下致哮喘急性发作提供思路。方法 选取2020年5月1日—2020年7月10日期间就诊于河北省中医院呼吸一科门诊的68例支气管哮喘患者,采用随机数字法分为对照组和贴敷组,每组各34例。对照组予基础治疗,贴敷组在对照组基础上予冬病夏治贴敷治疗。以低浓度雾霾月份7月为暴露前,高浓度雾霾月份12月为暴露后,观察比较两组患者临床疗效,暴露前后急性发作次数、哮喘控制测试问卷评分(Asthma Control Test questionnaire, ACT)、肺功能[第1秒用力呼气容积(Forced expiratory volume in 1 sec, FEV1)、第1秒用力呼气容积/用力肺活量(Forced expiratoryvolume in one second to forced vital capacity ratio, FEV1/FVC)、最大呼气流量(Peak Expiratory Flow, PEF)]、外周血嗜酸性粒细胞计数(Eosinophil count, EOS)及炎性因子[白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-8(Interleukin-8,IL-8)]水平。结果 治疗后贴敷组总有效率91.18%(31/34)明显高于对照组70.59%(24/34),差异有统计学意义(P<0.05)。暴露后两组患者急性发作次数较暴露前降低,ACT评分较暴露前升高,差异有统计学意义(P<0.05);且贴敷组急性发作次数明显低于对照组,ACT评分明显高于对照组,差异有统计学意义(P<0.05)。暴露后两组患FEV1、FEV1/FVC、PEF均较暴露前升高,差异有统计学意义(P<0.05);且贴敷组FEV1、FEV1/FVC、PEF明显高于对照组,差异有统计学意义(P<0.05)。暴露后两组患者IL-4、IL-8、EOS水平均较暴露前降低,差异有统计学意义(P<0.05);且贴敷组IL-4、IL-8、EOS水平明显低于对照组,差异有统计学意义(P<0.05)。结论 冬病夏治穴位贴敷治疗雾霾暴露下哮喘临床疗效显著,可改善哮喘患者急性发作次数、肺功能、ACT评分,降低血清EOS、IL-4、IL-8水平,减轻炎性反应,值得进一步推广。展开更多
目的观察不同季节中药穴位贴敷治疗哮喘的疗效,以及对肺功能:一秒用力呼气容积(Forced Expiratory Volume in one second,FEV1),用力肺活量(Forced Vital Capacity,FVC),呼气峰流速(Peak Expiratory Flow,PEF),一秒用力呼气容积/用力肺...目的观察不同季节中药穴位贴敷治疗哮喘的疗效,以及对肺功能:一秒用力呼气容积(Forced Expiratory Volume in one second,FEV1),用力肺活量(Forced Vital Capacity,FVC),呼气峰流速(Peak Expiratory Flow,PEF),一秒用力呼气容积/用力肺活量(FEV1/FVC)与血常规的影响。方法将92例哮喘患儿,根据贴敷时间分为两组,夏季组50例,冬季组42例,对其进行肺功能测定与血常规测定。结果夏季组总有效率88%,高于冬季组的78.57%(P<0.05);两组血常规中嗜酸性粒细胞百分数治疗后较治疗前均明显下降(P<0.05),夏季组中血小板计数治疗后较治疗前升高(P<0.05),其他血常规指标治疗前后及组间比较差异均无统计学意义(P>0.05);肺功能各指标夏季组治疗后较治疗前均有提高(P<0.05);冬季组的肺功能治疗前后差异无统计学意义(P>0.05),两组治疗后组间各肺功能指标对比,夏季组高于冬季组(P<0.05)。结论从肺功能而言,夏季(伏天)贴敷,较冬季贴敷疗效好,从而证实了传统的中医"冬病夏治"理论是正确有效的,并揭示了中药贴敷防治哮喘的作用机理。展开更多
基金National Key Research and Development Program:A Multicenter Randomized Controlled Study on the Treatment of Blood Stasis Syndrome in Psoriasis with the Method of Promoting Blood Circulation and Dispersing Blood Stasis(No.2018YFC1705303)Clinical Study of Long Snake Moxibustion in the Prevention and Treatment of Psoriasis of Yang Deficiency Syndrome Based on the Theory of"Treatment of Winter Disease in Summer"(No.2019SF-312)。
文摘Psoriasis is a chronic inflammatory skin disease with multiple layers of silvery white scales on the surface of erythema papule as the main clinical characteristics,of which yang-deficiency external cold psoriasis is refractory,recurrent and severe in winter and mild in summer,which has a great impact on patients'physical and mental health and quality of life.Traditional Chinese medicine has unique insights in the treatment of psoriasis,both curative effect and safety,have obvious advantages.Based on the concept of"winter disease and summer treatment",long-snake moxibustion gives full play to its functions of warming the kidney,invigorating the marrow,warming the meridians,activating blood circulation and removing blood stasis,so as to restore the deficiency of Yang in patients with psoriasis with external cold syndrome,enhance disease resistance,and prevent psoriasis recurrence or aggravation in winter.Therefore,based on the theory of"winter disease and summer treatment",this paper preliminarily discusses the mechanism of long-snake moxibustion in the prevention and treatment of psoriasis with external cold syndrome of Yang deficiency,and provides new ideas and directions for the prevention and treatment of psoriasis with traditional Chinese medicine.
基金Supported by the National Key Technology Research and Development Program for the Eleventh Five-Year Plan of China(No.2008BAI53B061)
文摘Objective: To examine the variations in the prevalence of skin reactions and the association between skin reactions and efficacy of summer acupoint application treatment (SAAT) on chronic pulmonary disease (CPD). Methods: A total of 2,038 patients with CPD were enrolled at 3 independent hospitals (defined as Groups A, B and C, respectively) in China. All patients were treated by SAAT, as applying a herbal paste onto the acupoints of Fengmen (BL 12) and Feishu (BL 13) on the dog days of summer, according to the lunar calendar, in 2008. Ten days after treatment, skin reaction data (no reaction, itching, stinging, blistering, and infection) were obtained via face-to-face interviews. Patients were retreated in the same hospital one year later, thereby allowing doctors to assess treatment efficacy based on the patients' symptoms, the severity of the spirometric abnormalities, and the concomitant medications used. Results: A large number of patients (85.3%) displayed reactive symptoms; however, the marked associations between reactive symptoms and age or gender were not observed. An increased number of patients from Group B (99.3%) and Group C (76.5%) displayed reactive symptoms due to the increased mass of crude Semen Sinapis Albae. The effective rate of SPAT was as high as 90.4% for patients of Group B, which was followed by Group A (70.9%) and Group C (42.2%). Using stratified analyses, a convincing association between reactive symptoms and therapeutic efficacy was observed for patients with asthma [itching: odds ratio (OR)=2,17, 95% confidence interval (CI): 1.49 to 3.14; blistering: OR=0.43, 95% Ch 0.25 to 0.73; and no reaction: OR=0.56, 95% CI: 0.35 to 0.90]. However, the same tendency was not observed for patients with chronic bronchitis and chronic obstructive pulmonary disease. Conclusions: SAAT can induce very mild skin reactions for patients with CPD, among which patients with asthma displayed a strong association between skin reactions and therapeutic efficacy. The skin reactions may be induced by the crude Semen Sinapis Albae.
基金Supported by a grant from the National Science and Technology Supporting Project in the 11th Five-year Plan(2008BAI53B061)
文摘OBJECTIVE:To preliminarily analyze key factors influencing curative effect through clinical observations of acupoint application for "treatment of win-ter disease in summer" used to prevent and treat bronchial asthma in children.METHODS:In an observational study and prospective cohort study,we observed children in remission of asthma at three class Ⅲ grade A TCM hospitals in Liaoning,Hubei,and Chengdu.RESULTS:A total of 609 children conformed to diagnostic and inclusive standards for remission of bronchial asthma.Through follow-up visits,we observed their skin reactions and the time and chance of treatment with different therapies in the three hospitals;we also compared and analyzed different drugs,acupoints,and preparations.We found that the key Chinese drugs were Bai Jie Zi(Semen Sinapis Albae) and Yian Hu Suo(Rhizoma Corydalis);the key acupoints were Feishu(BL 13),Gaohuang(BL 43),Dingchuan(EX-B1),Tiantu(CV 22),and Shanzhong(CV 17);and the best preparation was a mixture of drugs,ginger juice,and musk.Acupoint application was practiced on the hottest days of summer and the coldest days of winter for 0.5 to 2 h with the lowest rate of asthma relapse.CONCLUSIONS:The present data analysis shows that the curative effect of acupoint application for "treatment of winter disease in summer" may be influenced by recipes of Chinese drugs,preparations,prescriptions of acupoints,chance,time,and skin reactions.A curative effect is the result of the comprehensive action of these factors.
文摘Objective: To analyze the clinical effect of traditionaldog-days acupoint application and Magic Acupuncture Patch (Manji) in the prevention and treatment of chronic bronchitis (CB) in remission stage in the past five years, and explore the principle of action and effective stimulation, to provide the evidence for treating CB by acupoint application. Methods: A retrospective study was conducted on 405 patients with CB who met the inclusion criteria. All patients were treated with dog-days acupoint application or Magic Acupuncture Patch between 2013 and 2017. The clinical data of 405 patients were statistically analyzed to compare the prevention and treatment effects of dog-days acupoint application and Magic Acupuncture Patch, and different degrees of stimulation of dog-days acupoint application. Results: Among the dog-days acupoint application groups, the total effective rate was 63.6% in the light stimulation group, 93.1% in the moderate stimulation group, and 94.8% in the strong stimulation group. The differences in the total effective rate between the light stimulation group and the moderate stimulation group, as well as the strong stimulation group, were statistically significant (both P<0.05). There was no significant difference in the total effective rate between the moderate stimulation group and the strong stimulation group (P>0.05). The total effective rate was 83.9% in the dog-days acupoint application group, versus 45.4% in the Magic Acupuncture Patch group, and there was a statistically significant difference between the two groups (P<0.05). Conclusion: The efficacy of dog-days acupoint application in the prevention and treatment of CB is better than that of Magic Acupuncture Patch;the degree of stimulation is the basis for the effect of dog-days acupoint application on prevention and treatment of CB, and the moderate and strong stimulations are more appropriate.
文摘目的 观察冬病夏治对雾霾暴露下支气管哮喘患者的临床疗效和炎性因子影响,为防治雾霾暴露下致哮喘急性发作提供思路。方法 选取2020年5月1日—2020年7月10日期间就诊于河北省中医院呼吸一科门诊的68例支气管哮喘患者,采用随机数字法分为对照组和贴敷组,每组各34例。对照组予基础治疗,贴敷组在对照组基础上予冬病夏治贴敷治疗。以低浓度雾霾月份7月为暴露前,高浓度雾霾月份12月为暴露后,观察比较两组患者临床疗效,暴露前后急性发作次数、哮喘控制测试问卷评分(Asthma Control Test questionnaire, ACT)、肺功能[第1秒用力呼气容积(Forced expiratory volume in 1 sec, FEV1)、第1秒用力呼气容积/用力肺活量(Forced expiratoryvolume in one second to forced vital capacity ratio, FEV1/FVC)、最大呼气流量(Peak Expiratory Flow, PEF)]、外周血嗜酸性粒细胞计数(Eosinophil count, EOS)及炎性因子[白细胞介素-4(Interleukin-4,IL-4)、白细胞介素-8(Interleukin-8,IL-8)]水平。结果 治疗后贴敷组总有效率91.18%(31/34)明显高于对照组70.59%(24/34),差异有统计学意义(P<0.05)。暴露后两组患者急性发作次数较暴露前降低,ACT评分较暴露前升高,差异有统计学意义(P<0.05);且贴敷组急性发作次数明显低于对照组,ACT评分明显高于对照组,差异有统计学意义(P<0.05)。暴露后两组患FEV1、FEV1/FVC、PEF均较暴露前升高,差异有统计学意义(P<0.05);且贴敷组FEV1、FEV1/FVC、PEF明显高于对照组,差异有统计学意义(P<0.05)。暴露后两组患者IL-4、IL-8、EOS水平均较暴露前降低,差异有统计学意义(P<0.05);且贴敷组IL-4、IL-8、EOS水平明显低于对照组,差异有统计学意义(P<0.05)。结论 冬病夏治穴位贴敷治疗雾霾暴露下哮喘临床疗效显著,可改善哮喘患者急性发作次数、肺功能、ACT评分,降低血清EOS、IL-4、IL-8水平,减轻炎性反应,值得进一步推广。
文摘目的观察不同季节中药穴位贴敷治疗哮喘的疗效,以及对肺功能:一秒用力呼气容积(Forced Expiratory Volume in one second,FEV1),用力肺活量(Forced Vital Capacity,FVC),呼气峰流速(Peak Expiratory Flow,PEF),一秒用力呼气容积/用力肺活量(FEV1/FVC)与血常规的影响。方法将92例哮喘患儿,根据贴敷时间分为两组,夏季组50例,冬季组42例,对其进行肺功能测定与血常规测定。结果夏季组总有效率88%,高于冬季组的78.57%(P<0.05);两组血常规中嗜酸性粒细胞百分数治疗后较治疗前均明显下降(P<0.05),夏季组中血小板计数治疗后较治疗前升高(P<0.05),其他血常规指标治疗前后及组间比较差异均无统计学意义(P>0.05);肺功能各指标夏季组治疗后较治疗前均有提高(P<0.05);冬季组的肺功能治疗前后差异无统计学意义(P>0.05),两组治疗后组间各肺功能指标对比,夏季组高于冬季组(P<0.05)。结论从肺功能而言,夏季(伏天)贴敷,较冬季贴敷疗效好,从而证实了传统的中医"冬病夏治"理论是正确有效的,并揭示了中药贴敷防治哮喘的作用机理。