The treatment engineering of landslide hazard is a complicated systemengineering. The selecting treatment scheme is influenced by many factors such as technology,economics, environment, and risk. The decision-making o...The treatment engineering of landslide hazard is a complicated systemengineering. The selecting treatment scheme is influenced by many factors such as technology,economics, environment, and risk. The decision-making of treatment schemes of landslide hazard is aproblem of comprehensive judgment with multi-hierarchy and multi-objective. The traditional analysishierarchy process needs identity test. The traditional analysis hierarchy process is improved bymeans of optimal transfer matrix here. An improved hierarchy decision-making model for the treatmentof landslide hazard is set up. The judgment matrix obtained by the method can naturally meet therequirement of identity, so the identity test is not necessary. At last, the method is applied tothe treatment decision-making of the dangerous rock mass at the Slate Mountain, and its applicationis discussed in detail.展开更多
Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infecti...Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infection were selected and randomly assigned Combined treatment with omeprazole,amoxicillin and clarithromycin was named group A;Group B was treated with omeprazole,amoxicillin,clarithromycin and colloidal bismuth pectin;Group C was given omeprazole,amoxicillin,clarithromycin and metronidazole.Results:The symptom score and gastroscope score of group B or C were lower than those of group A(P<0.05);The incidence of adverse reactions and HP eradication rate in group C were lower than those in group B,and those in group B were lower than those in group A(P<0.05);The quality of life score of group C was higher than that of group B,and that of group B was higher than that of group A,P<0.05.Conclusions:The sequential therapy of omeprazole,amoxicillin,clarithromycin and metronidazole in patients with Helicobacter pylori infection can improve the HP eradication rate,improve the quality of life of patients,which is safe and efficient.展开更多
Objective:Using big data mining technology and network pharmacology,this study aimed to identify the dominant traditional Chinese medicine(TCM)for the prophylaxis and treatment of severe Corona Virus Disease 2019(COVI...Objective:Using big data mining technology and network pharmacology,this study aimed to identify the dominant traditional Chinese medicine(TCM)for the prophylaxis and treatment of severe Corona Virus Disease 2019(COVID-19),predict the pharmacological mechanism of the dominant anti-epidemic TCM,and provide clinical guidance for COVID-19 prevention and control.Methods:The Traditional Chinese Medicine Inheritance Computing Platform V3.0 was utilized to identify the high-frequency TCM in the adult severe prescriptions of the national Diagnosis and Treatment Plan for COVID-19(Trial 10th edition)and the TCM prophylaxis and cure plan for COVID-19 in 27 regions.The active ingredients and potential targets of the high-frequency core drugs were analyzed using Traditional Chinese Medicine Systems Pharmacology Technology Platform,Traditional Chinese Medicine Integrated Database,and Traditional Chinese Medicine Encyclopedia Database,and the network of“core drug active ingredient-potential targets”was obtained.The String platform was used to establish the protein-protein interaction structure chart,and Cytoscape software was used for visualization and network topology analysis to identify pivotal targets.Signal pathway enrichment analysis of the core targets was performed,and the affinity of the active components entering the blood was predicted by docking with the related targets of the novel coronavirus.Results:Ellagic acid,Vestitol,naringin,dehydroglyasperins C,quercetin,and kaemol were identified as 67 active constituents in the blood.After docking the active constituents with angiotensin-converting enzyme II,3C-likeProteinase,and tyrosine protein kinase receptor UFO,they all showed good affinity.The pivotal targets mainly involved inflammatory factors such as IL-6 and TNF.Pathway concentration analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways focused on inflammatory and immune-related pathways such as the TNF signaling pathway.Conclusion:The high-frequency core drugs may act on the body through active components such as ellagic acid,Vestitol,naringin,dehydroglyasperins C,quercetin,and kaemol.Inflammatory and related immune pathways,such as the TNF signaling pathway,may suppress cytokine storms and effectively treat patients with severe COVID-19.展开更多
文摘The treatment engineering of landslide hazard is a complicated systemengineering. The selecting treatment scheme is influenced by many factors such as technology,economics, environment, and risk. The decision-making of treatment schemes of landslide hazard is aproblem of comprehensive judgment with multi-hierarchy and multi-objective. The traditional analysishierarchy process needs identity test. The traditional analysis hierarchy process is improved bymeans of optimal transfer matrix here. An improved hierarchy decision-making model for the treatmentof landslide hazard is set up. The judgment matrix obtained by the method can naturally meet therequirement of identity, so the identity test is not necessary. At last, the method is applied tothe treatment decision-making of the dangerous rock mass at the Slate Mountain, and its applicationis discussed in detail.
文摘Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infection were selected and randomly assigned Combined treatment with omeprazole,amoxicillin and clarithromycin was named group A;Group B was treated with omeprazole,amoxicillin,clarithromycin and colloidal bismuth pectin;Group C was given omeprazole,amoxicillin,clarithromycin and metronidazole.Results:The symptom score and gastroscope score of group B or C were lower than those of group A(P<0.05);The incidence of adverse reactions and HP eradication rate in group C were lower than those in group B,and those in group B were lower than those in group A(P<0.05);The quality of life score of group C was higher than that of group B,and that of group B was higher than that of group A,P<0.05.Conclusions:The sequential therapy of omeprazole,amoxicillin,clarithromycin and metronidazole in patients with Helicobacter pylori infection can improve the HP eradication rate,improve the quality of life of patients,which is safe and efficient.
基金supported by the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine (No.2021175).
文摘Objective:Using big data mining technology and network pharmacology,this study aimed to identify the dominant traditional Chinese medicine(TCM)for the prophylaxis and treatment of severe Corona Virus Disease 2019(COVID-19),predict the pharmacological mechanism of the dominant anti-epidemic TCM,and provide clinical guidance for COVID-19 prevention and control.Methods:The Traditional Chinese Medicine Inheritance Computing Platform V3.0 was utilized to identify the high-frequency TCM in the adult severe prescriptions of the national Diagnosis and Treatment Plan for COVID-19(Trial 10th edition)and the TCM prophylaxis and cure plan for COVID-19 in 27 regions.The active ingredients and potential targets of the high-frequency core drugs were analyzed using Traditional Chinese Medicine Systems Pharmacology Technology Platform,Traditional Chinese Medicine Integrated Database,and Traditional Chinese Medicine Encyclopedia Database,and the network of“core drug active ingredient-potential targets”was obtained.The String platform was used to establish the protein-protein interaction structure chart,and Cytoscape software was used for visualization and network topology analysis to identify pivotal targets.Signal pathway enrichment analysis of the core targets was performed,and the affinity of the active components entering the blood was predicted by docking with the related targets of the novel coronavirus.Results:Ellagic acid,Vestitol,naringin,dehydroglyasperins C,quercetin,and kaemol were identified as 67 active constituents in the blood.After docking the active constituents with angiotensin-converting enzyme II,3C-likeProteinase,and tyrosine protein kinase receptor UFO,they all showed good affinity.The pivotal targets mainly involved inflammatory factors such as IL-6 and TNF.Pathway concentration analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways focused on inflammatory and immune-related pathways such as the TNF signaling pathway.Conclusion:The high-frequency core drugs may act on the body through active components such as ellagic acid,Vestitol,naringin,dehydroglyasperins C,quercetin,and kaemol.Inflammatory and related immune pathways,such as the TNF signaling pathway,may suppress cytokine storms and effectively treat patients with severe COVID-19.
