The title complex, tri(o-chlorobenzyl)tin ester of 4-pyridinecarboxylic acid, has been synthesized by the reaction of bis[tri(2-chlorobenzyl)tin] oxide with 4-pyridinyl carboxylic acid and characterized by elemental...The title complex, tri(o-chlorobenzyl)tin ester of 4-pyridinecarboxylic acid, has been synthesized by the reaction of bis[tri(2-chlorobenzyl)tin] oxide with 4-pyridinyl carboxylic acid and characterized by elemental analysis, IR and H NMR, and its crystal structure was 1 determined by X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P21/n with a = 8.821(7), b = 18.888(15), c = 15.333(12) ?, β = 92.390(12)°, Z = 4, V = 2552(3) ?3, Dc= 1.607 g/cm3, μ = 1.340 mm-1, F(000) = 1232, R = 0.0408 and wR = 0.0962. In the molecular structure of the title complex, the tin atoms are five-coordinated into a trigonal bipyramidal geometry by coordinating to the intermolecular pyridine N atoms of carboxylate groups. The resulting structure is a one-dimensional linear polymer containing Sn–O (2.150(4) ?) and Sn–N (2.522(4) ?) bonds.展开更多
Tri(o-chlorobenzyl)tin 2,4,6-trimethylbenzoate(1) and tri(o-bromobenzyl)tin salicylate(2) were synthesized and characterized by elemental analysis, IR spectroscopy, NMR(1H, 13C and 119Sn), thermogravimetric analysis, ...Tri(o-chlorobenzyl)tin 2,4,6-trimethylbenzoate(1) and tri(o-bromobenzyl)tin salicylate(2) were synthesized and characterized by elemental analysis, IR spectroscopy, NMR(1H, 13C and 119Sn), thermogravimetric analysis, and single-crystal X-ray diffraction. The initio calculation and in vitro anticancer activity test were performed for compounds 1 and 2. They are both single tin nucleus structures and the tin atoms were tetracoordinated in a distorted tetrahedral configuration;Compounds 1 and 2 showed stronger anticancer activity than cisplatin in human cervical cancer cells(Hela), liver cancer cells(Hu H-7), non-small cell lung cancer cells(A549), lung adenocarcinoma cells(H1975) and breast cancer(MCF-7).展开更多
文摘The title complex, tri(o-chlorobenzyl)tin ester of 4-pyridinecarboxylic acid, has been synthesized by the reaction of bis[tri(2-chlorobenzyl)tin] oxide with 4-pyridinyl carboxylic acid and characterized by elemental analysis, IR and H NMR, and its crystal structure was 1 determined by X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P21/n with a = 8.821(7), b = 18.888(15), c = 15.333(12) ?, β = 92.390(12)°, Z = 4, V = 2552(3) ?3, Dc= 1.607 g/cm3, μ = 1.340 mm-1, F(000) = 1232, R = 0.0408 and wR = 0.0962. In the molecular structure of the title complex, the tin atoms are five-coordinated into a trigonal bipyramidal geometry by coordinating to the intermolecular pyridine N atoms of carboxylate groups. The resulting structure is a one-dimensional linear polymer containing Sn–O (2.150(4) ?) and Sn–N (2.522(4) ?) bonds.
基金supported by the open fund project of Hunan Provincial innovation platform(18K089)the key project of Hunan Provincial education department(19A070)+2 种基金the open fund of Hunan Provincial key laboratory(M018K07)Hengyang science and technology plan project,Hunan Provincial applied characteristic discipline fundHunan Provincial science and technology innovation team support plan。
文摘Tri(o-chlorobenzyl)tin 2,4,6-trimethylbenzoate(1) and tri(o-bromobenzyl)tin salicylate(2) were synthesized and characterized by elemental analysis, IR spectroscopy, NMR(1H, 13C and 119Sn), thermogravimetric analysis, and single-crystal X-ray diffraction. The initio calculation and in vitro anticancer activity test were performed for compounds 1 and 2. They are both single tin nucleus structures and the tin atoms were tetracoordinated in a distorted tetrahedral configuration;Compounds 1 and 2 showed stronger anticancer activity than cisplatin in human cervical cancer cells(Hela), liver cancer cells(Hu H-7), non-small cell lung cancer cells(A549), lung adenocarcinoma cells(H1975) and breast cancer(MCF-7).
