Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed,synthesized,and evaluated through a Spirodela polyrrhiza test and a greenhouse test.Some compounds show 】 80% c...Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed,synthesized,and evaluated through a Spirodela polyrrhiza test and a greenhouse test.Some compounds show 】 80% chlorophyll inhibition of Spirodela polyrrhiza at 10 μg/mL and exhibit some herbicidal activities against Digitaria adscendens in the pre-emergence treatment at a rate of 150 g/ha.Moreover,the study of the structure-activity relationship(SAR) suggests that the appropriate bulky substituent at the right position is critical for the bleaching and herbicidal activities,which may be useful for the future design of new compounds.展开更多
In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)p...In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)piperazine.In this study,a new pretreatment method and gas chromatography(GC)/nitrogen–phosphorus detector detection technique were used to characterize these two kinds of drugs in urine and blood samples.For the purpose of isolation of these trace drugs from the samples,liquid‑liquid extraction/solid‑phase extraction was modified and validated for this specific study.The pretreatment method presented in this paper has many advantages,such as high recovery rate,high extraction efficiency,high detection sensitivity,low limit of detection,and simple operation.The GC/NPD instrument is popular in most laboratories because it can meet the routine requirements of forensic science.All these aspects make this combination of sample pretreatment and GC/NPD technique the most suitable choice for drug detection in biological samples.展开更多
基金support from the China 973 Program (Grant No.2010CB126103)the National Natural Science Foundation of China (Grant Nos.20572054 & 20972081)
文摘Three series of forty-nine novel 4-(3-trifluoromethylphenyl)-2H-pyridazin-3-one derivatives are designed,synthesized,and evaluated through a Spirodela polyrrhiza test and a greenhouse test.Some compounds show 】 80% chlorophyll inhibition of Spirodela polyrrhiza at 10 μg/mL and exhibit some herbicidal activities against Digitaria adscendens in the pre-emergence treatment at a rate of 150 g/ha.Moreover,the study of the structure-activity relationship(SAR) suggests that the appropriate bulky substituent at the right position is critical for the bleaching and herbicidal activities,which may be useful for the future design of new compounds.
基金supported by Fundamental research fund of Institute of Forensic Science,Ministry of Public Security(The detection of new drugs analysis in biological samples.No.2012JB005)Academician Foundation of the Ministry of Public Security of the People’s Republic of China(No.2011-23214203,23215243,23317015)+2 种基金Beijing Municipal Education Commission University Science and Technology Park Construction Project(2011-08111603)Program for Young Innovative Research Team in China University of Political Science and Law(2014CXTD04,16CXTD05)the opening project fund of Shanghai Key Laboratory of Criminal Scene Evidence(2011-23417049).
文摘In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)piperazine.In this study,a new pretreatment method and gas chromatography(GC)/nitrogen–phosphorus detector detection technique were used to characterize these two kinds of drugs in urine and blood samples.For the purpose of isolation of these trace drugs from the samples,liquid‑liquid extraction/solid‑phase extraction was modified and validated for this specific study.The pretreatment method presented in this paper has many advantages,such as high recovery rate,high extraction efficiency,high detection sensitivity,low limit of detection,and simple operation.The GC/NPD instrument is popular in most laboratories because it can meet the routine requirements of forensic science.All these aspects make this combination of sample pretreatment and GC/NPD technique the most suitable choice for drug detection in biological samples.
