The XCF_(3)groups(X=O,S,Se)play an increasingly important role in modern organic chemistry due to their unique electronegativity,lipophilic nature,metabolic stability,and bioavailability.Heterocyclic compounds are imp...The XCF_(3)groups(X=O,S,Se)play an increasingly important role in modern organic chemistry due to their unique electronegativity,lipophilic nature,metabolic stability,and bioavailability.Heterocyclic compounds are important scaffolds in many bioactive compounds and drugs.The incorporation of XCF_(3)groups into heterocyclic compounds can change their physicochemical and biological properties,which injects new vitality into the application of heterocyclic compounds in many fields such as organic chemistry,the pharmaceutical chemistry,and life sciences.In this paper,the recent progress in the synthesis of F_(3)CX-containing heterocycles is reviewed,and the application scope and mechanism of some reactions are discussed.展开更多
The preparation of heteroaryl trifluoromethyl selenoethers by the trifluoromethylselenolation of heteroaryl bro- mides with [（bpy）CuSeCF3]2 was investigated. Using this approach, a large number of trifluoromethylsel...The preparation of heteroaryl trifluoromethyl selenoethers by the trifluoromethylselenolation of heteroaryl bro- mides with [（bpy）CuSeCF3]2 was investigated. Using this approach, a large number of trifluoromethylselenolated heterocyclic compounds were synthesized in good to excellent yields. It was demonstrated that this procedure toler- ates a wide variety of functional groups.展开更多
基金supported by the National Natural Science Foundation of China(No.21801007)。
文摘The XCF_(3)groups(X=O,S,Se)play an increasingly important role in modern organic chemistry due to their unique electronegativity,lipophilic nature,metabolic stability,and bioavailability.Heterocyclic compounds are important scaffolds in many bioactive compounds and drugs.The incorporation of XCF_(3)groups into heterocyclic compounds can change their physicochemical and biological properties,which injects new vitality into the application of heterocyclic compounds in many fields such as organic chemistry,the pharmaceutical chemistry,and life sciences.In this paper,the recent progress in the synthesis of F_(3)CX-containing heterocycles is reviewed,and the application scope and mechanism of some reactions are discussed.
文摘The preparation of heteroaryl trifluoromethyl selenoethers by the trifluoromethylselenolation of heteroaryl bro- mides with [（bpy）CuSeCF3]2 was investigated. Using this approach, a large number of trifluoromethylselenolated heterocyclic compounds were synthesized in good to excellent yields. It was demonstrated that this procedure toler- ates a wide variety of functional groups.
