Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke

Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactive materials can repair the damage caused by ischemic stroke by activating endogenous neurogenesis and angiogenesis is still unknown.In this study,we applied chitosan gel loaded with basic fibroblast growth factor to the stroke cavity 7 days after ischemic stroke in rats.The gel slowly released basic fibroblast growth factor,which improved the local microenvironment,activated endogenous neural stem/progenitor cells,and recruited these cells to migrate toward the penumbra and stroke cavity and subsequently differentiate into neurons,while enhancing angiogenesis in the penumbra and stroke cavity and ultimately leading to partial functional recovery.This study revealed the mechanism by which bioactive materials repair ischemic strokes,thus providing a new strategy for the clinical application of bioactive materials in the treatment of ischemic stroke.

UNIFORM ANALYTIC CONSTRUCTION OF WAVELET ANALYSIS FILTERS BASED ON SINE AND COSINE TRIGONOMETRIC FUNCTIONS

Based on sine and cosine functions, the compactly supported orthogonal wavelet filter coefficients with arbitrary length are constructed for the first time. When N = 2(k-1) and N = 2k, the unified analytic constructions of orthogonal wavelet filters are put forward, respectively. The famous Daubechies filter and some other well-known wavelet filters are tested by the proposed novel method which is very useful for wavelet theory research and many application areas such as pattern recognition.

Effect and function mechanism of sinter basicity on softening-melting behaviors of mixed burden made from chromium-bearing vanadium-titanium magnetite

The effect of sinter basicity on softening-melting behaviors of mixed burden made from chromium-bearing vanadium-titanium magnetite(Cr-V-Ti magnetite) was investigated and the function mechanism was simultaneously analyzed.The results show that with increasing sinter basicity from 1.71 to 2.36,the softening interval tends to increase from 149.3 ℃ to 181.7 ℃while the melting interval tends to decrease from 178.0 ℃ to 136.7 ℃.The location of cohesive zone moves downwards firstly and then ascends slightly,but the cohesive zone becomes thinner.The softening-melting characteristic value becomes small,which indicates that the permeability of burden column is improved.The dripping ratio of mixed burden tends to increase firstly and then decrease,which comes to the highest value of 74.50%when the sinter basicity is 2.13.The content and the recovery of V and Cr in dripping iron are all increased.The generation amount of components with high melting point in slag becomes little with the increase of sinter basicity,which could improve the permeability of mixed burden.Taking softening-melting behaviors of mixed burden and recovery of valuable elements into account,the proper sinter basicity is no less than 2.13 for smelting mixed burden made from Cr-V-Ti magnetite in blast furnace.

Numerical Solution of Green’s Function for Solving Inhomogeneous Boundary Value Problems with Trigonometric Functions by New Technique

A numerical technique is presented for solving integration operator of Green’s function. The approach is based on Hermite trigonometric scaling function on [0,2π], which is constructed for Hermite interpolation. The operational matrices of derivative for trigonometric scaling function are presented and utilized to reduce the solution of the problem. One test problem is presented and errors plots show the efficiency of the proposed technique for the studied problem.

On Certain Properties of Trigonometrically <i>ρ</i>-Convex Functions

The aim of this paper is to prove that the average function of a trigonometrically ρ-convex function is trigonometrically ρ-convex. Furthermore, we show the existence of support curves implies the trigonometric ρ-convexity, and prove an extremum property of this function.

A constructive method for approximating trigonometric functions and their integrals

This paper presents an interpolation-based method(IBM)for approximating some trigonometric functions or their integrals as well.It provides two-sided bounds for each function,which also achieves much better approximation effects than those of prevailing methods.In principle,the IBM can be applied for bounding more bounded smooth functions and their integrals as well,and its applications include approximating the integral of sin(x)/x function and improving the famous square root inequalities.

Basic Functions for Computational Implementation of the Box-Cox Symmetric Class of Distributions

A class of distributions called Box-Cox symmetric was proposed for random variables with asymmetric distributions. This class allows through its structure an interpretation of the parameters in terms of quantiles (in particular, the median), relative dispersion and skewness. This study presents the initial results of the computational development of basic functions of each of the distributions that make up the Box-Cox symmetric class. Four functions have been developed to compose a routine in software R up to now. These functions are related to random numbers generation, probability density function, cumulative distribution function, and quantile function associated to a given probability. Examples of implemented functions were presented. The gamlss routine was used to check the performance of developed functions.

Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development

Basic helix-loop-helix （bHLH） transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila （larman et al., 1993, 1994）. Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs （Jar- man et al., 1993）. Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors （R1-R7） directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells （Jarman et al., 1994）.

Fractional Weierstrass Function by Application of Jumarie Fractional Trigonometric Functions and Its Analysis

The classical example of no-where differentiable but everywhere continuous function is Weierstrass function. In this paper we have defined fractional order Weierstrass function in terms of Jumarie fractional trigonometric functions. The H?lder exponent and Box dimension of this new function have been evaluated here. It has been established that the values of H?lder exponent and Box dimension of this fractional order Weierstrass function are the same as in the original Weierstrass function. This new development in generalizing the classical Weierstrass function by use of fractional trigonometric function analysis and fractional derivative of fractional Weierstrass function by Jumarie fractional derivative, establishes that roughness indices are invariant to this generalization.

开放型区域产教融合实践中心的基本特征、功能定位与推进路径

开放型区域产教融合实践中心(简称“产教融合实践中心”)是对标产业发展前沿,由政府搭台、市场驱动,汇集产教资源,政、校、行、企等多元主体参与,旨在推动区域职业教育实训实践资源均衡发展,提升职业学校关键办学能力,为企业培养急需人才和提供技术服务的生产性实践组织形态。产教融合实践中心分为学校实践中心、公共实践中心、企业实践中心,具有参与主体的多元性、服务面向的区域性以及运营模式的多样性等基本特征;具备实践教学、社会培训、真实生产和技术服务等功能。要扎实推进产教融合实践中心建设,必须坚持政府引导,统筹谋划产教融合实践中心建设;坚持市场驱动,以股份制混合所有制推进产教融合实践中心建设;坚持同步发力,分类推进产教融合实践中心建设。

职业教育数字教材建设与应用探析

职业教育数字化教材建设与应用前景广阔。通过对职业教育数字教材定义的辨析和梳理,以及将其和类似的教育信息化产品进行比较,厘清职业教育数字教材的概念和内涵,指出其应当具备特殊出版物特性、职业教育特点、数字化特征。进而,在回顾职业教育数字教材的发展与演进的基础上,阐述了其应当具备的三个层次功能。在刻画职业教育数字教材生态体系应具备的创作、审核、发布(发行)、应用的完整闭环,并涵盖作者服务、读者服务、管理者服务、出版者内部流程和线上编审校服务系统的基础上,提出建设普惠性标准化的数字教材出版平台,开发不同类型不同层次的数字化教材产品的工作要点。之后,辨析了其与新型活页式教材、工作手册式教材的不同点与整合创新的意义。梳理总结了此类教材的开发基本原则和主要策略。最后,从内容彰显职教特点、数字资源规范化开发、建立开发流程标准、建设质量评价体系四个方面提出了标准和规范化的开发策略。

因地制宜:基层人民法院职能定位和履行的地方性问题——以法律地理学为视阈

随着2021年启动的“完善四级法院审级职能定位”改革试点工作的停止,现行各级法院职能定位从司法体制改革的重点问题似乎变成了一个没有问题、无需改变的存在。但实践中,四级法院在审判职能和其他职能定位和履行两个方面,仍然存在如何进一步明确功能定位、优化权力配置、凸显正当程序价值的现实需要。基层人民法院作为基层审判机关,在参与社会治理、纠纷解决和实现司法公正方面具有举足轻重的作用。作为一个地域广袤、人口众多的多民族国家,由于地域差异极大,发展水平极不平衡,我国不同地区的基层法院在案件构成、法官办案能力以及办案人员配置等方面往往存在明显差异。运用法律地理学侧重于人、地、法之间的影响与关系的研究方法,揭示不同地区基层人民法院职能的地方性差异、特点和优化路径,能够为完善基层人民法院的职能构建提供借鉴和参考。

论教育法典的基本原则

基本原则是教育法典总则编的重要组成部分,既应发挥预期功能,又应具有坚实的规范基础。作为“总则—序编”合一立法模式下的必然产物,基本原则应当发挥统摄整个法典展开和作为法典实施依据两大功能。前者涉及基本原则作为法典内在体系和价值融贯性的体现;后者意味着基本原则在法典实施过程中发挥解释和补充功能。具备坚实的规范基础,要求提炼教育法典基本原则的主要路径应当是:承接自现行宪法教育相关条款,以《教育法》总则章为基础加以抽象,以及由其他教育单行法“提取公因式”。教育法典的基本原则应当包括立德树人原则、受教育权保障原则、教育平等原则以及教育自主性原则。

微惯性环节介入法与同阶闭环系统的稳定性

奈奎斯特判据是经典控制理论中最为重要的稳定性判据,但并不适用于同阶闭环系统。同时由于基本环节样式不全、开环传递函数含义易误解且使用不便,导致初学者对自控原理学习和理解的困扰。为此对频域法的一些概念和表达方式进行了梳理,对基本环节和控制系统进行了完整的分类,提出环路传递函数概念解决了开环传递函数含义易误解和使用不便的问题,提出微惯性环节介入法解决了同阶闭环系统稳定性判断的问题,环路传递函数、微惯性环节介入法、巨惯性环节与微阻尼振荡环节替代等方法大大地简化了系统特性的分析,从而完善了频域分析法及其知识体系。

Visual Basic 6.0在农药毒力测定数据处理中的应用

根据Logistic函数法原则,采用VisualBasic6.0编制农药毒力测定数据处理系统。该系统是基于Windows的操作系统。与机值分析法进行比较,运用该系统进行农药毒力测定数据处理的计算简便、快速,其计算结果与机值分析法基本一致。

动态法提取可溶性大豆多糖的纯化及其性能分析

旨在为可溶性大豆多糖(SSPS)的纯化工艺改进和豆渣资源综合利用提供参考,采用动态法从干豆渣中提取得到SSPS粗品后,通过酶解、活性炭吸附以及醇沉等步骤进行纯化,优化了纯化工艺,并考察了纯化对SSPS的基本成分、理化指标、挥发性成分、结构和性能的影响。结果表明,最适酶解条件为木瓜蛋白酶添加量1.0%、酶解pH 6、酶解温度60℃、酶解时间2 h;活性炭吸附最适条件为活性炭添加量1.0%、吸附pH 5、吸附温度65℃、吸附时间30 min;纯化处理后SSPS的蛋白质及灰分含量分别从3.60%、5.13%下降至2.19%、4.73%;纯化SSPS的透明度提高了71.94%,黏度降低,挥发性成分的数量减少了18种,而分子质量未发生显著性变化;纯化SSPS与市售SSPS在分子结构方面相似,但是结晶度存在一些差异;纯化SSPS的起泡性和乳化性分别达到213.70%和0.76,泡沫稳定性和乳化稳定性均优于市售SSPS和阿拉伯胶的。综上,经动态法提取的SSPS纯化后产品性能均有不同程度改善。

基于薄板样条径向基函数的复合材料层合板自由振动分析

基于复合材料层合板的三角剪切变形理论,推导了对称复合材料层合板的控制微分方程。利用基于薄板样条径向基函数的无网格配置方法离散的控制微分方程,预测了对称复合材料层合板的自由振动行为。计算了不同材料参数和层合板几何参数的固有频率,并与文献结果进行了比较。还研究了节点排布、模量比和边厚比对固有频率的影响。结果表明,本文结果与文献结果具有较好的一致性,节点数量越大,无量纲频率对网格分布越不敏感,固有频率随着边厚比和模量比的增加而增加。通过数值实验,证明了用薄板样条径向基函数离散的三角剪切变形理论对对称复合材料层合板的自由振动分析具有较高的数值精度和良好的收敛性。

Visual Basic中操作指针的技术及应用

由于Visual Basic语言中缺少指针这种现代编程语言中很重要的数据类型,使一些程序的编制复杂而运行低效。介绍了在VisualBasic语言中,通过API函数调用间接实现指针操作的技术,并将常用的指针操作集成到一个标准模块中。在未来的软件开发中,只需要简单调用这个标准模块,就可以编写出简洁高效的程序。给出并分析了一些实际利用指针操作的程序源代码,这些源代码解决了软件开发中经常遇到的几个问题。最后讨论了这些利用指针可能带来的弊端。

基于层次分析法(AHP)与模糊综合评价相结合的油区输电线路运行状态评价

油田快速建产对油区电力系统可靠性提出更高的要求,架空输电线路的运行状态评价是保障电路安全可靠运行的重要环节。为此,本文提出了基于层次分析法与模糊综合评价相结合的油区输电线路运行状态评价方法。通过选取相关评价指标,搭建输电线路运行状态评价体系,采用层次分析法和模糊综合评价相结合的方式,对输电线路展开综合评价。实验结果表明,该条输电线路运行状态处于“注意”,验证了所提出的状态评价方法的有效性。

基础医学综合性实验课程体系的建设与探索

文章以提高医学人才培养质量和岗位胜任力为目标,从修订实验教学大纲和编写实验教程着手,构建基础医学阶段基于创新实践能力培养的实验教学体系。包括:依托实验动物学、组织学技术和微血管技术,强化医学生基础医学阶段基本实验技能培训,使医学生在低年级阶段熟练掌握机能学和形态学常用实验技术;依托形态学实验和机能学实验,增加了一批从生理到病理、从形态到机能以及药物干预的综合性和创新性实验项目,培养学生的临床思维、整体医学观念以及综合分析能力;依托医学科研方法学,为学生开展文献阅读和创新性实验设计相关的培训,提高学生的科研与创新能力;为学有余力的高年级学生开放创新性实验平台,让学生在实践中验证基本理论的基础上,有能力、有兴趣、有机会开展创新性实验。环环相扣、逐层递进的课程体系将为学生创新实践能力的培养打下坚实的基础。