It was tried to microencapsulate the ascorbic acid powder as a redox initiator with tripalmitin by use of the dry coating method. In the experiment, the feed ratio of the amount of tripalmitin to that of ascorbic acid...It was tried to microencapsulate the ascorbic acid powder as a redox initiator with tripalmitin by use of the dry coating method. In the experiment, the feed ratio of the amount of tripalmitin to that of ascorbic acid, the coating time and the concentration of ethyl alcohol of pulverizing solvent were changed stepwise. The characteristics of microcapsules such as the content of core material, the yield, the water proof degree, the microencapsulation efficiency and the mean diameter were estimated. The yield, the microencapsulation efficiency and the water proof degree gradually increased with the feed ratio, the coating time and the concentration of pulverizing solvent. The microcapsules showed the thermal responsibility and induced polymerization of methyl methacrylate monomer.展开更多
Using the CO_(2)-and N2-assisted atomization processes,the production of ibuprofen/lipid composite microparticles is investigated,in which the lipid includes myristic acid and tripalmitin.The produced composite partic...Using the CO_(2)-and N2-assisted atomization processes,the production of ibuprofen/lipid composite microparticles is investigated,in which the lipid includes myristic acid and tripalmitin.The produced composite particles show similar morphology to that of the pure lipids obtained by the same process.In the case of the N2-assisted process,the average size of composite part-icles is slightly larger than that of the pure lipid particles due to the difficulty of solidification when using N2.In the case of the CO_(2)-assisted process,the average size of com-posite particles is slightly smaller than that of the pure myr-istic acid particles,but slightly larger than that of the pure tripalmitin particles.The dissolution study reveals that the drug release from the ibuprofen/myristic acid particles is enhanced in comparison with that of the unprocessed ibu-profen.For the particles produced by the N2-assisted pro-cess,the X-ray diffraction(XRD)patterns clearly indicate the encapsulation of ibuprofen into myristic acid.The obtained ibuprofen/tripalmitin composite particles with 5%or 20%of ibuprofen(in mass)evidently show the con-trolled drug release:only about 20%of the drug is released in 500 min from the ibuprofen/tripalmitin composite part-icles consisting of 20%ibuprofen prepared by the CO_(2)-assisted process,and the same release is obtained from the ibuprofen/tripalmitin composite particles containing 5%ibuprofen prepared by the N2-assisted process.展开更多
文摘It was tried to microencapsulate the ascorbic acid powder as a redox initiator with tripalmitin by use of the dry coating method. In the experiment, the feed ratio of the amount of tripalmitin to that of ascorbic acid, the coating time and the concentration of ethyl alcohol of pulverizing solvent were changed stepwise. The characteristics of microcapsules such as the content of core material, the yield, the water proof degree, the microencapsulation efficiency and the mean diameter were estimated. The yield, the microencapsulation efficiency and the water proof degree gradually increased with the feed ratio, the coating time and the concentration of pulverizing solvent. The microcapsules showed the thermal responsibility and induced polymerization of methyl methacrylate monomer.
基金support,the authors are grateful to New Century Excellent Talents and Natural Science Foundation of Fujian Province(E0710026),and SRF for ROCS,SEM.
文摘Using the CO_(2)-and N2-assisted atomization processes,the production of ibuprofen/lipid composite microparticles is investigated,in which the lipid includes myristic acid and tripalmitin.The produced composite particles show similar morphology to that of the pure lipids obtained by the same process.In the case of the N2-assisted process,the average size of composite part-icles is slightly larger than that of the pure lipid particles due to the difficulty of solidification when using N2.In the case of the CO_(2)-assisted process,the average size of com-posite particles is slightly smaller than that of the pure myr-istic acid particles,but slightly larger than that of the pure tripalmitin particles.The dissolution study reveals that the drug release from the ibuprofen/myristic acid particles is enhanced in comparison with that of the unprocessed ibu-profen.For the particles produced by the N2-assisted pro-cess,the X-ray diffraction(XRD)patterns clearly indicate the encapsulation of ibuprofen into myristic acid.The obtained ibuprofen/tripalmitin composite particles with 5%or 20%of ibuprofen(in mass)evidently show the con-trolled drug release:only about 20%of the drug is released in 500 min from the ibuprofen/tripalmitin composite part-icles consisting of 20%ibuprofen prepared by the CO_(2)-assisted process,and the same release is obtained from the ibuprofen/tripalmitin composite particles containing 5%ibuprofen prepared by the N2-assisted process.
