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Tuberculous peritonitis complicated by an intraperitoneal tuberculous abscess: A case report
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作者 Wei-Peng Liu Feng-Zhen Ma +3 位作者 Zhou Zhao Zong-Rui Li Bao-Guang Hu Tao Yang 《World Journal of Clinical Cases》 SCIE 2024年第27期6117-6123,共7页
BACKGROUND Tuberculous peritonitis(TBP)is a chronic,diffuse inflammation of the peritoneum caused by Mycobacterium tuberculosis.The route of infection can be by direct spread of intraperitoneal tuberculosis(TB)or by h... BACKGROUND Tuberculous peritonitis(TBP)is a chronic,diffuse inflammation of the peritoneum caused by Mycobacterium tuberculosis.The route of infection can be by direct spread of intraperitoneal tuberculosis(TB)or by hematogenous dissemination.The former is more common,such as intestinal TB,mesenteric lymphatic TB,fa-llopian tube TB,etc.,and can be the direct primary lesion of the disease.CASE SUMMARY We present an older male patient with TBP complicated by an abdominal mass.The patient's preoperative symptoms,signs and imaging data suggested a poss-ible abdominal tumor.After surgical treatment,the patient's primary diagnosis of TBP complicating an intraperitoneal tuberculous abscess was established by com-bining past medical history,postoperative pathology,and positive results of TB-related laboratory tests.The patient's symptoms were significantly reduced after surgical treatment,and he was discharged from the hospital with instructions to continue treatment at a TB specialist hospital and to undergo anti-TB treatment if necessary.CONCLUSION This case report analyses the management of TBP complicated by intraperitoneal tuberculous abscess and highlights the importance of early definitive diagnosis in the hope of improving the clinical management of this type of disease. 展开更多
关键词 Abdominal mass Tuberculous peritonitis Intraperitoneal tuberculous abscess Surgical treatment Case report
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Sensitivity of diagnosis of spontaneous bacterial peritonitis is higher with the automated cell count method
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作者 Juan G Acevedo-Haro Waddah Mohamed +8 位作者 Prebashan Moodley Oliver Bendall Kris Bennett Nigel Keelty Sally Chan Sam Waddy Joanne Hosking Wayne Thomas Robert Tilley 《World Journal of Hepatology》 2024年第11期1265-1281,共17页
BACKGROUND Spontaneous bacterial peritonitis(SBP)is one of the most important complications of patients with liver cirrhosis entailing high morbidity and mortality.Making an accurate early diagnosis of this infection ... BACKGROUND Spontaneous bacterial peritonitis(SBP)is one of the most important complications of patients with liver cirrhosis entailing high morbidity and mortality.Making an accurate early diagnosis of this infection is key in the outcome of these patients.The current definition of SBP is based on studies performed more than 40 years ago using a manual technique to count the number of polymorphs in ascitic fluid(AF).There is a lack of data comparing the traditional cell count method with a current automated cell counter.Moreover,current international guidelines do not mention the type of cell count method to be employed and around half of the centers still rely on the traditional manual method.AIM To compare the accuracy of polymorph count on AF to diagnose SBP between the traditional manual cell count method and a modern automated cell counter against SBP cases fulfilling gold standard criteria:Positive AF culture and signs/symptoms of peritonitis.METHODS Retrospective analysis including two cohorts:Cross-sectional(cohort 1)and case-control(cohort 2),of patients with decompensated cirrhosis and ascites.Both cell count methods were conducted simultaneously.Positive SBP cases had a pathogenic bacteria isolated on AF and signs/symptoms of peritonitis.RESULTS A total of 137 cases with 5 positive-SBP,and 85 cases with 33 positive-SBP were included in cohort 1 and 2,respectively.Positive-SBP cases had worse liver function in both cohorts.The automated method showed higher sensitivity than the manual cell count:80%vs 52%,P=0.02,in cohort 2.Both methods showed very good specificity(>95%).The best cutoff using the automated cell counter was polymorph≥0.2 cells×10^(9)/L(equivalent to 200 cells/mm^(3))in AF as it has the higher sensitivity keeping a good specificity.CONCLUSION The automated cell count method should be preferred over the manual method to diagnose SBP because of its higher sensitivity.SBP definition,using the automated method,as polymorph cell count≥0.2 cells×10^(9)/L in AF would need to be considered in patients admitted with decompensated cirrhosis. 展开更多
关键词 Spontaneous bacterial peritonitis DIAGNOSIS CIRRHOSIS Bacterial infection Automated cell count method Manual cell count method Ascitic fluid
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Comprehensive Review:Diagnosis,Classification,and Risk Factors of Peritoneal Dialysis-Associated Peritonitis
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作者 Lingling Guo Sairah Abdul Karim 《Journal of Clinical and Nursing Research》 2024年第7期1-9,共9页
Peritoneal dialysis(PD)is a predominant modality of renal replacement therapy(RRT)for individuals suffering from end-stage renal disease(ESRD).Peritoneal dialysis-associated peritonitis(PDAP)represents a frequent comp... Peritoneal dialysis(PD)is a predominant modality of renal replacement therapy(RRT)for individuals suffering from end-stage renal disease(ESRD).Peritoneal dialysis-associated peritonitis(PDAP)represents a frequent complication among patients undergoing PD,significantly contributing to adverse clinical outcomes.This review comprehensively examines the diagnosis,classification,and risk factors associated with PDAP,aiming to offer clinical practitioners essential guidance and a foundational framework for effective clinical management. 展开更多
关键词 Research progress Risk factors Peritoneal dialysis-associated peritonitis
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Neisseria mucosa-A rare cause of peritoneal dialysis-related peritonitis:A case report 被引量:1
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作者 Jian-Min Ren Xiao-Yao Zhang Si-Yu Liu 《World Journal of Clinical Cases》 SCIE 2023年第14期3311-3316,共6页
BACKGROUND Neisseria mucosa is a gram negative diplococcus belonging to the genus Neisseria found commonly in the upper respiratory tract.It is typically a commensal organism when it is parasitic on oral and nasal muc... BACKGROUND Neisseria mucosa is a gram negative diplococcus belonging to the genus Neisseria found commonly in the upper respiratory tract.It is typically a commensal organism when it is parasitic on oral and nasal mucosa.To our knowledge,it does not cause disease in healthy individuals with normal immunity,but can be pathogenic in those with impaired immune function or change in bacterial colonization site.Neisseria mucosa has been reported to cause bacterial meningitis,conjunctivitis,pneumonia,endocarditis,peritonitis and urethritis.However,peritoneal dialysis-related peritonitis caused by Neisseria mucosa is extremely rare in clinical practice,which has not previously been reported in China.CASE SUMMARY A 55-year-old female presented to the nephrology clinic with upper abdominal pain without apparent cause,accompanied by nausea,vomiting and diarrhea for two days.The patient had a history of Stage 5 chronic kidney disease for five years,combined with renal hypertension and renal anemia,and was treated with peritoneal dialysis for renal replacement therapy.The patient was subsequently diagnosed with peritoneal dialysis-related peritonitis.Routine examination of peritoneal dialysis fluid showed abdominal infection,and the results of microbial culture of the peritoneal dialysis fluid confirmed Neisseria mucosa.Imi-penem/cilastatin 1.0 g q12h was added to peritoneal dialysis fluid for anti-infection treatment.After 24 d,the patient underwent upper extremity arteriovenous fistulation.One month later,the patient was discharged home in a clinically stable state.CONCLUSION Peritonitis caused by Neisseria mucosa is rare.Patients with home-based self-dialysis cannot guarantee good medical and health conditions,and require education on self-protection. 展开更多
关键词 Peritoneal dialysis peritonitis Neisseria mucosa Case report
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Peritonitis: Perioperative Care in Surgical Emergencies CHU Ignace Deen
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作者 Abdoulaye Touré Amadou Yalla Camara +2 位作者 Almamy Bangoura M’Mah Lamine Camara Marie Paul Sidohon Okou 《Open Journal of Anesthesiology》 2023年第4期85-94,共10页
Objective: Describe the perioperative management of peritonitis in surgical emergencies. Methodology: This was a prospective observational study of the descriptive type over a period of 12 months from January 01 to De... Objective: Describe the perioperative management of peritonitis in surgical emergencies. Methodology: This was a prospective observational study of the descriptive type over a period of 12 months from January 01 to December 31, 2020 in the surgical emergency room at the CHU Ignace Deen. Included in the study were all patients admitted for peritonitis aged greater than or equal to 18 years. The parameters were epidemiological, clinical and anesthetic. Results: Of the 653 admissions to surgical emergencies in 2020, 185 cases presented with peritonitis, i.e. 29.3%. The average age was 38.6 ± 16.64 years with extremes of 18 and 90 years. The sex ratio was 1.89. The comorbidities were dominated by gastritis and hypertension, i.e. 22%. The patients were classified as ASA 3U (52.4%), ASA2 U (39.5%) and ASA 4 U (8.1%). Preoperative resuscitation was provided only with 100% saline. 25.5% of patients had received a blood transfusion. The response time was less than 48 hours, i.e. 77.6%. General anesthesia was performed for all patients. Ketamine was the most used IV hypnotic (56.3%) combined with 100% halothane. The curares used were suxamethonium at (81.6%), Atracurium (81.6%) and rocuronium at (18.3%). Fentanyl was the only morphine used. Senior anesthesia technicians provided anesthesia in (63.2%). Intraoperative incidents were dominated by hypotension, difficult intubation, cardiac arrest, respectively 10.3%, 8% and 0.5%. The immediate postoperative incidents were arterial hypotension, nausea and desaturation, respectively 52.9%, 80% and 32.4%. Mortality was 3.4%. Conclusion: The perioperative management of peritonitis in the emergency room must be as early as possible in order to reduce morbidity and mortality. 展开更多
关键词 Surgical Emergencies peritonitis ANESTHESIA PERIOPERATIVE
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腹膜透析相关性腹膜炎的致病菌及药敏试验分析 被引量:2
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作者 刘静 高玉伟 +5 位作者 王兴华 胡秀红 崔红蕊 徐保振 杨洪娟 王涛 《检验医学与临床》 CAS 2024年第2期183-187,191,共6页
目的回顾性分析该院腹膜透析相关性腹膜炎(PDAP)的病原菌谱特点及预后转归情况,为该院腹膜炎的防治提供科学依据。方法回顾性选取2017年1月至2023年2月该院收治的69例PDAP患者的临床资料,分析其发病原因、病原菌谱特点及预后转归情况。... 目的回顾性分析该院腹膜透析相关性腹膜炎(PDAP)的病原菌谱特点及预后转归情况,为该院腹膜炎的防治提供科学依据。方法回顾性选取2017年1月至2023年2月该院收治的69例PDAP患者的临床资料,分析其发病原因、病原菌谱特点及预后转归情况。结果69例PDAP患者腹膜透析透出液共培养出病原菌43例,阳性率为62.32%,43例病原菌中革兰阳性菌23例(53.49%),革兰阴性菌17例(39.53%),真菌3例(6.98%)。43例病原菌感染原因包括肠道感染18例(41.86%),换液操作不规范11例(25.58%),呼吸道感染8例(18.60%),原因不明6例(13.95%)。革兰阳性菌以表皮葡萄球菌(10例)为主,革兰阴性菌以大肠埃希菌(7例)为主。革兰阳性菌对万古霉素、利奈唑胺、替加环素、替考拉宁、莫西沙星均敏感,对克林霉素(52.17%)、红霉素(56.52%)、阿莫西林/克拉维酸(60.87%)、青霉素G(78.26%)耐药;革兰阴性菌对美罗培南、亚胺培南、黏菌素均敏感,对阿莫西林/克拉维酸(47.06%)、头孢呋辛(47.06%)、头孢唑啉(52.94%)、氨苄西林(82.35%)耐药;真菌对氟康唑、伏立康唑、两性霉素B和卡泊芬净均敏感。69例PDAP患者共治愈53例,退出14例,死亡2例,治愈率为76.81%,真菌性PDAP患者退出率明显高于革兰阳性菌、革兰阴性菌及培养阴性的PDAP患者。结论该院腹膜透析患者发生PDAP的主要原因为换液操作不规范和肠道感染,PDAP相关致病菌以革兰阳性菌为主,真菌性PDAP患者退出率较高。 展开更多
关键词 腹膜透析相关性腹膜炎 腹膜透析 革兰阳性菌 革兰阴性菌 药敏试验 治愈率
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Acute Peritonitis at the CSRef of the Commune I in the District of Bamako: Signs, Diagnosis and Treatment
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作者 Cheickna Tounkara Oumar Amadou Malle +5 位作者 Modibo Togola Hamidou Samake Lamine Soumare Sékou Koumare Zimogo Zié Sanogo Djibril Sangare 《Surgical Science》 2023年第10期626-636,共11页
Acute generalized peritonitis is an acute inflammation of the peritoneum. It is most often secondary to perforation of the digestive organ and/or the spread of an intra-abdominal septic focus. The absence of a study o... Acute generalized peritonitis is an acute inflammation of the peritoneum. It is most often secondary to perforation of the digestive organ and/or the spread of an intra-abdominal septic focus. The absence of a study on peritonitis in a reference health center motivated us for this work. The aim of this study was to study the inadequacies that could be seen in the management of peritonitis in the CSRef(s). We carried out a retrospective study of 40 patients received at the CSRéf of commune I for acute generalized peritonitis from 2011 to 2012. The average age was 30.1 years with a standard deviation of 3.4;extremes ranging from 14 years to 60 years and a Sex ratio = 1.22 (22 men out of 18 women). Abdominal pain was the main reason for consultation (present in all our patients). In most cases, clinical examination alone made it possible to make the diagnosis. Surgical treatment depended on the etiology (appendectomy associated with washing-drainage was the most commonly performed surgical procedure). All our patients received general anesthesia. The average length of hospitalization was 7 days with extremes ranging from 1 to 15 days. We noted a Morbidity rate of 22.5%, dominated by wall abscesses and a mortality of 2.5%. The delay in consultation and referrals constitutes a factor in mortality and high morbidity. 展开更多
关键词 peritonitis Surgery Csref CI Bamako Mali
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Acute Peritonitis at the Reference Health Center of Commune I of the District of Bamako: Epidemiological, Clinical and Therapeutic Aspects
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作者 Tounkara Cheickna Samake Hamidou +8 位作者 Maïga Amadou Cisse Alou Hamadoun Diarra Issaka Sanogo Modibo Togola Modibo Dembele Bakary Tientigui Traore Alhassane Togo Pierre Adegne Kante Lassana 《Surgical Science》 2023年第12期728-737,共10页
Acute peritonitis is most often secondary to perforation of the digestive organ and/or the spread of an intra-abdominal septic focus. The objectives of this work were to study acute peritonitis in the general surgery ... Acute peritonitis is most often secondary to perforation of the digestive organ and/or the spread of an intra-abdominal septic focus. The objectives of this work were to study acute peritonitis in the general surgery department of the Cs ref of commune I in Mali, to determine the frequency of peritonitis, to describe the epidemiological, clinical and therapeutic aspects in order to analyze the surgical consequences and to assess the additional cost of treating acute peritonitis. This study was prospective, descriptive, cross-sectional involving 40 patients received in the surgery department of the Cs ref of commune I for acute peritonitis from January 1, 2018 to December 31, 2018. There were 40 patients among whom 28 (70%) were men and 12 were women (30%), i.e. a sex ratio = 2.3. The average age was 25 years with extremes varying between 16 and 54 years and a standard deviation of 11.78. Abdominal pain was the main reason for consultation. Clinical examination alone made it possible to make the diagnosis in 75% of cases. Surgical treatment depended on the intraoperative etiology. The clinical diagnosis was supported by ASP and abdominal ultrasound;performed respectively in 10% and 90% of patients. Appendiceal peritonitis was the intraoperative diagnosis observed in 50% of cases. All our patients benefited from a peritoneal toilet with drainage. We noted a morbidity rate of 5% dominated by parietal suppuration. The average cost of care was 175,000 FCFA. 展开更多
关键词 Acute peritonitis Epidemiology Diagnostic Therapy Surgical Emergencies Cs Ref CI BAMAKO MALI
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Conservative management of multi-trauma induced peritonitis:Experience,outcomes,and indications
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作者 Qi Chen Tao Zhu +2 位作者 Jia-Kang Liu Jun Ding Lina Chen 《World Journal of Clinical Cases》 SCIE 2023年第25期5897-5902,共6页
BACKGROUND The concept of mandatory laparotomy in treating traumatic peritonitis has been increasingly questioned recently.AIM To summarize and share the experience of conservative treatment of patients with multi-tra... BACKGROUND The concept of mandatory laparotomy in treating traumatic peritonitis has been increasingly questioned recently.AIM To summarize and share the experience of conservative treatment of patients with multi-trauma induced peritonitis.METHODS A retrospective review was performed on patients with multiple injury induced traumatic peritonitis.RESULTS A total of 184 patients with multiple injury induced traumatic peritonitis were reviewed.46 of them underwent conservative treatment.None of the 46 patients with conservative treatment switched to surgical treatment,and all of them were cured and discharged after successful conservative treatment.No significant abnormal findings were observed at regular follow-up after discharge.CONCLUSION Conservative management is safe,effective,feasible,and beneficial in hemodynamically stable patients with traumatic peritonitis if there is no definite evidence of severe abdominal visceral organ injury. 展开更多
关键词 TRAUMA peritonitis Damage control Conservative treatment
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Acute diffuse peritonitis secondary to a seminal vesicle abscess:A case report
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作者 Kun Li Nan-Bin Liu +2 位作者 Jiang-Xi Liu Quan-Ning Chen Bao-Min Shi 《World Journal of Clinical Cases》 SCIE 2023年第3期645-654,共10页
BACKGROUND Seminal vesicle abscess(SVA)is the manifestation of a relatively rare urinary system infection.In response to urinary system inflammation,an abscess forms in special locations.However,acute diffuse peritoni... BACKGROUND Seminal vesicle abscess(SVA)is the manifestation of a relatively rare urinary system infection.In response to urinary system inflammation,an abscess forms in special locations.However,acute diffuse peritonitis(ADP)induced by SVA is unusual.CASE SUMMARY We report a case of a left SVA in a male patient complicated with pelvic abscess,ADP,multiple organ dysfunction syndrome,infectious shock,bacteremia,and acute appendiceal extraserous suppurative inflammation as a result of a long-term indwelling urinary catheter.The patient received a course of morinidazole+cefminol antibiotics but showed no obvious relief,so the perineal SVA underwent puncture drainage and abdominal abscess drainage+appendectomy was performed.The operations were successful.After the operation,anti-infection,anti-shock,and nutritional support treatments were continued and various laboratory indicators were regularly reviewed.The patient was discharged from the hospital after recovery.This disease is a challenge for the clinician because of the unusual spreading path of the abscess.Moreover,appropriate intervention and adequate drainage of abdominal and pelvic lesions are necessary,especially when the primary focus cannot be determined.CONCLUSION The etiology of ADP varies,but acute peritonitis secondary to SVA is very rare.In this patient,the left SVA not only affected the adjacent prostate and bladder but also spread retrogradely through the vas deferens,forming a pelvic abscess in the loose tissues of the extraperitoneal fascia layer.Inflammation involving the peritoneal layer led to ascites and pus accumulation in the abdominal cavity,and appendix involvement led to extraserous suppurative inflammation.In clinical practice,surgeons need to consider the results of various laboratory tests and imaging examinations to make comprehensive judgments involving the diagnosis and treatment plan. 展开更多
关键词 Seminal vesicle abscess Acute diffuse peritonitis Acute appendicitis Multiple organ dysfunction syndrome Case report
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Three-dimensional computed tomography reconstruction diagnosed digestive tract perforation and acute peritonitis caused by Monopterus albus:A case report
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作者 Jin-Han Yang Jin-Ying Lan +2 位作者 An-Yuan Lin Wei-Biao Huang Jin-Yuan Liao 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第10期2351-2356,共6页
BACKGROUND Few reports have described living foreign bodies in the human body.The current manuscript demonstrates that computed tomography(CT)is an effective tool for accurate preoperative evaluation of living foreign... BACKGROUND Few reports have described living foreign bodies in the human body.The current manuscript demonstrates that computed tomography(CT)is an effective tool for accurate preoperative evaluation of living foreign bodies in clinic.The threedimensional(3D)reconstruction technology could clearly display anatomical structures,lesions and adjacent organs,improving diagnostic accuracy and guiding the surgical decision-making process.CASE SUMMARY Herein we describe a 68-year-old man diagnosed with digestive tract perforation and acute peritonitis caused by a foreign body of Monopterus albus.The patient pre-sented to the emergency department with complaints of dull abdominal pain,profuse sweating and a pale complexion during work.A Monopterus albus had entered the patient’s body through the anus two hours ago.During hospitalization,the 3D reconstruction technology revealed a perforation of the middle rectum complicated with acute peritonitis and showed a clear and complete Monopterus albus bone morphology in the abdominal and pelvic cavities,with the Monopterus albus biting the mesentery.Laparoscopic examination detected a large(diameter of about 1.5 cm)perforation in the mid-rectum.It could be seen that a Monopterus albus had completely entered the abdominal cavity and had tightly bitten the mesentery of the small intestine.During the operation,the dead Monopterus albus was taken out.CONCLUSION The current manuscript demonstrates that CT is an effective tool for accurate preoperative evaluation of living foreign bodies in clinic. 展开更多
关键词 Digestive tract perforation Acute peritonitis Monopterus albus Three-dimensional computed tomography reconstruction Case report
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腹膜透析相关性腹膜炎病人就诊延迟情况及影响因素 被引量:1
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作者 陈萍丽 曾芳 +1 位作者 杨光 彭媛 《护理研究》 北大核心 2024年第8期1485-1489,共5页
目的:探讨腹膜透析相关性腹膜炎(PDAP)病人就诊延迟发生情况及影响因素,并分析就诊延迟病人腹膜炎相关结局。方法:回顾性分析2014年1月—2021年12月某三级甲等医院腹膜透析中心行持续不卧床腹膜透析病人发生PDAP的临床资料,根据就诊时... 目的:探讨腹膜透析相关性腹膜炎(PDAP)病人就诊延迟发生情况及影响因素,并分析就诊延迟病人腹膜炎相关结局。方法:回顾性分析2014年1月—2021年12月某三级甲等医院腹膜透析中心行持续不卧床腹膜透析病人发生PDAP的临床资料,根据就诊时间分为延迟组(≥24 h)和无延迟组(<24 h),采用Logistic回归法分析影响PDAP病人就诊延迟的危险因素。结果:纳入447例PDAP病人,其中无延迟组324例,延迟组123例,PDAP病人就诊延迟发生率为27.5%。Logistic回归分析显示,病人年龄、居住地、是否腹痛、是否第1次发作是PDAP病人就诊延迟的影响因素(P<0.05)。结论:PDAP病人就诊延迟发生率较高,应加强病人在腹膜炎发生时及时就诊重要性的教育,促进病人及时就诊,以改善PDAP病人的预后。 展开更多
关键词 腹膜透析 腹膜透析相关性腹膜炎 就诊延迟 影响因素
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Effect of different nursing interventions on the incidence of peritonitis in peritoneal dialysis patients at home: a network meta-analysis
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作者 Mei Wang Xin Fan Xiang-Shu Cui 《Nursing Communications》 2023年第13期1-6,共6页
Objective:Bayesian network meta-analysis was used to evaluate the effect of different nursing interventions on the incidence of peritonitis in peritoneal dialysis patients at home.Methods:Cochrane Library,PubMed,Embas... Objective:Bayesian network meta-analysis was used to evaluate the effect of different nursing interventions on the incidence of peritonitis in peritoneal dialysis patients at home.Methods:Cochrane Library,PubMed,Embase,Web of Science,China Biology Medicine disc,CNKI and Wanfang data were searched to identify randomized controlled trials(RCTs)investigating the effects of different nursing interventions or health education on peritonitis in home peritoneal dialysis patients from the establishment of each database to March 2022.After literature screening,the Cochrane 5.1 evaluation tool was used to assess quality,Review Manager 5.4 software was used to generate a literature quality evaluation chart and R4.1.2 software,JAGS package,and GEMTC package were used for statistical analysis.Results:A total of 9 RCTs involving 8 different nursing interventions and a total of 1011 patients were included in the meta-analysis.The incidence of peritonitis for the eight nursing interventions,ranked from highest to lowest,were:systematic nursing,Omaha system case management intervention,routine care+health promotion mode,PD specialist nurse-led multi-disciplinary network platform management mode,5E rehabilitation nursing mode,routine care+Omaha extended nursing service,one-on-one coordinated family support intervention,and routine care.Conclusions:Systematic nursing was found to be the most effective intervention in reducing the incidence of peritonitis in peritoneal dialysis patients at home.However,this conclusion needs to be further verified by more high-quality,multicenter and large sample RCTs. 展开更多
关键词 peritoneal dialysis peritonitis NURSING network meta-analysis
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尿毒症腹膜透析相关胃肠功能紊乱的临床特征及影响因素研究 被引量:1
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作者 李静 马雷雷 +3 位作者 王冠然 姜晨 邢海涛 杨洪涛 《中国全科医学》 CAS 北大核心 2024年第18期2198-2204,共7页
背景胃肠功能紊乱是腹膜透析患者常见的并发症,严重影响患者食欲和情绪,致使患者营养不良、脱水、电解质紊乱或诱发全身炎症反应等,还会导致腹膜透析效能下降,增加医疗难度,降低患者的生活水平。目的观察尿毒症患者腹膜透析相关胃肠功... 背景胃肠功能紊乱是腹膜透析患者常见的并发症,严重影响患者食欲和情绪,致使患者营养不良、脱水、电解质紊乱或诱发全身炎症反应等,还会导致腹膜透析效能下降,增加医疗难度,降低患者的生活水平。目的观察尿毒症患者腹膜透析相关胃肠功能紊乱的临床特征并分析其影响因素,为防治腹膜透析相关胃肠道功能紊乱的临床诊治提供参考。方法本研究为回顾性研究,选取2019-09-01—2021-09-01在天津中医药大学第一附属医院肾病科进行维持性腹膜透析的304例尿毒症患者为研究对象。根据是否合并胃肠功能紊乱将患者分为胃肠功能紊乱组和无胃肠功能紊乱组。收集两组患者的一般资料、合并症、实验室检查指标、透析充分性相关指标等并进行比较。运用SPSS 23.0软件对临床资料进行统计,总结分析腹膜透析相关胃肠功能紊乱的临床特征,采用多因素Logistic回归分析探讨尿毒症患者发生腹膜透析相关胃肠道功能紊乱的影响因素。结果304例尿毒症腹膜透析患者中合并胃肠道功能紊乱189例(62.2%),胃肠功能紊乱组患者中位年龄为62(52,67)岁。两组患者年龄、糖尿病肾病原发病比例、合并高血压比例、合并冠心病比例比较,差异有统计学意义(P<0.05);两组患者血钙、胆固醇、肌酸激酶、C反应蛋白、总胆红素、血糖、糖化血红蛋白、降钙素原、三酰甘油水平比较,差异均有统计学意义(P<0.05);两组患者血尿素氮、残肾尿素清除指数(Kt/V)、腹膜Kt/V、总肌酐清除率(Ccr)、残肾Ccr、总Ccr标准化比较,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,糖尿病肾病原发病(OR=7.471,95%CI=1.161~48.061,P=0.034)、糖化血红蛋白升高(OR=1.367,95%CI=1.080~1.731,P=0.009)是尿毒症患者发生腹膜透析相关胃肠功能紊乱的独立危险因素,残肾Ccr升高(OR=0.952,95%CI=0.908~0.997,P=0.038)是尿毒症患者发生腹膜透析相关胃肠功能紊乱的独立保护因素。结论尿毒症患者腹膜透析相关胃肠道功能紊乱发生率较高,多发于老年患者;糖尿病肾病原发病、糖化血红蛋白升高可能是尿毒症患者发生腹膜透析相关胃肠功能紊乱的独立危险因素,残肾Ccr升高可能是尿毒症患者发生腹膜透析相关胃肠功能紊乱的独立保护因素。 展开更多
关键词 尿毒症 腹膜透析 胃肠道功能紊乱 临床特征 影响因素分析
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慢性肾脏病腹膜透析患者血脂水平与冠状动脉钙化严重程度的关系 被引量:1
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作者 王树龙 王云 +3 位作者 尚瑞华 鲍妍 韩惠淑 刘向东 《中国动脉硬化杂志》 CAS 2024年第1期31-39,共9页
[目的]探讨慢性肾脏病(CKD)腹膜透析(PD)患者血脂水平与冠状动脉钙化(CAC)严重程度的关系。[方法]选取2018年6月—2021年12月本院收治的205例进行PD治疗的CKD患者作为研究对象,根据CAC评分将患者分为钙化组(n=152)和未钙化组(n=53),并... [目的]探讨慢性肾脏病(CKD)腹膜透析(PD)患者血脂水平与冠状动脉钙化(CAC)严重程度的关系。[方法]选取2018年6月—2021年12月本院收治的205例进行PD治疗的CKD患者作为研究对象,根据CAC评分将患者分为钙化组(n=152)和未钙化组(n=53),并将钙化组分为轻度钙化组(n=61)、中度钙化组(n=50)和重度钙化组(n=41),采用单因素分析比较患者临床资料及实验室指标差异;采用限制性三次样条拟合Logistic回归模型分析血脂水平与CAC的关系;采用多元Logistic回归模型分析影响因素,并绘制受试者工作特征(ROC)曲线探讨血脂水平对CAC严重程度的预测价值。[结果]与未钙化组相比,钙化组年龄、糖尿病比例、体质指数(BMI)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、血磷水平显著增加,血尿酸(UA)、高密度脂蛋白胆固醇(HDLC)、血镁、25-羟维生素D3(25-(OH)-VitD3)水平显著降低(P<0.05);Logistic回归显示,调整年龄、糖尿病等因素后TC(OR=1.79,95%CI:1.56~2.10)、TG(OR=2.13,95%CI:1.86~2.41)、HDLC(OR=0.67,95%CI:0.42~0.84)、LDLC(OR=2.01,95%CI:1.78~2.32)仍是CAC发生的危险因素,且随着TG、TC、LDLC水平升高,HDLC水平降低,其关联效应值也相应增高(P趋势<0.05);与轻度钙化组相比,中度钙化组、重度钙化组年龄、TG、TC均显著增加,HDLC均显著降低,中度钙化组UA显著增加,重度钙化组LDLC、血磷显著增加,血镁、25-(OH)-VitD3显著降低;与中度钙化组相比,重度钙化组TC、LDLC显著增加,UA、HDLC显著降低(均P<0.05),且多元Logistic回归模型表明高龄,TG、TC、LDLC水平升高及HDLC水平降低是CKD患者PD治疗后发生重度CAC的独立危险因素(均P<0.05);限制性三次样条回归分析表明血脂水平与CAC严重程度呈明显的相关性;ROC曲线分析显示,血TG、TC、HDLC、LDLC联合检测的AUC为0.897,灵敏度为0.899,特异度为0.826,表明TG、TC、HDLC、LDLC联合检测对进行PD治疗的CKD患者CAC严重程度的预测价值高于任一单一指标。[结论]进行PD治疗的CKD患者,血TG、TC、LDLC水平升高及HDLC水平降低与CAC发生风险显著相关,并且参与了CAC的发生发展,临床可通过联合检测提高其预测价值。 展开更多
关键词 慢性肾脏病 腹膜透析 血脂水平 冠状动脉钙化
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持续不卧床腹膜透析患者因梗阻性脓肾致腹膜透析相关性腹膜炎1例并文献复习
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作者 吴晓凤 黎渐英 +3 位作者 李剑波 林建雄 刘苑莹 郭群英 《中国血液净化》 CSCD 2024年第1期75-77,共3页
腹膜透析(peritoneal dialysis,PD)相关性腹膜炎通常由于接触污染或者出口处感染引起。也有少部分腹膜炎起因于肠道疾病,其中最常见的病因包括胃肠道穿孔、缺血性肠病和胆囊炎等。因梗阻性脓肾引起的腹膜炎极为罕见。该文报道了1例72岁... 腹膜透析(peritoneal dialysis,PD)相关性腹膜炎通常由于接触污染或者出口处感染引起。也有少部分腹膜炎起因于肠道疾病,其中最常见的病因包括胃肠道穿孔、缺血性肠病和胆囊炎等。因梗阻性脓肾引起的腹膜炎极为罕见。该文报道了1例72岁男性腹膜透析患者因梗阻性左肾积脓引起的继发性腹膜炎,行左肾盂造瘘引流术和左肾切除术,最后未拔除腹膜透析管而继续腹膜透析治疗。随访8个月未再次发生腹膜炎。本研究报道了国内首例因梗阻性脓肾引起的持续不卧床腹膜透析合并继发性腹膜炎的病例,以提醒临床医生腹膜透析继发性腹膜炎可能的病因,为临床治疗决策提供依据。 展开更多
关键词 腹膜透析 继发性腹膜炎 梗阻性肾积脓
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罗沙司他治疗腹膜透析贫血疗效及对腹膜转运能力变化的影响
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作者 任荣 陈凯旋 +3 位作者 贾依娜西·阿扎提 张静 曹冰 姜鸿 《实用药物与临床》 CAS 2024年第4期260-264,共5页
目的观察罗沙司他治疗腹膜透析贫血的疗效及其对腹膜溶质转运能力变化的影响。方法纳入新疆医科大学第五附属医院和新疆维吾尔自治区人民医院2022年1月至2023年1月接受规律腹膜透析贫血的患者100例,随机分为试验组(55例)、对照组(45例)... 目的观察罗沙司他治疗腹膜透析贫血的疗效及其对腹膜溶质转运能力变化的影响。方法纳入新疆医科大学第五附属医院和新疆维吾尔自治区人民医院2022年1月至2023年1月接受规律腹膜透析贫血的患者100例,随机分为试验组(55例)、对照组(45例),分别使用罗沙司他和促红素注射液治疗。比较治疗前后试验组和对照组的贫血指标、铁代谢指标、炎症指标、腹膜溶质转运能力。结果①治疗8周后,两组患者贫血情况均较治疗前改善(P<0.05)。试验组贫血治疗总有效率略高于对照组(87.04%vs.84.44%),但差异无统计学意义(P>0.05)。②两组患者血清铁蛋白均低于100μg/L,转铁状态蛋白饱和度均>20%,血清铁浓度均处于正常范围,治疗前以及治疗后组间比较差异均无统计学意义(P>0.05)。③治疗前后的C反应蛋白(CRP)中位数均处于正常范围内,但试验组治疗后水平增高,差异有统计学意义(P<0.05)。④两组患者腹膜溶质转运能力中位数水平较治疗前轻度增高(P<0.05),但两组患者腹膜转运能力比较,差异无统计学意义(P>0.05)。结论罗沙司他可以在轻微炎症状态下有效改善腹膜透析患者血红蛋白水平,轻度增加患者腹膜溶质转运能力。罗沙司他与促红素注射液纠正贫血能力和影响腹膜溶质转运能力方面作用相当。 展开更多
关键词 罗沙司他 肾性贫血 腹膜透析 腹膜转运功能
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黄芪多糖对腹膜透析大鼠腹膜纤维化和血管生成的影响及机制
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作者 冯雪 彭斌 +4 位作者 冯立 朱双益 胡溪 熊玮 高智 《中国药房》 CAS 北大核心 2024年第6期712-717,共6页
目的探讨黄芪多糖(APS)对腹膜透析(PD)大鼠腹膜纤维化和血管生成的影响及机制。方法将大鼠分为正常对照组(Control组)、模型组(PD组)、70 mg/kgAPS组(APS-L组)、140 mg/kgAPS组(APS-H组)、140 mg/kgAPS+40 mg/kg缺氧诱导因子1α(HIF-1α... 目的探讨黄芪多糖(APS)对腹膜透析(PD)大鼠腹膜纤维化和血管生成的影响及机制。方法将大鼠分为正常对照组(Control组)、模型组(PD组)、70 mg/kgAPS组(APS-L组)、140 mg/kgAPS组(APS-H组)、140 mg/kgAPS+40 mg/kg缺氧诱导因子1α(HIF-1α)激动剂DMOG组(APS-H+DMOG组),每组12只。后4组大鼠构建PD大鼠模型。各给药组大鼠灌胃相应剂量的APS及腹腔注射相应剂量的DMOG,Control组和PD组大鼠灌胃等体积生理盐水,每天给药1次,连续4周。末次给药后,检测大鼠腹膜超滤量(UF)、葡萄糖转运量(MTG)和血清中肌酐(Scr)、尿素氮(BUN)水平;观察腹膜组织病理学变化和纤维化情况(腹膜厚度和胶原纤维沉积占比);检测腹膜组织微血管密度和α-平滑肌肌动蛋白(α-SMA)、层粘连蛋白(LN)、HIF-1α、血管内皮生长因子(VEGF)蛋白表达水平。结果与Control组比较,PD组大鼠间皮细胞结构疏松,腹膜间皮细胞脱落,炎症细胞浸润,腹膜厚度和胶原纤维沉积占比均显著增加(P<0.05);MTG,血清中Scr、BUN水平,腹膜组织微血管密度和α-SMA、LN、HIF-1α、VEGF蛋白表达水平均显著升高,而UF显著降低(P<0.05);与PD组比较,APS-L组、APS-H组大鼠上述指标均显著改善(P<0.05),其中APS-H组改善效果优于APS-L组(P<0.05);与APS-H组比较,APS-H+DMOG组大鼠上述指标变化均逆转(P<0.05)。结论APS可以通过抑制HIF-1α/VEGF信号通路来抑制PD大鼠腹膜纤维化及血管新生。 展开更多
关键词 黄芪多糖 缺氧诱导因子-1α/血管内皮生长因子信号通路 腹膜透析 腹膜纤维化 血管生成
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腹膜透析液培养阳性腹膜炎临床特征
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作者 罗军 邓劲 康梅 《四川医学》 CAS 2024年第4期377-382,共6页
目的探讨腹膜透析中由不同病原菌引起的腹膜炎的临床特点。方法回顾性分析2018年1月至2022年12月在我院肾病护理单元收治的腹膜透析相关性腹膜炎(PDAP)患者的临床资料。根据检出病原菌的不同,分为革兰阳性(G^(+))菌组、革兰阴性(G^(-))... 目的探讨腹膜透析中由不同病原菌引起的腹膜炎的临床特点。方法回顾性分析2018年1月至2022年12月在我院肾病护理单元收治的腹膜透析相关性腹膜炎(PDAP)患者的临床资料。根据检出病原菌的不同,分为革兰阳性(G^(+))菌组、革兰阴性(G^(-))菌组和真菌组,比较3组间病原学分布特点和临床特征。根据患者是否拔管分为两组,分析两组间白介素6(IL-6)、降钙素原(PCT)、白细胞、血小板(PLT)、血红蛋白、白蛋白、C反应蛋白(CRP)等指标,二元Logistic回归分析拔管的影响因素。结果共送检1066例腹透液样本,其中332例检出病原菌,阳性检出率为31.14%(332/1066),病原菌检出337株。G^(+)菌组244株,占比72.40%(244/337);以凝固酶阴性葡萄球菌(57.37%)、链球菌(19.67%)为主。G^(-)菌组64株,占比18.99%(64/337);以大肠埃希菌(26.56%)和铜绿假单胞菌(17.18%)为主。真菌组29株,占比8.61%(29/337);以近平滑念珠菌(41.37%)为主。拔管组与非拔管组在年龄、IL-6、CRP、PLT和病原菌感染类型比较差异有统计学意义,二元回归分析显示真菌感染是腹膜炎拔管的独立危险因素。结论PDAP的主要致病菌以G^(+)菌为主,G^(-)菌感染患者具有更高水平的PCT和IL-6,真菌感染者具有更高水平的PLT数量;感染性腹膜炎尤其是真菌性腹膜炎是患者终止腹膜透析改为血液透析的主要危险因素。 展开更多
关键词 腹膜透析 腹膜炎 临床特点
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腹膜透析患者发生腹膜透析相关性腹膜炎影响因素分析及病原菌分布特点
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作者 毛雨河 肖丹 +1 位作者 邓声京 薛少清 《新乡医学院学报》 CAS 2024年第3期257-261,共5页
目的分析腹膜透析患者发生腹膜透析相关性腹膜炎(PDAP)的影响因素及病原菌分布特点。方法回顾性分析2012年1月至2022年10月于梅州市人民医院行腹膜透析(PD)治疗并规律复查的257例患者的病历资料,根据是否发生PDAP将患者分为PDAP组(n=102... 目的分析腹膜透析患者发生腹膜透析相关性腹膜炎(PDAP)的影响因素及病原菌分布特点。方法回顾性分析2012年1月至2022年10月于梅州市人民医院行腹膜透析(PD)治疗并规律复查的257例患者的病历资料,根据是否发生PDAP将患者分为PDAP组(n=102)和非PDAP组(n=155)。用无菌注射器抽取透出液5~10 mL,采用血培养法进行病原菌鉴定。收集患者的性别、年龄、原发疾病、文化程度、是否合并高血压、是否合并糖尿病、是否合并心血管疾病、豢养宠物或家禽、体质量指数(BMI)及透析龄等一般资料。于确诊次日清晨抽取空腹肘静脉血,检测血红蛋白(Hb)、白蛋白(ALB)、血钾、血磷、血钙水平,并记录肾小球滤过率估算值(eGFR)及尿素清除指数(UCI)。采用多因素logistic回归分析影响PD患者发生PDAP的危险因素。结果102例PDAP患者共发生PDAP 217例次,病原菌培养阳性124例次,培养阳性率为57.14%;共分离出127株病原菌,其中革兰阳性菌84株(66.14%),革兰阴性菌39株(30.71%),真菌4株(3.15%)。培养出的84株革兰阳性菌中,表皮葡萄球菌25株(29.76%),金黄色葡萄球菌17株(20.24%),溶血葡萄球菌12株(14.29%),沃氏葡萄球菌8株(9.52%),唾液链球菌10株(11.90%),血链球菌5株(5.95%),其他7株(8.33%);39株革兰阴性菌中,大肠埃希菌20株(51.28%),铜绿假单胞菌6株(15.38%),鲍曼不动杆菌6株(15.38%),肺炎克雷伯菌5株(12.82%),阴沟肠杆菌2株(5.13%);4株真菌中,近平滑假丝酵母菌3株(75.00%),光滑念珠菌1株(25.00%)。PDAP组与非PDAP组患者的性别、年龄、原发疾病、文化程度、BMI及合并高血压、糖尿病、心血管疾病占比比较差异无统计学意义(P>0.05)。PDAP组豢养宠物或家禽患者占比高于非PDAP组,透析龄长于非PDAP组(P<0.05)。PDAP组与非PDAP组患者的血磷、血钙、eGFR、UCI比较差异无统计学意义(P>0.05)。PDAP组患者的Hb、ALB、血钾水平显著低于非PDAP组(P<0.05)。Logistic回归分析显示,豢养宠物或家禽、透析龄长是PD患者发生PDAP的危险因素(P<0.05);高Hb、ALB水平是PD患者发生PDAP的保护因素(P<0.05);血钾与PD患者发生PDAP无相关性(P>0.05)。结论革兰阳性菌为PDAP的主要致病菌,其中以表皮葡萄球菌为主;豢养宠物或家禽、透析龄长是PD患者发生PDAP的危险因素,高Hb、ALB水平是PD患者发生PDAP的保护因素。 展开更多
关键词 腹膜透析相关性腹膜炎 病原菌 影响因素
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