High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor

The specific detection of tumor markers is crucial in early tumor screening and subsequent treatment processes.To ac-curately distinguish the signal response caused by trace markers,the high demodulation resolution of the sensor is nec-essary.In this paper,we propose a dual-wavelength fiber laser sensing system enhanced with microwave photonics de-modulation technology to achieve high-resolution tumor marker detection.This sensing system can simultaneously per-form spectral wavelength-domain and frequency-domain analyses.Experimental results demonstrate that this system's refractive index(RI)sensitivity reaches 1083 nm/RIU by wavelength analysis and-1902 GHz/RIU by frequency analysis,with ideal detection resolutions of 1.85×10^(-5)RIU and 5.26×10^(-8)RIU,respectively.Compared with traditional wavelength domain analysis,the demodulation resolution is improved by three orders of magnitude,based on the same sensing structure.To validate its biosensing performance,carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5)is selected as the detection target.Experimental results show that the improved sensing system has a limit of detection(LOD)of 0.076 ng/mL and a detection resolution of 0.008 ng/mL.Experimental results obtained from human serum samples are consistent with clinical data,highlighting the strong clinical application potential of the proposed sens-ing system and analysis method.

Evaluating the Efficacy of Fecal Occult Blood Test and Tumor Marker Combined Screening for Colorectal Cancer

Objective:To analyze the screening effectiveness of combining the fecal occult blood test with tumor marker detection for colorectal cancer.Methods:A total of thirty patients with colorectal cancer and thirty patients with benign colon hyperplasia who received treatment from January 2020 to January 2023 were selected.These patients were assigned to the observation group and the control group,respectively.All patients in both groups underwent both fecal occult blood tests and tumor marker detection.The levels of tumor markers between the two groups were compared,the tumor marker levels in different stages were assessed within the observation group,and the positive detection rates for single detection and combined detection were compared.Results:The levels of various tumor markers in the observation group were significantly higher than those in the control group(P<0.05).Furthermore,as the Duke stage increased within the observation group,the levels of various tumor markers also increased(P<0.05).The positive detection rate of the combined test was notably higher than that of single detection(P<0.05).Conclusion:Combining the fecal occult blood test with tumor marker detection in colorectal cancer screening can significantly improve the overall detection rate.