Objective To investigate the relationship between carotid intima-media thickness (IMT) and pulse pressure (PP), and evaluate the role of tumor necrosis factor -α(TNF-α) in hypertensive patients. MethodsOne hundred a...Objective To investigate the relationship between carotid intima-media thickness (IMT) and pulse pressure (PP), and evaluate the role of tumor necrosis factor -α(TNF-α) in hypertensive patients. MethodsOne hundred and twenty six essential hypertensive patients were divided into 3 groups according to PP magnitude (group A≤60 mm Hg, group B 61-89 mm Hg, group C≥90 mm Hg). IMT and carotid plaque incidence were assessed by high frequency ultrasonography, and the level of plasma TNF-α was determined by radio-immunity assay.ResultsIMT, incidence rate of carotid plaque and plasma TNF-α were increased in the order of group C>group B>group A (P<0.05). IMT was positively related to PP (r=0.749, P<0.01). The level of plasma TNF-α was correlated positively with IMT and PP, respectively (r=0.497, 0.412, P<0.05).ConclusionPP seems to be a risk factor for assessing subclinical atherosclerosis in hypertensive patients. TNF-α may be involved in the inflammation process of atherosclerotic changes in hypertension.展开更多
文摘Objective To investigate the relationship between carotid intima-media thickness (IMT) and pulse pressure (PP), and evaluate the role of tumor necrosis factor -α(TNF-α) in hypertensive patients. MethodsOne hundred and twenty six essential hypertensive patients were divided into 3 groups according to PP magnitude (group A≤60 mm Hg, group B 61-89 mm Hg, group C≥90 mm Hg). IMT and carotid plaque incidence were assessed by high frequency ultrasonography, and the level of plasma TNF-α was determined by radio-immunity assay.ResultsIMT, incidence rate of carotid plaque and plasma TNF-α were increased in the order of group C>group B>group A (P<0.05). IMT was positively related to PP (r=0.749, P<0.01). The level of plasma TNF-α was correlated positively with IMT and PP, respectively (r=0.497, 0.412, P<0.05).ConclusionPP seems to be a risk factor for assessing subclinical atherosclerosis in hypertensive patients. TNF-α may be involved in the inflammation process of atherosclerotic changes in hypertension.
文摘目的探讨糖尿病肾病（DN）患者同型半胱氨酸水平（Hcy）及其与炎症因子的关系。方法在本院就诊的2型糖尿病（T2DM ）的患者120例，按DN不同进展期分为：DM正常白蛋白尿组（DM A组）；早期糖尿病肾病组（DMB组）；临床糖尿病肾病组（DMC组）各40例。另以同期健康体检正常者40例为对照组。检测四组研究对象血浆 Hcy、高敏 C 反应蛋白（hs‐CRP）、肿瘤坏死因子‐α（TNF‐α）、白介素‐6（IL‐6）水平。结果与健康对照组比较，DN 患者的血浆 Hcy水平、炎症因子指标明显升高，差异有统计学意义（ P ＜0．01）；随着DN尿蛋白的升高，血浆 Hcy及hs‐CRP、TNF‐α、IL‐6水平显著递增，差异有统计学意义（ P ＜0．01）；DN患者血浆Hcy升高与hs‐CRP、TNF‐α、IL‐6的水平呈正相关（ r分别为0．420、0．461、0．429，P ＜0．01）。结论高Hcy血症及炎症因子参与了DN的发生和发展过程，Hcy可能通过促进机体炎症状态的产生促进DN的发生和发展。
