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枸杞多糖对荷瘤小鼠肿瘤微环境T淋巴细胞亚群及树突状细胞的影响 被引量:39
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作者 何彦丽 应逸 +3 位作者 许艳丽 苏俊芳 罗惠 王惠峰 《中西医结合学报》 CAS 2005年第5期374-377,共4页
目的:研究枸杞多糖(Lyciumbarbarumpolysaccharide,LBP)对荷瘤小鼠体内肿瘤微环境中T淋巴细胞亚群和树突状细胞(dendriticcells,DCs)的影响,探讨LBP对荷瘤机体免疫逃逸的干预作用。方法:用LBP给H22荷瘤小鼠灌胃,连续2周后,测定肿瘤重量... 目的:研究枸杞多糖(Lyciumbarbarumpolysaccharide,LBP)对荷瘤小鼠体内肿瘤微环境中T淋巴细胞亚群和树突状细胞(dendriticcells,DCs)的影响,探讨LBP对荷瘤机体免疫逃逸的干预作用。方法:用LBP给H22荷瘤小鼠灌胃,连续2周后,测定肿瘤重量,采用流式细胞术检查肿瘤浸润淋巴细胞(tumor-infiltratinglymphocyte,T1L)中T淋巴细胞亚群和DCs的数量,以及协同刺激分子CD80(B7-1)表达的变化。结果:LBP可明显抑制肿瘤细胞的生长,增加肿瘤浸润CD4+、CD8+。细胞的数量。LBP高剂量组CD4+和CD8+细胞数量的百分比高于模型组(P<0.05)。LBP低剂量和高剂量组肿瘤浸润DCs数量及B7-1表达均较模型组升高,但差异无统计学意义。结论:LBP的抗肿瘤作用可能与恢复荷瘤小鼠TIL中CD4+、CD8+的细胞数量、解除机体的免疫抑制状态及增强机体的抗肿瘤免疫功能有关。LBP能否恢复荷瘤机体DCs的表型及功能尚待进一步研究。 展开更多
关键词 枸杞多糖 免疫抑制 淋巴细胞亚群 肿瘤浸润淋巴细胞 树突状细胞
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人肿瘤浸润性树突状细胞的表型分析及原因探讨 被引量:11
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作者 王正昕 曹雪涛 +2 位作者 张明徽 李楠 王元和 《中国免疫学杂志》 CAS CSCD 北大核心 1999年第11期509-511,共3页
目的:树突状细胞作为抗原提呈细胞在机体的抗肿瘤免疫反应中起重要作用,对肿瘤浸润性树突状细胞的研究有助于揭示肿瘤免疫逃逸机制。方法:采用酶消化、细胞分离、流式细胞仪分析等方法研究了14 例胃肠道肿瘤患者肿瘤浸润性树突状... 目的:树突状细胞作为抗原提呈细胞在机体的抗肿瘤免疫反应中起重要作用,对肿瘤浸润性树突状细胞的研究有助于揭示肿瘤免疫逃逸机制。方法:采用酶消化、细胞分离、流式细胞仪分析等方法研究了14 例胃肠道肿瘤患者肿瘤浸润性树突状细胞的表型,并用RTPCR检测了IL10、VEGF和TGFβ13 种免疫抑制因子在14 例肿瘤细胞中的表达。结果: 肿瘤浸润性单核细胞中有CD1a+ 的树突状细胞存在,该类细胞的表面分子如MHCII类分子、CD80 及CD54 等共刺激分子和粘附分子有低表达或不表达,14 例肿瘤细胞中IL10、VEGF及TGFβ1 的表达率均较高。结论:肿瘤浸润性树突状细胞可能是一种无功能或功能低下的树突状细胞,肿瘤细胞在肿瘤局部分泌的免疫抑制因子可能是导致肿瘤浸润性树突状细胞功能低下的原因之一。 展开更多
关键词 树突状细胞 肿瘤浸润 MHC-Ⅱ类分子 免疫抑制
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Heparanase expression,degradation of basement membrane and low degree of infi ltration by immunocytes correlate with invasion and progression of human gastric cancer 被引量:4
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作者 Zun-Jiang Xie Ying Liu Li-Min Jia Ye-Chun He 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第24期3812-3818,共7页
AIM: To disclose the mechanisms that accelerate or limit tumor invasion and metastasis in gastric cancer patients. METHODS: The heparanase expression, continuity of basement, degree of infiltration by dendritic cell... AIM: To disclose the mechanisms that accelerate or limit tumor invasion and metastasis in gastric cancer patients. METHODS: The heparanase expression, continuity of basement, degree of infiltration by dendritic cells and lymphocytes in gastric cancer tissues from 33 the early and late stage patients were examined by immunohistochemistry, in situ hybridization and transmission electron microscopy. RESULTS: Heparanase mRNA expression in the late stage patients with gastric cancer was stronger than that in the early stage gastric cancer patients. In the early stage gastric cancer tissues, basement membrane (BM) appeared intact, whereas in the late stage, discontinuous BM was often present. The density of Sl00 protein positive tumor infiltrating dendritic cells (TIDC) in the early stage gastric cancer tissues was higher than that in the late stage. The infiltrating degree of tumor infiltrating lymphocytes (TIL) in the early stage patients whose tumor tissues contained a high density of TIDC was significantly higher than that in the late stage gastric cancer tissues patients with a low density of TIDC. There were few cancer cells penetrated through the continuous BM of cancer nests in the early stage gastric cancers, but many cancer cells were found outside of the defective BM of cancer nests in the late stage. CONCLUSION: Our results suggest that strongheparanase expression is related with the degradation of BM which allows or accelerates tumor invasion and metastasis. However, high density of TIDC and degree of infiltration by TIL are associated with tumor progression in human gastric cancers. 展开更多
关键词 HEPARANASE Basement membrane tumorinfiltrating dendritic cell Tumor infiltrating lymphocyte Gastric cancer
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