Drug therapy towards tumours often causes adverse effects because of their non-specific nature.Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and sa...Drug therapy towards tumours often causes adverse effects because of their non-specific nature.Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery.By camouflaging the nanoparticles with natural derived or artificially modified cell membranes,the nano-payloads are bestowed with properties from cell membranes such as longer circulation,tumour or inflammation-targeting,immune stimulation,augmenting the performance of traditional therapeutics.In this review,we review the development of membrane coating technology,and summarise the technical details,physicochemical properties,and research status of membrane-coated nanoparticles from different sources in tumour treatment.Finally,we also look forward to the prospects and challenges of transforming membrane coating technology from experiment into clinical use.Taken together,membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future.展开更多
The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy(PDT).Hence,in this study,indocyanine green(ICG)-loaded lipid-coated zinc peroxide(ZnO_(2))nanoparticles(ZnO_(2)@Lip-ICG)was ...The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy(PDT).Hence,in this study,indocyanine green(ICG)-loaded lipid-coated zinc peroxide(ZnO_(2))nanoparticles(ZnO_(2)@Lip-ICG)was constructed to realize tumour microenvironment(TME)-responsive self-oxygen supply.Near infrared light irradiation(808 nm),the lipid outer layer of ICG acquires sufficient energy to produce heat,thereby elevating the localised temperature,which results in accelerated ZnO_(2)release and apoptosis of tumour cells.The ZnO_(2)rapidly generates O_(2)in the TME(pH 6.5),which alleviates tumour hypoxia and then enhances the PDT effect of ICG.These results demonstrate that ZnO_(2)@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics,and thus,achieve good tumour proliferation suppression.展开更多
文摘Drug therapy towards tumours often causes adverse effects because of their non-specific nature.Membrane-coated technology and membrane-coated nanoparticles provide an advanced and promising platform of targeted and safe delivery.By camouflaging the nanoparticles with natural derived or artificially modified cell membranes,the nano-payloads are bestowed with properties from cell membranes such as longer circulation,tumour or inflammation-targeting,immune stimulation,augmenting the performance of traditional therapeutics.In this review,we review the development of membrane coating technology,and summarise the technical details,physicochemical properties,and research status of membrane-coated nanoparticles from different sources in tumour treatment.Finally,we also look forward to the prospects and challenges of transforming membrane coating technology from experiment into clinical use.Taken together,membrane-coated nanoparticles are bound to become one of the most potential anti-tumour strategies in the future.
基金supported by the National Natural Science Foundation of China (No. 81771002, 82071057 and 82000988)
文摘The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy(PDT).Hence,in this study,indocyanine green(ICG)-loaded lipid-coated zinc peroxide(ZnO_(2))nanoparticles(ZnO_(2)@Lip-ICG)was constructed to realize tumour microenvironment(TME)-responsive self-oxygen supply.Near infrared light irradiation(808 nm),the lipid outer layer of ICG acquires sufficient energy to produce heat,thereby elevating the localised temperature,which results in accelerated ZnO_(2)release and apoptosis of tumour cells.The ZnO_(2)rapidly generates O_(2)in the TME(pH 6.5),which alleviates tumour hypoxia and then enhances the PDT effect of ICG.These results demonstrate that ZnO_(2)@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics,and thus,achieve good tumour proliferation suppression.
