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WIN55212-2通过调控mTOR/HIF-1α/PFKFB3信号通路抑制糖酵解并减轻脓毒症小鼠急性肺损伤
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作者 段倩雯 董旭鹏 +3 位作者 马源 刘澈 张铭 马玉清 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第3期521-526,共6页
目的:探究大麻素受体激动剂WIN55212-2(WIN)对脓毒症小鼠急性肺损伤(ALI)的影响,并探讨其通过糖酵解发挥作用的可能机制。方法:采用腹腔注射脂多糖(LPS)创建小鼠脓毒症ALI模型。将雄性C57BL/6J小鼠随机分为4组:对照(control)组、LPS组(... 目的:探究大麻素受体激动剂WIN55212-2(WIN)对脓毒症小鼠急性肺损伤(ALI)的影响,并探讨其通过糖酵解发挥作用的可能机制。方法:采用腹腔注射脂多糖(LPS)创建小鼠脓毒症ALI模型。将雄性C57BL/6J小鼠随机分为4组:对照(control)组、LPS组(腹腔注射10 mg/kg LPS)、LPS+WIN组(注射LPS前30 min腹腔注射1 mg/kg WIN)和LPS+WIN+MHY1485[哺乳动物雷帕霉素靶蛋白(mTOR)活化剂]组(LPS造模前1 d腹腔注射10 mg/kg MHY1485,并在造模前30 min腹腔注射1 mg/kg WIN和10 mg/kg MHY1485),每组6只。造模24 h后取材,计算肺指数;HE染色观察肺组织病理变化;ELISA检测肺组织炎症因子白细胞介素1β(IL-1β)和IL-10表达水平,以及血清乳酸和乳酸脱氢酶A(LDHA)水平;Western blot检测mTOR/缺氧诱导因子1α(HIF-1α)/6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶3(PFKFB3)信号通路相关蛋白水平。结果:相比于control组,LPS组小鼠肺指数增加,HE染色显示肺组织受损,肺组织中IL-10水平降低(P<0.05),IL-1β水平升高(P<0.05),血清乳酸和LDHA水平升高(P<0.05),磷酸化mTOR(p-mTOR)、HIF-1α和PFKFB3蛋白水平升高(P<0.05)。相较于LPS组,LPS+WIN组肺指数降低(P<0.05),HE染色显示肺组织受损减轻,肺组织IL-1β水平降低(P<0.05),IL-10水平升高(P<0.05),血清乳酸和LDHA水平降低(P<0.05),p-mTOR、HIF-1α和PFKFB3蛋白水平降低(P<0.05)。相较于LPS+WIN组,LPS+WIN+MHY1485组肺指数增加,HE染色显示肺组织受损,肺组织IL-1β水平升高(P<0.05),IL-10水平降低(P<0.05),血清乳酸和LDHA水平升高(P<0.05),p-mTOR、HIF-1α和PFKFB3蛋白水平升高(P<0.05)。结论:WIN55212-2可以减轻脓毒症小鼠ALI,其机制可能是通过调控mTOR/HIF-1α/PFKFB3信号通路,抑制糖酵解,减轻炎症反应。 展开更多
关键词 win55212-2 脓毒症 急性肺损伤 糖酵解 mTOR/HIF-1α/PFKFB3信号通路
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Business Community in East Asia Searching for a Win-win Cooperation
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作者 Liu Yusong Zhang Fan 《China's Foreign Trade》 2024年第3期11-13,共3页
Inaugurated in 2009,the China-Japan-ROK Business Summit serves as an important side event of the Trilateral Summit Meeting among China,Japan and the ROK.The 8th edition held on May 27 was co-hosted by the China Counci... Inaugurated in 2009,the China-Japan-ROK Business Summit serves as an important side event of the Trilateral Summit Meeting among China,Japan and the ROK.The 8th edition held on May 27 was co-hosted by the China Council for the Promotion of International Trade (CCPIT),the Korea Chamber of Commerce and Industry (KCCI),and the KEIDANREN (Japan Business Federation).Business people from the three countries congregated and discussed for future cooperation. 展开更多
关键词 TRADE BUSINESS win
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Mutual Respect and Win-Win Cooperation 50 years of China-Malaysia relations
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作者 Xu Liping Wang Rong 《China Report ASEAN》 2024年第6期44-47,共4页
Friendly exchanges between China and Malaysia date back more than 2,000 years,and a profound traditional friendship has been forged between the two countries.By adhering to the principles of mutual trust,win-win coope... Friendly exchanges between China and Malaysia date back more than 2,000 years,and a profound traditional friendship has been forged between the two countries.By adhering to the principles of mutual trust,win-win cooperation,and equal assistance,China and Malaysia have become good neighbors,good friends,and good partners.In 2013,China and Malaysia established a comprehensive strategic partnership,accelerating the development of bilateral relations. 展开更多
关键词 MALAYSIA mutual win
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Winning a Nobel Prize
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作者 许文龙 《英语知识》 2010年第2期37-37,共1页
A man is driving down a country road,when he spots a farmer standing in the middle of a huge field of grass.He pulls the car over to the side of the road and notices that the farmer is just standing there, doing nothi... A man is driving down a country road,when he spots a farmer standing in the middle of a huge field of grass.He pulls the car over to the side of the road and notices that the farmer is just standing there, doing nothing,looking at nothing. 展开更多
关键词 英语学习 学习方法 阅读 winning a NOBEL Prize》
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Mechanism of combination membrane and electro-winning process on treatment and remediation of Cu^(2+) polluted water body 被引量:3
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作者 ZHANG Linnan WU Yanjun +2 位作者 QU Xiaoyan LI Zhenshan NI Jinren 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2009年第6期764-769,共6页
Mechanism of treatment and remediation of synthetic Cu^2+ polluted water body by membrane and electro-winning combination process was investigated.The influences of electrolysis voltage,pH,and electrolysis time on th... Mechanism of treatment and remediation of synthetic Cu^2+ polluted water body by membrane and electro-winning combination process was investigated.The influences of electrolysis voltage,pH,and electrolysis time on the metal recovery effciencies were studied.Relationship between trans-membrane pressure drop(△P),additions ratio,initial Cu^2+ concentration on operating effciency,stability of membrane and the possibility of water reuse were also investigated.The morphology of membrane and electrodes were observed using scanning electron microscopy(SEM),the composition of surface deposits was ascertained using combined energy dispersive X-ray spectroscopy(EDX) and atomic absorption spectrophotometer.The results showed that using low pressure reverse osmosis(LPRO),Cu^2+ concentration could increase from 20 to 100 mg/L or even higher in concentrated solutions and permeate water conductivity could be less than 20 μS/cm.The addition of sodium dodecy/sulfate sodium dodecyl sulfate improved Cu^2+ removal effciency,while EDTA had little side influence.In electro-reduction process,using plante electrode cell,Cu^2+ concentration could be further reduced to 5 mg/L,and the average current effciency ranged from 9% to 40%.Using 3D electrolysis treatment,Cu^2+ concentration could be reduced to 0.5 mg/L with a current effciency range 60%-70%. 展开更多
关键词 heavy metal water body membranes electro-winning REMEDIATION
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Study on the Winning Probability for a Bid in Procurement Combinational Auction with Tree Structure 被引量:1
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作者 CHEN Jian, HUANG He (Research Center for Contemporary Management, Tsinghua University Beijing 10084 China) 《Journal of Electronic Science and Technology of China》 2004年第3期18-21,46,共5页
In this paper, the processes to determine winning probability for the corresponding bidder's deterministic bid are presented. The analysis of the winning probability is crucial for studying the bidding equilibria ... In this paper, the processes to determine winning probability for the corresponding bidder's deterministic bid are presented. The analysis of the winning probability is crucial for studying the bidding equilibria and designing the mechanism of procurement combinational auctions (CAs), and it also provides the decision making support for bidders who are in commercial synergies surrounding. Finally, an example is used to illustrate the feasibility and detailed processes of calculating winning probability. 展开更多
关键词 procurement combinational auctions bidding winning probability computation strategy
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Analysis of Noise at Coal Face by Fully-Mechanized Coal Winning Technology 被引量:1
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作者 刘照鹏 《Journal of China University of Mining and Technology》 2003年第1期113-116,共4页
The noise level of coal face by full-mechanized coal winning technology was measured in a coal mine. And then it was analyzed and evaluated using environment science, ergonomics and fussy mathematics analysis. Basis o... The noise level of coal face by full-mechanized coal winning technology was measured in a coal mine. And then it was analyzed and evaluated using environment science, ergonomics and fussy mathematics analysis. Basis of the statistics and analysis of the measured noise level some measures, such as applying the new materials and improving the construction of the equipment, were carried out. The resuts show that they can reduce the noise level, improve the working environment and enhance the work efficiency. 展开更多
关键词 噪声 采煤工作面 机械化回采 个人心理 控制方法 模糊数学分析 工作环境
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Winning Strategies and Complexity of Nim-Type Computer Game on Plane
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作者 Boris S. Verkhovsky 《International Journal of Communications, Network and System Sciences》 2010年第10期793-800,共8页
A Nim-type computer game of strategy on plane is described in this paper. It is demonstrated that winning strategies of this two-person game are determined by a system of equations with two unknown integer sequences. ... A Nim-type computer game of strategy on plane is described in this paper. It is demonstrated that winning strategies of this two-person game are determined by a system of equations with two unknown integer sequences. Properties of winning points/states are discussed and an O(loglogn) algorithm for the winning states is provided. Two varieties of the Game are also introduced and their winning strategies are analyzed. 展开更多
关键词 Nim-type GAME Two-person Strategy GAME winning Strategies NEWTON Algorithm FIBONACCI NUMBERS
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Using Sports Wagering Markets to Evaluate and Compare Team Winning Streaks in Sports
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作者 R. Alan Bowman Thomas Ashman James Lambrinos 《American Journal of Operations Research》 2015年第5期357-366,共10页
Point spreads and money lines from sports wagering markets are used to evaluate the impressiveness of team streaks. Sports wagering data have previously been useful in assessing competitive balance in sports. Our appr... Point spreads and money lines from sports wagering markets are used to evaluate the impressiveness of team streaks. Sports wagering data have previously been useful in assessing competitive balance in sports. Our approach was motivated by the amount of media scrutiny that accompanied the winning streak of the NBA’s Miami Heat and the point streak of the NHL’s Chicago Blackhawks which occurred simultaneously for the most part in 2013. The topic came to the forefront again with the 2014-2015 winning streak of the Atlanta Hawks. Three streaks are highlighted in our paper. The length of the streaks, the quality of the competition, injuries, and a variety of other factors were mentioned in the media but the discussion was limited to subjective opinions as no way of properly weighing relative influence of the factors was identified. Wagering markets provide an excellent source of information for making these judgments. Several complementary measures are described and the most impressive team streaks within and across professional baseball, basketball, football, and ice hockey are identified. 展开更多
关键词 winning STREAKS SPORTS Wagering Markets BASEBALL BASKETBALL Football HOCKEY
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TELUS and ZTE Launch Award Winning Wireless Phone Featuring Fastap Keypad
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《ZTE Communications》 2007年第3期5-5,共1页
August 9,2007,Vancouver,B.C.— TELUS,a leading national telecommunications company in Canada
关键词 PHONE ZTE TELUS and ZTE Launch Award winning Wireless Phone Featuring Fastap Keypad
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Topics of Contraceptive Research Winning Awards
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《China Population Today》 1996年第2期15-15,共1页
TopicsofContraceptiveResearchWinningAwardsSponsoredbytheStateFamilyPlanningCommission,1995Studyofchangesofco... TopicsofContraceptiveResearchWinningAwardsSponsoredbytheStateFamilyPlanningCommission,1995Studyofchangesofcontraceptionpracti... 展开更多
关键词 Topics of Contraceptive Research winning Awards
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Ascending to the Throne After Winning the Horse Race
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《China's Tibet》 1995年第3期12-15,共4页
AscendingtotheThroneAfterWinningtheHorseRace¥//Thegrandhorseracewasabouttobegin,andthebeautifulMalungGrassla... AscendingtotheThroneAfterWinningtheHorseRace¥//Thegrandhorseracewasabouttobegin,andthebeautifulMalungGrasslandwasabuzzwithmer... 展开更多
关键词 HORSE Ascending AFTER RACE Throne winning the to
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Acrobatic Drama Pilgrimage to the West Winning Wenhua Award
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作者 王玉 《杂技与魔术》 2007年第6期27-,共1页
The 8th China Arts Festival was held in Wuhan from 5th to 20th of November.Guangzhou Acrobatic Troupe's acrobatic drama-"Pilgrimage to the West"competed for the Wenhua Award, which is the most prestigiou... The 8th China Arts Festival was held in Wuhan from 5th to 20th of November.Guangzhou Acrobatic Troupe's acrobatic drama-"Pilgrimage to the West"competed for the Wenhua Award, which is the most prestigious prize for performance art given by the Chinese government. 展开更多
关键词 PI WEST Acrobatic Drama Pilgrimage to the West winning Wenhua Award
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2011DICEChinaWinningTeamWORKSHOP在烟台圆满结束
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作者 张倩 《交通世界》 2011年第21期20-20,共1页
秋风送爽,又迎来了收获希望的季节.为了创造有效的沟通平台.憧憬”ONEDOOSAN”的未来.强化竞争力,创建一流企业.9月29日,DICEChina的高管与85个Team的TeamLeader汇聚烟台.
关键词 企业 CEO 经理 “2011 DICE China winning TEAM WORKSHOP”
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CAS Projects Winning State S&T Awards in 2005
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《Bulletin of the Chinese Academy of Sciences》 2007年第1期35-54,共20页
At the National S&T Conference held on 9 January, 2006 in Beijing, CAS received 43 prizes from China's 2005 S&T awards in the capacity of the lead research institution (or principal researcher). Among the ... At the National S&T Conference held on 9 January, 2006 in Beijing, CAS received 43 prizes from China's 2005 S&T awards in the capacity of the lead research institution (or principal researcher). Among the prize-winning projects, 17 were honored with the second prizes of the National Award for Natural Sciences, eight with the second prizes of the National Award for Invention, and 18 with the second prizes from the National Award for S&T Progress. A total of 314 projects received the 2005 national S&T awards nationwide. Of them, 38 were second-place winners from the National Award for Natural Sciences (first-place winners were vacant); 40 won the National Award for Invention (one first-place winner) and 236 won the National Award for S&T Progress (18 first-place winners). In addition, five foreign scientists received National Award for S&T Cooperation. The following is a brief account of some of the CAS projects. 展开更多
关键词 winNER honored dispersed elliptical NATIONWIDE PRIZE utilized CITED winning brief
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AIYIMEI insists on winning by quality
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作者 Zhao Zihan 《China Textile》 2017年第12期30-31,共2页
'Currently,we cannot enjoy a famous brand;however,we are able to win by quality.'Mr.Yin Heming,Deputy General Manager of AIYIMEI Group,told the reporters during an interview in the 21st Ningbo International Fa... 'Currently,we cannot enjoy a famous brand;however,we are able to win by quality.'Mr.Yin Heming,Deputy General Manager of AIYIMEI Group,told the reporters during an interview in the 21st Ningbo International Fashion Fair this October.AIYIMEI Group,founded in 1979,has developed into a 展开更多
关键词 winning Ningbo INTERVIEW founded ENJOY GARMENT DEPUTY constantly SHARES COVERING
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Winning Foreign Hearts
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作者 Tang Yuankai 《ChinAfrica》 2015年第11期26-27,共2页
the global market, Chinese TV dramas have seen more success in Africa than in any other region. A family comedy, A Beautiful Daughter-in-Law Era, which tells the story of a newly married couple coping with meddling i... the global market, Chinese TV dramas have seen more success in Africa than in any other region. A family comedy, A Beautiful Daughter-in-Law Era, which tells the story of a newly married couple coping with meddling in-laws, became a hit in Tanzania after premiering there in 2013. 展开更多
关键词 winning Foreign Hearts RADIO
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Winning the Investment War
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作者 Aggrey Mutambo 《ChinAfrica》 2013年第7期36-36,共1页
AFRICA'S level of foreign investment has grown over the past five years, but it is the emerging markets, which include China, that are winning hearts and wallets in Sub-Saharan Africa, pushing aside traditional inves... AFRICA'S level of foreign investment has grown over the past five years, but it is the emerging markets, which include China, that are winning hearts and wallets in Sub-Saharan Africa, pushing aside traditional investors from the West. 展开更多
关键词 FDI winning the Investment War
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Messe Dusseldorf GmbH WINNING IN 2004
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《中国会展》 2005年第1期52-52,共1页
Welcome to CEFCO Beijing! Reporter:Would you please briefly introduce the exhibition business of Messe Duesseldorf GmbH in 2004? Werner:In 2004 the turnover of Messe Dusseldorf GmbH lies at over 300 million Euros, thi... Welcome to CEFCO Beijing! Reporter:Would you please briefly introduce the exhibition business of Messe Duesseldorf GmbH in 2004? Werner:In 2004 the turnover of Messe Dusseldorf GmbH lies at over 300 million Euros, this means that all set targets of the company have been achieved. Thus, in spite of a difficult economic situation, 2004 is the best year for trade fairs in the history of the company. 展开更多
关键词 In Messe Dusseldorf GmbH winning IN 2004
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A Winning Goal
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作者 Xia Yuanyuan Koceila Bouhanik 《ChinAfrica》 2017年第9期52-52,共1页
Chinese teenagers come up with their own solutions to assist African development.
关键词 A winning Goal
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