Erroneous presentation of respiratory-hemodynamic disturbances and postsurgical inflammatory responses in patients having undergone abdominal cavity cancer surgery

In this letter to the editor,the authors discuss the findings and shortcomings of a published retrospective study,including 120 patients undergoing surgery for gastric or colon cancer under general anesthesia.The study focused on perioperative dynamic respiratory and hemodynamic disturbances and early postsurgical inflammatory responses.

Experimental Investigation and Optimization Design of Multi-Support Pipeline System

The design of aircraft hydraulic pipeline system is limited by many factors,such as the integrity of aviation structure or narrow installation space,so the limited clamp support position should be considered.This paper studied the frequency adjustment and dynamic responses reduction of the multi-support pipeline system through experiment and numerical simulation.To avoid the resonance of pipeline system,we proposed two different optimization programs,one was to avoid aero-engine working range,and another was to avoid aircraft hydraulic pump pulsation range.An optimization method was introduced in this paper to obtain the optimal clamp position.The experiments were introduced to validate the optimization results,and the theoretical optimization results can agree well with the test.With regard to avoiding the aero-engine vibration frequency,the test results revealed that the first natural frequency was far from the aero-engine vibration frequency.And the dynamic frequency sweep results showed that no resonance occurred on the pipeline in the engine vibration frequency range after optimization.Additionally,with regard to avoiding the pump vibration frequency,the test results revealed that natural frequencies have been adjusted and far from the pump vibration frequency.And the dynamic frequency sweep results showed that pipeline under optimal clamp position cannot lead to resonance.The sensitivity analysis results revealed the changing relationships between different clamp position and natural frequency.This study can provide helpful guidance on the analysis and design of practical aircraft pipeline.

Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive

AIM： To determine the changes of quantitative hepatitis B e antigen （HBeAg） that predicts early detection of non-response or breakthrough to long-term lamivudine （LAM） therapy. METHODS： Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 too, we retrospectively analyzed 220 patients who had received LAM more than 24 too. RESULTS： The mean duration of LAM therapy was 36 （range, 24-72） mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 （24.1%） patients. Viral breakthrough was observed in 105 （47.7%） patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg： decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non-response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 （92.5%） of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four （7.5%） had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 too, 95.2% （negative predictive value） failed to achieve HBeAg seroconversion. CONCLUSION： Almost all patients who failed to show a continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough.

Severity of Symptoms of Systemic Inflammatory Response Syndrome and Congestive Heart Failure Caused by Chronic Aortic Stenosis and Its Pharmacological Correction

Systemic inflammatory response syndrome (SIRS) is one of the key accompanied states that worsens severity of congestive heart failure (CHF) and leads refractory CHF to conventional therapy. We investigated whether the cessation of the symptoms and signs of SIRS prevents the progression of the CHF caused by chronic aortic stenosis in rabbits. 8 weeks after induced CHF by left descending coronary artery stenosis, all animals were randomly assigned into 3 groups: control (CG)—without therapy (infusion of 0.9% NaCl);main I— receive mg/kg of Adenocin®dissolved in water for injection i.v., once daily and main II—animals receive 0.25 mg/kg enalapril i.m, furosemide 1.0 mg/kg i.v. (bolus) and pimobendan 0.1 mg/kg i.v. once daily. All animals were euthanized after 14 days of the beginning of treatment. Long-term aortic stenosis leads to a simultaneously developing of CHF, diagnosed by developing cardiac hypertrophy, increased level of BNP and myocardial oedema and SIRS, confirmed by increasing markers and symptoms of endotoxemia, tissue dysoxia and decreasing reserve ability of intrinsic defense systems. Restoration of myocardium redox-potential and level of NAD under treatment with Adenocin®leads unlike combined treatment with enalapril, furosemide and pimobendan to restoration, the regulatory pathways of TNF-α synthesis, cessation of the hypoxic/ischemic, lysosomal dysfunction and free radical-induced damage in myocardium and symptoms of CHF. Potential important link between cellular metabolism (hypoxia/ischemia), endotoxemia and disturbances in intrinsic defense system is the level of redox-potentail, NAD/NADH in myocardium. Influence of oxidized form of NAD-containing positive inotropic drug Adenocin®leads to the decreasing symptoms of CHF and beneficial action occurs on all the key links of SIRS.

Efficacy of Nilotinib versus Imatinib in Philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib

Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib at 400 mg BID in CML patients with suboptimal molecular response after at least 12 months of daily dose 400 mg of imatinib therapy. Patients and Methods: This study included a total number of 50 patients, divided into two groups (25 patients each). The first group (Group I): Patients received imatinib at 400 mg BID, second group (Group II): Patients had a suboptimal molecular response to imatinib and received nilotinib at 400 mg BID in early chronic phase. During the two years period of data collection, the primary end included median survival. The secondary end included response rate, type of response, duration of response and progression free survival. Also side effects were recorded. Patients were followed up every month by complete and differential blood counts, liver function test, renal function test and (PCR) every three months for two year. Results: Nilotinib group had significantly higher frequency of major molecular response (MMR) where 23 (92%) patients achieved it while only 16 (64%) patients in Imatinib group achieved MMR (P = 0.01). Nilotinib had better toxicities profile than Imatinib. Conclusion: Both Nilotinib and high dose Imatinib achieved response in CML patients with suboptimal response with rapid and deeper molecular response, better survival outcomes and less side effects in nilotinib.

The Influence of Surface Building's Relative Position on the Seismic Response of Subway Structures

By using the finite element method and viscoelastic artificial boundary, a soil-structure interaction system is established to simulate the influence of surface buildings on the seismic response of subway structures. The conditions of different relative positions between ground building and subway structure are analyzed. The result~ indicate that when considering the existence of surface buildings, the relative story displacements and internal forces of subway structures are changed greatly. Further the influence of surface buildings on subway structure changes as the distance increases.

Robot Positioning Based on Multiple Quick Response Code Landmarks

The scheme of robot positioning based on multiple quick response(QR)code landmarks is proposed.Firstly,the pose of the robot relative to the QR code landmarks is obtained by extracting the feature points of the QR code,combined with the visual computing technology.Then,the conversion of the absolute pose of the robot is completed based on the absolute position of the QR code landmark,and thus the real-time position of the robot is obtained.The proposed scheme makes full use of the QR code fault tolerance and multiple QR code landmarks to improve the calculation accuracy.It has good robustness and versatility,and it is easy to implement.It can help the robot to complete the positioning in the actual work,making robot navigation more accurate.

辅导员在高校“三全育人”中的角色定位与实现路径

构建全员全过程全方位育人格局是落实立德树人根本任务的内在要求和战略举措。高校辅导员在“三全育人”体系中肩负着重要使命,是全员育人中的主导者、全程育人中的统筹者、全方位育人中的串联者。然而,囿于思想认识、能力素质、边界划分等方面的现实困境问题,真正实现好这一角色担当,还需要从激发内生动力、加大资源供给、明确职责边界等方面持续用力,不断提升新时代辅导员育人能力和水平。

有运动高血压反应的患者平板运动试验假阳性相关因素分析

目的:探讨有运动高血压反应的患者平板运动试验假阳性的相关因素。方法:选取2019年11月至2022年10月在江苏省省级机关医院心脏康复门诊平板运动试验(treadmill exercise test,TET)检查阳性且有运动高血压反应的患者154例,根据有无冠心病分为假阳性组72例、真阳性组82例,比较两组人口统计学及TET相关参数。结果:TET假阳性组与真阳性组性别比较差异有统计学意义(P<0.05),与男性相比,女性更易得到假阳性结果。假阳性组和真阳性组出现ST段压低时的收缩压(systolic blood pressure,SBP)分别为203.87±8.70 mmHg和187.25±16.66 mmHg,两组之间差异有统计学意义(P<0.05)。应用Logistic回归分析,仅ST段压低时的SBP和性别与TET假阳性之间显著相关(P<0.05)。利用受试者工作特征曲线(receiver operating characteristic,ROC)描绘出的ST段压低时的SBP临界值为188mmHg,其敏感性为1、特异性为0.625,曲线下面积为0.813。结论:在有运动高血压反应的患者中,ST段压低时的SBP可考虑作为预测TET假阳性的指标,当其数值≥188 mm Hg时,特别是在女性患者中,要慎重得出TET阳性的结论。

体位指导联合气道干预在老年重症肺炎患者呼吸机治疗中的应用效果

目的:探讨体位指导联合气道干预在老年重症肺炎患者呼吸机治疗中的应用效果。方法:选取2022年1月—2023年1月广州市第一人民医院收治的60例老年重症肺炎患者。根据随机数表法将其分为对照组和观察组,各30例。对照组采用常规护理,观察组在对照组基础上采用体位指导联合气道干预。比较两组干预前、干预7 d后心功能及肾功能指标、应激指标及并发症。结果:干预7 d后,两组左室射血分数(LVEF)升高,舒张早期充盈峰速度/舒张晚期充盈峰速度(E/A)、血肌酐、血尿素氮(BUN)均降低,观察组LVEF高于对照组,血肌酐、BUN均低于对照组,差异有统计学意义(P<0.05)。干预7 d后,两组皮质醇(Cor)、血管紧张素Ⅰ(AngⅠ)及血管紧张素Ⅱ(AngⅡ)均降低,观察组Cor、AngⅠ、AngⅡ均低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:体位指导联合气道干预用于老年重症肺炎患者呼吸机治疗中,能改善患者心功能及肾脏功能,减轻应激反应及降低并发症发生率。

正流量控制挖掘机泵阀响应特性及匹配优化研究

以正流量控制挖掘机液压系统为研究对象,建立主泵排量调节系统与多路换向系统数学模型,搭建其AMESim仿真模型,探究铲斗联主阀开启过程中泵阀系统响应特性。针对铲斗主阀开启过程阀口流量和压力波动过大、速度响应匹配不当等问题,提出降低先导压力与泵排量比例系数k和优化节流槽特征参数的正控泵与阀控系统响应匹配优化方案,并通过试验验证优化方案的有效性。结果表明:优化后阀芯在开启阶段的流量波动幅值和压力波动显著降低,流量波动幅值降低了18.19%,压力波动峰值降低了2.8 MPa。

国土空间规划下海岸带的功能定位及空间响应——以上海海岸带为例

海岸带规划作为国土空间规划体系中的唯一涉海规划,不仅要对海岸带地区进行陆海统筹综合管控,而且要对海岸带地区的发展进行战略功能引导,以适应海洋强国建设的蓝色发展要求。文章分析新一轮国土空间规划对海岸带规划的新要求,提出海岸带规划进行功能定位和空间响应的规划策略和方法;结合上海海岸带发展实际,从多维战略对接、区域功能耦合、未来发展趋势应对3个方面谋划海岸带功能定位,提出海岸带“三心二市”的功能内涵;在此基础上提出海岸带空间响应策略,主要包括对接国土空间分层逻辑、海洋功能区划和岸线区段功能耦合、开放式分圈层分区划分、落实核心功能诉求。

正负压气吸式精量排种器设计与试验

为了更好地适配非圆小籽粒种子的播种,解决机械式排种器易伤种,对种子尺寸适应性差的问题,设计了1种正负压气吸式精量排种器。根据农艺要求对排种器整体进行了设计;同时以小麦为研究对象,通过单因素试验,分析了吸种负压、排种器转速以及投种高度3个因素对排种器性能的影响;通过响应面试验,得到了较优的参数组合:吸种负压为-3.5 kPa,排种器转速为19 r/min,投种高度为180 mm;对最优参数下精量排种器进行台架试验,结果表明,合格率为80.62%,重播率为9.22%,漏播率为10.16%。符合JB/T—10293—2013《单粒(精密)播种机技术条件》的要求。

Catalytic Hydrothermal Liquefaction of Water Hyacinth Using Fe3O4/NiO Nanocomposite: Optimization of Reaction Conditions by Response Surface Methodology

This research aimed at optimizing the reaction conditions for the catalytic hydrothermal liquefaction (HTL) of water hyacinth using iron oxide/nickel oxide nanocomposite as catalysts. The iron oxide/nickel oxide nanocomposite was synthesized by the co-precipitation method and used in the hydrothermal liquefaction of water hyacinth. The composition and structural morphology of the synthesized catalysts were determined using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic absorption spectroscopy (AAS). The particle size distribution of the catalyst nanoparticles was determined by the Image J software. Three reaction parameters were optimized using the response surface methodology (RSM). These were: temperature, residence time, and catalyst dosage. A maximum bio-oil yield of 59.4 wt% was obtained using iron oxide/nickel oxide nanocomposite compared to 50.7 wt% obtained in absence of the catalyst. The maximum bio-oil yield was obtained at a temperature of 320°C, 1.5 g of catalyst dosage, and 60 min of residence time. The composition of bio-oil was analyzed using gas chromatography-mass spectroscopy (GC-MS) and elemental analysis. The GC-MS results showed an increase of hydrocarbons from 58.3% for uncatalyzed hydrothermal liquefaction to 88.66% using iron oxide/nickel oxide nanocomposite. Elemental analysis results revealed an increase in the hydrogen and carbon content and a reduction in the Nitrogen, Oxygen, and Sulphur content of the bio-oil during catalytic HTL compared to HTL in absence of catalyst nanoparticles. The high heating value increased from 33.5 MJ/Kg for uncatalyzed hydrothermal liquefaction to 38.6 MJ/Kg during the catalytic HTL. The catalyst nanoparticles were recovered from the solid residue by sonication and magnetic separation and recycled. The recycled catalyst nanoparticles were still efficient as hydrothermal liquefaction (HTL) catalysts and were recycled four times. The application of iron oxide/ nickel oxide nanocomposites in the HTL of water hyacinth increases the yield of bio-oil and improves its quality by reducing hetero atoms thus increasing its energy performance as fuel. Iron oxide/nickel oxide nanocomposites used in this study are widely available and can be easily recovered magnetically and recycled. This will potentially lead to an economical, environmentally friendly, and sustainable way of converting biomass into biofuel.

人工耳蜗植入术后电诱发听性脑干反应的电生理特征与参数优化研究

目的研究不同测试参数对电诱发听性脑干反应(electrical auditory brainstem response,EABR)波形的影响,选择优化的人工耳蜗术后EABR测试参数,探讨EABR与人工耳蜗术后行为测试结果之间的关系。方法选取17名人工耳蜗植入者,记录和分析不同刺激电极位置、脉冲间隔和交替/非交替双相脉冲电流下EABR波V的引出率、阈值和潜伏期等特征,分析不同刺激电极位置下EABR阈值与行为学T、C值的相关性。结果(1)蜗顶处EABR的V波阈值(90.58±27.39 CU)显著小于蜗中处(106.98±15.66 CU);(2)蜗顶处的V波潜伏期(4.47±0.357 ms)显著短于蜗中处(4.72±0.335 ms);(3)采用交替双相脉冲电流的电伪迹幅值(9.40±12.35μV)显著小于非交替脉冲(19.49±15.12μV);(4)蜗顶处EABR阈值与行为测试的T值和C值均有显著相关性。结论EABR的刺激电极位置和脉冲电流类型均影响波形结果,蜗顶电刺激比蜗中更易引出理想的EABR波形,使用交替双相脉冲电流刺激可有效减少电伪迹的影响。EABR阈值可为人工耳蜗术后开机和调试提供参考。

高校全员大安全责任制建设与岗位安全标准化实践探索

国内实验室安全管理水平严重滞后于高校学科建设快速发展步伐与安全环境的要求。通过对新安全生产法等文件解读,开展全员参与、全过程履责的大安全观制度建设,提高实验室管理整体安全性。从安全风险防控系统性视角,构建以岗位作业行为标准化、岗位作业环境标准化及岗位安全信息标准化为主要手段的可目视化标准化管理模式,实现高校实验室安全管理模式由经验粗放型、分散化管理向精细化、目标化、责任制、标准化管理转变;打造全员、全组织安全责任制全过程全覆盖,形成高校全员全方位安全责任内生机制,推动构建“大安全”管理体系,为实验室安全治理体系与治理能力现代化提供有益探索。

双轨正性暗示在发育性髋关节发育不良患者手术室等候期间的应用研究

目的 探讨双轨正性暗示在发育性髋关节发育不良(DDH)患者手术室等候期间的应用效果。方法 选取医院2021年8月-2023年10月拟行手术治疗的DDH患者108例,以随机数字表法分为对照组(54例)、观察组(54例);对照组于手术室等候期间行常规护理,研究组基于对照组行双轨正性暗示护理;对比两组生理应激反应、焦虑程度、心理等候时间及满意度。结果 观察组麻醉成功时心率(HR)、平均动脉压(MAP)较对照组低,差异有统计学意义(P<0.05);观察组入手术室时、术后1d焦虑自评量表(SAS)评分较对照组低,差异有统计学意义(P<0.05);观察组心理等候时间较对照组短,总满意度较对照组高,差异有统计学意义(P<0.05)。结论 DDH患者手术室等候期间采用双轨正性暗示护理可减轻生理应激反应,改善焦虑程度,缩短心理等候时间,提高满意度。

环保产业“政府背景”企业研究:市场地位、社会责任承担与效率

如何客观评价政府背景企业在节能环保领域所作的贡献,尤其辨析非平等市场问题和企业社会责任担当,是环保产业研究中尚未能清晰回答的重要问题。本文利用手工搜集的中国环保企业数据这一独特数据集,通过识别每个企业三层股权穿透关系,测度其中央和地方政府背景。通过线性模型和反事实匹配,本文验证了政府背景造成的市场(份额)加成,并判断其本质是非平等市场地位还是社会责任。数据分析发现,整体来讲,政府背景企业既担当了低利润项目的社会责任,也形成了干扰市场自由竞争的非平等市场地位,各城市非平等市场地位差异明显。非平等市场环境损害所有企业效率,“被照顾”的政府背景企业所受负面影响尤为显著;政府背景企业的社会责任承担显著惠及非政府背景企业效率,但是其自身承担了效率损失代价。

考虑隧道掘进过程的新建隧道下穿既有隧道力学响应研究

为有效评估新建隧道下穿施工对既有隧道的影响,确保既有隧道运营安全,将既有隧道简化为放置在Pasternak地基模型上的Euler-Bernoulli梁,基于两阶段分析法提出新建隧道下穿施工引起既有隧道力学响应的计算方法。通过与现场监测和既有方法的结果进行对比,验证了本文方法的准确性。研究结果表明:当新建隧道开挖面位于既有隧道中点时,既有隧道差异沉降达到最大值,转角曲线关于既有隧道中心线对称;在新建隧道掘进过程中,既有隧道的最大正弯矩和最大负弯矩分别出现在既有隧道长度的2/5和3/5位置附近,最大负剪力出现在既有隧道中点处;当新建隧道开挖面到达既有隧道长度的1/4和3/4位置时既有隧道产生最大正剪力;随着隧道轴线夹角和相对弯曲刚度增大,既有隧道的内力显著增大;增大隧道竖向净距有利于控制既有隧道的力学响应。本文方法考虑了新建隧道掘进过程和新建隧道与既有隧道的不同相对位置,可为类似穿越工程风险防控提供理论依据。

基于动态理论模型的电液伺服加载前馈补偿复合控制系统

针对一般电液伺服系统存在的非预期负载扰动和非线性干扰等问题,为了提高系统的自适应能力和动态响应的品质,减小系统跟踪和输出响应的误差,提出了一种基于动态理论模型的电液伺服加载前馈补偿复合控制方法。首先,阐释了电液伺服试验台的结构组成及其数学模型,分析了系统力矩控制和位置控制的结构关系;然后,论证了自适应前馈补偿复合控制的伺服原理,阐述了以调速理论模型和实际模型的误差函数作为调速依据的前馈补偿和复合控制的原理和方法;最后,进行了系统仿真,同时为了验证基于动态理论模型的自适应前馈补偿复合控制策略的合理性和有效性,对伺服系统进行了加载试验。研究结果表明:采用该复合控制策略可以精确算出对伺服马达进行转速补偿的基准值和调整参数,系统动态响应速度比采用传统闭环控制算法提高了8%以上;系统控制器自适应能力和抗扰动性能也明显优于采用传统PI闭环控制及模糊PI闭环控制算法的系统;通过对比分析0.2 Hz和0.5 Hz的正弦响应曲线可知,该系统的位置跟踪曲线性能最优,控制精度最高,实际输出值的误差也最小。