The role of university English instructors has evolved significantly over the years,encompassing various aspects.This paper explores the evolution of the role of university English instructors and examines the current...The role of university English instructors has evolved significantly over the years,encompassing various aspects.This paper explores the evolution of the role of university English instructors and examines the current challenges and opportunities they face in today’s educational landscape.It delves into the multifaceted nature of their responsibilities and discusses the importance of continuous professional development to meet the evolving needs of students and the demands of the profession.展开更多
This research focused on the social roles of women in Al-Abassiya locality,South Kordofan State,examining the obstacles they face and the impact on their participation in peace building.Using qualitative methods,data ...This research focused on the social roles of women in Al-Abassiya locality,South Kordofan State,examining the obstacles they face and the impact on their participation in peace building.Using qualitative methods,data were collected through various means,revealing that conflicts have significantly affected women’s lives,particularly in rural areas.Women play key roles in family,education,health services,and humanitarian aid,but their involvement in conflict resolution and peace building activities is limited.Obstacles include cognitive,economic,social,and institutional barriers.Recommendations include providing education and training programs,strengthening economic status,ensuring women’s representation in decision-making bodies,advocating for legal reforms promoting gender equality,improving access to information technologies,educating communities on women’s involvement in peace building,and providing support services for women affected by conflicts.展开更多
The related work to reveal the primary characteristics of roles underlying the existing approaches is analyzed. Then, it is demonstrated that the representation of roles is rather complex and error-prone in these appr...The related work to reveal the primary characteristics of roles underlying the existing approaches is analyzed. Then, it is demonstrated that the representation of roles is rather complex and error-prone in these approaches. Especially, the constraints among roles in the same context cannot be expressed by the current web ontology language (OWL). To solve these problems, a novel model of role is presented and a corresponding ontology language is provided for representing this model. The key idea underlying the solution is that a role should be regarded as an element of a certain context and a context as a structured thing which is comprised of some internal elements. The structure of context possesses inherent modularity and local semantics, whereby the representation of roles and context is significantly simplified.展开更多
The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers' roles in this learning process in students' perception through the m...The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers' roles in this learning process in students' perception through the means of questionnaires and interviews. It further analyzes the possible reasons why students perceive their teachers' roles in such a way, in the hope of providing some implications for web-based college English autonomous learning.展开更多
This paper gives an account of characteristics of the intensive reading in English teaching, and change of teachers’ roles in the learner-centered teaching approach. Suggestions are put forward as to how to be a qual...This paper gives an account of characteristics of the intensive reading in English teaching, and change of teachers’ roles in the learner-centered teaching approach. Suggestions are put forward as to how to be a qualified teacher in the intensive reading class accordingly.展开更多
Traditionally, in a teacher-centered class, students are deprived of right, for teachers take up the platform and play a “leading” role. What are the college English teacher′s possible roles? The paper tends to she...Traditionally, in a teacher-centered class, students are deprived of right, for teachers take up the platform and play a “leading” role. What are the college English teacher′s possible roles? The paper tends to shed light on it by kicking the teacher′s traditional roles.展开更多
It is commonly known that writing is an advanced skill which is essential in language learning but at the same time the most difficult task for learners. This paper is with the aim to explore helpful roles that teache...It is commonly known that writing is an advanced skill which is essential in language learning but at the same time the most difficult task for learners. This paper is with the aim to explore helpful roles that teacher can play to help non-English major students improve their English writing, so as to help improve their writing ability in the author's context.展开更多
With continuing advances in technology, computer-assisted instruction provides opportunities for individualized, interactive instruction. The philosophy of constructivism has encouraged instructional designers to crea...With continuing advances in technology, computer-assisted instruction provides opportunities for individualized, interactive instruction. The philosophy of constructivism has encouraged instructional designers to create less behavioral, more democratic programs that promote learner control. In the area of ESL (English as a second language), computers are seen to be a highly motivating, instructional tool.展开更多
Endoscopic ultrasound(EUS), developed in the 1980 s, was initially predominantly used for guidance of fine needle aspiration; the last 25 years, however, have witnessed a major expansion of EUS to various applications...Endoscopic ultrasound(EUS), developed in the 1980 s, was initially predominantly used for guidance of fine needle aspiration; the last 25 years, however, have witnessed a major expansion of EUS to various applications, both diagnostic and therapeutic. EUS has become much more than a tool to differentiate different tissue densities;tissue can now be characterized in great detail using modalities such as elastography; the extent of tissue vascularity can now be learned with increasing precision. Using these various techniques, targets for biopsy can be precisely pinpointed. Upon reaching the target, tissue can then be examined microscopically in real-time, ensuring optimal targeting and diagnosis. This article provides a comprehensive review of the various current roles of EUS, including drainage of lesions, visualization and characterization of lesions, injection, surgery, and vascular intervention. With EUS technology continuing to develop exponentially, the article emphasizes the future directions of each modality.展开更多
As a new member of carbon material family, carbon quantum dots (CQDs) have attracted tremendous attentions for their potentials in the heterogeneous photocatalysis applications. Due to the unique microstructure and op...As a new member of carbon material family, carbon quantum dots (CQDs) have attracted tremendous attentions for their potentials in the heterogeneous photocatalysis applications. Due to the unique microstructure and optical properties, the roles of CQDs played in the CQDs-based photocatalytic systems have been found to be diverse with the continuous researches in this regard. Herein, we provide a concise minireview to elaborate the multifarious roles of CQDs in photocatalysis, including photoelectron mediator and acceptor, photosensitizer, photocatalyst, reducing agent for metal salt, enhancing adsorption capacity and spectral converter. In addition, the perspectives on future research trends and challenges are proposed, which are anticipated to stimulate further research into this promising field on designing a variety of efficient CQDs-based photocatalysts for solar energy conversion. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B. V. and Science Press. All rights reserved.展开更多
The issue of improving the efficiency of college English teaching and learning has long puzzled our educators and English teachers.There are many ways to help the solving of the problem,but in China,where English is m...The issue of improving the efficiency of college English teaching and learning has long puzzled our educators and English teachers.There are many ways to help the solving of the problem,but in China,where English is mainly taught in classroom,the teacher is a very important factor to influence the result of English teaching.In order to solve the problem,the teacher must know exactly what roles he should play in the process of teaching and make some changes in his old teaching methods.展开更多
The main causes of non-point source pollution in Taihu Lake are the improper ways of crop production, animal husbandry, and daily runoff. The paper discusses the relationship between countrywomen and non-point source ...The main causes of non-point source pollution in Taihu Lake are the improper ways of crop production, animal husbandry, and daily runoff. The paper discusses the relationship between countrywomen and non-point source pollution control by 731 questionnaires in Weidu village and 466 questionnaires in Dapu Town. The roles of countrywomen have changed in families and they have close relationship with non-point source pollution. Furthermore, we discuss the possibility and methods of organizing countrywomen in non-point source pollution control.展开更多
With the rapid development of modern technology and all-round reform in national college English teaching,Internet-Based teaching mode has become a new trend of college English teaching.Therefore,in the new teaching m...With the rapid development of modern technology and all-round reform in national college English teaching,Internet-Based teaching mode has become a new trend of college English teaching.Therefore,in the new teaching mode,the teacher should turn an inculcator into an instructor,facilitator and participant in teaching;a passive user of textbook into a dominant and modeler of courses;a planner of teaching specific tasks into an organizer of teaching process,a helper and shepherd of learning knowledge.展开更多
Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a clas...Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a class of complex assignment problems.At present,there are few generally efficient solutions to this category of problems.Each special problem case requires a specific solution.Group multi-role assignment(GMRA)and GRA with conflicting agents on roles(GRACAR)are two problem cases in GRA+.The contributions of this paper include:1)The formalization of a new problem of GRA+,called group multi-role assignment with conflicting roles and agents(GMAC),which is an extension to the combination of GMRA and GRACAR;2)A practical solution based on an optimization platform;3)A sufficient condition,used in planning,for solving GMAC problems;and 4)A clear presentation of the benefits in avoiding conflicts when dealing with GMAC.The proposed methods are verified by experiments,simulations,proofs and analysis.展开更多
Theoretic and practical significance has been highlighted in the research of the roles and functions of destinations,as destinations are restricted by the spatial structure based on tourist flow network from the persp...Theoretic and practical significance has been highlighted in the research of the roles and functions of destinations,as destinations are restricted by the spatial structure based on tourist flow network from the perspective of relationship.This article conducted an empirical analysis for Tourism Region of South Anhui(TRSA) and revealed the necessity and feasibility of studying the roles and functions of destinations from tourist flow network's perspective.The automorphic equivalence analysis and centrality analysis were used to classify 16 destinations in TRSA into six role types:tourist flow distribution center,hub of tourist flows,passageway destination,common touring destination,attached touring destination,and nearly isolated destination.Some suggestions were given on suitable infrastructure construction and destinations service designs according to their functions in network.This destination role positioning was based on tourist flow network structure in integral and macroscopic way.It provided an important reference for the balanced and harmonious development of all the destinations of TRSA.In addition,this article verified the applicability of social network analysis on tourist flow research in local scale,and expanded this method to destination role and function positioning.展开更多
The studies on prediction of climate in Xinjiang almost show that the precipitation would increase in the coming 50 years, although there were surely some uncertainties in precipitation predictions. On the basis of th...The studies on prediction of climate in Xinjiang almost show that the precipitation would increase in the coming 50 years, although there were surely some uncertainties in precipitation predictions. On the basis of the structure of glacier system and nature of equilibrium line altitude at steady state (ELAo), a functional model of the glacier system responding to climate changes was established, and it simultaneously involved the rising of summer mean temperature and increasing of mean precipitation. The results from the functional model under the climatic scenarios with temperature increasing rates of 0.01, 0.03 and 0.05 K/year indicated that the precipitation increasing would play an evident role in glacier system responding to climate change: if temperature become 1 ℃ higher, the precipitation would be increased by 10%, which can slow down the glaciers retreating rate in the area by 4 %, accelerate runoff increasing rate by 8 % and depress the ELAo rising gradient by 24 m in northern Xinjiang glacier system where semi-continental glaciers dominate, while it has corresponding values of only 1%, 5 % and 18m respectively in southern Xinjiang glacier system, where extremely continental glaciers dominate.展开更多
For the adverse impacts of climate change, China gov- ernment should place the problem of adaptation to climate change on the agenda. It is time to institute and implement a state adap- tive strategy to reduce the adv...For the adverse impacts of climate change, China gov- ernment should place the problem of adaptation to climate change on the agenda. It is time to institute and implement a state adap- tive strategy to reduce the adverse impacts on economy, commu- nity and people's health and life by international cooperation and our own endeavor. A state strategy of adaptation to climate change should be closely linked with other current interrelated national strategies, and they should be supplemented and improved by each other. This paper discusses the roles of the state strategy of adaptation to climate change in the state climate change integra- tive strategy, the environmental protection strategy, and the sus- tainable development strategy in China. Furthermore, it proposes the main aims of the state adaptive strategy of China.展开更多
Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiolo...Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiological and pathological processes by participating in material and information exchange between cells,which can playmultiple roles in tumor treatment.On the one hand,exosomes can be used as carriers and biomarkers,participate in the apoptosis signaling pathway and improve chemotherapy resistance,thus playing beneficial roles in tumor treatment.On the other hand,exosomes play unfavorable roles in tumor treatment.Tumor cell exosomes contain PD-L1,which is a nuclear weapon for tumor growth,metastasis,and immunosuppression.In addition,exosomes can not only promote the epithelial-mesenchymal transition process,tumor angiogenesis and chemoresistance,but also participate in the autocrine pathway.In this review,the multiple roles of exosomes and their prospects in the treatment of tumor were reviewed in detail.展开更多
To accelerate the selection process of feature subsets in the rough set theory (RST), an ensemble elitist roles based quantum game (EERQG) algorithm is proposed for feature selec- tion. Firstly, the multilevel eli...To accelerate the selection process of feature subsets in the rough set theory (RST), an ensemble elitist roles based quantum game (EERQG) algorithm is proposed for feature selec- tion. Firstly, the multilevel elitist roles based dynamics equilibrium strategy is established, and both immigration and emigration of elitists are able to be self-adaptive to balance between exploration and exploitation for feature selection. Secondly, the utility matrix of trust margins is introduced to the model of multilevel elitist roles to enhance various elitist roles' performance of searching the optimal feature subsets, and the win-win utility solutions for feature selec- tion can be attained. Meanwhile, a novel ensemble quantum game strategy is designed as an intriguing exhibiting structure to perfect the dynamics equilibrium of multilevel elitist roles. Finally, the en- semble manner of multilevel elitist roles is employed to achieve the global minimal feature subset, which will greatly improve the fea- sibility and effectiveness. Experiment results show the proposed EERQG algorithm has superiority compared to the existing feature selection algorithms.展开更多
Graphene(GR),a single‐layer carbon sheet with a hexagonal packed lattice structure,has displayed attractive potential and demonstrably become the research focus in artificial photocatalysis due to its enchanting prop...Graphene(GR),a single‐layer carbon sheet with a hexagonal packed lattice structure,has displayed attractive potential and demonstrably become the research focus in artificial photocatalysis due to its enchanting properties in enhancing light absorption,electron transfer dynamics,and surface reactions.Currently,numerous efforts have shown that the properties of GR,which are closely correlated to the photocatalytic performance of GR‐based composites are significantly affected by the synthesis methods.Herein,we first introduce the optimization strategies of GR‐based hybrids and then elaborate the synthesis of GR‐based composite photocatalysts oriented by manifold roles of GR in photoredox catalysis,containing photoelectron mediator and acceptor,improving adsorption capacity,regulating light absorption range and intensity,as well as macromolecular photosensitizer.Beyond that,a brief outlook on the challenges in this burgeoning research field and potential evolution strategies for enhancing the photoactivity of GR‐based hybrids is presented and we anticipate that this review could provide some enlightenments for the rational construction and application of multifunctional GR‐based composite photocatalysts.展开更多
文摘The role of university English instructors has evolved significantly over the years,encompassing various aspects.This paper explores the evolution of the role of university English instructors and examines the current challenges and opportunities they face in today’s educational landscape.It delves into the multifaceted nature of their responsibilities and discusses the importance of continuous professional development to meet the evolving needs of students and the demands of the profession.
基金The researcher would like to thank Dr.Afag Mohamed Sadig as supervisor and Prof Hazel Barrett as co-supervisor for the paper。
文摘This research focused on the social roles of women in Al-Abassiya locality,South Kordofan State,examining the obstacles they face and the impact on their participation in peace building.Using qualitative methods,data were collected through various means,revealing that conflicts have significantly affected women’s lives,particularly in rural areas.Women play key roles in family,education,health services,and humanitarian aid,but their involvement in conflict resolution and peace building activities is limited.Obstacles include cognitive,economic,social,and institutional barriers.Recommendations include providing education and training programs,strengthening economic status,ensuring women’s representation in decision-making bodies,advocating for legal reforms promoting gender equality,improving access to information technologies,educating communities on women’s involvement in peace building,and providing support services for women affected by conflicts.
基金The National Natural Science Foundation of China(No.90612009,60403050),the National Basic Research Program of China (973Program)(No.2005CB321802).
文摘The related work to reveal the primary characteristics of roles underlying the existing approaches is analyzed. Then, it is demonstrated that the representation of roles is rather complex and error-prone in these approaches. Especially, the constraints among roles in the same context cannot be expressed by the current web ontology language (OWL). To solve these problems, a novel model of role is presented and a corresponding ontology language is provided for representing this model. The key idea underlying the solution is that a role should be regarded as an element of a certain context and a context as a structured thing which is comprised of some internal elements. The structure of context possesses inherent modularity and local semantics, whereby the representation of roles and context is significantly simplified.
文摘The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers' roles in this learning process in students' perception through the means of questionnaires and interviews. It further analyzes the possible reasons why students perceive their teachers' roles in such a way, in the hope of providing some implications for web-based college English autonomous learning.
文摘This paper gives an account of characteristics of the intensive reading in English teaching, and change of teachers’ roles in the learner-centered teaching approach. Suggestions are put forward as to how to be a qualified teacher in the intensive reading class accordingly.
文摘Traditionally, in a teacher-centered class, students are deprived of right, for teachers take up the platform and play a “leading” role. What are the college English teacher′s possible roles? The paper tends to shed light on it by kicking the teacher′s traditional roles.
文摘It is commonly known that writing is an advanced skill which is essential in language learning but at the same time the most difficult task for learners. This paper is with the aim to explore helpful roles that teacher can play to help non-English major students improve their English writing, so as to help improve their writing ability in the author's context.
文摘With continuing advances in technology, computer-assisted instruction provides opportunities for individualized, interactive instruction. The philosophy of constructivism has encouraged instructional designers to create less behavioral, more democratic programs that promote learner control. In the area of ESL (English as a second language), computers are seen to be a highly motivating, instructional tool.
文摘Endoscopic ultrasound(EUS), developed in the 1980 s, was initially predominantly used for guidance of fine needle aspiration; the last 25 years, however, have witnessed a major expansion of EUS to various applications, both diagnostic and therapeutic. EUS has become much more than a tool to differentiate different tissue densities;tissue can now be characterized in great detail using modalities such as elastography; the extent of tissue vascularity can now be learned with increasing precision. Using these various techniques, targets for biopsy can be precisely pinpointed. Upon reaching the target, tissue can then be examined microscopically in real-time, ensuring optimal targeting and diagnosis. This article provides a comprehensive review of the various current roles of EUS, including drainage of lesions, visualization and characterization of lesions, injection, surgery, and vascular intervention. With EUS technology continuing to develop exponentially, the article emphasizes the future directions of each modality.
基金financial support from the key project of the National Natural Science Foundation of China (U1463204)the project of National Natural Science Foundation of China (NSFC) (20903023,21173045)+4 种基金the Award Program for Minjiang Scholar Professorshipthe Natural Science Foundation (NSF) of Fujian Province for Distinguished Young Investigator Grant (2012J06003)the Independent Research Project of State Key Laboratory of Photocatalysis on Energy and Environment (No.2014A05)the 1st Program of Fujian Province for Top Creative Young Talentsthe Program for Returned High-Level Overseas Chinese Scholars of Fujian Province
文摘As a new member of carbon material family, carbon quantum dots (CQDs) have attracted tremendous attentions for their potentials in the heterogeneous photocatalysis applications. Due to the unique microstructure and optical properties, the roles of CQDs played in the CQDs-based photocatalytic systems have been found to be diverse with the continuous researches in this regard. Herein, we provide a concise minireview to elaborate the multifarious roles of CQDs in photocatalysis, including photoelectron mediator and acceptor, photosensitizer, photocatalyst, reducing agent for metal salt, enhancing adsorption capacity and spectral converter. In addition, the perspectives on future research trends and challenges are proposed, which are anticipated to stimulate further research into this promising field on designing a variety of efficient CQDs-based photocatalysts for solar energy conversion. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B. V. and Science Press. All rights reserved.
文摘The issue of improving the efficiency of college English teaching and learning has long puzzled our educators and English teachers.There are many ways to help the solving of the problem,but in China,where English is mainly taught in classroom,the teacher is a very important factor to influence the result of English teaching.In order to solve the problem,the teacher must know exactly what roles he should play in the process of teaching and make some changes in his old teaching methods.
文摘The main causes of non-point source pollution in Taihu Lake are the improper ways of crop production, animal husbandry, and daily runoff. The paper discusses the relationship between countrywomen and non-point source pollution control by 731 questionnaires in Weidu village and 466 questionnaires in Dapu Town. The roles of countrywomen have changed in families and they have close relationship with non-point source pollution. Furthermore, we discuss the possibility and methods of organizing countrywomen in non-point source pollution control.
文摘With the rapid development of modern technology and all-round reform in national college English teaching,Internet-Based teaching mode has become a new trend of college English teaching.Therefore,in the new teaching mode,the teacher should turn an inculcator into an instructor,facilitator and participant in teaching;a passive user of textbook into a dominant and modeler of courses;a planner of teaching specific tasks into an organizer of teaching process,a helper and shepherd of learning knowledge.
基金supported in part by Natural Sciences and Engineering Research Council,Canada(NSERC)(RGPIN-2018-04818)the funding from the Innovation for Defence Excellence and Security(IDEaS)Program from the Canadian Department of National Defence(DND)。
文摘Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a class of complex assignment problems.At present,there are few generally efficient solutions to this category of problems.Each special problem case requires a specific solution.Group multi-role assignment(GMRA)and GRA with conflicting agents on roles(GRACAR)are two problem cases in GRA+.The contributions of this paper include:1)The formalization of a new problem of GRA+,called group multi-role assignment with conflicting roles and agents(GMAC),which is an extension to the combination of GMRA and GRACAR;2)A practical solution based on an optimization platform;3)A sufficient condition,used in planning,for solving GMAC problems;and 4)A clear presentation of the benefits in avoiding conflicts when dealing with GMAC.The proposed methods are verified by experiments,simulations,proofs and analysis.
基金Under the auspices of National Natural Science Foundation of China(No.41001070,40801054,40371030)
文摘Theoretic and practical significance has been highlighted in the research of the roles and functions of destinations,as destinations are restricted by the spatial structure based on tourist flow network from the perspective of relationship.This article conducted an empirical analysis for Tourism Region of South Anhui(TRSA) and revealed the necessity and feasibility of studying the roles and functions of destinations from tourist flow network's perspective.The automorphic equivalence analysis and centrality analysis were used to classify 16 destinations in TRSA into six role types:tourist flow distribution center,hub of tourist flows,passageway destination,common touring destination,attached touring destination,and nearly isolated destination.Some suggestions were given on suitable infrastructure construction and destinations service designs according to their functions in network.This destination role positioning was based on tourist flow network structure in integral and macroscopic way.It provided an important reference for the balanced and harmonious development of all the destinations of TRSA.In addition,this article verified the applicability of social network analysis on tourist flow research in local scale,and expanded this method to destination role and function positioning.
基金supported by grants from the National Natural Science Foundation of China(40371027).
文摘The studies on prediction of climate in Xinjiang almost show that the precipitation would increase in the coming 50 years, although there were surely some uncertainties in precipitation predictions. On the basis of the structure of glacier system and nature of equilibrium line altitude at steady state (ELAo), a functional model of the glacier system responding to climate changes was established, and it simultaneously involved the rising of summer mean temperature and increasing of mean precipitation. The results from the functional model under the climatic scenarios with temperature increasing rates of 0.01, 0.03 and 0.05 K/year indicated that the precipitation increasing would play an evident role in glacier system responding to climate change: if temperature become 1 ℃ higher, the precipitation would be increased by 10%, which can slow down the glaciers retreating rate in the area by 4 %, accelerate runoff increasing rate by 8 % and depress the ELAo rising gradient by 24 m in northern Xinjiang glacier system where semi-continental glaciers dominate, while it has corresponding values of only 1%, 5 % and 18m respectively in southern Xinjiang glacier system, where extremely continental glaciers dominate.
文摘For the adverse impacts of climate change, China gov- ernment should place the problem of adaptation to climate change on the agenda. It is time to institute and implement a state adap- tive strategy to reduce the adverse impacts on economy, commu- nity and people's health and life by international cooperation and our own endeavor. A state strategy of adaptation to climate change should be closely linked with other current interrelated national strategies, and they should be supplemented and improved by each other. This paper discusses the roles of the state strategy of adaptation to climate change in the state climate change integra- tive strategy, the environmental protection strategy, and the sus- tainable development strategy in China. Furthermore, it proposes the main aims of the state adaptive strategy of China.
文摘Exosomes are vesicles secreted by a variety of living cells,containing proteins,RNA and other components,which are nanoscale capsules commonly existed in the body.Exosomes play important roles in a variety of physiological and pathological processes by participating in material and information exchange between cells,which can playmultiple roles in tumor treatment.On the one hand,exosomes can be used as carriers and biomarkers,participate in the apoptosis signaling pathway and improve chemotherapy resistance,thus playing beneficial roles in tumor treatment.On the other hand,exosomes play unfavorable roles in tumor treatment.Tumor cell exosomes contain PD-L1,which is a nuclear weapon for tumor growth,metastasis,and immunosuppression.In addition,exosomes can not only promote the epithelial-mesenchymal transition process,tumor angiogenesis and chemoresistance,but also participate in the autocrine pathway.In this review,the multiple roles of exosomes and their prospects in the treatment of tumor were reviewed in detail.
基金supported by the National Natural Science Foundation of China(6113900261171132+4 种基金61300167)the Natural Science Foundation of Jiangsu Education Department(12KJB520013)the Open Project Program of Jiangsu Provincial Key Laboratory of Computer Information Processing Technologythe Qing Lan Project of Jiangsu Provincethe Starting Foundation for Doctoral Scientific Research,Nantong University(14B20)
文摘To accelerate the selection process of feature subsets in the rough set theory (RST), an ensemble elitist roles based quantum game (EERQG) algorithm is proposed for feature selec- tion. Firstly, the multilevel elitist roles based dynamics equilibrium strategy is established, and both immigration and emigration of elitists are able to be self-adaptive to balance between exploration and exploitation for feature selection. Secondly, the utility matrix of trust margins is introduced to the model of multilevel elitist roles to enhance various elitist roles' performance of searching the optimal feature subsets, and the win-win utility solutions for feature selec- tion can be attained. Meanwhile, a novel ensemble quantum game strategy is designed as an intriguing exhibiting structure to perfect the dynamics equilibrium of multilevel elitist roles. Finally, the en- semble manner of multilevel elitist roles is employed to achieve the global minimal feature subset, which will greatly improve the fea- sibility and effectiveness. Experiment results show the proposed EERQG algorithm has superiority compared to the existing feature selection algorithms.
文摘Graphene(GR),a single‐layer carbon sheet with a hexagonal packed lattice structure,has displayed attractive potential and demonstrably become the research focus in artificial photocatalysis due to its enchanting properties in enhancing light absorption,electron transfer dynamics,and surface reactions.Currently,numerous efforts have shown that the properties of GR,which are closely correlated to the photocatalytic performance of GR‐based composites are significantly affected by the synthesis methods.Herein,we first introduce the optimization strategies of GR‐based hybrids and then elaborate the synthesis of GR‐based composite photocatalysts oriented by manifold roles of GR in photoredox catalysis,containing photoelectron mediator and acceptor,improving adsorption capacity,regulating light absorption range and intensity,as well as macromolecular photosensitizer.Beyond that,a brief outlook on the challenges in this burgeoning research field and potential evolution strategies for enhancing the photoactivity of GR‐based hybrids is presented and we anticipate that this review could provide some enlightenments for the rational construction and application of multifunctional GR‐based composite photocatalysts.