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Analysis of a Type Ⅱ Snowstorm Process in the Early Spring of 2022 in Ulanqab
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作者 Haofeng GUO 《Meteorological and Environmental Research》 2024年第2期4-9,共6页
Based on the observation data of meteorological stations,Doppler radar observation data of Ulanqab City,and ERA-5 reanalysis data,a snowstorm process in Ulanqab City from March 17 to 18,2022 was analyzed.The results s... Based on the observation data of meteorological stations,Doppler radar observation data of Ulanqab City,and ERA-5 reanalysis data,a snowstorm process in Ulanqab City from March 17 to 18,2022 was analyzed.The results show that this was a type Ⅱ snowstorm process generated under the joint influence of upper trough and ground low inverted trough and frontal cyclone.The main period of snowfall can be divided into two time stages,and the total snowfall was more in the south and less in the north,which was consistent with that of average specific humidity field.Water vapor conditions provided by strong water vapor transport and convergence,strong upward movement shown by large vertical velocity field,and the suction action of high-and low-layer divergence and convergence were the reasons for the hourly heavy snowfall on the 18^(th).During the process,radar echoes were mainly sheet-shaped,and composite reflectivity was 15-25 dBZ in most areas.The zero speed line in the first period was positively"S"-shaped,and there was warm advection and southwest wind.On the morning of the 18^(th),after the cold front transited the city,Ulanqab City was gradually controlled by northwest wind,and the snow tended to end. 展开更多
关键词 typesnowstorm Influencing system Diagnostic analysis Radar echo characteristics
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A statistical inference for generalized Rayleigh model under Type-Ⅱ progressive censoring with binomial removals 被引量:2
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作者 REN Junru GUI Wenhao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2020年第1期206-223,共18页
This paper considers the parameters and reliability characteristics estimation problem of the generalized Rayleigh distribution under progressively Type-Ⅱ censoring with random removals,that is,the number of units re... This paper considers the parameters and reliability characteristics estimation problem of the generalized Rayleigh distribution under progressively Type-Ⅱ censoring with random removals,that is,the number of units removed at each failure time follows the binomial distribution.The maximum likelihood estimation and the Bayesian estimation are derived.In the meanwhile,through a great quantity of Monte Carlo simulation experiments we have studied different hyperparameters as well as symmetric and asymmetric loss functions in the Bayesian estimation procedure.A real industrial case is presented to justify and illustrate the proposed methods.We also investigate the expected experimentation time and discuss the influence of the parameters on the termination point to complete the censoring test. 展开更多
关键词 type-progressive censoring with random removals generalized Rayleigh distribution reliability characteristic maximum likelihood estimation Markov chain Monte Carlo method expected experimentation time
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Statistical Analysis for the Birnbaum-Saunders Fatigue Life Distribution under Type-Ⅱ Bilateral Censoring and Multiply Type-II Censoring 被引量:12
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作者 WANGRong-hua FEIHe-liang 《Chinese Quarterly Journal of Mathematics》 CSCD 2004年第2期126-132,共7页
In present paper, we obtain the inverse moment estimations of parameters of the Birnbaum-Saunders fatigue life distribution based on Type-Ⅱ bilateral censored samples and multiply Type-Ⅱ censored sample. In this pap... In present paper, we obtain the inverse moment estimations of parameters of the Birnbaum-Saunders fatigue life distribution based on Type-Ⅱ bilateral censored samples and multiply Type-Ⅱ censored sample. In this paper, we also get the interval estimations of the scale parameters. 展开更多
关键词 统计数学 参数估计 区间概算 可靠性理论
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Statistical Analysis for the Birnbaum-Saunders Fatigue Life Distribution under Multiply Type-ⅡCensoring 被引量:5
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作者 WANG Rong-hua FEI He-liang 《Chinese Quarterly Journal of Mathematics》 CSCD 北大核心 2006年第1期15-27,共13页
In present paper, we derive the quasi-least squares estimation(QLSE) and approximate maximum likelihood estimation(AMLE) for the Birnbaum-Saunders fatigue life distribution under multiply Type-Ⅱcensoring. Furthermore... In present paper, we derive the quasi-least squares estimation(QLSE) and approximate maximum likelihood estimation(AMLE) for the Birnbaum-Saunders fatigue life distribution under multiply Type-Ⅱcensoring. Furthermore, we get the variance and covariance of the approximate maximum likelihood estimation. 展开更多
关键词 Birnbaum-Saunders疲劳寿命分布 准最小正方估值 最大近似值 可靠性理论
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BAYESIAN PREDICTION FOR THE TWO-PARAMETER EXPONENTIAL DISTRIBUTION BASED ON TYPE Ⅱ DOUBLY CENSORING
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作者 LiYanling ZhaoXuanmin XieWenxian 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2005年第1期75-84,共10页
The two-parameter exponential distribution is proposed to be an underlying model,and prediction bounds for future observations are obtained by using Bayesian approach.Prediction intervals are derived for unobserved li... The two-parameter exponential distribution is proposed to be an underlying model,and prediction bounds for future observations are obtained by using Bayesian approach.Prediction intervals are derived for unobserved lifetimes in one-sample prediction and two-sample prediction based on type Ⅱ doubly censored samples.A numerical example is given to illustrate the procedures,prediction intervals are investigated via Monte Carlo method,and the accuracy of prediction intervals is presented. 展开更多
关键词 type doubly censoring two-parameter exponential distribution Bayesian prediction Monte Carlo method.
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SAMPLING INSPECTION OF RELIABILITY IN (LOG)NORMAL CASE WITH TYPE I CENSORING 被引量:4
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作者 吴启光 吕建华 《Acta Mathematica Scientia》 SCIE CSCD 2006年第2期331-343,共13页
This article proposes a statistical method for working out reliability sampling plans under Type I censored sample for items whose failure times have either normal or lognormal distributions. The quality statistic is ... This article proposes a statistical method for working out reliability sampling plans under Type I censored sample for items whose failure times have either normal or lognormal distributions. The quality statistic is a method of moments estimator of a monotonous function of the unreliability. An approach of choosing a truncation time is recommended. The sample size and acceptability constant are approximately determined by using the Cornish-Fisher expansion for quantiles of distribution. Simulation results show that the method given in this article is feasible. 展开更多
关键词 type I censoring lognormal distribution normal distribution reliability sampling plans
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Clinical and genetic diagnosis of autosomal dominant osteopetrosis typeⅡin a Chinese family:A case report
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作者 Hong-Ping Gong Yan Ren +4 位作者 Pan-Pan Zha Wen-Yan Zhang Jin Zhang Zhi-Wen Zhang Chun Wang 《World Journal of Clinical Cases》 SCIE 2023年第3期700-708,共9页
BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of osteoclasts.Approximately,80%of autosomal dominant osteopetrosis type II(ADO-II)patients ... BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of osteoclasts.Approximately,80%of autosomal dominant osteopetrosis type II(ADO-II)patients were usually affected by heterozygous dominant mutations in the chloride voltage-gated channel 7(ClCN7)gene and present early-onset osteoarthritis or recurrent fractures.In this study,we report a case of persistent joint pain without bone injury or underlying history.CASE SUMMARY We report a 53-year-old female with joint pain who was accidentally diagnosed with ADO-II.The clinical diagnosis was based on increased bone density and typical radiographic features.Two heterozygous mutations in the ClCN7 and Tcell immune regulator 1(TCIRG1)genes by whole exome sequencing were identified in the patient and her daughter.The missense mutation(c.857G>A)occurred in the CLCN7 gene p.R286Q,which is highly conserved across species.The TCIRG1 gene point mutation(c.714-20G>A)in intron 7(near the splicing site of exon 7)had no effect on subsequent transcription.CONCLUSION This ADO-II case had a pathogenic CLCN7 mutation and late onset without the usual clinical symptoms.For the diagnosis and assessment of the prognosis for osteopetrosis,genetic analysis is advised. 展开更多
关键词 OSTEOPETROSIS Autosomal dominant osteopetrosis type DIAGNOSIS Genetic analysis Case report
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鲤疱疹病毒二型(CyHV-Ⅱ)疫苗研究进展
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作者 吴琳娇 孙丽芳 +4 位作者 朱春华 张红 董盼盼 陈磊清 吴允昆 《中国农业科技导报》 CAS CSCD 北大核心 2024年第2期137-144,共8页
鲤疱疹病毒Ⅱ型(Cyprinid herpesvirus Ⅱ,CyHV-Ⅱ)对任何发育时期的金鱼、鲫鱼及其杂交品种均具有感染能力,能够引起金鱼疱疹病(goldfish haematopoietic necrosis, GFHN),是一种传染性强且死亡率极高的疫病,给我国金鱼和鲫鱼养殖业造... 鲤疱疹病毒Ⅱ型(Cyprinid herpesvirus Ⅱ,CyHV-Ⅱ)对任何发育时期的金鱼、鲫鱼及其杂交品种均具有感染能力,能够引起金鱼疱疹病(goldfish haematopoietic necrosis, GFHN),是一种传染性强且死亡率极高的疫病,给我国金鱼和鲫鱼养殖业造成巨大经济损失,鱼用疫苗的研发是预防和治疗该疫病最有效的办法。综述了CyHV-Ⅱ灭活疫苗、亚单位疫苗、核酸疫苗、活载体疫苗和纳米递送疫苗的研究进展,并对鱼用疫苗纳米材料的应用前景进行了探讨,以期为金鱼疱疹病害防治和鱼用疫苗研究提供新技术方法和新思路策略。 展开更多
关键词 鲤疱疹病毒二型(CyHV-) 免疫途径 纳米材料 疫苗类型
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Reliability evaluation for Weibull distribution under multiply type-? censoring 被引量:1
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作者 贾祥 蒋平 郭波 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第9期3506-3511,共6页
The multiply type-? censoring represented that all units in life test were terminated at different times. For estimations of Weibull parameters, it was easy to compute the maximum likelihood estimation(MLE) and least-... The multiply type-? censoring represented that all units in life test were terminated at different times. For estimations of Weibull parameters, it was easy to compute the maximum likelihood estimation(MLE) and least-squares estimation(LSE) while it was hard to build confidence intervals(CI). The concept of generalized confidence interval(GCI) was introduced to build CIs of parameters under multiply type-I censoring. Further, GCI based on LSE and GCI based on MLE were proposed. It is mathematically proved that the former is exact and the latter is approximate. Besides, a Monte Carlo simulation study and an illustrative example also turn out that the GCI method based on LSE yields rather satisfactory results by comparison with the ones based on MLE. It should be clear that the GCI method is a sensible choice to evaluate reliability under multiply type-I censoring. 展开更多
关键词 定时截尾数据缺失 WEIBULL分布 可靠性评估 定时截尾寿命试验 最小二乘估计 最大似然估计 极大似然估计 置信区间
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改良经腹食管裂孔入路行Siewert Ⅱ型食管胃结合部腺癌根治术的经验总结
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作者 杨根荣 胡宝利 韦海涛 《河南医学研究》 CAS 2024年第13期2343-2346,共4页
目的探讨改良经腹食管裂孔入路实施SiewertⅡ型食管胃结合部腺癌根治术的创新性和优势,总结此改良术式的经验。方法回顾性分析2022年2月至2023年3月接受改良经腹食管裂孔入路的手术方式治疗SiewertⅡ型食管胃结合部腺癌12例病例资料。结... 目的探讨改良经腹食管裂孔入路实施SiewertⅡ型食管胃结合部腺癌根治术的创新性和优势,总结此改良术式的经验。方法回顾性分析2022年2月至2023年3月接受改良经腹食管裂孔入路的手术方式治疗SiewertⅡ型食管胃结合部腺癌12例病例资料。结果12例手术均顺利完成,术中应用切割闭合器打开部分左侧膈肌,联合左侧胸腔辅助操作孔完成下纵膈淋巴结清扫及消化道重建,手术时间(209.0±38.3)min,下纵膈淋巴结清扫数(7.1±2.7)枚,食管切除长度(7.7±0.8)cm,术中出血(168.2±83.1)mL,术后住院时间(11.6±1.8)d。结论改良经腹食管裂孔入路的手术方式治疗SiewertⅡ型食管胃结合部腺癌安全可行,此术式下纵隔淋巴结清扫及消化道重建的难度显著降低,保证足够的食管切缘长度,适合在临床广泛开展。 展开更多
关键词 改良经腹食管裂孔入路 Siewert 型食管胃结合部腺癌 Orvil管形吻合 经验
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8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ与T2MD患者血糖在目标范围内时间的相关性及预测糖尿病周围神经病变的价值
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作者 徐云 陈雪辉 +3 位作者 白立炜 耿锐娜 孟祥雨 覃艳 《海南医学》 CAS 2024年第10期1390-1395,共6页
目的探讨8-异前列腺素F2α(8-isoPGF2α)、镍纹样蛋白(Metrnl)、微管相关蛋白3B-Ⅱ(LC3B-Ⅱ)/微管相关蛋白-Ⅰ(LC3B-Ⅰ)与2型糖尿病(T2MD)患者血糖在目标范围内时间(TIR)的相关性及对糖尿病周围神经病变(DPN)预测价值。方法选取2020年5... 目的探讨8-异前列腺素F2α(8-isoPGF2α)、镍纹样蛋白(Metrnl)、微管相关蛋白3B-Ⅱ(LC3B-Ⅱ)/微管相关蛋白-Ⅰ(LC3B-Ⅰ)与2型糖尿病(T2MD)患者血糖在目标范围内时间(TIR)的相关性及对糖尿病周围神经病变(DPN)预测价值。方法选取2020年5月至2022年10月新乡医学院第一附属医院收治的187例T2DM患者进行前瞻性研究,根据是否合并DPN分为DPN组(n=48)和无DPN组(n=139)。比较两组患者及根据TIR四分位数分组的患者8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ水平,采用Pearson相关性分析8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ与TIR相关性,采用多因素Logistic回归分析DPN的相关影响因素;绘制受试者工作特征曲线(ROC)评价8-isoPGF2α、Metrnl、LC3B-Ⅱ预测DPN的价值。结果DPN组患者的TIR为(51.43±7.68)%,明显低于无DPN组的(56.94±8.12)%,差异有统计学意义(P<0.05);DPN组患者的8-isoPGF2α、Metrnl分别为(162.78±51.33)pg/mL、(259.18±74.42)pg/mL,明显高于无DPN组的(129.56±43.00)pg/mL、(208.37±65.61)pg/mL,LC3B-Ⅱ/LC3B-Ⅰ为0.89±0.27,明显低于无DPN组的1.15±0.31,差异均有统计学意义(P<0.05);根据TIR第25、50、75百分位数将全部患者分为Q1~Q4四组,8-isoPGF2α、Metrnl在Q4组最低,LC3B-Ⅱ/LC3B-Ⅰ在Q4组最高;8-isoPGF2α、Metrnl随着TIR降低逐渐升高,LC3B-Ⅱ/LC3B-Ⅰ随着TIR降低而降低,四组间比较差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,8-isoPGF2α、Metrnl与TIR呈显著负相关(r=-0.786、-0.665,P<0.01),LC3B-Ⅱ/LC3B-Ⅰ与TIR呈显著正相关(r=0.711,P<0.01);多因素Logistic回归分析结果显示,TIR、LC3B-Ⅱ/LC3B-Ⅰ是DPN的独立相关保护因素(P<0.05),8-isoPGF2α、Metrnl是DPN的独立相关危险因素(P<0.05);ROC分析结果显示,单一指标中,Metrnl预测DPN的AUC最大(0.830),特异度最高(87.05%),8-isoPGF2α+Metrnl+LC3B-Ⅱ预测DPN的AUC为0.923(95%CI:0.875~0.957),大于Metrnl,预测敏感度为87.50%,特异度为85.61%(P<0.05)。结论8-isoPGF2α、Metrnl、LC3B-Ⅱ/LC3B-Ⅰ与T2MD患者TIR有关,均是患者并发DPN的预警因素。联合检测三者能为临床分层管理和早期识别DPN高风险人群提供参考。 展开更多
关键词 8-异前列腺素F2Α 镍纹样蛋白 微管相关蛋白3B-/微管相关蛋白-Ⅰ 2型糖尿病 血糖在目标范围内时间 糖尿病周围神经病变 相关性 预测价值
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On Marginal Distributions under Progressive Type II Censoring: Similarity/Dissimilarity Properties
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作者 Amal Helu Hani Samawi 《Open Journal of Statistics》 2017年第4期633-644,共12页
Currently, progressive censoring is intensively investigated by several researchers due to its ability to remove subjects from the experiment before the final termination point, thus saving time and cost. The closed f... Currently, progressive censoring is intensively investigated by several researchers due to its ability to remove subjects from the experiment before the final termination point, thus saving time and cost. The closed form of marginal density of failure times under progressive type II censoring is essential to study the properties of statistical analysis under different censoring schemes. In this paper, we provide a different presentation of the marginal distribution under progressive type-II censoring and we derive closed forms for different special cases. In order to study the similarity/dissimilarity of marginal densities of order statistics for failure times, the overlap measure is used. We discovered that the overlap measure depends only on the effective size m. A numerical example based on a real life data regarding failure times of aircrafts' windshields is provided to quantify the amount of redundant information provided by the order statistics of the failure times under different progressive type-II schemes based on the overlap measure. Moreover, this data set is used as a pilot study to estimate the effective size m needed for future studies. 展开更多
关键词 Weitzman’s MEASURE PROGRESSIVE censoring MARGINAL Density type II censoring
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Estimation of Generalized Pareto under an Adaptive Type-II Progressive Censoring 被引量:1
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作者 Mohamed A. W. Mahmoud Ahmed A. Soliman +1 位作者 Ahmed H. Abd Ellah Rashad M. El-Sagheer 《Intelligent Information Management》 2013年第3期73-83,共11页
In this paper, based on a new type of censoring scheme called an adaptive type-II progressive censoring scheme introduce by Ng et al. [1], Naval Research Logistics is considered. Based on this type of censoring the ma... In this paper, based on a new type of censoring scheme called an adaptive type-II progressive censoring scheme introduce by Ng et al. [1], Naval Research Logistics is considered. Based on this type of censoring the maximum likelihood estimation (MLE), Bayes estimation, and parametric bootstrap method are used for estimating the unknown parameters. Also, we propose to apply Markov chain Monte Carlo (MCMC) technique to carry out a Bayesian estimation procedure and in turn calculate the credible intervals. Point estimation and confidence intervals based on maximum likelihood and bootstrap method are also proposed. The approximate Bayes estimators obtained under the assumptions of non-informative priors, are compared with the maximum likelihood estimators. Numerical examples using real data set are presented to illustrate the methods of inference developed here. Finally, the maximum likelihood, bootstrap and the different Bayes estimates are compared via a Monte Carlo simulation study. 展开更多
关键词 Generalized PARETO (GP) Distribution AN ADAPTIVE type-II Progressive censoring Scheme BAYESIAN and Non-Bayesian Estimations Gibbs and Metropolis Sampler Bootstrap
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Estimations of Weibull-Geometric Distribution under Progressive Type II Censoring Samples
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作者 Azhari A. Elhag Omar I. O. Ibrahim +1 位作者 Mohamed A. El-Sayed Gamal A. Abd-Elmougod 《Open Journal of Statistics》 2015年第7期721-729,共9页
This paper deals with the Bayesian inferences of unknown parameters of the progressively Type II censored Weibull-geometric (WG) distribution. The Bayes estimators cannot be obtained in explicit forms of the unknown p... This paper deals with the Bayesian inferences of unknown parameters of the progressively Type II censored Weibull-geometric (WG) distribution. The Bayes estimators cannot be obtained in explicit forms of the unknown parameters under a squared error loss function. The approximate Bayes estimators will be computed using the idea of Markov Chain Monte Carlo (MCMC) method to generate from the posterior distributions. Also the point estimation and confidence intervals based on maximum likelihood and bootstrap technique are also proposed. The approximate Bayes estimators will be obtained under the assumptions of informative and non-informative priors are compared with the maximum likelihood estimators. A numerical example is provided to illustrate the proposed estimation methods here. Maximum likelihood, bootstrap and the different Bayes estimates are compared via a Monte Carlo Simulation 展开更多
关键词 Weibull-Geometric Distribution Progressive type II censoring SAMPLES Bayesian ESTIMATION Maximum LIKELIHOOD ESTIMATION Bootstrap CONFIDENCE INTERVALS Markov Chain Monte Carlo
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逐步Ⅱ型混合截尾下Lomax分布多部件应力强度模型的可靠性分析
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作者 龙芳 蔡静 朱艳 《广西师范大学学报(自然科学版)》 CAS 北大核心 2024年第2期120-130,共11页
基于逐步Ⅱ型混合截尾样本,研究Lomax分布多部件应力强度模型的可靠性分析问题。假设应力和强度具有不同形状参数和共同尺度参数,利用极大似然理论及迭代方法获得可靠度函数的极大似然估计(MLE),并给出渐近置信区间;然后,运用贝叶斯理论... 基于逐步Ⅱ型混合截尾样本,研究Lomax分布多部件应力强度模型的可靠性分析问题。假设应力和强度具有不同形状参数和共同尺度参数,利用极大似然理论及迭代方法获得可靠度函数的极大似然估计(MLE),并给出渐近置信区间;然后,运用贝叶斯理论,借助Tierney-Kadane(TK)近似方法、MCMC算法,讨论平方误差损失函数下未知参数及可靠度的贝叶斯估计,给出其最大后验密度可信区间(HPD);最后,利用Monte-Carlo模拟方法对估计结果进行对比分析。模拟结果显示:贝叶斯估计整体上优于极大似然估计,并且随样本量的增大,2种估计的均方误差(MSE)均逐渐减小,HPD可信区间的效果优于渐近置信区间。 展开更多
关键词 逐步型混合截尾 Lomax分布 多部件应力强度可靠性 极大似然估计 贝叶斯估计
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基于问题为导向的安全管理对无创呼吸机治疗Ⅱ型呼吸衰竭患者自我管理能力、血气及炎性反应情况的影响
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作者 李闪闪 王岚 +1 位作者 宋欣欣 杨亚旭 《四川生理科学杂志》 2024年第5期954-956,共3页
目的:研究基于问题为导向的安全管理对无创呼吸机治疗Ⅱ型呼吸衰竭患者自我管理能力、血气及炎性反应情况的影响。方法:我院2021年2月至2022年12月期间91例行无创呼吸机治疗Ⅱ型呼吸衰竭患者随机分为对照组和观察组。对照组45例实施常... 目的:研究基于问题为导向的安全管理对无创呼吸机治疗Ⅱ型呼吸衰竭患者自我管理能力、血气及炎性反应情况的影响。方法:我院2021年2月至2022年12月期间91例行无创呼吸机治疗Ⅱ型呼吸衰竭患者随机分为对照组和观察组。对照组45例实施常规干预,观察组46例联合以问题为导向的安全教育管理。干预前及干预4 w后,采用血气分析仪检测两组患者血氧分压(Arterial partial pressure of oxygen,PaO_(2))、二氧化碳分压(Partial pressure of carbon dioxide in artery,PaCO_(2))、血氧饱和度(Spot oxygen saturation,SpO_(2))水平;采用酶联免疫吸附法检测白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)及超敏C反应蛋白(Hypersensitive C-reactive protein,hs-CRP)水平;采用自我护理能力(Exercise of Self-Care Agency Scale,ESCA)量表评估两组患者自我管理能力。结果:与干预前相比,两组PaO_(2)、SpO_(2)、健康认知水平、自我责任感、自我管理技能和自我概念评分均升高,IL-6、TNF-α、hs-CRP、PaCO_(2)水平均降低(P<0.05)。其中观察组变化更为显著(P<0.05)。结论:基于问题为导向的安全管理对无创呼吸机治疗Ⅱ型呼吸衰竭患者效果确切,能够改善患者血气水平,降低炎症反应水平,提高自我管理能力。 展开更多
关键词 安全教育管理 型呼吸衰竭 自我管理能力 炎症反应
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体外二氧化碳清除治疗Ⅱ型呼吸衰竭的临床初探
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作者 万静怡 鲁杨 +3 位作者 户俊凯 马旭 闫国胜 张宏涛 《中国血液净化》 CSCD 2024年第4期245-249,共5页
目的探讨体外二氧化碳清除(extracorporeal carbon dioxide removal,ECCO_(2)R)治疗接受连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)合并Ⅱ型呼吸衰竭患者的临床疗效。方法回顾性分析2020年12月—2022年7月就诊于... 目的探讨体外二氧化碳清除(extracorporeal carbon dioxide removal,ECCO_(2)R)治疗接受连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)合并Ⅱ型呼吸衰竭患者的临床疗效。方法回顾性分析2020年12月—2022年7月就诊于重症监护室(intensive care unit,ICU)应用ECCO_(2)R治疗合并Ⅱ型呼吸衰竭的CRRT患者(干预组)11例和同期未应用ECCO_(2)R治疗的合并Ⅱ型呼吸衰竭的CRRT患者(对照组)11例,收集患者开始治疗前和治疗24小时后的血气分析结果,比较患者治疗前后动脉血二氧化碳分压(PaCO_(2))、pH值、动脉血氧分压(PaO_(2))、碱剩余(BE)、碳酸氢根(HCO_(3)^(-))、乳酸(Lac)等指标的变化。结果与对照组相比,应用ECCO_(2)R治疗前干预组PaCO_(2)较高(Z=2.988,P=0.002),治疗后差异无统计学意义(Z=-0.230,P=0.847);应用ECCO_(2)R治疗24小时后干预组pH值(t=-3.656,P=0.002)、BE(t=3.185,P=0.001)、HCO_(3)^(-)(t=2.791,P=0.004)、Lac(Z=-2.397,P=0.016)较对照组高。干预组应用ECCO_(2)R治疗后,pH值较治疗前升高(t=-2.948,P=0.008),PaCO_(2)较治疗前下降(Z=-3.447,P<0.001)。结论EC-CO_(2)R可纠正合并Ⅱ型呼吸衰竭CRRT患者的高碳酸血症,但能否改善预后尚需大样本临床研究。 展开更多
关键词 体外二氧化碳清除 连续性肾脏替代治疗 型呼吸衰竭 高碳酸血症
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Ⅱ型子宫内膜癌患者癌组织中IMP3、PTEN表达及其临床意义
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作者 李颖 马媛 李凯丽 《实用癌症杂志》 2024年第5期753-756,共4页
目的分析Ⅱ型子宫内膜癌(EC)患者癌组织中胰岛素样生长因子Ⅱ信使RNA结合蛋白3(IMP3)和磷酸酶与张力蛋白同源物(PTEN)的表达情况,并探讨其临床意义。方法收集60例Ⅱ型EC患者手术切除的癌组织及20例对应癌旁组织的存档石蜡标本,采用免疫... 目的分析Ⅱ型子宫内膜癌(EC)患者癌组织中胰岛素样生长因子Ⅱ信使RNA结合蛋白3(IMP3)和磷酸酶与张力蛋白同源物(PTEN)的表达情况,并探讨其临床意义。方法收集60例Ⅱ型EC患者手术切除的癌组织及20例对应癌旁组织的存档石蜡标本,采用免疫组织化学法(IHC)检测标本中IMP3、PTEN蛋白表达情况;分析IMP3、PTEN蛋白表达与EC患者临床病理特征及预后的关系。结果EC患者癌组织中IMP3阳性表达率高于癌旁组织,PTEN阳性表达率低于癌旁组织,差异均有统计学意义(P<0.05)。EC患者癌组织IMP3阳性表达率与肌层浸润深度、FIGO分期及淋巴结转移有关(P<0.05),即肌层浸润深度越深、FIGO分期越晚、合并淋巴结转移者IMP3阳性表达率越高。PTEN阳性表达率与FIGO分期、淋巴结转移有关(P<0.05),即FIGO分期越晚、合并淋巴结转移者PTEN阳性表达率越低。Spearman相关性分析结果显示,EC患者癌组织中IMP3和PTEN蛋白表达无显著相关性(P>0.05)。IMP3阳性组整体生存情况差于IMP3阴性组,PTEN阳性组整体生存情况优于PTEN阴性组(P<0.05)。结论Ⅱ型EC患者癌组织中IMP3表达上调,而PTEN表达下调,二者表达异常可能参与了Ⅱ型EC的发生与发展,且IMP3阳性表达、PTEN阴性表达与Ⅱ型EC患者不良预后相关。 展开更多
关键词 型子宫内膜癌 胰岛素样生长因子信使RNA结合蛋白3 磷酸酶与张力蛋白同源物 预后
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无创呼吸机标准化治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的效果分析
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作者 唐艳茹 《中国标准化》 2024年第12期261-264,共4页
目的:分析无创呼吸机标准化治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的效果。方法:抽取2021年9月—2023年10月在长江大学附属仙桃市第一人民医院接受治疗的86例慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者,应用计算机1:1分组,每组各43例。将实... 目的:分析无创呼吸机标准化治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的效果。方法:抽取2021年9月—2023年10月在长江大学附属仙桃市第一人民医院接受治疗的86例慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者,应用计算机1:1分组,每组各43例。将实施常规治疗的作为对照组,在常规治疗基础上采用无创呼吸机标准治疗的为研究组。分析治疗效果。结果:研究组肺功能各项指标改善效果显著优于对照组(P<0.05);研究组血气指标改善效果优于对照组(P<0.05);研究组较对照组慢性阻塞性肺疾病评估测试评分(CAT)更高,6 min步行距离更远(P<0.05)。结论:慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者应用无创呼吸机采取标准化治疗效果良好,对于患者的肺功能和血气指标均有较高的改善效果,并且不良反应更少,预后显著。 展开更多
关键词 慢性阻塞性肺疾病 型呼吸衰竭 无创呼吸机 肺功能 血气指标
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Inference on Constant-Partially Accelerated Life Tests for Mixture of Pareto Distributions under Progressive Type-II Censoring
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作者 Tahani A. Abushal Areej M. AL-Zaydi 《Open Journal of Statistics》 2017年第2期323-346,共24页
The main purpose of this paper is to obtain the inference of parameters of heterogeneous population represented by finite mixture of two Pareto (MTP) distributions of the second kind. The constant-partially accelerate... The main purpose of this paper is to obtain the inference of parameters of heterogeneous population represented by finite mixture of two Pareto (MTP) distributions of the second kind. The constant-partially accelerated life tests are applied based on progressively type-II censored samples. The maximum likelihood estimates (MLEs) for the considered parameters are obtained by solving the likelihood equations of the model parameters numerically. The Bayes estimators are obtained by using Markov chain Monte Carlo algorithm under the balanced squared error loss function. Based on Monte Carlo simulation, Bayes estimators are compared with their corresponding maximum likelihood estimators. The two-sample prediction technique is considered to derive Bayesian prediction bounds for future order statistics based on progressively type-II censored informative samples obtained from constant-partially accelerated life testing models. The informative and future samples are assumed to be obtained from the same population. The coverage probabilities and the average interval lengths of the confidence intervals are computed via a Monte Carlo simulation to investigate the procedure of the prediction intervals. Analysis of a simulated data set has also been presented for illustrative purposes. Finally, comparisons are made between Bayesian and maximum likelihood estimators via a Monte Carlo simulation study. 展开更多
关键词 Pareto Distribution Finite Mixtures Constant—Partially ALT Progressive type-II censoring BAYESIAN ESTIMATION Maximum Likelihood ESTIMATION BAYESIAN PREDICTION the Two-Sample PREDICTION MCMC
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