Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from A Data-driven Perspective

Comprehensive characterization of spatial and temporal gene expression patterns in humans is critical for uncovering the regulatory codes of the human genome and understanding the molecular mechanisms of human diseases.Ubiquitously expressed genes(UEGs)refer to the genes expressed across a majority of,if not all,phenotypic and physiological conditions of an organism.It is known that many human genes are broadly expressed across tissues.However,most previous UEG studies have only focused on providing a list of UEGs without capturing their global expression patterns,thus limiting the potential use of UEG information.In this study,we proposed a novel data-driven framework to leverage the extensive collection of40,000 human transcriptomes to derive a list of UEGs and their corresponding global expression patterns,which offers a valuable resource to further characterize human transcriptome.Our results suggest that about half(12,234;49.01%)of the human genes are expressed in at least 80%of human transcriptomes,and the median size of the human transcriptome is 16,342 genes(65.44%).Through gene clustering,we identified a set of UEGs,named LoVarUEGs,which have stable expression across human transcriptomes and can be used as internal reference genes for expression measurement.To further demonstrate the usefulness of this resource,we evaluated the global expression patterns for 16 previously predicted disallowed genes in islet beta cells and found that seven of these genes showed relatively more varied expression patterns,suggesting that the repression of these genes may not be unique to islet beta cells.

Blockchain with Explainable Artificial Intelligence Driven Intrusion Detection for Clustered IoT Driven Ubiquitous Computing System

In the Internet of Things(IoT)based system,the multi-level client’s requirements can be fulfilled by incorporating communication technologies with distributed homogeneous networks called ubiquitous computing systems(UCS).The UCS necessitates heterogeneity,management level,and data transmission for distributed users.Simultaneously,security remains a major issue in the IoT-driven UCS.Besides,energy-limited IoT devices need an effective clustering strategy for optimal energy utilization.The recent developments of explainable artificial intelligence(XAI)concepts can be employed to effectively design intrusion detection systems(IDS)for accomplishing security in UCS.In this view,this study designs a novel Blockchain with Explainable Artificial Intelligence Driven Intrusion Detection for IoT Driven Ubiquitous Computing System(BXAI-IDCUCS)model.The major intention of the BXAI-IDCUCS model is to accomplish energy efficacy and security in the IoT environment.The BXAI-IDCUCS model initially clusters the IoT nodes using an energy-aware duck swarm optimization(EADSO)algorithm to accomplish this.Besides,deep neural network(DNN)is employed for detecting and classifying intrusions in the IoT network.Lastly,blockchain technology is exploited for secure inter-cluster data transmission processes.To ensure the productive performance of the BXAI-IDCUCS model,a comprehensive experimentation study is applied,and the outcomes are assessed under different aspects.The comparison study emphasized the superiority of the BXAI-IDCUCS model over the current state-of-the-art approaches with a packet delivery ratio of 99.29%,a packet loss rate of 0.71%,a throughput of 92.95 Mbps,energy consumption of 0.0891 mJ,a lifetime of 3529 rounds,and accuracy of 99.38%.

Ubiquitous CSCL的概念模型与关键技术要素

以自然、和谐的学习交互环境为主要特征的计算机支持的泛在协作学习(Ubiquitous CSCL)是近年来国内外CSCL研究领域关注的热点。本文通过文献研究、内容分析和归纳演绎等过程,探讨了Ubiquitous CSCL的概念模型、关键交互技术、普适终端技术、协作知识建构的基本过程和基于智能空间的交互模型。

基于Ubiquitous-Joint模型的层状岩坡稳定性分析

在应力的作用下,层状岩土体表现出来的力学行为比较复杂,目前广泛使用的各向同性模型不再适用,因此,有必要建立合理描述层状岩质边坡的力学模型。以某公路边坡为工程背景,首先,探讨了层状岩质边坡的失稳机制;然后,利用快速拉格朗日差分法(FLAC3D),建立该边坡的数值分析模型,探讨了强度折减技术在U-biquitous-Joint模型中的实施方法,即对岩体和层理面参数同时进行折减,采用计算不收敛作为边坡临界失稳判据;最后,通过数值计算,分析层状岩质边坡稳定性的影响因素,得到边坡整体安全系数F随节理倾角β先减小后增大,呈现两头高中间低的形态。

支持泛在学习(u-Learning)环境的关键技术分析

泛在(Ubiquitous)技术的发展,给教育领域也带来了深刻的影响,泛在学习(u-Learning)这一概念的出现可谓是其标志之一。在本文中,笔者首先对泛在学习(u-Learning)下定义,然后,提出了实现泛在学习的条件。通过这些勾勒出泛在学习(u-Learning)的系统模型,再提炼出为实现这一模型所必需的关键技术。最后,在跟e-Learning的比较中,总结出u-Learning的特性与通过u-Learning学习者所能够享受的优惠。

关于高校人事档案管理信息化建设的思考

高校人事档案信息化建设是时代发展的需要,是档案工作的主流。本文在分析高校人事档案管理信息化工作中存在诸多问题的基础上,就当前高校人事档案管理的信息化建设内容进行了阐述。

北京信息化与经济增长——基于ICT资本存量和Ubiquitous指数的分析

信息化对经济增长的影响主要表现在信息化投资和信息化资源利用两个方面,在核算ICT资本存量和建立Ubiquitous指数的基础上,需要将ICT投资和信息化的普及与应用纳入一个统一的框架进行分析。利用ICT增长模型对ICT投资贡献度以及网络外部性的计量分析表明,ICT投资对北京经济增长发挥了重要作用,ICT投资与普及应用之间的交互作用产生了明显的溢出效应和网络效应,从而进一步增强了ICT对经济增长的影响力。软件投资与硬件投资相比较,软件投资的作用更为显著,对北京经济增长的影响更大。

MI MO雷达抗干扰性能分析

MIMO(多输入多输出)雷达采用收发分离体制,在发射端和接收端均采用数字阵技术,可以在同一时刻实现多种功能,从而极大地丰富了系统的时间资源。介绍了MIMO雷达的工作原理,分析了该雷达的杂波强度、被截获概率和抗干扰性能,结果表明:与传统相控阵雷达相比,MIMO雷达具有更好的ECCM性能。

“Ubiquitous”环境下商业展示信息传达与导航界面的应用——基于GUI的导航原型设计的3D要素应用提案

会展业的商业展示中,计算机信息导航是信息传达过程的重要组成部分,通常依赖于界面设计来实现,经历了命令语言界面到图形用户界面（GUI）等发展阶段,适于更优越的人机交互（HCI）及展示信息导航的新概念随着技术环境的改变,必将持续发展。

Study on the Ubiquitous English Learning Environment in Vocational Colleges

Ubiquitous learning is a new type of learning method with rich learning concepts and educational significance. The study of ubiquitous learning began in 1991, and has experienced three stages of gestation, start-up and formation and development.After entering the 21 st century, new technologies and new ideas have emerged endlessly. The change in learning methods has led to the flip of classroom teaching, and ubiquitous learning has become more known as the pace of social development. The current higher vocational education presents the characteristics of disjointed education content, misaligned learning roles, and single teaching form. The integration of ubiquitous learning environment into vocational education teaching is a new direction for the development of vocational education.

μ-and m-calpain expression and activity changes following diethylstilbestrol injection in the rat anterior pituitary

Little is known about changes in calpain activity in the pituitary gland. In the present study,μ- and m-calpain activity changes were detected in the rat anterior pituitary following intraperitoneal injection of diethylstilbestrol. Double-immunofluorescence labeling confirmed colocalization of μ- and m-calpain in prolactin-secreting cells （lactotrophs）. Western blot analysis revealed significantly increased expression of both calpains, which accompanied upregulated cytosol and membrane zymographic activities at 12 weeks following diethylstilbestrol injection, compared with rats injected with sunflower oil. Moreover, following estrogen injection, pituitary gland pathological damage gradually worsened with increasing time. Results demonstrated that estrogen regulated calpain expression and activity, and both calpains participated in the pathophysiological processes of the pituitary gland. Ubiquitous calpain expression could serve as an effective target for anti-estrogen drugs.

Understanding roof deformation mechanics and parametric sensitivities of coal mine entries using the discrete element method

Although conventional coal mine designs are conservative regarding pillar strength,local failures such as roof-falls and pillar bursts still affect mine safety and operations.Previous studies have identified that discontinuous,layered roof materials have some self-supporting capacity.This research is a preliminary step towards understanding these mechanics in coal-measure rocks.Although others have considered broad conceptual models and simplified analogs for mine roof behavior,this study presents a unique numerical model that more completely represents in-situ roof conditions.The discrete element method(DEM)is utilized to conduct a parametric analysis considering a range of in-situ stress ratios,material properties,and joint networks to determine the parameters controlling the stability of single-entries modeled in two-dimensions.Model results are compared to empirical observations of roof-support effectiveness(ARBS)in the context of the coal mine roof rating(CMRR)system.Results such as immediate roof displacement,overall stability,and statistical relationships between model parameters and outcomes are presented herein.Potential practical applications of this line of research include:(1)roof-support optimization for a range of coal-measure rocks,(2)establishment of a relationship between roof stability and pillar stress,and(3)determination of which parameters are most critical to roof stability and therefore require concentrated evaluation.

Ubiquitous Learning Environment as a Solution to Education Problem

Ubiquitous learning means the intelligent learning environment that enables people to learn using any terminal at any place and at any time no matter what the contents may be.This is different from the existing method of learning the information through the internet or studying at specific place,such as school or library,and so on.People do not need to go to specific place at specific time to access the information that they want,but the learning information finds its way to people,which is the biggest difference from the existing method. Ubiquitous learning aims to solve current problems of education in more creative and learner-oriented way by creating an education environment where learners can learn with any terminal anytime and anywhere without regard to contents.The presentation this time would help promote the understanding of the Ubiquitous and explore the ubiquitous education environment that is capable of solving overall problems of education.In addition,it will propose a direction of ubiquitous learning scenario and the change in the educational environment.

Evolution Toward Artificial Intelligence of Things Under 6G Ubiquitous⁃X

With the evolution of cellular networks,6G is a promising technology to provide ubiquity of communications,computing,control,and consciousness(UC4)for“human⁃machine⁃thing⁃genie”and build a ubiquitous intelligent mobile society.Genie,which can act as the artificial intelligence assistance for 6G users,is the key enabler to realize the unprecedented transformation from mobile Internet to network of intelligence.While Internet of Things(IoT)is the digital nervous system,genie acts like the brain of the overall system.Supported by 6G,IoT will step into the Artificial Intelligence of Things(AIoT)era and the AIoT networks have the abilities of intelligent perception,intelligent analysis,and intelligent control.In this paper,the concept of Ubiquitous⁃X is introduced,which is considered as the fundamental architecture of 6G network,and the definition and architecture of AIoT under Ubiquitous⁃X is also presented.Several major technical challenges posed by the service requirements of novel AIoT applications are pinpointed,including massive and intelligent connectivity,efficient computing,security,privacy,authentication,high scalability and efficiency.Potential enabling technologies to support seamless service experiences across terminals to realize AIoT are introduced as well.

Ubiquitous环境下高校图书馆空间布局模型研究——以韩国延世大学三星图书馆为例

介绍了韩国延世大学新建的三星图书馆的整体空间布局情况以及人性化服务,以期对我国图书馆有所启示。

Architecture design and demand analysis on application layer of standard system for ubiquitous power Internet of Things

The ubiquitous power Internet of Things(UPIoT)is an intelligent service system with comprehensive state perception,efficient processing,and flexible application of information.It focuses on each link of the power system and makes full use of the mobile internet,artificial intelligence,and other advanced information and communication technologies in order to realize the inter-human interaction of all things in all links of the power system.This article systematically presents to the national and international organizations and agencies in charge of UPIoT layer standardization the status quo of the research on the Internet of Things(IoT)-related industry standards system.It briefly describes the generic standard classification methods,layered architecture,conceptual model,and system tables in the UPIoT application layer.Based on the principles of inheritance,innovation,and practicability,this study divides the application layer into customer service,power grid operation,integrated energy,and enterprise operation,emerging business and analyzes the standard requirements of these five fields.This study also proposes a standard plan.Finally,it summarizes the research report and provides suggestions for a follow-up work.

Mobile Ubiquitous Service Environment

The Mobile Ubiquitous Service Environment (MUSE),established through the coordination and integration of mobile telecommunications and ubiquitous network,in the pursuit of Always Best Experience (ABE),represents the major development trend for the next generation mobile wireless network. Research on MUSE will involve the integration of the computing model system,service platform system,operating system and terminal structure system,all of which involve exploration and innovation of a new networking structure,its control and management as well as way of measuring. The change in network resources triggers the change in network computing models. To let readers have a basic understanding of MUSE,this lecture introduces it in four sections. This section focuses on the development and demand analysis of the service platform.

Long term integration of radar signals with unknown Doppler shift for ubiquitous radar

Ubiquitous radar is a new radar system that provides continuous and uninterrupted multifunction capability within a coverage volume. Continuous coverage from close-in ＂pop-up＂ targets in clutter to long-range targets impacts selection of waveform parameters. The coherent processing interval （CPI） must be long enough to achieve a certain signal-to-noise ratio （SNR） that ensures the efficiency of detection. The condition of detection in the case of low SNR is analyzed, and three different cases that would occur during integration are discussed and a method to determine the CPI is presented. The simulation results show that targets detection with SNR as low as -26 dB in the experimental system can possibly determine the CPI.

Numerical investigations of rock bridge effect on open pit slope stability

In this study,the effect of rock bridges on rock slope stability was investigated by incorporating nonpersistent joint networks in numerical models,and the critical profiles of an open pit mine were analysed.Parallel deterministic networks of infinite and finite lengths,ubiquitous joint network model and Veneziano joint network model were used in order to simulate the rock fractures.Materials were modelled based on the generalised Hoek-Brown and equivalent Mohr-Coulomb failure criteria.The parallel deterministic infinite and the ubiquitous joint network models produced lower safety factors.The introduction of rock bridges along discontinuity planes in the parallel deterministic network and Veneziano joint network models significantly contributed to the stability and strain distribution,which should be considered in stability analysis of rock mass in open pit by rock slope practitioners.The results show the significance of joints in hard rock behaviour and the joints should be included in order to attain practical and realistic simulations.

Development of Ubiquitous Simulation Service Structure Based on High Performance Computing Technologies

The simulation field became essential in designing or developing new casting products and in improving manufacturing processes within limited time, because it can help us to simulate the nature of processing, so that developers can make ideal casting designs. To take the prior occupation at commercial simulation market, so many development groups in the world are doing their every effort. They already reported successful stories in manufacturing fields by developing and providing the high performance simulation technologies for multipurpose. But they all run at powerful desk-side computers by well-trained experts mainly, so that it is hard to diffuse the scientific designing concept to newcomers in casting field. To overcome upcoming problems in scientific casting designs, we utilized information technologies and full-matured hardware backbones to spread out the effective and scientific casting design mind, and they all were integrated into Simulation Portal on the web. It professes scientific casting design on the NET including ubiquitous access way represented by ＂Anyone, Anytime, Anywhere＂ concept for casting designs.