BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare tumors of the gastrointestinal tract accounting for less than 1%of all gut tumors.GISTs occurring in the rectum are extremely rare,and these usually present at...BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare tumors of the gastrointestinal tract accounting for less than 1%of all gut tumors.GISTs occurring in the rectum are extremely rare,and these usually present at an advanced stage compared with other sites.CASE SUMMARY A 60-year-old male who presented with features of sensations of rectal tenesmus was referred to our department with a mass in the lower rectum that was detected during a routine checkup.Colonoscopy,transrectal ultrasound,perianal magnetic resonance imaging and ultrasonic contrast were used to diagnose the rectum GIST,and then the patient underwent complete transanal resection using the ultrasonic scalpel.The patient was discharged ten days after the operation and was defined as low risk.Therefore,he had no need to receive subsequent adjuvant therapies,and he had not suffered any anal dysfunction or had any evidence of recurrence at follow up.CONCLUSION Surgical resection with histologically negative margins is the standard curative treatment for rectal GISTs.Appropriate surgical techniques based on the location,size,and resectability of the tumor should attract great attention from clinicians.展开更多
The ultrasonic bone scalpel was often used in all kinds of clinical orthopedic surgery as a new type of medical instrument.Based on the working theory of the ultrasonic bone scalpel and combined with the design method...The ultrasonic bone scalpel was often used in all kinds of clinical orthopedic surgery as a new type of medical instrument.Based on the working theory of the ultrasonic bone scalpel and combined with the design method of a quarter wavelength transducer and horn,this study proposed an optimization design method for the ultrasonic bone scalpel with a composite horn structure.The structure of the ultrasonic bone scalpel was simplified,and its length was shortened.Finite element analysis,modal analysis,and harmonic response analysis were used to optimize the design of the ultrasonic bone scalpel.The performance of the ultrasonic bone scalpel was explored through impedance analysis,amplitude measurement,temperature measurement,and cutting tests,and the feasibility of the design was verified through torque analysis.The results showed that when the torque force was 4.0 N,the resonance frequency of the ultrasonic bone scalpel was 30,540 Hz,and the maximum amplitude of the ultrasonic bone scalpel could reach 62μm.After spray cooling,the maximum surface temperature of the rear end cover was reduced from 51.8 to 36.3℃,the maximum surface temperature of the composite horn was reduced from 71 to 45.3℃,and the maximum surface temperature of the cutter head was reduced from 101 to 46.1℃,demonstrating a good cooling effect.Under 89 Voltage,the optimal cutting force for cutting chicken leg bones was 0.1 N,the optimal cutting force for cutting pork ribs was 0.3 N,and the cutting process showed tissue selectivity.展开更多
Objective The aim of this study was to investigate the potential adverse effects of electrosurgical smoke on medical staff performing malignant tumor surgery.Methods This study was divided into two parts:in vitro and ...Objective The aim of this study was to investigate the potential adverse effects of electrosurgical smoke on medical staff performing malignant tumor surgery.Methods This study was divided into two parts:in vitro and in vivo experiments.The human thyroid cancer cell line,ARO,was cultured and passaged.The tumor cells were burned with an ultrasonic scalpel,and the surgical smoke was absorbed by a transwell membrane.The captured particles were diluted in 3 mL of culture medium,and cell survival was assessed under a microscope.DNA was extracted from the cells for genotyping.BALB/c mice were used to construct thyroid cancer xenograft models.The tumor tissues were dissected on day 14 using an ultrasonic scalpel.The smoke from the electrosurgical procedure was collected on a transwell membrane.The membrane was washed in 2 mL of rinsing solution,and the solution was then injected into the right armpit of 10 mice.After sacrifice,the tumor tissues were removed and stained with hematoxylin and eosin(HE).Results Viable ARO cells could be seen on the first day after culturing cell fragments from surgical smoke,and vigorous cell proliferation could be seen on the 17th day of incubation.The genotype of the cells cultured in the presence of smoke particles was identical to the genotype of the original cells.Tumor growth was observed in four out of 10 mice injected with the smoke particle rinse.HE staining showed a significantly increased number of nuclei in the tumor tissue,which was consistent with the general morphological characteristics of malignant tumors.Conclusion Viable tumor cells were detected in surgical smoke generated by ultrasonic scalpel dissection,and these cells had growth activity.Thus,it is necessary to protect patients and medical staff from electrosurgical smoke.展开更多
In the natural world,leaf-cutting ants cause vibrations through their mutual scraping of file-scraper organs.In this study,we designed a Biomimetic Ultrasonic Exciter(BUE)that imitates leaf-cutting ants.The operating ...In the natural world,leaf-cutting ants cause vibrations through their mutual scraping of file-scraper organs.In this study,we designed a Biomimetic Ultrasonic Exciter(BUE)that imitates leaf-cutting ants.The operating characteristics of the BUE were studied through experimental testing and finite element simulations.The results showed that the BUE could generate stable ultrasonic vibrations,and that the excitation frequency only needed to be half the Output Frequency(OF).This frequency-doubling phenomenon was conducive to achieving BUE miniaturization.To further explore the phenomenon of frequency-doubling vibration output,this study designed scrapers of five different sizes,conducted excitation and first-order natural frequency measurement tests,and the corresponding finite element simulations.It was found that each scraper could operate in frequency-doubling mode,but the operating frequency and natural mode frequencies did not correspond with one another.To further explicate experimental and simulation results,a two-degrees-of-freedom vibration model was developed.It was evident that the contact relationship between the dentate disc and scraper introduced strong nonlinear factors into the system,accounting for the frequency-doubling phenomenon and the difference between the BUE’s operating and mode frequencies.The BUE could be expected to facilitate the production of high-power micro-ultrasonic generators and has potential application value in the fields of mechanical processing,industrial production,and medical health.展开更多
基金Supported by National Nature Science Foundation of China,No.82004374the second round of construction project for the National Traditional Chinese Medicine Academic School Inheritance Studio+1 种基金the three-year action project for Shanghai to further accelerate the inheritance innovation and development of traditional Chinese medicine,No.ZY[2021-2023]-0209Shanghai"Rising Stars of Medical Talents"Youth Development Program,Youth Medical Talents–Specialist Program,No.[2021]-099.
文摘BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare tumors of the gastrointestinal tract accounting for less than 1%of all gut tumors.GISTs occurring in the rectum are extremely rare,and these usually present at an advanced stage compared with other sites.CASE SUMMARY A 60-year-old male who presented with features of sensations of rectal tenesmus was referred to our department with a mass in the lower rectum that was detected during a routine checkup.Colonoscopy,transrectal ultrasound,perianal magnetic resonance imaging and ultrasonic contrast were used to diagnose the rectum GIST,and then the patient underwent complete transanal resection using the ultrasonic scalpel.The patient was discharged ten days after the operation and was defined as low risk.Therefore,he had no need to receive subsequent adjuvant therapies,and he had not suffered any anal dysfunction or had any evidence of recurrence at follow up.CONCLUSION Surgical resection with histologically negative margins is the standard curative treatment for rectal GISTs.Appropriate surgical techniques based on the location,size,and resectability of the tumor should attract great attention from clinicians.
基金financially supported by the National Natural Science Foundation of China(No.52275420)the Natural Science Foundation of Hunan Province of China(No.2022JJ30136)the Natural Science Foundation of Fujian Province of China(No.2021J05108).
文摘The ultrasonic bone scalpel was often used in all kinds of clinical orthopedic surgery as a new type of medical instrument.Based on the working theory of the ultrasonic bone scalpel and combined with the design method of a quarter wavelength transducer and horn,this study proposed an optimization design method for the ultrasonic bone scalpel with a composite horn structure.The structure of the ultrasonic bone scalpel was simplified,and its length was shortened.Finite element analysis,modal analysis,and harmonic response analysis were used to optimize the design of the ultrasonic bone scalpel.The performance of the ultrasonic bone scalpel was explored through impedance analysis,amplitude measurement,temperature measurement,and cutting tests,and the feasibility of the design was verified through torque analysis.The results showed that when the torque force was 4.0 N,the resonance frequency of the ultrasonic bone scalpel was 30,540 Hz,and the maximum amplitude of the ultrasonic bone scalpel could reach 62μm.After spray cooling,the maximum surface temperature of the rear end cover was reduced from 51.8 to 36.3℃,the maximum surface temperature of the composite horn was reduced from 71 to 45.3℃,and the maximum surface temperature of the cutter head was reduced from 101 to 46.1℃,demonstrating a good cooling effect.Under 89 Voltage,the optimal cutting force for cutting chicken leg bones was 0.1 N,the optimal cutting force for cutting pork ribs was 0.3 N,and the cutting process showed tissue selectivity.
基金Supported by grants from the Sichuan Youth Science and Technology Fund(No.1886521)the Mianyang Science and Technology Plan Project(No.17YFZ-0016)。
文摘Objective The aim of this study was to investigate the potential adverse effects of electrosurgical smoke on medical staff performing malignant tumor surgery.Methods This study was divided into two parts:in vitro and in vivo experiments.The human thyroid cancer cell line,ARO,was cultured and passaged.The tumor cells were burned with an ultrasonic scalpel,and the surgical smoke was absorbed by a transwell membrane.The captured particles were diluted in 3 mL of culture medium,and cell survival was assessed under a microscope.DNA was extracted from the cells for genotyping.BALB/c mice were used to construct thyroid cancer xenograft models.The tumor tissues were dissected on day 14 using an ultrasonic scalpel.The smoke from the electrosurgical procedure was collected on a transwell membrane.The membrane was washed in 2 mL of rinsing solution,and the solution was then injected into the right armpit of 10 mice.After sacrifice,the tumor tissues were removed and stained with hematoxylin and eosin(HE).Results Viable ARO cells could be seen on the first day after culturing cell fragments from surgical smoke,and vigorous cell proliferation could be seen on the 17th day of incubation.The genotype of the cells cultured in the presence of smoke particles was identical to the genotype of the original cells.Tumor growth was observed in four out of 10 mice injected with the smoke particle rinse.HE staining showed a significantly increased number of nuclei in the tumor tissue,which was consistent with the general morphological characteristics of malignant tumors.Conclusion Viable tumor cells were detected in surgical smoke generated by ultrasonic scalpel dissection,and these cells had growth activity.Thus,it is necessary to protect patients and medical staff from electrosurgical smoke.
基金supported by the National Natural Science Foundation of China(grant nos.91960203,51975035)。
文摘In the natural world,leaf-cutting ants cause vibrations through their mutual scraping of file-scraper organs.In this study,we designed a Biomimetic Ultrasonic Exciter(BUE)that imitates leaf-cutting ants.The operating characteristics of the BUE were studied through experimental testing and finite element simulations.The results showed that the BUE could generate stable ultrasonic vibrations,and that the excitation frequency only needed to be half the Output Frequency(OF).This frequency-doubling phenomenon was conducive to achieving BUE miniaturization.To further explore the phenomenon of frequency-doubling vibration output,this study designed scrapers of five different sizes,conducted excitation and first-order natural frequency measurement tests,and the corresponding finite element simulations.It was found that each scraper could operate in frequency-doubling mode,but the operating frequency and natural mode frequencies did not correspond with one another.To further explicate experimental and simulation results,a two-degrees-of-freedom vibration model was developed.It was evident that the contact relationship between the dentate disc and scraper introduced strong nonlinear factors into the system,accounting for the frequency-doubling phenomenon and the difference between the BUE’s operating and mode frequencies.The BUE could be expected to facilitate the production of high-power micro-ultrasonic generators and has potential application value in the fields of mechanical processing,industrial production,and medical health.