Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human exposure.Given their estrogenic properties,the potential health ri...Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human exposure.Given their estrogenic properties,the potential health risks associated with exposure to BPs have become a public health concern.This review aims to summarize sources and pathways of exposure to BPs and associated health risks.Dermal exposure,primarily through the use of sunscreens,constitutes a major pathway for BP exposure.At a recommended application rate,dermal exposure of BP-3 via the application of sunscreens may reach or exceed the suggested reference dose.Other exposure pathways to BPs,such as drinking water,seafood,and packaged foods,contribute minimal to the overall dose.Inhalation is a minor pathway of exposure;however,its contribution cannot be ignored.Human exposure to BPs is an order of magnitude higher in North America than in Asia and Europe.Studies conducted on laboratory animals and cells have consistently demonstrated the toxic effects of BP exposure.BPs are estrogenic and elicit reproductive and developmental toxicities.Furthermore,neurotoxicity,hepatotoxicity,nephrotoxicity,and carcinogenicity have been reported from chronic BP exposure.In addition to animal and cell studies,epidemiological investigations have identified associations between BPs and couples'fecundity and other reproductive disorders,as well as adverse birth outcomes.Further studies are urgently needed to understand the risks posed by BPs on human health.展开更多
基金supported by the Natural Science Foundation of China(No.22022612,and No.21677184)Natural Science Foundation of Guangdong Province,China(No.2020A0104006 and No.2021A1515010243)+1 种基金the Fundamental Research Funds for the Central Universitiessupported,in part,by the National Institute of Environmental Health Sciences(NIEHS)under award number U2CES026542(KK).
文摘Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human exposure.Given their estrogenic properties,the potential health risks associated with exposure to BPs have become a public health concern.This review aims to summarize sources and pathways of exposure to BPs and associated health risks.Dermal exposure,primarily through the use of sunscreens,constitutes a major pathway for BP exposure.At a recommended application rate,dermal exposure of BP-3 via the application of sunscreens may reach or exceed the suggested reference dose.Other exposure pathways to BPs,such as drinking water,seafood,and packaged foods,contribute minimal to the overall dose.Inhalation is a minor pathway of exposure;however,its contribution cannot be ignored.Human exposure to BPs is an order of magnitude higher in North America than in Asia and Europe.Studies conducted on laboratory animals and cells have consistently demonstrated the toxic effects of BP exposure.BPs are estrogenic and elicit reproductive and developmental toxicities.Furthermore,neurotoxicity,hepatotoxicity,nephrotoxicity,and carcinogenicity have been reported from chronic BP exposure.In addition to animal and cell studies,epidemiological investigations have identified associations between BPs and couples'fecundity and other reproductive disorders,as well as adverse birth outcomes.Further studies are urgently needed to understand the risks posed by BPs on human health.
