In this paper,we investigate sufficient and necessary conditions such that generalized Forelli-Rudin type operators T_(λ,τ,k),S_(λ,τ,k),Q_(λ,τ,k)and R_(λ,τ,k)are bounded between Lebesgue type spaces.In order t...In this paper,we investigate sufficient and necessary conditions such that generalized Forelli-Rudin type operators T_(λ,τ,k),S_(λ,τ,k),Q_(λ,τ,k)and R_(λ,τ,k)are bounded between Lebesgue type spaces.In order to prove the main results,we first give some bidirectional estimates for several typical integrals.展开更多
Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to spe...Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to specific data ranges with an average absolute percentage relative error(AAPRE)of more than 10%.The published gated recurrent unit(GRU)models do not consider trend analysis to show physical behaviors.In this study,we aim to develop a GRU model using trend analysis and three inputs for predicting n s based on a broad range of data,n s(value of 0.1627-0.4492),bulk formation density(RHOB)(0.315-2.994 g/mL),compressional time(DTc)(44.43-186.9 μs/ft),and shear time(DTs)(72.9-341.2μ s/ft).The GRU model was evaluated using different approaches,including statistical error an-alyses.The GRU model showed the proper trends,and the model data ranges were wider than previous ones.The GRU model has the largest correlation coefficient(R)of 0.967 and the lowest AAPRE,average percent relative error(APRE),root mean square error(RMSE),and standard deviation(SD)of 3.228%,1.054%,4.389,and 0.013,respectively,compared to other models.The GRU model has a high accuracy for the different datasets:training,validation,testing,and the whole datasets with R and AAPRE values were 0.981 and 2.601%,0.966 and 3.274%,0.967 and 3.228%,and 0.977 and 2.861%,respectively.The group error analyses of all inputs show that the GRU model has less than 5% AAPRE for all input ranges,which is superior to other models that have different AAPRE values of more than 10% at various ranges of inputs.展开更多
In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A...In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.展开更多
一、内容分析本课时为故事教学,讲述了Mocky与Ann,Ken相识的过程,自然呈现了用"Hello!"打招呼以及用"What’s your name?""My name is..."来询问和介绍姓名的表达法。本课的故事贴近学生生活,语言简单,...一、内容分析本课时为故事教学,讲述了Mocky与Ann,Ken相识的过程,自然呈现了用"Hello!"打招呼以及用"What’s your name?""My name is..."来询问和介绍姓名的表达法。本课的故事贴近学生生活,语言简单,便于学生理解。同时,介绍以姓名为主题的歌曲和问答活动,有利于学生的理解和巩固。在学习故事的过程中,认识故事主人公,记住他们的姓名Mocky、Ann、Ken也是本课时的重点。展开更多
In this article, the authors give a typical integral＇s bidirectional estimates for allcases. At the same time, several equivalent characterizations on the F（p, q, s, k） space in theunit ball of Cn are given.
This paper deals with the boundedness and compactness of the weighted composition operators from the F（p, q, s） spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to ...This paper deals with the boundedness and compactness of the weighted composition operators from the F（p, q, s） spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to Bers-type spaces Hv^∞（ or little Bers-type spaces Hv,o∞ ）, where v is normal.展开更多
The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen.This supply is coordinated by the action of neurons,glial and vas...The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen.This supply is coordinated by the action of neurons,glial and vascular cells,known collectively as the neurovascular unit,which temporally and spatially regulate local cerebral blood flow through a process known as neurovascular coupling.In many neurodegenerative diseases,changes in functions of the neurovascular unit not only impair neurovascular coupling but also permeability of the blood-brain barrier,cerebral blood flow and clearance of waste from the brain.In order to study disease mechanisms,we need improved physiologicallyrelevant human models of the neurovascular unit.Advances towards modeling the cellular complexity of the neurovascular unit in vitro have been made using stem-cell derived organoids and more recently,vascularized organoids,enabling intricate studies of non-cell autonomous processes.Engineering and design innovations in microfluidic devices and tissue engineering are progressing our ability to interrogate the cerebrovasculature.These advanced models are being used to gain a better understanding of neurodegenerative disease processes and potential therapeutics.Continued innovation is required to build more physiologically-relevant models of the neurovascular unit encompassing both the cellular complexity and designed features to interrogate neurovascular unit functionality.展开更多
In this paper, the status quo and modeling principles of R/S analysis of non-linear theory are introduced and reviewed. Given the hydro-geological conditions of the Wutongzhuang coal mine, Hurst exponents of mine infl...In this paper, the status quo and modeling principles of R/S analysis of non-linear theory are introduced and reviewed. Given the hydro-geological conditions of the Wutongzhuang coal mine, Hurst exponents of mine inflow for the main shaft, venti- lating shaft and auxiliary shaft were obtained using R/S analysis, which are 0.772 0, 0.824 7 and 0.905 1 respectively. Since all of the three Hurst exponents are larger than 0.5, it can be concluded that the trend of mine inflow are a long-term as well as persistent problem. Based on the level of duration, the shafts can be listed in decreasing order as the auxiliary shaft, the ventilation shaft and the main shaft, which appears identical with the actual situation of the mine inflow. With R/S analysis, a new method for long-term forecasting of mine inflows is provided.展开更多
An M_(S)6.4 earthquake occurred in Yangbi,Yunnan province,on May 21,2021.According to related investigations,the macro-epicenter of the earthquake is 6 km northwest of Yangbi County,and the seismogenic structure is th...An M_(S)6.4 earthquake occurred in Yangbi,Yunnan province,on May 21,2021.According to related investigations,the macro-epicenter of the earthquake is 6 km northwest of Yangbi County,and the seismogenic structure is the NW-trending Weixi-Qiaohou fault.The earthquake area is located in the hinterland of the Hengduan Mountains in the northwest of Yunnan Province,a region dominated by high and medium-high mountains,with deep canyons and tectonic basins in between.Various geomorphic features are derived from drastic topographic changes and huge geological differences in the earthquake area.There are a variety of buildings in the earthquake-affected zone,including civil and brick-wood structures ones with weak seismic performance,as well as brick-concrete and frame ones with better seismic performance.This paper summarizes and analyzes different characteristics of the earthquake in different geomorphic units through field investigations of different buildings and geological disasters in the affected area.The results show that under the same earthquake intensity,the damage to most buildings(located in slope areas or rooted in weak strata)is amplified by the earthquake.The earthquake has exerted an obvious propagation effect along the direction of the seismogenic structure.Moreover,local ground fissures will aggravate the damage to the buildings even without surface dislocation.Thus,we suggest that attention should be paid to the ground fissures caused by the slope effect.The fissure areas may also be the disaster spot of collapses and landslides in case of a high-magnitude earthquake.展开更多
Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is...Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is immediate cause for post-discharge medical problems in premature and neonates readmission to NICU. Hence, this study aims to evaluate mothers’ knowledge of caring for premature infants post-discharge from Neonatal Intensive Care Units in the Gaza strip. Methods: A Quantitative-based cross-sectional designs study was used to survey 120 mothers of preterm neonates at the time of preterm neonates discharge by face-to-face interview at Al-Shifa medical complex and Nasser hospital between February and June 2018. Results: The results showed that only about 58.4% of mothers of premature babies had good knowledge about health care needed for premature infants after discharge from NICU. Furthermore, there was no statistically significant difference between the level of knowledge and mother’s sociodemographic characteristics (P-values > 0.05). Conclusion: Mothers’ knowledge of premature infants care was not at the optimal level, which might put the newborns at risk. Therefore, the study emphasizes the necessity of thoughtful exchange of health information between team members and mothers and establishing pre- and post-discharge plans with mothers to start their healthy transition of preterm neonate to home and to ameliorate family concerns.展开更多
Unifying quantum and classical physics has proved difficult as their postulates are conflicting. Using the notion of counts of the fundamental measures—length, mass, and time—a unifying description is resolved. A th...Unifying quantum and classical physics has proved difficult as their postulates are conflicting. Using the notion of counts of the fundamental measures—length, mass, and time—a unifying description is resolved. A theoretical framework is presented in a set of postulates by which a conversion between expressions from quantum and classical physics can be made. Conversions of well-known expressions from different areas of physics (quantum physics, gravitation, optics and cosmology) exemplify the approach and mathematical procedures. The postulated integer counts of fundamental measures change our understanding of length, suggesting that our current understanding of reality is distorted.展开更多
基金supported by the Natural Science Foundation of Hunan Province of China(2022JJ30369)the Education Department Important Foundation of Hunan Province in China(23A0095)。
文摘In this paper,we investigate sufficient and necessary conditions such that generalized Forelli-Rudin type operators T_(λ,τ,k),S_(λ,τ,k),Q_(λ,τ,k)and R_(λ,τ,k)are bounded between Lebesgue type spaces.In order to prove the main results,we first give some bidirectional estimates for several typical integrals.
基金The authors thank the Yayasan Universiti Teknologi PETRONAS(YUTP FRG Grant No.015LC0-428)at Universiti Teknologi PETRO-NAS for supporting this study.
文摘Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to specific data ranges with an average absolute percentage relative error(AAPRE)of more than 10%.The published gated recurrent unit(GRU)models do not consider trend analysis to show physical behaviors.In this study,we aim to develop a GRU model using trend analysis and three inputs for predicting n s based on a broad range of data,n s(value of 0.1627-0.4492),bulk formation density(RHOB)(0.315-2.994 g/mL),compressional time(DTc)(44.43-186.9 μs/ft),and shear time(DTs)(72.9-341.2μ s/ft).The GRU model was evaluated using different approaches,including statistical error an-alyses.The GRU model showed the proper trends,and the model data ranges were wider than previous ones.The GRU model has the largest correlation coefficient(R)of 0.967 and the lowest AAPRE,average percent relative error(APRE),root mean square error(RMSE),and standard deviation(SD)of 3.228%,1.054%,4.389,and 0.013,respectively,compared to other models.The GRU model has a high accuracy for the different datasets:training,validation,testing,and the whole datasets with R and AAPRE values were 0.981 and 2.601%,0.966 and 3.274%,0.967 and 3.228%,and 0.977 and 2.861%,respectively.The group error analyses of all inputs show that the GRU model has less than 5% AAPRE for all input ranges,which is superior to other models that have different AAPRE values of more than 10% at various ranges of inputs.
基金supported by STI2030-Major Projects,No.2021ZD 0201801(to JG)Shanxi Province Basic Research Program,No.20210302123429(to QS).
文摘In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of Alzheimer’s disease remains unclear.This study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying mechanism.We observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse model.Additionally,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive deficits.Interestingly,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 mice.This effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa B.Our findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 mice.These findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.
文摘一、内容分析本课时为故事教学,讲述了Mocky与Ann,Ken相识的过程,自然呈现了用"Hello!"打招呼以及用"What’s your name?""My name is..."来询问和介绍姓名的表达法。本课的故事贴近学生生活,语言简单,便于学生理解。同时,介绍以姓名为主题的歌曲和问答活动,有利于学生的理解和巩固。在学习故事的过程中,认识故事主人公,记住他们的姓名Mocky、Ann、Ken也是本课时的重点。
基金supported by the National Natural Science Foundation of China(11571104)the Hunan Provincial Innovation Foundation for Postgraduate(CX2017B220)Supported by the Construct Program of the Key Discipline in Hunan Province
文摘In this article, the authors give a typical integral＇s bidirectional estimates for allcases. At the same time, several equivalent characterizations on the F（p, q, s, k） space in theunit ball of Cn are given.
基金Supported by the National Natural Science Foundation of China (10771064)the Natural Science Foundation of Zhejiang province (Y6090036+1 种基金Y7080197,Y606197)the Foundation of Department of Education of Zhejiang Province (20070482)
文摘This paper deals with the boundedness and compactness of the weighted composition operators from the F（p, q, s） spaces, including Hardy space, Bergman space, Qp space, BMOA space, Besov space and α-Bloch space, to Bers-type spaces Hv^∞（ or little Bers-type spaces Hv,o∞ ）, where v is normal.
基金supported by the Weston Brain Institute Rapid Response Grant,No.RR182093(to JR).
文摘The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen.This supply is coordinated by the action of neurons,glial and vascular cells,known collectively as the neurovascular unit,which temporally and spatially regulate local cerebral blood flow through a process known as neurovascular coupling.In many neurodegenerative diseases,changes in functions of the neurovascular unit not only impair neurovascular coupling but also permeability of the blood-brain barrier,cerebral blood flow and clearance of waste from the brain.In order to study disease mechanisms,we need improved physiologicallyrelevant human models of the neurovascular unit.Advances towards modeling the cellular complexity of the neurovascular unit in vitro have been made using stem-cell derived organoids and more recently,vascularized organoids,enabling intricate studies of non-cell autonomous processes.Engineering and design innovations in microfluidic devices and tissue engineering are progressing our ability to interrogate the cerebrovasculature.These advanced models are being used to gain a better understanding of neurodegenerative disease processes and potential therapeutics.Continued innovation is required to build more physiologically-relevant models of the neurovascular unit encompassing both the cellular complexity and designed features to interrogate neurovascular unit functionality.
基金Project 40472146 supported by the National Natural Science Foundation of China
文摘In this paper, the status quo and modeling principles of R/S analysis of non-linear theory are introduced and reviewed. Given the hydro-geological conditions of the Wutongzhuang coal mine, Hurst exponents of mine inflow for the main shaft, venti- lating shaft and auxiliary shaft were obtained using R/S analysis, which are 0.772 0, 0.824 7 and 0.905 1 respectively. Since all of the three Hurst exponents are larger than 0.5, it can be concluded that the trend of mine inflow are a long-term as well as persistent problem. Based on the level of duration, the shafts can be listed in decreasing order as the auxiliary shaft, the ventilation shaft and the main shaft, which appears identical with the actual situation of the mine inflow. With R/S analysis, a new method for long-term forecasting of mine inflows is provided.
基金the support from the National Natural Science Foundation of China Projects (41472204, U2002211).
文摘An M_(S)6.4 earthquake occurred in Yangbi,Yunnan province,on May 21,2021.According to related investigations,the macro-epicenter of the earthquake is 6 km northwest of Yangbi County,and the seismogenic structure is the NW-trending Weixi-Qiaohou fault.The earthquake area is located in the hinterland of the Hengduan Mountains in the northwest of Yunnan Province,a region dominated by high and medium-high mountains,with deep canyons and tectonic basins in between.Various geomorphic features are derived from drastic topographic changes and huge geological differences in the earthquake area.There are a variety of buildings in the earthquake-affected zone,including civil and brick-wood structures ones with weak seismic performance,as well as brick-concrete and frame ones with better seismic performance.This paper summarizes and analyzes different characteristics of the earthquake in different geomorphic units through field investigations of different buildings and geological disasters in the affected area.The results show that under the same earthquake intensity,the damage to most buildings(located in slope areas or rooted in weak strata)is amplified by the earthquake.The earthquake has exerted an obvious propagation effect along the direction of the seismogenic structure.Moreover,local ground fissures will aggravate the damage to the buildings even without surface dislocation.Thus,we suggest that attention should be paid to the ground fissures caused by the slope effect.The fissure areas may also be the disaster spot of collapses and landslides in case of a high-magnitude earthquake.
文摘Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is immediate cause for post-discharge medical problems in premature and neonates readmission to NICU. Hence, this study aims to evaluate mothers’ knowledge of caring for premature infants post-discharge from Neonatal Intensive Care Units in the Gaza strip. Methods: A Quantitative-based cross-sectional designs study was used to survey 120 mothers of preterm neonates at the time of preterm neonates discharge by face-to-face interview at Al-Shifa medical complex and Nasser hospital between February and June 2018. Results: The results showed that only about 58.4% of mothers of premature babies had good knowledge about health care needed for premature infants after discharge from NICU. Furthermore, there was no statistically significant difference between the level of knowledge and mother’s sociodemographic characteristics (P-values > 0.05). Conclusion: Mothers’ knowledge of premature infants care was not at the optimal level, which might put the newborns at risk. Therefore, the study emphasizes the necessity of thoughtful exchange of health information between team members and mothers and establishing pre- and post-discharge plans with mothers to start their healthy transition of preterm neonate to home and to ameliorate family concerns.
文摘Unifying quantum and classical physics has proved difficult as their postulates are conflicting. Using the notion of counts of the fundamental measures—length, mass, and time—a unifying description is resolved. A theoretical framework is presented in a set of postulates by which a conversion between expressions from quantum and classical physics can be made. Conversions of well-known expressions from different areas of physics (quantum physics, gravitation, optics and cosmology) exemplify the approach and mathematical procedures. The postulated integer counts of fundamental measures change our understanding of length, suggesting that our current understanding of reality is distorted.
