An Updated Lagrangian Particle Hydrodynamics (ULPH)-NOSBPD Coupling Approach forModeling Fluid-Structure Interaction Problem

A fluid-structure interaction approach is proposed in this paper based onNon-Ordinary State-Based Peridynamics(NOSB-PD)and Updated Lagrangian Particle Hydrodynamics(ULPH)to simulate the fluid-structure interaction problem with large geometric deformation and material failure and solve the fluid-structure interaction problem of Newtonian fluid.In the coupled framework,the NOSB-PD theory describes the deformation and fracture of the solid material structure.ULPH is applied to describe the flow of Newtonian fluids due to its advantages in computational accuracy.The framework utilizes the advantages of NOSB-PD theory for solving discontinuous problems and ULPH theory for solving fluid problems,with good computational stability and robustness.A fluidstructure coupling algorithm using pressure as the transmission medium is established to deal with the fluidstructure interface.The dynamic model of solid structure and the PD-ULPH fluid-structure interaction model involving large deformation are verified by numerical simulations.The results agree with the analytical solution,the available experimental data,and other numerical results.Thus,the accuracy and effectiveness of the proposed method in solving the fluid-structure interaction problem are demonstrated.The fluid-structure interactionmodel based on ULPH and NOSB-PD established in this paper provides a new idea for the numerical solution of fluidstructure interaction and a promising approach for engineering design and experimental prediction.

Updated Lagrangian Particle Hydrodynamics (ULPH)Modeling of Natural Convection Problems

Natural convection is a heat transfer mechanism driven by temperature or density differences,leading to fluid motion without external influence.It occurs in various natural and engineering phenomena,influencing heat transfer,climate,and fluid mixing in industrial processes.This work aims to use the Updated Lagrangian Particle Hydrodynamics(ULPH)theory to address natural convection problems.The Navier-Stokes equation is discretized using second-order nonlocal differential operators,allowing a direct solution of the Laplace operator for temperature in the energy equation.Various numerical simulations,including cases such as natural convection in square cavities and two concentric cylinders,were conducted to validate the reliability of the model.The results demonstrate that the proposed model exhibits excellent accuracy and performance,providing a promising and effective numerical approach for natural convection problems.

Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention

BACKGROUND New markers are needed to improve the effectiveness of serological screening for atrophic gastritis.AIM To develop a cost-effective method for serological screening of atrophic gastritis with a high level of sensitivity.METHODS Of the 169 patients with atrophic gastritis,selected by the visual endoscopic Kimura-Takemoto method,165 showed histological mucosal atrophy using the updated Kimura-Takemoto method.All 169 patients were examined for postprandial levels of gastrin-17(G17)and pepsinogen-1(PG1)using Gastro-Panel®(Biohit Plc,Helsinki,Finland).RESULTS We used the histological standard of five biopsies of the gastric mucosa,in accordance with the Kimura-Takemoto classification system to assess the sensitivity of G17 in detecting gastric mucosal atrophy.We also compared the morphofunctional relationships between the detected histological degree of gastric mucosal atrophy and the serological levels of G17 and PG1,as the markers of atrophic gastritis.The sensitivity of postprandial G17 was 62.2%for serological levels of G17(range:0-4 pmol/L)and 100%for serological G17(range:0-10 pmol/L)for the detection of monofocal severe atrophic gastritis.No strong correlation was found between the levels of PG1 and degree of histological atrophy determined by the Kimura-Takemoto classification system to identify the severity of mucosal atrophy of the gastric corpus.In the presented clinical case of a 63-year-old man with multifocal atrophic gastritis,there is a pronounced positive long-term dynamics of the serological marker of atrophy-postprandial G17,after five months of rennet replacement therapy.CONCLUSION Serological screening of multifocal atrophic gastritis by assessment of postprandial G17 is a cost-effective method with high sensitivity.Postprandial G17 is an earlier marker of regression of atrophic gastritis than a morphological examination of a gastric biopsy in accordance with the Sydney system.Therefore,postprandial G17 is recommended for dynamic monitoring of atrophic gastritis after treatment.

Finite element analysis of spatial curved beam in large deformation

For the purpose of carrying out the large deformation finite element analysis of spatial curved beams,the total Lagrangian（TL）and the updated Lagrangian（UL）incremental formulations for arbitrary spatial curved beam elements are established with displacement vector interpolation,which is improved from component interpolation of the straight beam displacement.A strategy of replacing the actual curve with the isoparametric curve is used to expand the applications of the UL formulation.The examples indicate that the process of establishing the curved beam element is correct,and the accuracy with the curved beam element is obviously higher than that with the straight beam element.Generally,the same level of computational accuracy can be achieved with 1/5 as many curved beam elements as otherwise with straight beam elements.

Mechanical analysis of transmission lines based on linear sliding cable element

In order to study the sliding characteristics when the cable structures are connected with other rods, a string of sliding cable dements （SCE） consisting of one active threenode SCE passing through the sliding point and multiple inactive two-node SCEs is put forward. Based on the updated Lagrangian formulation, the geometric nonlinear stiffness matrix of the three-node straight sliding cable dement is deduced. The examples about two-span and three-span continuous cable structures are studied to verify the effectiveness of the derived SCE. Comparing the cable tension of SCE with the existing research results, the calculating results show that the error is less than 1%. The sliding characteristics should be considered in practical engineering because of the obvious difference between the cable tension of the SCE and that of the cable element without considering sliding characteristics.

大变形有限元法计算水闸地基稳定性(Ⅰ)—基本原理

在水闸地基整体稳定性研究中,选择弹塑性大变形有限元进行计算。采用大变形问题的UpdatedLagrangian描述方法,基于土体失稳过程是弹塑性大变形的问题,建立了土体稳定分析的弹塑性大变形有限元模型,提出了坐标更新和非线性方程组线性化的方法,推导了相应的计算公式。

大变形有限元法计算水闸地基稳定性(Ⅱ)—数值算例

在水闸地基整体稳定性研究中,选择弹塑性大变形有限元进行计算。采用Updated Lagrangian法的有限元模型,用Fortran语言编制了相应的计算程序,计算有斜向荷载及渗透力并考虑了土体自重情况下的水闸地基稳定性。结果与弹塑性小变形有限元法对比,说明用弹塑性大变形有限元法计算地基土体稳定是合理和安全的。

Cancer statistics: updated cancer burden in China

Cancer is a major public health issue in most of countries, including China. Accurate and valid information on cancer incidence, mortality, survival and relevant factors is irreplaceable for cancer prevention and control. Since the national program of cancer registry was launched by the Ministry of Health of China in 2008, the National Central Cancer Registry （NCCR） has been releasing the cancer incidence and mortality based on the data collected from cancer registries supported by the program. The cancer statistics provide current data from registered areas and aims to accurately reflect the cancer burden and epidemic in China. In 2014, the NCCR collected data for calendar year 2011 from 234 registries. After comprehensive quality＇ evaluation, data from 177 registries have been selected as sources of the reports reflecting cancer incidence and mortaliD, in the registration areas in 2011. These reports are the updated cancer statistics so far, covering much more registries and a hig population.

Expression of mutant type-p53 products in H pylori-associated chronic gastritis

AIM： To investigate the mutation of p53 immunohistochemically in non-tumorous gastric mucosa with H pylori infection before and aEer H pylori eradication therapy. METHODS： 53 subjects （36 male, 17 female, mean age ± SEM, 57.1 ± 12.1） undergoing endoscopic examination were included in this study. 42 of 53 patients were H pylori-positive, and 11 were H pylorinegative. All H pylori-positive patients had successful eradication therapy. Biopsy specimens were taken from five points of the stomach, as recommended by the updated Sydney system. Immunohistochemical studies were performed by using primary antibodies against p53 （DO-7 and PAb240）. RESULTS： p53 （DO-7 and PAb240） immunoreactivity was shown in the neck region of the gastric pits, however, quite a few cells were found to be immunopositive for p53 （PAb240）in the Hpylori-infected gastric mucosa. The proportion of patients immunopositive for p53 （PAb240） was significantly reduced 6 mo after eradication [28/42 （66.7%） to 6/42 （14.3%）] （P 〈 0.05）, while the biopsies taken from H pylori-negative patients showed no immunoreactivity for p53 （PAb240）. p53 （PAb240）-positive patients were divided into two groups by the number of positive cells detected： one with more than six positive cells per 10 gastric pits （group A, n = 12）, and the other with less than five positive cells per 10 gastric pits （group B, n = 30）. Atrophy scores in group A were significant higher than those in group B at the greater curvature of the antrum （group A： 2.00 ± 0.14 vs group B： 1.40 ± 0.15, P = 0.012）, the lesser curvature of the corpus （group A： 2.00 ± 0.21 vs group B： 1.07 ± 0.23, P = 0.017）, and the greater curvature of the corpus （group A： 1.20 ± 0.30 vs group B： 0.47 ±0.21, P = 0.031）. Group A showed significant higher intestinal metaplasia scores than group B only at the lesser curvature of the antrum （group A： 2.10 ± 0.41 vs group B： 1.12 ± 0.29, P = 0.035）. CONCLUSION： H pylori-associated chronic gastritis expressed the mutant-type p53, which was significantly associated with more severe atrophic and metaplastic changes. Hpylori eradication led to a significant reduction in the expression of the mutant-type p53. It is considered that H pylori-infected chronic gastritis is associated with a genetic instability that leads to gastric carcinogenesis, and H pylori eradication may prevent gastric cancer.

Updated Kimura-Takemoto classification of atrophic gastritis

BACKGROUND The Updated Sydney system for visual evaluation of gastric mucosal atrophy viaendoscopic observation is subject to sampling error and interobserver variability.The Kimura-Takemoto classification system was developed to overcome theselimitations.AIMTo compare the morphological classification of atrophic gastritis between theKimura-Takemoto system and the Updated Sydney system.METHODSA total of 169 patients with atrophic gastritis were selected according to diagnosisby the visual endoscopic Kimura-Takemoto method. Following the UpdatedKimura-Takemoto classification system, one antrum biopsy and five gastriccorpus biopsies were taken according to the visual stages of the Kimura-Takemoto system. The Updated Kimura-Takemoto classification system was thenapplied to each and showed 165 to have histological mucosal atrophy;theremaining 4 patients had no histological evidence of atrophy in any biopsy. The Updated Kimura-Takemoto classification was verified as a referencemorphological method and applied for the diagnosis of atrophic gastritis. Addingone more biopsy from the antrum to the six biopsies according to the Updated Kimura-Takemoto classification, constitutes the updated combined Kimura-Takemoto classification and Sydney system.RESULTSThe sensitivity for degree of mucosal atrophy assessed by the Updated Sydneysystem was 25% for mild, 36% for moderate, and 42% for severe, when comparedwith the Updated Kimura-Takemoto classification of atrophic gastritis formorphological diagnosis. Four types of multifocal atrophic gastritis wereidentified: sequential uniform (type 1;in 28%), sequential non-uniform (type 2;in7%), diffuse uniform (type 3;in 23%), diffuse non-uniform (type 4;in 24%), and"alternating atrophic – non-atrophic" (type 5;in 18%). The pattern of the spread ofatrophy, sequentially from the antrum to the cardiac segment of the stomach,which was described by the Updated Kimura-Takemoto system, washistologically confirmed in 82% of cases evaluated.CONCLUSIONThe Updated Sydney system is significantly inferior to the Updated Kimura-Takemoto classification for morphological verification of atrophic gastritis.

An Improved Model for Calculating CO_2 Solubility in Aqueous NaCl Solutions and the Application to CO_2-H_2O-NaCl Fluid Inclusions

To determine compositions,homogenization pressures and isopleths of CO2-H2O-NaCl fluid inclusions,an improved activity-fugacity model is developed to calculate CO2solubility in aqueous NaCl solutions.The model can predict the solubility of CO2in aqueous NaCl solutions from 273 K to 723 K,from1 bar to 1500 bar and from 0 to 4.5 mol kg-1of NaCl,within or close to experimental uncertainties.The average deviation between the solubility predicted

Mechanical response of transmission lines based on sliding cable element

In order to study the sliding characteristics when the cable is connected with the other rods in the transmission line structures,a linear sliding cable element based on updated Lagrangian formulation and a sliding catenary element considering the out-of-plane stiffness coefficient are put forward.A two-span and a three-span cable structures are taken as examples to verify the sliding cable elements.By comparing the tensions of the two proposed cable elements with the existing research results,the error is less than 1%,which proves the correctness of the proposed elements.The sliding characteristics should be considered in the practical engineering because of the significant difference between the tensions of sliding cable elements and those of cable element without considering sliding.The out-of-plane stiffness coefficient and friction characteristics do not obviously affect the cable tensions.

条形基础稳定性弹塑性大变形有限元分析

对土体失稳过程中弹塑性大变形的问题,采用大变形问题的UpdatedLagrangian描述方法,建立了土体稳定分析的弹塑性大变形有限元模型,提出了坐标更新和非线性方程组线性化的方法:计算了均布竖向荷载情况下的条形基础地基稳定性,通过与Prandtl解和弹塑性小变形有限元法所得结果的对比,说明了用弹塑性大变形有限元法进行土体稳定性计算是可行的.通过对倾斜荷载作用并考虑土体自重情况下的条形基础地基稳定性分析,表明弹塑性大变形有限元法不仅能反映土体抗剪强度指标对土体稳定性影响,而且也能反映土体弹性参数对土体稳定性影响,说明了用弹塑性大变形有限元法计算土体稳定性的合理性及对工程安全的重要性.

Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity

BACKGROUND Endoscopy-based Kyoto classification for gastritis and pathological topographic distribution of neutrophil infiltration are correlated with gastric cancer risk.AIM To investigate the association between Kyoto classification and the topographic distribution of neutrophil activity.METHODS Kyoto classification score,ranging from 0 to 8,consisted of atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness.Neutrophil activity was scored according to the updated Sydney System using biopsy samples obtained from the greater curvature of the corpus and the antrum.The participants were divided into four categories,inactive stomach,antrumpredominant gastritis,pangastritis,and corpus-predominant gastritis,based on the topographic distribution of neutrophil activity.Effects of sex,age,body mass index,drinking habit,smoking habit,family history of gastric cancer,serum Helicobacter pylori(H.pylori)antibody,and Kyoto score on topography of neutrophil infiltration were analyzed.RESULTS A total of 327 patients(comprising 50.7%women,with an average age of 50.2 years)were enrolled in this study.H.pylori infection rate was 82.9%with a mean Kyoto score of 4.63.The Kyoto score was associated with the topographic distribution of neutrophil activity.Kyoto scores were significantly higher in the order of inactive stomach,antrum-predominant gastritis,pangastritis,and corpuspredominant gastritis(3.05,4.57,5.21,and 5.96,respectively).Each individual score of endoscopic findings(i.e.,atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness)was correlated with the topographic distribution of neutrophil activity.On multivariate analysis,the Kyoto score,age,and serum H.pylori antibody were independently associated with the topographic distribution of neutrophil activity.CONCLUSION The Kyoto classification score was associated with the topographic distribution of neutrophil activity.

A co-rotational updated Lagrangian formulation for a 2D beam element with consideration of the deformed curvature

A tensor-based updated Lagrangian （UL） formulation for the geometrically nonlinear analysis of 2D beam-column structures is developed by using curvilinear coordinates, which has considered the effects of the deformed curvature. Between the known configuration C1 and the desired configuration C2, a configuration C2^＊ derived by rigid-body motion of C1 is introduced to eliminate the element-end transverse displacements between C2^＊ and C2. A stiffness matrix is obtained in C2^＊; and then by a transformation defined by the element-end displacements, the stiffness matrix in C2^＊ is transformed into that in CI. Comparing the stiffness matrix with that in the conventional UL formulation for a 2D beam element, the initial displacement stiffness matrix emerges, which results from the deformed curvature within the element. Numerical examples have verified the accuracy and efficiency of the present formulation, and the results show that the deformed curvatures have significant effects when deformations are large.

NDC-IVM:An automatic segmentation of optic disc and cup region from medical images for glaucoma detection

Glaucoma is an eye disease that usually occurs with the increased Intra-Ocular Pressure(IOP),which damages the vision of eyes.So,detecting and classifying Glaucoma is an important and demanding task in recent days.For this purpose,some of the clustering and segmentation techniques are proposed in the existing works.But,it has some drawbacks that include ineficient,inaccurate and estimates only the affected area.In order to solve these issues,a Neighboring Differential Clustering(NDC)-Intensity V ariation Making(IVM)are proposed in this paper.The main intention of this work is to extract and diagnose the abnormal retinal image by identifying the optic disc.This work includes three stages such as,preprocessing,clustering and segmentation.At first,the given retinal image is preprocessed by using the Gaussian Mask Updated(GMU)model for eliminating the noise and improving the quality of the image.Then,the cluster is formed by extracting the threshold and patterns with the help of NDC technique.In the segmentation stage,the weight is calculated for pixel matching and ROI extraction by using the proposed IVM method.Here,the novelty is presented in the clustering and segmentation processes by developing NDC and IVM algorithms for accurate Glaucoma identification.In experiments,the results of both existing and proposed techniques are evaluated in terms of sensitivity,specificity,accuracy,Hausdorff distance,Jaccard and dice metrics.

Instructions for authors

Journal of Genetics and Genomics (JGG, formerly known as Acta Genetica Sinica) is one of the China’s leading journals in the life science. JGG is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology, the Chinese Academy of

Instructions for authors

Last updated on Novermber 15, 2007 Journal of Genetics and Genomics (JGG, formerly known as Acta Genetica Sinica) is one of China’s leading journals in the life science.

Common Medical Problems in the Tropics-C.R.Schull

Common Medical Problems in the Tropics has been expanded to provide a comprehensive reference book on adult internal medicine for use in tropical developing countries.It is intended for use by senior paramedical workers,such as clinical officers,health officers,medical assistants,health extension officers, senior nurses and others.It will be particularly useful for students and those newly qualified;and for those who have other specialisms or who do not usually deal with medical problems in tropical developing countries.

Definition of hyperparasitemia in severe falciparum malaria should be updated

Hyperparasitemia is one criterion of severe falciparum malariaby World Health Organization(WHO)for more than two decades[1].Although there is a correlation between density of parasittemiaand severity of malaria,some individuals with high parasite countsmay not be severely ill,whereas others with low parasitemia mayhave ultimately fatal infections.Hyperparasitemia(more than 5%