Understanding the physiological adaptations of non-treeline trees to environmental stress is important to understand future shifts in species composition and distribution of current treeline ecotone.The aim of the pre...Understanding the physiological adaptations of non-treeline trees to environmental stress is important to understand future shifts in species composition and distribution of current treeline ecotone.The aim of the present study was to elucidate the mechanisms of the formation of the upper elevation limit of non-treeline tree species,Picea jezoensis,and the carbon allocation strategies of the species on Changbai Mountain.We employed the^(13)C in situ pulse labeling technique to trace the distribution of photosynthetically assimilated carbon in Picea jezoensis at different elevational positions(tree species at its upper elevation limit(TSAUE,1,700 m a.s.l.)under treeline ecotone;tree species at a lower elevation position(TSALE,1,400 m a.s.l.).We analyzed^(13)C and the non-structural carbohydrate(NSC)concentrations in various tissues following labeling.Our findings revealed a significant shift in carbon allocation in TSAUE compared to TSALE.There was a pronounced increase inδ^(13)C allocation to belowground components(roots,soil,soil respiration)in TSAUE compared to TSALE.Furthermore,the C flow rate within the plant-soil-atmosphere system was faster,and the C residence time in the plant was shorter in TSAUE.The trends indicate enhanced C sink activity in belowground tissues in TSAUE,with newly assimilated C being preferentially directed there,suggesting a more conservative C allocation strategy by P.jezoensis at higher elevations under harsher environments.Such a strategy,prioritizing C storage in roots,likely aids in withstanding winter cold stress at the expense of aboveground growth during the growing season,leading to reduced growth of TSAUE compared to TSALE.The results of the present study shed light on the adaptive mechanisms governing the upper elevation limits of non-treeline trees,and enhances our understanding of how non-treeline species might respond to ongoing climate change.展开更多
We discuss how to determine and combine upper limits based on observed events and estimated back- grounds with a Bayesian method, when insignificant signals are observed in independent measurements. In addition to som...We discuss how to determine and combine upper limits based on observed events and estimated back- grounds with a Bayesian method, when insignificant signals are observed in independent measurements. In addition to some general features deduced from the analytical formulae, systematic numerical results are obtained by a C++ program (CULBA) for low-count experiments, which can be used as a reference to combine two upper limits.展开更多
In this paper, the method of relaxed boundary conditions is applied to rectangular plates with edges which are a sort of the mixture of simply supported portions and clamped portions, so that the lower limit of fundam...In this paper, the method of relaxed boundary conditions is applied to rectangular plates with edges which are a sort of the mixture of simply supported portions and clamped portions, so that the lower limit of fundamental frequency of such plates is evaluated. A kind of polynomial satisfying the displacement boundary conditions is designed, os that it is enabled to evaluate the upper limit of fundamental frequency by Ritz' method. The practical calculation examples solved by these methods have given satisfactory results. At the end of this paper, it is pointed out that the socalled exact solution of such plates usually evaluated by the force superposition method is essentially a kind of lower limit of solution, if the truncated error of series which occurs in actual calculation is considered.展开更多
The growing prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)is being driven by the obesity epidemic.The quest for solutions continues particularly with regard to early detection.This edito...The growing prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)is being driven by the obesity epidemic.The quest for solutions continues particularly with regard to early detection.This editorial comments on the utility of long-term high-normal alanine aminotransferase(ALT)in screening for MASLD.Chen et al found that new onset MASLD can be detected by repetitively high normal ALT.Implicit in this concept is the question of what should be the accepted upper limit of normal(ULN)for ALT.It was previously set at 40 IU/L based on studies that included people with subclinical liver disease but the new consensus is 30/19 U/L in healthy males/females.Thus,when Chen et al defines the ULN as 40 U/L,others may view it as excessively high.It is important to recognize the variables affecting ULN e.g.instrumentation,diurnal variations,exercise and ageing.These variables matter when the distinctions are subtle e.g.normal vs high-normal.In this regard,the utility of long-term high normal ALT as a disease marker could be enhanced by combining it with other biomarkers,imaging and MASLD genetics to create machine learning classifiers.All in all,Chen et al’s work on long-term high normal ALT as a marker of new-onset MASLD deserves merit.展开更多
In this editorial,we offer commentary on the article published by Chen et al in a recent issue of the World Journal of Gastroenterology(2024;30:1346-1357).The study highlights a noteworthy association between persiste...In this editorial,we offer commentary on the article published by Chen et al in a recent issue of the World Journal of Gastroenterology(2024;30:1346-1357).The study highlights a noteworthy association between persistently elevated,yet highnormal levels of alanine transaminase(ALT)and an escalated cumulative risk of developing metabolic dysfunction-associated fatty liver disease(MAFLD).MAFLD has emerged as a globally prevalent chronic liver condition,whose incidence is steadily rising in parallel with improvements in living standards.Left unchecked,MAFLD can progress from hepatic steatosis to liver fibrosis,cirrhosis,and even hepatocellular carcinoma,underscoring the importance of early screening and diagnosis.ALT is widely recognized as a reliable biomarker for assessing the extent of hepatocellular damage.While ALT levels demonstrate a significant correlation with the severity of fatty liver disease,they lack specificity.The article by Chen et al contributes to our understanding of the development of MAFLD by investigating the long-term implications of high-normal ALT levels.Their findings suggest that sustained elevation within the normal range is linked to an increased likelihood of developing MAFLD,emphasizing the need for closer monitoring and potential intervention in such cases.展开更多
Let x 1,x 2,… be independent identically distributed (i.i.d.) random variables, in which x n=0 or 1 and the probability of {x n=1} is p. Here p is unknown. Let τ be any finite stopping ...Let x 1,x 2,… be independent identically distributed (i.i.d.) random variables, in which x n=0 or 1 and the probability of {x n=1} is p. Here p is unknown. Let τ be any finite stopping time for (x n,n1). For any sequential sample (x 1,x 2,…,x τ ) and γ∈(0,1), we have given an optimal confidence limit of p with confidence level γ . Some related problems are also discussed.展开更多
High pressure and water-bearing caverns ahead of a karst tunnel face tend to cause geological disasters, such as water and mud bursts. So, the determination of safe thickness of the reserved rock plug is a key technic...High pressure and water-bearing caverns ahead of a karst tunnel face tend to cause geological disasters, such as water and mud bursts. So, the determination of safe thickness of the reserved rock plug is a key technical problem to be solved for karst tunnel construction. Based on the Hoek-Brown nonlinear failure criterion, the minimum safe thickness of rock plug was investigated in the light of the limit analysis theory. On the basis of the proposed failure mode, the expression of the minimum thickness for rock plug was obtained by means of upper bound theorem in combination with variational principle. The calculation results show the influence of each parameter on safe thickness and reveal the damage range of rock plug. The proposed method is verified by comparing the results with those of the drain cavern of Maluqing Tunnel. The research shows that with the increase of compressive strength and tensile strength as well as constant A of Hoek-Brown criterion, the safe thickness decreases, whereas with the increase of cavern pressure, tunnel diameter, and constant B from Hoek-Brown criterion, the safe thickness increases. Besides, the tensile strength, or constants A and B affect the shear failure angle of rock plug structure, but other parameters do not. In conclusion, the proposed method can predict the minimum safe thickness of rock plug, and is useful for water burst study and prevention measures of tunnels constructed in high-risk karst regions.展开更多
Based on the nonlinear Mohr-Coulomb failure criterion and the associated flow rules,the three-dimensional(3-D)axisymmetric failure mechanism of shallow horizontal circular plate anchors that are subjected to the ultim...Based on the nonlinear Mohr-Coulomb failure criterion and the associated flow rules,the three-dimensional(3-D)axisymmetric failure mechanism of shallow horizontal circular plate anchors that are subjected to the ultimate pullout capacity(UPC)is determined.A derivative function of the projection function for projecting the 3-D axisymmetric failure surface on plane is deduced using the variation theory.By using difference principle,the primitive function of failure surface satisfying boundary condition and numerical solution to its corresponding ultimate pullout capacity function are obtained.The influences of nonlinear Mohr-Coulomb parameters on UPC and failure mechanism are studied.The result shows that UPC decreases with dimensionless parameter m and uniaxial tensile strength increases but increases when depth and radius of plate anchor,surface overload,initial cohesion,geomaterial density and friction angle increase.The failure surface is similar to a symmetrical spatial funnel,and its shape is mainly determined by dimensionless parameter m;the surface damage range expands with the increase of radius and depth of the plate anchor as well as initial cohesion but decreases with the increase of dimensionless parameter m and uniaxial tensile strength as well as geomaterial density.As the dimensionless parameter m=2.0,the numerical solution of UPC based on the difference principle is proved to be feasible and effective through the comparison with the exact solution.In addition,the comparison between solutions of UPC computed by variation method and those computed by upper bound method indicate that variation method outperforms upper bound method.展开更多
We analyzed the influence of climate change over the past 50 years on the radial growth of two tree species: Korean pine (Pinus koraiensis) and Yezo spruce (Picea jezoensis), located on Changbai Mountain, Northeast Ch...We analyzed the influence of climate change over the past 50 years on the radial growth of two tree species: Korean pine (Pinus koraiensis) and Yezo spruce (Picea jezoensis), located on Changbai Mountain, Northeast China, using a dendrochronology approach to understand factors that limit the altitude for tree species. Elevated temperatures increased the radial growth of Korean pine and decreased that of Yezo spruce. The positive response of tree growth to hydrothermal conditions was the key reason that the upper limit of elevation of Korean pine followed the temperature fluctuation pattern. Increased temperatures and precipitation and longer growing seasons accelerated Korean pine growth. As the temperature increased, correlations between Korean pine ring-width chronology and precipitation changed from negative to positive. In Yezo spruce, increasing monthly temperatures and inadequate precipitation during the middle and late parts of the growing season led to narrow growth rings, whereas decreasing monthly temperatures and sufficient precipitation during the late growing season promoted growth. Rising temperatures and adequate precipitation increases Korean pine growth, possibly elevating the upper range limit in altitude for this species. In contrast, Yezo spruce growth is negatively affected by warming temperatures and limited precipitation. Under future temperature increases and precipitation fluctuations, the upper limit altitude of Korean pine can reasonably be expected to shift upward and Yezo spruce downward.展开更多
A generalized nonlinear Baker failure criterion is employed with the upper bound limit analysis to study the surrounding rock stability of underground cavities. A three-dimensional(3D) failure mode is established by e...A generalized nonlinear Baker failure criterion is employed with the upper bound limit analysis to study the surrounding rock stability of underground cavities. A three-dimensional(3D) failure mode is established by extending the two-dimensional(2D) failure mode, which offers an upper bound expression of the surrounding rock pressure. This method is validated with a series of examples before the influence of four parameters of scale parameter, curvature parameter, shift parameter and lateral pressure coefficient, on the surrounding rock pressure is analyzed. According to these results, failure ranges of the underground cavities are determined. The following conclusions are reached:(1) the proposed approach is more accurate to predict surrounding rock pressure than the Mohr-Coulomb failure criterion;(2) the surrounding rock with large scale parameter, curvature parameter, shift parameter, and lateral pressure coefficient can lead to a more stable underground cavity;(3) the failure range in 3D mode can be predicted according to the upper bound solutions.展开更多
We demonstrate a diode pumped Yb:LuVO4 laser that can be passively Q-switched by a Cr^(4+):YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generat...We demonstrate a diode pumped Yb:LuVO4 laser that can be passively Q-switched by a Cr^(4+):YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generated at a repetition rate of 285.7 kHz,approaching or very near the intrinsic upper limit imposed by the recovery time of the Cr^(4+):YAG saturable absorber,and the resulting pulse energy,duration and peak power are,respectively,8.2μJ,39.2ns and 0.209kW.展开更多
The natural element method (NEM) is a newly- developed numerical method based on Voronoi diagram and Delaunay triangulation of scattered points, which adopts natural neighbour interpolation to construct trial functi...The natural element method (NEM) is a newly- developed numerical method based on Voronoi diagram and Delaunay triangulation of scattered points, which adopts natural neighbour interpolation to construct trial functions in the framework of Galerkin method. Owing to its distinctive advantages, the NEM is used widely in many problems of computational mechanics. Utilizing the NEM, this paper deals with numerical limit analysis of structures made up of perfectly rigid-plastic material. According to kinematic the- orem of plastic limit analysis, a mathematical programming natural element formulation is established for determining the upper bound multiplier of plane problems, and a direct iteration algorithm is proposed accordingly to solve it. In this algorithm, the plastic incompressibility condition is handled by two different treatments, and the nonlinearity and nons- moothness of the goal function are overcome by distinguishing the rigid zones from the plastic zones at each iteration. The procedure implementation of iterative process is quite simple and effective because each iteration is equivalent to solving an associated elastic problem. The obtained limit load multiplier is proved to monotonically converge to the upper bound of true solution. Several benchmark examples are investigated to validate the significant performance of the NEM in the application field of limit analysis.展开更多
The analytical solutions for predicting the exact shape of collapse mechanisms in shallow tunnels with arbitrary excavation profiles were obtained by virtue of the upper bound theorem of limit analysis and variation p...The analytical solutions for predicting the exact shape of collapse mechanisms in shallow tunnels with arbitrary excavation profiles were obtained by virtue of the upper bound theorem of limit analysis and variation principle according to Hoek-Brown failure criterion. The seepage force was included in the upper bound limit analysis, and it was computed from the gradient of excess pore pressure distribution. The seepage was regarded as a work rate of external force. The numerical results of roof collapse in square and circular tunnels with different rock parameters were derived and discussed, which proves to be valid in comparison with the previous work. The influences of different parameters on the shape of collapsing blocks were also discussed.展开更多
A kinematically admissible velocity field which is different from Avitzur's is established in Cartesian Coordinates. An upper-bound analytical solution to strip drawing andextrusion is obtained by using the integr...A kinematically admissible velocity field which is different from Avitzur's is established in Cartesian Coordinates. An upper-bound analytical solution to strip drawing andextrusion is obtained by using the integral as a function of the upper limit in this paper.展开更多
The paper is a contribution to the technical discussion concerning the collapses of the WTC buildings. It returns to the problem of the dynamics of the collapses;it does not concern the reason why the buildings starte...The paper is a contribution to the technical discussion concerning the collapses of the WTC buildings. It returns to the problem of the dynamics of the collapses;it does not concern the reason why the buildings started collapsing, but investigates the dynamics of the collapse itself. It works with the same assumptions as the official NIST report [1], i.e. that the falling mass hits the motionless mass beneath;the supporting columns loose stability and the mass of the pertinent floor starts to fall together with the falling mass. The aim was to derive the theoretical upper limit of the speed of the collapse, supposing that influence of the columns which resist the fall, is neglected. The differential equation of the fall was obtained using two independent laws of mechanics, with the identical result. Its solution can be found from a very simple explicit formula. The theoretical upper limit acceleration of the fall obtained by such formula is one third of the gravitational acceleration, which is faster than it was observed in the case of the collapses of WTC1 and WTC2. This leads to the conclusion that the mechanism of the collapse must be different from the assumed and the falling mass must not hit the motionless mass bellow it, but rather a mass which had started to fall before the impact of the falling mass occurred.展开更多
This paper presents two kinematic failure mechanisms of threc-dimensional rectangular footing resting on homogeneous undrained clay foundation under uniaxial vertical loading and uniaxial moment loading. The failure m...This paper presents two kinematic failure mechanisms of threc-dimensional rectangular footing resting on homogeneous undrained clay foundation under uniaxial vertical loading and uniaxial moment loading. The failure mechanism under vertical loading comprises a plane strain Prandti-type mechanism over the central part of the longer side, and the size of the mechanism gradually reduces at the ends of the longer side and over the shorter side as the corner of rectangular footing is being approached where the direction of soil motion remains normal to each corresponding side respectively. The failure mechanism under moment loading comprises a plane strain scoop sliding mechanism over the central part of the longer side, and the radius of scoop sliding mechanism increases linearly at the ends of the longer side. On the basis of the kinematic failure mechanisms mentioned above, the vertical ultimate bearing capacity and the ultimate bearing capacity against moment or moment ultimate bearing capacity are obtained by use of upper bound limit analysis theory. At the same time, numerical analysis results, Skempton' s results and Salgado et al. 's results are compared with this upper bound solution. It shows that the presented failure mechanisms and plastic limit analysis predictions are validated. In order to investigate the behaviors of undrained clay foundation beneath the rectangular footing subjected to the combined loadings, numerical analysis is adopted by virtue of the general-purpose FEM software ABAQUS, where the clay is assumed to obey the Mohr-Coulomb yielding criterion. The failure envelope and the ultimate bearing capacity are achieved by the numerical analysis results with the varying aspect ratios from length L to breadth B of the rectangular footing. The failure mechanisms of rectangular footing which are subjected to the combined vertical loading V and horizontal loading H (Vertical loading V and moment loading M, and horizontal loading H and moment loading M respectively are observed in the finite element analysis. ) is explained by use of the upper bound plasticity limit analysis theory. Finally, the reason of eccentricity of failure envelope in H-M loading space is given in this study, which can not be explained by use of the traditional ' swipe test'.展开更多
Non-liner wave equation inversion,wavelet analysis and artificial neural networks were used to obtain stratum parameters and the distribution of thin coal seams.The lithology of the water-bearing/resisting layer in th...Non-liner wave equation inversion,wavelet analysis and artificial neural networks were used to obtain stratum parameters and the distribution of thin coal seams.The lithology of the water-bearing/resisting layer in the Quaternary system was also predicted.The implementation process included calculating the well log parameters,stratum contrasting the seismic data and the well logs,and extracting,studying and predicting seismic attributes.Seismic inversion parameters,including the layer velocity and wave impedance,were calculated and effectively used for prediction and analysis.Prior knowledge and seismic interpretation were used to remedy a dearth of seismic data during the inversion procedure.This enhanced the stability of the inversion method.Non-linear seismic inversion and artificial neural networks were used to interpret coal seismic lithology and to study the water-bearing/resisting layer in the Quaternary system.Interpretation of the 1~2 m thin coal seams,and also of the water-bearing/resisting layer in the Quaternary system,is provided.The upper mining limit can be lifted from 60 m to 45 m.The predictions show that this method can provide reliable data useful for thin coal seam exploitation and for lifting the upper mining limit,which is one of the principles of green mining.展开更多
Based on the slip-line field theory, a two-dimensional slip failure mechanism with mesh-like rigid block system was constructed to analyze the ultimate bearing capacity problems of rough foundation within the framewor...Based on the slip-line field theory, a two-dimensional slip failure mechanism with mesh-like rigid block system was constructed to analyze the ultimate bearing capacity problems of rough foundation within the framework of the upper bound limit analysis theorem. In the velocity discontinuities in transition area, the velocity changes in radial and tangent directions are allowed. The objective functions of the stability problems of geotechnical structures are obtained by equating the work rate of external force to internal dissipation along the velocity discontinuities, and then the objective functions are transformed as an upper-bound mathematic optimization model. The upper bound solutions for the objective functions are obtained by use of the nonlinear sequential quadratic programming and interior point method. From the numerical results and comparative analysis, it can be seen that the method presented in this work gives better calculation results than existing upper bound methods and can be used to establish the more accurate plastic collapse load for the ultimate bearing capacity of rough foundation.展开更多
In the framework of upper bound theorem of limit analysis, the progressive collapse of shallow rectangular tunnels with double-layer rock mass has been theoretically analyzed based on the three-dimensional (3D) veloci...In the framework of upper bound theorem of limit analysis, the progressive collapse of shallow rectangular tunnels with double-layer rock mass has been theoretically analyzed based on the three-dimensional (3D) velocity discontinuity surfaces. According to the virtual work principle, the difference theorem and the variation method, the collapse surface of double-layer rock mass is determined based on the Hoek-Brown failure criterion. The formula can be degenerated to a single-layer rock collapsing problem when the rock mass is homogeneous. To estimate the validity of the result, the numerical simulation software PLAXIS 3D is used to simulate the collapse of shallow tunnels with double-layer rock mass, and the comparative analysis shows that numerical results are in good agreement with upper-bound solutions. According to the results of parametric analysis, the potential range of collapse of a double-layer rock mass above a shallow cavity decreases with a decrease in A1/A2,σci1/σci2 and σtm1/σtm2 and an increase in B1/B2,γ1/γ2. The range will decrease with a decrease in support pressure q and increase with a decrease in surface overload σs. Therefore, reinforced supporting is beneficial to improve the stability of the cavity during actual construction.展开更多
A high-voltage transverse pulsed nanosecond discharge with a slotted hollow cathode was found to be a source of high-energy (few kV) ribbon electron beams. Conditions for the formation and extinction of electron bea...A high-voltage transverse pulsed nanosecond discharge with a slotted hollow cathode was found to be a source of high-energy (few kV) ribbon electron beams. Conditions for the formation and extinction of electron beams were experimentally studied in discharges in helium at pressures of 1-100 Torr. It was found that interaction of fast electrons with a non-uniform electric field near the slotted cathode led to limitation of the magnitude of the discharge current. A physical model was developed to describe the discharge current self-limitation that was in satisfactory agreement with the experimental results. Some technical solutions that are expected to increase the upper current limits in transverse nanosecond discharge are discussed.展开更多
基金supported by the National Natural Science Foundation of China(Grant numbers 4237105242271100+3 种基金4197112442371095)the Natural Science Foundation of Jilin Province,China(Nos.YDZJ202201ZYTS483YDZJ202201ZYTS470)。
文摘Understanding the physiological adaptations of non-treeline trees to environmental stress is important to understand future shifts in species composition and distribution of current treeline ecotone.The aim of the present study was to elucidate the mechanisms of the formation of the upper elevation limit of non-treeline tree species,Picea jezoensis,and the carbon allocation strategies of the species on Changbai Mountain.We employed the^(13)C in situ pulse labeling technique to trace the distribution of photosynthetically assimilated carbon in Picea jezoensis at different elevational positions(tree species at its upper elevation limit(TSAUE,1,700 m a.s.l.)under treeline ecotone;tree species at a lower elevation position(TSALE,1,400 m a.s.l.).We analyzed^(13)C and the non-structural carbohydrate(NSC)concentrations in various tissues following labeling.Our findings revealed a significant shift in carbon allocation in TSAUE compared to TSALE.There was a pronounced increase inδ^(13)C allocation to belowground components(roots,soil,soil respiration)in TSAUE compared to TSALE.Furthermore,the C flow rate within the plant-soil-atmosphere system was faster,and the C residence time in the plant was shorter in TSAUE.The trends indicate enhanced C sink activity in belowground tissues in TSAUE,with newly assimilated C being preferentially directed there,suggesting a more conservative C allocation strategy by P.jezoensis at higher elevations under harsher environments.Such a strategy,prioritizing C storage in roots,likely aids in withstanding winter cold stress at the expense of aboveground growth during the growing season,leading to reduced growth of TSAUE compared to TSALE.The results of the present study shed light on the adaptive mechanisms governing the upper elevation limits of non-treeline trees,and enhances our understanding of how non-treeline species might respond to ongoing climate change.
基金Supported by National Natural Science Foundation of China(NSFC)(11005115),Joint Funds of the NSFC and Chinese Academia Sinica's Big Scientific Apparatus(U1232109)
文摘We discuss how to determine and combine upper limits based on observed events and estimated back- grounds with a Bayesian method, when insignificant signals are observed in independent measurements. In addition to some general features deduced from the analytical formulae, systematic numerical results are obtained by a C++ program (CULBA) for low-count experiments, which can be used as a reference to combine two upper limits.
文摘In this paper, the method of relaxed boundary conditions is applied to rectangular plates with edges which are a sort of the mixture of simply supported portions and clamped portions, so that the lower limit of fundamental frequency of such plates is evaluated. A kind of polynomial satisfying the displacement boundary conditions is designed, os that it is enabled to evaluate the upper limit of fundamental frequency by Ritz' method. The practical calculation examples solved by these methods have given satisfactory results. At the end of this paper, it is pointed out that the socalled exact solution of such plates usually evaluated by the force superposition method is essentially a kind of lower limit of solution, if the truncated error of series which occurs in actual calculation is considered.
文摘The growing prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)is being driven by the obesity epidemic.The quest for solutions continues particularly with regard to early detection.This editorial comments on the utility of long-term high-normal alanine aminotransferase(ALT)in screening for MASLD.Chen et al found that new onset MASLD can be detected by repetitively high normal ALT.Implicit in this concept is the question of what should be the accepted upper limit of normal(ULN)for ALT.It was previously set at 40 IU/L based on studies that included people with subclinical liver disease but the new consensus is 30/19 U/L in healthy males/females.Thus,when Chen et al defines the ULN as 40 U/L,others may view it as excessively high.It is important to recognize the variables affecting ULN e.g.instrumentation,diurnal variations,exercise and ageing.These variables matter when the distinctions are subtle e.g.normal vs high-normal.In this regard,the utility of long-term high normal ALT as a disease marker could be enhanced by combining it with other biomarkers,imaging and MASLD genetics to create machine learning classifiers.All in all,Chen et al’s work on long-term high normal ALT as a marker of new-onset MASLD deserves merit.
基金Supported by the Natural Science Foundation of Sichuan Province,No.24NSFSC0163State Key Clinical Department of Oral&Maxillofacial Surgery。
文摘In this editorial,we offer commentary on the article published by Chen et al in a recent issue of the World Journal of Gastroenterology(2024;30:1346-1357).The study highlights a noteworthy association between persistently elevated,yet highnormal levels of alanine transaminase(ALT)and an escalated cumulative risk of developing metabolic dysfunction-associated fatty liver disease(MAFLD).MAFLD has emerged as a globally prevalent chronic liver condition,whose incidence is steadily rising in parallel with improvements in living standards.Left unchecked,MAFLD can progress from hepatic steatosis to liver fibrosis,cirrhosis,and even hepatocellular carcinoma,underscoring the importance of early screening and diagnosis.ALT is widely recognized as a reliable biomarker for assessing the extent of hepatocellular damage.While ALT levels demonstrate a significant correlation with the severity of fatty liver disease,they lack specificity.The article by Chen et al contributes to our understanding of the development of MAFLD by investigating the long-term implications of high-normal ALT levels.Their findings suggest that sustained elevation within the normal range is linked to an increased likelihood of developing MAFLD,emphasizing the need for closer monitoring and potential intervention in such cases.
文摘Let x 1,x 2,… be independent identically distributed (i.i.d.) random variables, in which x n=0 or 1 and the probability of {x n=1} is p. Here p is unknown. Let τ be any finite stopping time for (x n,n1). For any sequential sample (x 1,x 2,…,x τ ) and γ∈(0,1), we have given an optimal confidence limit of p with confidence level γ . Some related problems are also discussed.
基金Project(2013CB036004)supported by the National Basic Research Program of ChinaProject(51378510)supported by the National Natural Science Foundation of ChinaProject(CX2014B069)supported by Hunan Provincial Innovation Foundation for Postgraduate,China
文摘High pressure and water-bearing caverns ahead of a karst tunnel face tend to cause geological disasters, such as water and mud bursts. So, the determination of safe thickness of the reserved rock plug is a key technical problem to be solved for karst tunnel construction. Based on the Hoek-Brown nonlinear failure criterion, the minimum safe thickness of rock plug was investigated in the light of the limit analysis theory. On the basis of the proposed failure mode, the expression of the minimum thickness for rock plug was obtained by means of upper bound theorem in combination with variational principle. The calculation results show the influence of each parameter on safe thickness and reveal the damage range of rock plug. The proposed method is verified by comparing the results with those of the drain cavern of Maluqing Tunnel. The research shows that with the increase of compressive strength and tensile strength as well as constant A of Hoek-Brown criterion, the safe thickness decreases, whereas with the increase of cavern pressure, tunnel diameter, and constant B from Hoek-Brown criterion, the safe thickness increases. Besides, the tensile strength, or constants A and B affect the shear failure angle of rock plug structure, but other parameters do not. In conclusion, the proposed method can predict the minimum safe thickness of rock plug, and is useful for water burst study and prevention measures of tunnels constructed in high-risk karst regions.
基金Project(51478477)supported by the National Natural Science Foundation of ChinaProject(2016CX012)supported by the Innovation-driven Project of Central South University,ChinaProject(2014122006)supported by the Guizhou Provincial Department of Transportation Foundation,China
文摘Based on the nonlinear Mohr-Coulomb failure criterion and the associated flow rules,the three-dimensional(3-D)axisymmetric failure mechanism of shallow horizontal circular plate anchors that are subjected to the ultimate pullout capacity(UPC)is determined.A derivative function of the projection function for projecting the 3-D axisymmetric failure surface on plane is deduced using the variation theory.By using difference principle,the primitive function of failure surface satisfying boundary condition and numerical solution to its corresponding ultimate pullout capacity function are obtained.The influences of nonlinear Mohr-Coulomb parameters on UPC and failure mechanism are studied.The result shows that UPC decreases with dimensionless parameter m and uniaxial tensile strength increases but increases when depth and radius of plate anchor,surface overload,initial cohesion,geomaterial density and friction angle increase.The failure surface is similar to a symmetrical spatial funnel,and its shape is mainly determined by dimensionless parameter m;the surface damage range expands with the increase of radius and depth of the plate anchor as well as initial cohesion but decreases with the increase of dimensionless parameter m and uniaxial tensile strength as well as geomaterial density.As the dimensionless parameter m=2.0,the numerical solution of UPC based on the difference principle is proved to be feasible and effective through the comparison with the exact solution.In addition,the comparison between solutions of UPC computed by variation method and those computed by upper bound method indicate that variation method outperforms upper bound method.
基金financially supported by the Key Basic Research Project‘‘973’’(2010CB951301-5)the China Bureau of Foreign Experts and the Ministry of Education of China(111 Program,Grant 2008-B08044)
文摘We analyzed the influence of climate change over the past 50 years on the radial growth of two tree species: Korean pine (Pinus koraiensis) and Yezo spruce (Picea jezoensis), located on Changbai Mountain, Northeast China, using a dendrochronology approach to understand factors that limit the altitude for tree species. Elevated temperatures increased the radial growth of Korean pine and decreased that of Yezo spruce. The positive response of tree growth to hydrothermal conditions was the key reason that the upper limit of elevation of Korean pine followed the temperature fluctuation pattern. Increased temperatures and precipitation and longer growing seasons accelerated Korean pine growth. As the temperature increased, correlations between Korean pine ring-width chronology and precipitation changed from negative to positive. In Yezo spruce, increasing monthly temperatures and inadequate precipitation during the middle and late parts of the growing season led to narrow growth rings, whereas decreasing monthly temperatures and sufficient precipitation during the late growing season promoted growth. Rising temperatures and adequate precipitation increases Korean pine growth, possibly elevating the upper range limit in altitude for this species. In contrast, Yezo spruce growth is negatively affected by warming temperatures and limited precipitation. Under future temperature increases and precipitation fluctuations, the upper limit altitude of Korean pine can reasonably be expected to shift upward and Yezo spruce downward.
基金Projects(51679117,11772358,51774322,51474249,51404179,51274249)supported by the National Natural Science Foundation of China。
文摘A generalized nonlinear Baker failure criterion is employed with the upper bound limit analysis to study the surrounding rock stability of underground cavities. A three-dimensional(3D) failure mode is established by extending the two-dimensional(2D) failure mode, which offers an upper bound expression of the surrounding rock pressure. This method is validated with a series of examples before the influence of four parameters of scale parameter, curvature parameter, shift parameter and lateral pressure coefficient, on the surrounding rock pressure is analyzed. According to these results, failure ranges of the underground cavities are determined. The following conclusions are reached:(1) the proposed approach is more accurate to predict surrounding rock pressure than the Mohr-Coulomb failure criterion;(2) the surrounding rock with large scale parameter, curvature parameter, shift parameter, and lateral pressure coefficient can lead to a more stable underground cavity;(3) the failure range in 3D mode can be predicted according to the upper bound solutions.
基金Supported by the National Natural Science Foundation of China under Grant No 11574170
文摘We demonstrate a diode pumped Yb:LuVO4 laser that can be passively Q-switched by a Cr^(4+):YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generated at a repetition rate of 285.7 kHz,approaching or very near the intrinsic upper limit imposed by the recovery time of the Cr^(4+):YAG saturable absorber,and the resulting pulse energy,duration and peak power are,respectively,8.2μJ,39.2ns and 0.209kW.
基金supported by the National Foundation for Excellent Doctoral Thesis of China (200025)the Program for New Century Excellent Talents in University (NCET-04-0075)the National Natural Science Foundation of China (19902007)
文摘The natural element method (NEM) is a newly- developed numerical method based on Voronoi diagram and Delaunay triangulation of scattered points, which adopts natural neighbour interpolation to construct trial functions in the framework of Galerkin method. Owing to its distinctive advantages, the NEM is used widely in many problems of computational mechanics. Utilizing the NEM, this paper deals with numerical limit analysis of structures made up of perfectly rigid-plastic material. According to kinematic the- orem of plastic limit analysis, a mathematical programming natural element formulation is established for determining the upper bound multiplier of plane problems, and a direct iteration algorithm is proposed accordingly to solve it. In this algorithm, the plastic incompressibility condition is handled by two different treatments, and the nonlinearity and nons- moothness of the goal function are overcome by distinguishing the rigid zones from the plastic zones at each iteration. The procedure implementation of iterative process is quite simple and effective because each iteration is equivalent to solving an associated elastic problem. The obtained limit load multiplier is proved to monotonically converge to the upper bound of true solution. Several benchmark examples are investigated to validate the significant performance of the NEM in the application field of limit analysis.
基金Project(2013CB036004)supported by the National Basic Research Program of ChinaProjects(51178468,51378510)supported by National Natural Science Foundation of China
文摘The analytical solutions for predicting the exact shape of collapse mechanisms in shallow tunnels with arbitrary excavation profiles were obtained by virtue of the upper bound theorem of limit analysis and variation principle according to Hoek-Brown failure criterion. The seepage force was included in the upper bound limit analysis, and it was computed from the gradient of excess pore pressure distribution. The seepage was regarded as a work rate of external force. The numerical results of roof collapse in square and circular tunnels with different rock parameters were derived and discussed, which proves to be valid in comparison with the previous work. The influences of different parameters on the shape of collapsing blocks were also discussed.
文摘A kinematically admissible velocity field which is different from Avitzur's is established in Cartesian Coordinates. An upper-bound analytical solution to strip drawing andextrusion is obtained by using the integral as a function of the upper limit in this paper.
基金supported from the project of Ministry of Educa-tion,Youth and Sports of the Czech Republic AdMaS UP(Advanced Materials,Structures and Technologies),National Sustainability Programme I,LO1408.
文摘The paper is a contribution to the technical discussion concerning the collapses of the WTC buildings. It returns to the problem of the dynamics of the collapses;it does not concern the reason why the buildings started collapsing, but investigates the dynamics of the collapse itself. It works with the same assumptions as the official NIST report [1], i.e. that the falling mass hits the motionless mass beneath;the supporting columns loose stability and the mass of the pertinent floor starts to fall together with the falling mass. The aim was to derive the theoretical upper limit of the speed of the collapse, supposing that influence of the columns which resist the fall, is neglected. The differential equation of the fall was obtained using two independent laws of mechanics, with the identical result. Its solution can be found from a very simple explicit formula. The theoretical upper limit acceleration of the fall obtained by such formula is one third of the gravitational acceleration, which is faster than it was observed in the case of the collapses of WTC1 and WTC2. This leads to the conclusion that the mechanism of the collapse must be different from the assumed and the falling mass must not hit the motionless mass bellow it, but rather a mass which had started to fall before the impact of the falling mass occurred.
基金This project is financially supported by the National Natural Science Foundation of China(Grant Nos.50639010,50579006 and 50179006)
文摘This paper presents two kinematic failure mechanisms of threc-dimensional rectangular footing resting on homogeneous undrained clay foundation under uniaxial vertical loading and uniaxial moment loading. The failure mechanism under vertical loading comprises a plane strain Prandti-type mechanism over the central part of the longer side, and the size of the mechanism gradually reduces at the ends of the longer side and over the shorter side as the corner of rectangular footing is being approached where the direction of soil motion remains normal to each corresponding side respectively. The failure mechanism under moment loading comprises a plane strain scoop sliding mechanism over the central part of the longer side, and the radius of scoop sliding mechanism increases linearly at the ends of the longer side. On the basis of the kinematic failure mechanisms mentioned above, the vertical ultimate bearing capacity and the ultimate bearing capacity against moment or moment ultimate bearing capacity are obtained by use of upper bound limit analysis theory. At the same time, numerical analysis results, Skempton' s results and Salgado et al. 's results are compared with this upper bound solution. It shows that the presented failure mechanisms and plastic limit analysis predictions are validated. In order to investigate the behaviors of undrained clay foundation beneath the rectangular footing subjected to the combined loadings, numerical analysis is adopted by virtue of the general-purpose FEM software ABAQUS, where the clay is assumed to obey the Mohr-Coulomb yielding criterion. The failure envelope and the ultimate bearing capacity are achieved by the numerical analysis results with the varying aspect ratios from length L to breadth B of the rectangular footing. The failure mechanisms of rectangular footing which are subjected to the combined vertical loading V and horizontal loading H (Vertical loading V and moment loading M, and horizontal loading H and moment loading M respectively are observed in the finite element analysis. ) is explained by use of the upper bound plasticity limit analysis theory. Finally, the reason of eccentricity of failure envelope in H-M loading space is given in this study, which can not be explained by use of the traditional ' swipe test'.
基金Projects 40574057 and 40874054 supported by the National Natural Science Foundation of ChinaProjects 2007CB209400 by the National Basic Research Program of ChinaFoundation of China University of Mining and Technology (OF4471)
文摘Non-liner wave equation inversion,wavelet analysis and artificial neural networks were used to obtain stratum parameters and the distribution of thin coal seams.The lithology of the water-bearing/resisting layer in the Quaternary system was also predicted.The implementation process included calculating the well log parameters,stratum contrasting the seismic data and the well logs,and extracting,studying and predicting seismic attributes.Seismic inversion parameters,including the layer velocity and wave impedance,were calculated and effectively used for prediction and analysis.Prior knowledge and seismic interpretation were used to remedy a dearth of seismic data during the inversion procedure.This enhanced the stability of the inversion method.Non-linear seismic inversion and artificial neural networks were used to interpret coal seismic lithology and to study the water-bearing/resisting layer in the Quaternary system.Interpretation of the 1~2 m thin coal seams,and also of the water-bearing/resisting layer in the Quaternary system,is provided.The upper mining limit can be lifted from 60 m to 45 m.The predictions show that this method can provide reliable data useful for thin coal seam exploitation and for lifting the upper mining limit,which is one of the principles of green mining.
基金Projects(51078359, 51208522) supported by the National Natural Science Foundation of ChinaProjects(20110491269, 2012T50708) supported by China Postdoctoral Science FoundationProject supported by Postdoctoral Science Foundation of Central South University, China
文摘Based on the slip-line field theory, a two-dimensional slip failure mechanism with mesh-like rigid block system was constructed to analyze the ultimate bearing capacity problems of rough foundation within the framework of the upper bound limit analysis theorem. In the velocity discontinuities in transition area, the velocity changes in radial and tangent directions are allowed. The objective functions of the stability problems of geotechnical structures are obtained by equating the work rate of external force to internal dissipation along the velocity discontinuities, and then the objective functions are transformed as an upper-bound mathematic optimization model. The upper bound solutions for the objective functions are obtained by use of the nonlinear sequential quadratic programming and interior point method. From the numerical results and comparative analysis, it can be seen that the method presented in this work gives better calculation results than existing upper bound methods and can be used to establish the more accurate plastic collapse load for the ultimate bearing capacity of rough foundation.
基金Projects(51478477,51878074)supported by the National Natural Science Foundation of ChinaProject(2017-123-033)supported by the Guizhou Provincial Department of Transportation Foundation,ChinaProjects(2018zzts663,2018zzts656)supported by the Fundamental Research Funds for the Central Universities,China
文摘In the framework of upper bound theorem of limit analysis, the progressive collapse of shallow rectangular tunnels with double-layer rock mass has been theoretically analyzed based on the three-dimensional (3D) velocity discontinuity surfaces. According to the virtual work principle, the difference theorem and the variation method, the collapse surface of double-layer rock mass is determined based on the Hoek-Brown failure criterion. The formula can be degenerated to a single-layer rock collapsing problem when the rock mass is homogeneous. To estimate the validity of the result, the numerical simulation software PLAXIS 3D is used to simulate the collapse of shallow tunnels with double-layer rock mass, and the comparative analysis shows that numerical results are in good agreement with upper-bound solutions. According to the results of parametric analysis, the potential range of collapse of a double-layer rock mass above a shallow cavity decreases with a decrease in A1/A2,σci1/σci2 and σtm1/σtm2 and an increase in B1/B2,γ1/γ2. The range will decrease with a decrease in support pressure q and increase with a decrease in surface overload σs. Therefore, reinforced supporting is beneficial to improve the stability of the cavity during actual construction.
基金financially supported by the project part of the state assignment of the Ministry of Education and Science of Russia in scientific activities,project 3.1262.2014K
文摘A high-voltage transverse pulsed nanosecond discharge with a slotted hollow cathode was found to be a source of high-energy (few kV) ribbon electron beams. Conditions for the formation and extinction of electron beams were experimentally studied in discharges in helium at pressures of 1-100 Torr. It was found that interaction of fast electrons with a non-uniform electric field near the slotted cathode led to limitation of the magnitude of the discharge current. A physical model was developed to describe the discharge current self-limitation that was in satisfactory agreement with the experimental results. Some technical solutions that are expected to increase the upper current limits in transverse nanosecond discharge are discussed.