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Contemporary outcomes of patients undergoing robotic-assisted radical cystectomy:A comparative analysis between intracorporeal ileal conduit and neobladder urinary diversions
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作者 Jordan M.Rich Shivaram Cumarasamy +6 位作者 Daniel Ranti Etienne Lavallee Kyrollis Attalla John P.Sfakianos Nikhil Waingankar Peter N.Wiklund Reza Mehrazin 《Asian Journal of Urology》 CSCD 2023年第4期446-452,共7页
Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary diversion.Methods Pati... Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary diversion.Methods Patients undergoing RARC with intracorporeal urinary diversion between January 2017 and January 2022 at the Icahn School of Medicine at Mount Sinai,New York,NY,USA were indexed.Baseline demographics,clinical characteristics,perioperative,and oncologic outcomes were analyzed.Survival was estimated with Kaplan-Meier plots.Results Of 261 patients(206[78.9%]male),190(72.8%)received IC while 71(27.2%)received NB diversion.Median age was greater in the IC group(71[interquartile range,IQR 65-78]years vs.64[IQR 59-67]years,p<0.001)and BMI was 26.6(IQR 23.2-30.4)kg/m^(2).IC group was more likely to have prior abdominal or pelvic radiation(15.8%vs.2.8%,p=0.014).American Association of Anesthesiologists scores were comparable between groups.The IC group had a higher proportion of patients with pathological tumor stage 2(pT2)tumors(34[17.9%]vs.10[14.1%],p=0.008)and pathological node stages pN2-N3(28[14.7%]vs.3[4.2%],p<0.001).The IC group had less median operative time(272[IQR 246-306]min vs.341[IQR 303-378]min,p<0.001)and estimated blood loss(250[150-500]mL vs.325[200-575]mL,p=0.002).Thirty-and 90-day complication rates were 44.4%and 50.2%,respectively,and comparable between groups.Clavien-Dindo grades 3-5 complications occurred in 27(10.3%)and 34(13.0%)patients within 30 and 90 days,respectively,with comparable rates between groups.Median follow-up was 324(IQR 167-552)days,and comparable between groups.Kaplan-Meier estimate for overall survival at 24 months was 89%for the IC cohort and 93%for the NB cohort(hazard ratio 1.23,95%confidence interval 1.05-2.42,p=0.02).Kaplan-Meier estimate for recurrence-free survival at 24 months was 74%for IC and 87%for NB(hazard ratio 1.81,95%confidence interval 0.82-4.04,p=0.10).Conclusion Patients undergoing intracorporeal IC urinary diversion had higher postoperative cancer stage,increased nodal involvement,similar complications outcomes,decreased overall survival,and similar recurrence-free survival compared to patients undergoing RARC with intracorporeal NB urinary diversion. 展开更多
关键词 ROBOTIC Radical cystectomy INTRACORPOREAL Ileal conduit Neobladder urinary diversion Oncologic outcome
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Multi-modality imaging review of congenital abnormalities of kidney and upper urinary tract 被引量:13
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作者 Subramaniyan Ramanathan Devendra Kumar +4 位作者 Maneesh Khanna Mahmoud Al Heidous Adnan Sheikh Vivek Virmani Yegu Palaniappan 《World Journal of Radiology》 CAS 2016年第2期132-141,共10页
Congenital abnormalities of the kidney and urinary tract(CAKUT) include a wide range of abnormalities ranging from asymptomatic ectopic kidneys to life threatening renal agenesis(bilateral). Many of them are detected ... Congenital abnormalities of the kidney and urinary tract(CAKUT) include a wide range of abnormalities ranging from asymptomatic ectopic kidneys to life threatening renal agenesis(bilateral). Many of them are detected in the antenatal or immediate postnatal with a significant proportion identified in the adult population with varying degree of severity. CAKUT can be classified on embryological basis in to abnormalities in the renal parenchymal development, aberrant embryonic migration and abnormalities of the collecting system. Renal parenchymal abnormalities include multi cystic dysplastic kidneys, renal hypoplasia, number(agenesis or supernumerary), shape and cystic renal diseases. Aberrant embryonic migration encompasses abnormal location and fusion anomalies. Collecting system abnormalities include duplex kidneys and Pelvi ureteric junction obstruction. Ultrasonography(US) is typically the first imaging performed as it is easily available, noninvasive and radiation free used both antenatally and postnatally. Computed tomography(CT) and magnetic resonance imaging(MRI) are useful to confirm the ultrasound detected abnormality, detection of complex malformations, demonstration of collecting system and vascular anatomy and more importantly for early detection of complications like renal calculi, infection and malignancies. As CAKUT are one of the leading causes of end stage renal disease, it is important for the radiologists to be familiar with the varying imaging appearances of CAKUT on US, CT and MRI, thereby helping in prompt diagnosis and optimal management. 展开更多
关键词 CONGENITAL ABNORMALITIES KIDNEY urinary TRACT Multi cystic dysplastic KIDNEYS Pelvi ureteric junction obstruction Computed tomography urography CONGENITAL ABNORMALITIES of the KIDNEY and urinary TRACT End stage renal disease Horse shoe KIDNEYS
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Totally intracorporeal robot-assisted urinary diversion for bladder cancer(Part 1).Review and detailed characterization of ileal conduit and modified Indiana pouch 被引量:4
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作者 Hugo Otaola-Arca Rafael Coelho +1 位作者 Vipul R.Patel Marcelo Orvieto 《Asian Journal of Urology》 CSCD 2021年第1期50-62,共13页
Objective:To review the most used robot-assisted cutaneous urinary diversion(CUD)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent image... Objective:To review the most used robot-assisted cutaneous urinary diversion(CUD)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent images Methods:A non-systematic review of the literature with the keywords“bladder cancer”,“cutaneous urinary diversion”,and“radical cystectomy”was performed.Results:Twenty-four studies of intracorporeal ileal conduit(ICIC)and two of intracorporeal Indiana pouch(ICIP)were included in the analysis.Regarding ICIC,the patients’age ranged from 60 to 76 years.The operative time to perform a urinary diversion ranged from 60 to 133 min.The total estimated blood loss ranged from 200 to 1117 mL.The rate of positive surgical margins ranged from 0%to 14.3%.Early minor and major complication rates ranged from 0%to 71.4%and from 0%to 53.4%,respectively.Late minor and major complication rates ranged from 0%to 66%and from 0%to 32%,respectively.Totally ICIP data are limited to one case report and one clinical series.Conclusion:The most frequent type of CUD is ICIC.Randomized studies comparing the performance of the different types of CUD,the performance in an intra-or extracorporeal manner,or the performance of a CUD versus orthotopic ileal neobladder are lacking in the literature.To this day,there are not enough quality data to determine the supremacy of one technique.This manuscript represents a compendium of the most used CUD with detailed descriptions of the technical aspects,operative and perioperative outcomes,and new consistent images for each technique. 展开更多
关键词 Bladder cancer Ileal conduit Indiana pouch Intracorporeal urinary diversion Robot-assisted radical cystectomy Surgical technique
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The “3 Genomic Numbers” Discovery: How Our Genome Single-Stranded DNA Sequence Is “Self-Designed” as a Numerical Whole
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作者 Jean-Claude Perez 《Applied Mathematics》 2013年第10期37-53,共17页
This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the... This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it’s as if the memory of a fossil genome with multiple symmetries persists. This recalls the “intermingling” of information characterizing the fractal universe of chaos theory. The result leads to a balanced and perfect tuning between the masses of the two strands of the huge DNA molecule that constitute our genome. We show here how codon populations forming the single-stranded DNA sequences can constitute a critical approach to the understanding of junk DNA function. Then, we suggest revisiting certain methods published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how the universal genetic code table is a powerful analytical filter to characterize single-stranded DNA sequences constituting chromosomes and genomes. We can then show that any genomic DNA sequence is featured by three numbers, which characterize it and its 64 codon populations with correlations greater than 99%. The number “1” is common to all sequences, expressing the second law of Chargaff. The other 2 numbers are related to each specific DNA sequence case characterizing life species. For example, the entire human genome is characterized by three remarkable numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these three numbers, we can match three axes of symmetry, then “imagine” a kind of hyperspace formed by these codon populations. Then we revisit the value (3-Phi)/2 which is probably universal and common to both the scale of quarks and atomic levels, balancing and tuning the whole human genome codon population. Finally, we demonstrate a new kind of duality between “form and substance” overlapping the whole human genome: we will show that—simultaneously with the duality between genes and junk DNA—there is a second layer of embedded hidden structure overlapping all the DNA of the whole human genome, dividing it into a second type of duality information/redundancy involving golden ratio proportions. 展开更多
关键词 Genetic Code CODON Populations Junk DNA Cancer Genomics Chromosomal Translocations Genomes Diversity Chromosomes Diversity WHOLE Human GENOME DNA SEQUENCE Phi the Golden Ratio Fibonacci NUMBERS Information Theory SYMMETRY Cellular Automata Chargaffs CODON Level SYMMETRY Principle Fractal Self-Similarity e Eulers Number Pi form and Substance Redundancy Encryption
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Totally intracorporeal robot-assisted urinary diversion for bladder cancer(part 2).Review and detailed characterization of the existing intracorporeal orthotopic ileal neobladder 被引量:5
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作者 Hugo Otaola-Arca Kulthe Ramesh Seetharam Bhat +2 位作者 Vipul R.Patel Marcio Covas Moschovas Marcelo Orvieto 《Asian Journal of Urology》 CSCD 2021年第1期63-80,共18页
Objective:To review the most used intracorporeal orthotopic ileal neobladder(ICONB)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent ima... Objective:To review the most used intracorporeal orthotopic ileal neobladder(ICONB)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent images.Methods:We performed a non-systematic review of the literature with the keywords“bladder cancer”,“urinary diversion”,“radical cystectomy”,and“neobladder”.Results:Forty studies were included in the analysis.The most frequent type of ICONB was the modified Studer“U”neobladder(70%)followed by the Hautmann“W”modified neobladder(7.5%),the“Y”neobladder(5%),and the Padua neobladder(5%).The operative time to perform a urinary diversion ranged from 124 to 553 min.The total estimated blood loss ranged from 200 to 900 mL.The rate of positive surgical margins ranged from 0%to 8.1%.Early minor and major complication rates ranged from 0%to 100%and from 0%to 33%,respectively.Late minor and major complication rates ranged from 0%to 70%and from 0%to 25%,respectively.Conclusion:The most frequent types of ICONB are Studer“U”neobladder,Hautmann“W”neobladder,“Y”neobladder,and the Padua neobladder.Randomized studies comparing the performance of the different types of ICONB,the performance in an intra or extracorporeal manner,or the performance of an ICONB versus ICIC are lacking in the literature.To this day,there are not sufficient quality data to determine the supremacy of one technique.This manuscript represents a compendium of the most used ICONB with detailed descriptions of the technical aspects,operative and perioperative outcomes,and new consistent images of each technique. 展开更多
关键词 Bladder cancer Ileal orthotopic neobladder Intracorporeal urinary diversion Robot-assisted radical cystectomy Surgical technique
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Sacral neuromodulation therapy of the lower urinary tract: A review of the literature and unanswered questions
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作者 Golnaz Alemi Vani Dandolu 《Open Journal of Obstetrics and Gynecology》 2013年第4期1-6,共6页
Objective: To review the evidence surrounding Sacral Neuromodulation therapy and delineate areas that will need more research. Methods: An extensive search was performed on the available literature on SNM for lower ur... Objective: To review the evidence surrounding Sacral Neuromodulation therapy and delineate areas that will need more research. Methods: An extensive search was performed on the available literature on SNM for lower urinary tract dysfunction. Based on the results of the search, the mechanisms of action, indications, technique, and patient characteristics of therapy failures and success are presented and discussed. Results: SNM is accepted by the FDA since 1997 for the treatment of lower urinary tract dysfunction. As it is a relatively new procedure, there are variations in the technique of lead placement, generator choice, testing interval, patient selection, time to explantation, and definitions of therapy failures and successes. Conclusions: SNM is a safe and therapeutic option for the treatment of urgencyfrequency syndrome, urge incontinence, and idiopathic urinary retention. However, there are multiple unanswered questions that require extensive research. 展开更多
关键词 SACRAL NEUROMODULATION SNM Peripheral Nerve Evaluation PNE InterStim Tined Lead Electrode Implantable Pulse Generator Lower urinary Tract Dysfunction EXPLANTATION URGENCY Frequency Syndrome urinary Retention INCONTINENCE
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Robot-assisted laparoscopic radical cystectomy with complete intracorporeal urinary diversion 被引量:3
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作者 Jason M.Sandberg Ashok K.Hemal 《Asian Journal of Urology》 2016年第3期156-166,共11页
Robot-assisted radical cystectomy with intracorporeal urinary diversion(RARCICUD)has only recently been explored as a viable surgical option for patients with muscle-invasive bladder cancer seeking satisfactory oncolo... Robot-assisted radical cystectomy with intracorporeal urinary diversion(RARCICUD)has only recently been explored as a viable surgical option for patients with muscle-invasive bladder cancer seeking satisfactory oncologic control while benefiting from minimally invasive surgical techniques.Inspired by earlier open and laparoscopic work,initial descriptions of RARC-ICUD were published in 2003,and have since been followed by multiple larger case series which have suggested promising outcomes for our patients.However,the rate of adoption has remained relatively slow when compared to other robotassisted procedures such as the radical prostatectomy,likely owing to longer operative times,operative complexity,costs,and uncertainty regarding oncologic efficacy.The operative technique for RARC-ICUD has evolved over the past decade and several high-volume centers have shared tips to improve efficiency and make the operation possible for a growing number of urologists.Though there are still questions regarding economic costs,effectiveness,and generalizability of outcomes reported in published data,a growing dataset has brought us ever closer to the answers.Here,we present our current operative technique for RARC-ICUD and discuss the state of the literature so that the urologist may hold an informed discussion with his or her patients. 展开更多
关键词 CYSTECTOMY ROBOTICS urinary bladder neoplasms urinary diversion
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Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney 被引量:4
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作者 Basma Merhi George Bayliss Reginald Y Gohh 《World Journal of Transplantation》 2015年第4期251-260,共10页
Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graf... Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graft failure. Current detection of acute rejection relies on frequent monitoring of the serum creatinine followed by a diagnostic renal biopsy. This strategy is flawed since an alteration in the serum creatinine is a late clinical event and significant irreversible histologic damage has often already occurred. Furthermore, biopsies are invasive procedures that carry their own inherent risk. The discovery of non-invasive urinary biomarkers to help diagnose acute rejection has been the subject of a significant amount of investigation. We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B m RNAs, FOXP3 m RNA, CXCL9/CXCL10 and mi RNAs. These and other biomarkers are not yet widely used in clinical settings, but our review of the literature suggests that biomarkers may correlate with biopsy findings and provide an important early indicator of rejection, allowing more rapid treatment and better graft survival. 展开更多
关键词 urinary biomarkers Acute renal allograft rejection Serum creatinine Graft outcome urinary perforin granzyme B and FAS-LIGAND MRNA urinary CXCL9 and CXCL10 urinary FOXP3 MRNA urinary miRNA
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A Preliminary Investigation: Alvimopan Use to Prevent Post-Operative Ileus after Radical Cystectomy with Urinary Diversion
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作者 Benjamin F. Katz Geoffrey S. Gaunay +1 位作者 Basir U. Tareen Erik T. Goluboff 《Open Journal of Urology》 2013年第7期272-275,共4页
Background: Postoperative ileus (POI) is a common and frustrating patient complication after a urinary diversion by using a segment of bowel. Alvimopan is an oral selective antagonist to the peripheral μ-opioid recep... Background: Postoperative ileus (POI) is a common and frustrating patient complication after a urinary diversion by using a segment of bowel. Alvimopan is an oral selective antagonist to the peripheral μ-opioid receptor. Our study investigates the effect of alvimopan on POI in patients undergoing radical cystectomy. There are no documented studies on alvimopan’s efficacy in urologic surgery literature. Methods: Approval from the Institutional Review Board was obtained to conduct a retrospective review of patients’ records from August 2009 until August 2011. The study included sixteen patients who had undergone radical cystectomy with ileal diversion. Exclusion criteria included patients with chronic opioid use, previous colostomy or ileostomy, or significant comorbidities which could cause increased postoperative complications. Statistical analysis was performed to examine the association of alvimopan use with decreased time to dietary advancement and decreased length of hospital stay. Results: The alvimopan group advanced their diet more than 24 hours earlier in comparison with the alvimopan naive group (P < 0.0433), and the alvimopan group had a greater had a greater or 26% shorter hospital length (P < 0.0451) than one day. We showed a reduced risk of POI and subsequent decreased hospital course length. There was no significant difference in readmission rate or need for nasogastric tube (NGT). Interpretation: To our knowledge we report one of the first uses of alvimopan in reducing POI in the urological surgery literature. Our novel experience with using this drug is encouraging. Further research will ultimately determine if standard use of alvimopan to decrease POI in radical cystectomy with ileal diversion will be implemented. 展开更多
关键词 CYSTECTOMY urinary diversion ALVIMOPAN ILEUS
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小麦纹枯病菌核糖体基因内转录区序列比较 被引量:19
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作者 陈怀谷 方正 +2 位作者 陈厚德 林玲 王裕中 《植物病理学报》 CAS CSCD 北大核心 2005年第1期24-29,共6页
对 7个从江苏省小麦纹枯病样本分离到的丝核菌菌株,进行形态学鉴定、融合群分类和致病性测定,提取病菌的DNA,采用通用引物ITS1(TCCGTAGGTGAACCTGCGG)和ITS4 (TCCTCCGCTTATTGATATGC),扩增病菌的rDNA内转录区(ITS),并对扩增产物进行了测... 对 7个从江苏省小麦纹枯病样本分离到的丝核菌菌株,进行形态学鉴定、融合群分类和致病性测定,提取病菌的DNA,采用通用引物ITS1(TCCGTAGGTGAACCTGCGG)和ITS4 (TCCTCCGCTTATTGATATGC),扩增病菌的rDNA内转录区(ITS),并对扩增产物进行了测序。用这些序列在NCBI中进行BLAST分析,得到与这些菌株亲缘关系最近的菌株序列,并明确了这些菌株的分类地位。对以上的菌株序列进行Alignment分析,结果表明,病菌的 5. 8SrDNA序列高度保守,而ITS区的可变性则相对较高,在双核和多核丝核菌、双核丝核菌CAG1融合群和非CAG1融合群菌株间存在差异,可用于反映菌株间的进化关系和双核丝核菌种下分类。 展开更多
关键词 rDNA BLAST NCBI ITS TAT GTA GGT CCT GCG TCC TGA
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“Tradamixina TP” Compound in Monotherapy for Three Months in Patients with LUTS: Observational Study on Improvement of Urinary Symptoms and Sexual Function in Men
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作者 Trama Francesco Riccardo Filippo +1 位作者 Romeo Giuseppe Ruffo Antonio 《Health》 2019年第6期621-629,共9页
Introduction: Benign Prostatic Hypertrophy (BPH) and Lower Urinary Tract Symptoms (LUTS) frequently affect the male population after the age of 50. Moreover, it is well known that there is a correlation of these sympt... Introduction: Benign Prostatic Hypertrophy (BPH) and Lower Urinary Tract Symptoms (LUTS) frequently affect the male population after the age of 50. Moreover, it is well known that there is a correlation of these symptoms with Erectile Dysfunction (ED) that can reach a frequency of roughly 52% in men aged between 40 and 70 years old. In this study, we aimed at evaluating the effect of a new natural compound “Tradamixina TP” (composed of 80 mg of the algae Ecklonia Bicyclis, 100 mg of Tribulus terrestris and 100 mg of Chitosan Water-soluble oligosaccharide 320 mg of Serenoa repens) in the improvement of Lower Urinary Tract Symptoms (LUTS). Materials & Methods: One-hundred patients with an average age of 64 years old and who were not taking any medication or phytotherapy for prostatic hypertrophy or erectile dysfunction were recruited in the study. All participants were subjected to serum prostate antigen (PSA) and uroflowmetry measuring maximal urine flow/sec (Qmax), at baseline and after 12 weeks. In addition, patients were asked to take the Tradamixina TP for 3 months and to complete at the beginning and end of the treatment the following questionnaires: 1) the IPSS investigating the level of LUTS, and 2) the IIEF-15 investigating the erectile dysfunction. Results: After the treatment, the IPSS scores were lower than those before the treatment. Moreover, a significant effect was found for the IIEF erectile subdomain with scores that were significantly higher at 12 weeks than at baseline. A similar result was found for the IIEF overall subdomain. A decrease of total serum PSA was also observed. Conclusions: After 3 months of daily treatment, the new compound “Tradamixina TP” improved patients’ sexual function, LUTS and led also to a decrease in serum PSA levels. 展开更多
关键词 Lower urinary Tract Symptoms Benign PROSTATIC HYPERPLASIA Tradamixina TP Erectile Dysfunction Tribulus Terrestris Algae Ecklonia Bicyclis Chitosan Water-Soluble OLIGOSACCHARIDE
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球蚜科分类概述 被引量:8
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作者 任珊珊 乔格侠 张广学 《动物分类学报》 CSCD 北大核心 2005年第2期266-274,共9页
球蚜科是蚜虫类的一个重要类群,包括多种林业害虫和检疫害虫,本文从形态特征、生活史、寄主植物、地理分布,进化起源等方面对世界及中国球蚜物种进行了综合论述。结果表明,球蚜科具有较多原始的特征,是蚜虫中较为古老的一类;球蚜具有包... 球蚜科是蚜虫类的一个重要类群,包括多种林业害虫和检疫害虫,本文从形态特征、生活史、寄主植物、地理分布,进化起源等方面对世界及中国球蚜物种进行了综合论述。结果表明,球蚜科具有较多原始的特征,是蚜虫中较为古老的一类;球蚜具有包括异寄主全周期、异寄主不全周期、同寄主不全周期等复杂的生活周期,形成虫瘿是其主要的为害特征;球蚜科物种专性寄生在松科植物上,主要包括云杉属Picea、松属Pinus、落叶松属Larix、冷杉属Abies等属的植物,在蚜虫物种和寄主植物之间存在着平行演化的现象;球蚜的分布与寄主植物的分布相一致,主要是北半球温带和亚热带高山。世界球蚜有8属5 9种,区系成分主要是新北区、古北区。中国球蚜科有6属2 0种,分布在黑龙江、云南、四川等地,主要是古北区成分。初步推测球蚜科可能首先在松属植物上起源。 展开更多
关键词 Pinus
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Serum cystatin C can be used as a marker of renal function even in patients with intestinal urinary diversion
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作者 Masahiro Matsuki Toshiaki Tanaka +6 位作者 Takeshi Maehana Koji Ichihara Masahiro Yanase Masanori Matsukawa Hideki Adachi Satoshi Takahashi Naoya Masumori 《Asian Journal of Urology》 2015年第3期167-169,共3页
Objective:Recently,serum cystatin C(CysC)has been used as a novel marker of renal function.However,there is a lack of data on CysC levels in patients with intestinal urinary diversion(UD).Here we report CysC levels in... Objective:Recently,serum cystatin C(CysC)has been used as a novel marker of renal function.However,there is a lack of data on CysC levels in patients with intestinal urinary diversion(UD).Here we report CysC levels in such patients.Methods:We prospectively observed 38 patients who were diagnosed with bladder cancer and subsequently treated with radical cystectomy and UD at our institution in 2012 and 2013.Serum creatinine(sCr)and CysC were obtained optionally at the same time at least 1 month after radical cystectomy and UD.Results:The median CysC and sCr concentrations were 1.12 mg/L(range 0.75-2.47 mg/L)and 0.99 mg/dL(range 0.61-2.22 mg/dL),respectively.The median estimated concentrations of glomerular filtration rate(GFR)based on CysC(eGFRcys)and GFR based on creatinine(eGFRcreat)were 61.08 mL/min/1.73 m^2(range 22.64e99.89 mL/min/1.73 m^2)and 58.01 mL/min/1.73 m^2(range 23.48e91.82 mL/min/1.73 m2),respectively.CysC had a significant correlation with sCr(r=0.8607,p<0.0001)and eGFRcreat(r=-0.8993,p<0.0001).eGFRcys also had a significant correlation with eGFRcreat(r=0.8104,p<0.0001).Conclusion:The correlation between CysC and sCr was strong and the correlation coefficient was equivalent to that in patients without UD.The results suggest that CysC is not affected by UD and can be used as a marker of renal function similarly to sCr in patients with UD. 展开更多
关键词 Renal function Cystatin C urinary diversion
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互花米草入侵东滩盐沼对大型底栖无脊椎动物群落的影响 被引量:72
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作者 陈中义 付萃长 +3 位作者 王海毅 李博 吴纪华 陈家宽 《湿地科学》 CSCD 2005年第1期1-7,共7页
外来种互花米草 (Spartina alterniflora)已经成功入侵崇明东滩 ,正在大量取代潮间带的优势种海三棱草 (Scirpus mariqueter)。采用圆筒取样比较了大型底栖无脊椎动物 (不包含蟹类 )的密度、多样性和群落结构在这两种植物群落的变化... 外来种互花米草 (Spartina alterniflora)已经成功入侵崇明东滩 ,正在大量取代潮间带的优势种海三棱草 (Scirpus mariqueter)。采用圆筒取样比较了大型底栖无脊椎动物 (不包含蟹类 )的密度、多样性和群落结构在这两种植物群落的变化差异。大型底栖无脊椎动物的密度在互花米草群落和海三棱草群落中分别为 3119个 /m2 和 345 9个 /m2 ,两者之间没有显著差异 ,但一些常见种的密度在两种植物群落中存在显著差异。从物种的相对多度看 ,两种植物群落中 ,大型底栖无脊椎动物的优势种都是堇拟沼螺 (Assimineaviolacea)和丝异须虫(Heteromastusfiliforms)。物种多样性分析表明 ,互花米草群落中 ,平均每一个圆筒取样中大型底栖无脊椎动物的物种丰富度、香农 -威纳指数、均匀度都显著低于海三棱草群落中 ,而优势度则相反。互花米草群落中 ,食碎屑者的数量百分比显著大于海三棱草群落中 ,食悬浮物者和食植者的数量百分比显著小于海三棱草群落中。这表明互花米草入侵东滩海三棱草群落 ,竞争取代土著植物后 ,显著降低了大型底栖无脊椎动物的物种多样性 ,同时显著改变了营养类群的结构。互花米草入侵所引起的植物群落高度、密度、盖度、生物量的变化可能是造成大型底栖无脊椎动物群落结构改变的主要原因。 展开更多
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骨代谢生化指标临床应用专家共识(2020) 被引量:191
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作者 张萌萌 张秀珍 +30 位作者 邓伟民 张智海 徐辉 葛继荣 王永福 黄宏兴 史晓林 张东伟 毛未贤 马倩倩 高远 杨茂伟 郭郡浩 张红红 张晓梅 印平 赵方 郑洪新 晁爱军 张岩 孔西建 李英华 李毅中 赵国阳 胡玲 董红宇 吴岩 吴涤 邹军 周惠琼 范馨月 《中国骨质疏松杂志》 CAS CSCD 北大核心 2020年第6期781-796,共16页
骨代谢生化指标包括钙磷代谢调节指标、骨形成标志物、骨吸收标志物、激素与细胞因子。骨代谢生化指标分别来源于骨、软骨、软组织、皮肤、肝、肾、小肠、血液及内分泌腺体等,是由成骨细胞或破骨细胞分泌的酶和激素,以及骨基质的胶原蛋... 骨代谢生化指标包括钙磷代谢调节指标、骨形成标志物、骨吸收标志物、激素与细胞因子。骨代谢生化指标分别来源于骨、软骨、软组织、皮肤、肝、肾、小肠、血液及内分泌腺体等,是由成骨细胞或破骨细胞分泌的酶和激素,以及骨基质的胶原蛋白或非胶原蛋白代谢产物。骨代谢生化指标可及时反映骨转换状态,灵敏度高、特异性强,用于骨质疏松诊断分型、预测骨折风险、抗骨质疏松治疗疗效评价,以及代谢性骨病的诊断与鉴别诊断。并且在骨质疏松流行病学、发病机制、骨质疏松药物的研究方面具有重要的临床意义。本文对《骨代谢生化指标临床应用专家共识(2019)》进行了修订,共有41处修改,保留了经典文献,删减了部分内容,增加了近三年的文献,收集整理了骨代谢指标实验检测参考范围。 展开更多
关键词 D3 25-D3 1 25-D3 IC- IN- IC- IN- 尿 尿 -1 -6 β
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准噶尔盆地东南缘不同生境条件下梭梭群落结构特征研究 被引量:70
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作者 王春玲 郭泉水 +2 位作者 谭德远 史作民 马超 《应用生态学报》 CAS CSCD 北大核心 2005年第7期1224-1229,共6页
在新疆准噶尔盆地东南缘,以平缓低洼地、平缓沙地、半流动沙丘等3种不同生境类型上的天然梭梭群落为研究对象,从物种结构、物种多样性、生物量以及梭梭天然更新幼苗幼树种群分布格局等方面,研究不同生境条件下梭梭群落的结构特征.结果表... 在新疆准噶尔盆地东南缘,以平缓低洼地、平缓沙地、半流动沙丘等3种不同生境类型上的天然梭梭群落为研究对象,从物种结构、物种多样性、生物量以及梭梭天然更新幼苗幼树种群分布格局等方面,研究不同生境条件下梭梭群落的结构特征.结果表明,以平缓低洼地上梭梭群落的植物种类最丰富,其次是平缓沙地,半流动沙丘上的植物种类最少.3种生境类型上群落中的植物种类分别为16种、15种和12种;梭梭天然更新幼苗幼树以半流动沙丘上的梭梭群落为最多,达6687株·hm-2,但幼苗幼树在梭梭群落内分布不均匀,平缓低洼地上梭梭群落内的幼苗幼树比半流动沙丘上的略少,为5799株·hm-2,但幼苗幼树在梭梭群落内分布均匀,总体评价以平缓低洼地上梭梭群落的天然更新最好;平缓低洼地上梭梭群落的总生物量为19.39t·hm-2,平缓沙地上为9.32t·hm-2,半流动沙丘上为6.69t·hm-2;不同生境类型上梭梭群落天然更新幼苗幼树的分布格局均为聚集分布.平缓低洼地地面固定,土壤水分和肥力较好,比较适宜梭梭林木生长和梭梭群落的发育,平缓沙地和半流动沙丘的地面容易产生风蚀,土壤水分和肥力较差,生境条件比较严酷. 展开更多
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Association of Erectile Dysfunction and Hypogonadism with Metabolic Syndrome in Men with Lower Urinary Tract Symptoms of Younger and Older Age Groups
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作者 Elena Novikova Vera Selyatitskaya +2 位作者 Igor Mitrofanov Boris Pinkhasov Ani Karapetyan 《Advances in Sexual Medicine》 2014年第4期55-64,共10页
The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and old... The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and older (40 - 60 years old) age groups depending on the presence of metabolic syndrome (MetS). Triglycerides, glucose and high-density lipoprotein cholesterol, serum total testosterone (TT), sex hormone-binding globulin, prostate-specific antigen, pituitary hormones levels were measured in serum. Standardized criteria (2009) were used to determine the prevalence of MetS. Patients were assessed based on the International Prostate Symptom Score (IPSS) and the IPSS-Quality of Life (IPSS-QoL) for LUTSs and the International Index of Erectile Function (IIEF) for ED. Hypogonadism was determined in accordance with the ISA, ISSAM, EAU, EAA and ASA recommendations. In men with MetS in the younger age group the incidence of ED was 2.4 times higher, and that of low TT level and hypogonadism was 8.4 times higher compared to men without the syndrome. In the older age group, an increased incidence of ED and low TT level in men with MetS compared to men without the syndrome was on the trend level, but the incidence of hypogonadism was for sure higher (by 1.6 times). In conclusion, the study showed that ED and hypogonadism are associated with MetS by a high degree of certainty in young men with LUTSs. In men of the older age group with LUTSs, the presence of MetS is not so clearly associated with ED and hypogonadism due to the fact that the incidence of these urogenital diseases is also high in men without MetS. 展开更多
关键词 Erectile Dysfunction TESTOSTERONE HYPOGONADISM Metabolic Syndrome MEN of YOUNGER and Older Age Groups Lower urinary TRACT Symptoms
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Update summarising the conclusions of the international consultation on male lower urinary tract symptoms 被引量:7
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作者 Altaf Mangera Christopher Chapple 《World Journal of Clinical Urology》 2015年第2期83-91,共9页
The International Consultation on Urological Disease have recently published comprehensive conclusions, based on evidence reviewed by eight committees, on aspects of male lower urinary tract symptoms(LUTS). In this re... The International Consultation on Urological Disease have recently published comprehensive conclusions, based on evidence reviewed by eight committees, on aspects of male lower urinary tract symptoms(LUTS). In this review, we summarise the conclusions from fourof the committees, namely, the evidence regarding the epidemiology of male LUTS, patient assessment, nocturia and medical management. It is indisputable that with an expanding and ageing global population the prevalence of male LUTS is likely to increase. Therefore symptom prevention and preservation of quality of life(Qo L) feature highly in the guidelines. There are now a number of different medical options, proven to lead to significant improvements in symptom scores, flow rate and Qo L available to men with LUTS. Metaanalyses have shown the benefits for alpha blockers, antimuscarinics, 5-α reductase and phosphodiesterase-5 inhibitors. High level evidence also exists for combinations of all of the above with alpha blockers and so men with concomitant storage symptoms, prostate volume > 30 mL, PSA > 1.4 or erectile dysfunction may be considered for combination treatment of an alpha blocker with an antimuscarinic, 5-α reductase inhibitor or phosphodiesterase-5 inhibitor respectively. In an era of personalised medicine, appropriate patient selection is likely to provide the key to the most effective clinical management strategy. 展开更多
关键词 INTERNATIONAL CONSULTATION ANTIMUSCARINIC MALE lower urinary tract symptoms Guidelines NOCTURIA Epidemiology 5-αreductase Phosphodiesterase-5 inhibitors Alpha antagonist
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九顶山药用植物资源多样性研究 被引量:3
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作者 吴勇 苏智先 方精云 《西华师范大学学报(自然科学版)》 2005年第1期25-31,36,共8页
九顶山是青藏高原向四川盆地过渡的山地之一,山体高大,垂直生境变化明显,孕育了丰富的药用植物.本次调查获得药用资源植物 184种,其中以多年生植物为主 (51. 1% ),其次为矮小高位芽植物 (15. 8% )和中高位芽植物(10. 9% ),大高位芽植物... 九顶山是青藏高原向四川盆地过渡的山地之一,山体高大,垂直生境变化明显,孕育了丰富的药用植物.本次调查获得药用资源植物 184种,其中以多年生植物为主 (51. 1% ),其次为矮小高位芽植物 (15. 8% )和中高位芽植物(10. 9% ),大高位芽植物、小高位芽植物和一年生植物比例相对较小,它们分属 72科,种数较多的科依次是菊科、蔷薇科、唇形科、伞形科、毛茛科、禾本科、豆科、百合科、蓼科和芸香科,单种科比较多,约有 40余科.在野外调查的基础上分析了九顶山药用资源的生态学特征、资源特点,并根据调查中发现的问题提出了保护和合理开发药用植物资源的措施. 展开更多
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原、异位保存普通野生稻种质资源的遗传多样性比较研究 被引量:29
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作者 杨庆文 余丽琴 +4 位作者 张万霞 陈大洲 时津霞 任军方 苗晗 《中国农业科学》 CAS CSCD 北大核心 2005年第6期1073-1079,共7页
为了明确我国异位保存的普通野生稻是否能够代表原居群遗传多样性的完整性,利用SSR(简单序列重复)方法对江西省东乡县庵家山和水桃树2个普通野生稻居群的原、异位群体进行了遗传多样性比较研究。结果表明,庵家山居群原、异位保存群体的... 为了明确我国异位保存的普通野生稻是否能够代表原居群遗传多样性的完整性,利用SSR(简单序列重复)方法对江西省东乡县庵家山和水桃树2个普通野生稻居群的原、异位群体进行了遗传多样性比较研究。结果表明,庵家山居群原、异位保存群体的遗传多样性指数分别为0.5000和0.3555,异位保存群体的遗传多样性只有原位保存群体的71.1%,并且异位保存材料在聚类图中聚集在一起,仅为原位保护材料聚类图中的一个分支;虽然水桃树居群原、异位群体的遗传多样性指数分别为0.4100和0.4577,相差较小,并且原、异位保存材料在聚类图中混合聚类,似乎异位保存群体能够代表原居群的遗传多样性,但异位保存的14份材料在聚类图中有6份相邻的材料聚集在一起,说明异位保存取样时没有考虑野生稻植株的空间分布,属于重复取样,重复取样的比率高达42.9%。将2个分布点原、异位材料合并进行遗传多样性研究,结果与庵家山分布点的研究结果基本一致。据此推测我国保存的普通野生稻资源所包含的遗传变异相对较少,重复频率较高。建议进行普通野生稻遗传资源的再收集,并对已保存的野生稻种质资源进行全面鉴定,剔出重复样品。 展开更多
关键词 5000 西 SSR
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