Impact of Action Observation Therapy along with Usual Physiotherapy Intervention of Individual with Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive impairments in the initial stage, which lead to severe cognitive dysfunction in the later stage. Action observation therapy (AOT) is a multisensory cognitive rehabilitation technique where the patient initially observes the actions and then tries to perform. The study aimed to examine the impact of AOT along with usual physiotherapy interventions to reduce depression, improve cognition and balance of a patient with AD. A 67 years old patient with AD was selected for this study because the patient has been suffering from depression, dementia, and physical dysfunction along with some other health conditions like diabetes and hypertension. Before starting intervention, a baseline assessment was done through the Beck Depression Inventory (BDI) tool, the Mini-Cog Scale, and the Berg Balance Scale (BBS). The patient received 12 sessions of AOT along with usual physiotherapy interventions thrice a week for four weeks, which included 45 minutes of each session. After four weeks of intervention, the patient demonstrated significant improvement in depression, cognition, and balance, whereas the BDI score declined from moderate 21/63 to mild 15/63 level of depression. The Mini-Cog score improved from 2/5 to 4/5, and the BBS score increased from 18/56 to 37/56. It is concluded that AOT along with usual physiotherapy intervention helps to reduce depression, improve cognition and balance of people with AD.

Combining ability and gene action studies for yield and fibre traits in Gossypium arboreum using Griffings numerical and Haymans graphical approach

Background For the purpose of utilising hybrid vigour to produce possible hybrids with a suitable level of stability,the knowledge of gene activity and combining ability is a crucial prerequisite before choosing desirable parents.The present study was carried out with six parents crossed in full diallel fashion and generated 30 F1 hybrids.These hybrids were evaluated in two replications in Randomized Block Design at Department of Cotton,TNAU for combining ability and gene action.Diallel analysis was carried out according to Griffing’s method-I(parents + F_(1) + reciprocals) and model-I and Hayman’s graphical approach by using INDOSTAT software.Results Analysis of variance for combining ability indicated that mean square values of GCA,SCA and reciprocals were highly significant for all the traits except for the uniformity index.RG763 and K12 showed highly positively significant GCA effects for most of the yield traits while PA838 and K12 for fibre quality traits,so they were found as best general combiners.PAIG379 × K12 and PDB29 × K12 for yield traits,and PDB29 × PA838,RG763 × PA838,and CNA1007 × RG763 cross combinations for fibre quality traits could be recommended for future breeding programms.Conclusion The results of both Griffing’s and Hayman’s approaches showed that non-additive gene action predominates as SCA variance was bigger than GCA variance,so heterosis breeding is thought to be a more fruitful option for enhancing GCA of many traits.

Empirical Verification of Swanson’s Caring Processes Found in Nursing Actions: Systematic Review

Caring has long been recognized as central to nursing and is increasingly posited as a core concept although developing a theoretical description of caring which is adequate in the 21st. century continues to be a difficult task for nursing scholars. Consequently, verifying existing theoretical structures of caring remains an ongoing challenge. The aim of this article is to provide empirical verification of the caring processes of “knowing,” “being with,” “doing for,” “enabling” and “maintaining belief” from Swanson’s Middle Range Caring Theory based on the categorization of nursing actions from a systematic literature review on care. Methods: A systematic literature review was conducted in the fields of nursing sciences, medicine and psychology. Purposeful sampling was carried out covering a period from 2003-2013. The final sample included 25 articles. Results: Major themes of nursing actions included “knowing” which consisted of centering, nurturing, informed understanding, assessment skills, communication and respect for individual differences. “Being with” was characterized by intimate relationship, connecting, presencing, emotional adaptability awareness of self/other and decentering. “Doing for” included competence, knowledge, professional/technical skills, helping actions, anticipatory, multidisciplinary and preserving dignity. “Enabling” was characterized by self care, commitment, complexity of care, appropriate communication, information/education, sharing power, enabling choice and ongoing validation. Finally, “maintaining belief” was characterized by spiritual being, humanistic view, harmonious balance, hope, love, and compassion, meaning, and religious and spiritual orientation. Conclusion: Empirical verification was shown for the caring processes described in Swanson’s Caring Theory grounded in concrete nursing actions.

基于ActionScript3语言的组件库架构研究

根据松耦合的原则,通过软件工程中样式展现与逻辑处理相分离,构建一套完整的组件库,该组件库可以使程序开发人员与美术人员的工作不再相互依赖,让频繁的需求变更不再过多的影响到项目开发的进度,有效提高前端Flash界面组件的开发效率和团队的工作效率。组件的具体皮肤样式可以完全通过美术所提供的素材决定,因此组件皮肤样式可以实现完全自定义。通过直接加载素材、位图渲染的形式,提高程序的执行效率。同时,组件库的设计初衷就是尽量避免过于依赖某一个具体语言的某种特性,借助软件工程中松耦合的通用性,可以较为轻松地实现使用其他计算机语言。

Review on dietary supplements as an effective improvement of Alzheimer's disease:focus on structures and mechanisms

Alzheimer’s disease(AD),the major form of neurodegenerative diseases that can severely impede normal cognitive function,makes it one of the most common fatal diseases.There are currently over 50 million AD patients worldwide.The neuropathology of AD is perplexing and there is a scarcity of disease-modifying treatments.Currently,early diagnosis of AD has been made possible with the discovery of biological markers associated with pathology,providing strong support for the improvement of the disease status.The search for inhibitors of AD markers from dietary supplements(DSs)has become a major hot topic.Especially with the widespread use of DSs,DSs containing polyphenols,alkaloids,terpenes,polysaccharides and other bioactive components can prevent AD by reducing Aβdeposition,inhibiting tau protein hyperphosphorylation,reconstructing synaptic dysfunction,weakening cholinesterase activity,regulating mitochondrial oxidative stress,neuronal inflammation and apoptosis.This review summarizes the anti-AD effects of the main DSs and their bioactive constituents,as well as the potential molecular mechanisms covers from 2017 to 2023.Additionally,we discussed the opportunities and challenges faced by DSs in the process of AD prevention and treatment,aiming to further provide new perspectives for functional food development.

Heuristic Estimation of the Vacuum Energy Density of the Universe: Part II-Analysis Based on Frequency Domain Electromagnetic Radiation

In Part I of this paper, an inequality satisfied by the vacuum energy density of the universe was derived using an indirect and heuristic procedure. The derivation is based on a proposed thought experiment, according to which an electron is accelerated to a constant and relativistic speed at a distance L from a perfectly conducting plane. The charge of the electron was represented by a spherical charge distribution located within the Compton wavelength of the electron. Subsequently, the electron is incident on the perfect conductor giving rise to transition radiation. The energy associated with the transition radiation depends on the parameter L. It was shown that an inequality satisfied by the vacuum energy density will emerge when the length L is pushed to cosmological dimensions and the product of the radiated energy, and the time duration of emission is constrained by Heisenberg’s uncertainty principle. In this paper, a similar analysis is conducted with a chain of electrons oscillating sinusoidally and located above a conducting plane. In the thought experiment presented in this paper, the behavior of the energy radiated by the chain of oscillating electrons is studied in the frequency domain as a function of the length L of the chain. It is shown that when the length L is pushed to cosmological dimensions and the energy radiated within a single burst of duration of half a period of oscillation is constrained by the fact that electromagnetic energy consists of photons, an inequality satisfied by the vacuum energy density emerges as a result. The derived inequality is given by where is the vacuum energy density. This result is consistent with the measured value of the vacuum energy density, which is 5.38 × 10-10 J/m. The result obtained here is in better agreement with experimental data than the one obtained in Part I of this paper with time domain radiation.

基于S-O-R理论的新型公共阅读空间用户流失行为分析——来自大众点评网用户评论

文章以大众点评网站中新型公共阅读空间的评论数据为对象,以S-O-R模型为理论基础,利用Python爬取其“中评”与“差评”的评论数据,运用内容分析法归纳得出新型公共阅读空间用户流失行为的主要因素,并构建新型公共阅读空间用户流失行为模型。在此基础上,提出提高新型公共阅读空间服务效能的相关建议,为提高新型阅读空间的服务质量,降低用户流失率提供参考。

Customization Product Design Based on User's Emotion and Needs

The paper presents a design method that ensures the ingenuity of the product form as well as the whole and exact expression of user’s needs. The key idea is to establish an automatic design system which can transform the user’s language needs into the product features in real-time. A rifle was taken as a research instance and soldiers were chosen as evaluation customers. The theory of fuzzy set and semantic difference are adopted to evaluate the relationship between user’s needs and product features as well as their alternatives. FAHP (fuzzy analytic hierarchy process) is utilized to judge the user’s satisfactory forms. This method can also be applied to other product form designs.

Use of methotrexate in inflammatory bowel disease in 2014: A User's Guide

Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios:(1) steroid dependant Crohn's disease(CD);(2) maintenance of remission in steroid free CD;(3) azathioprine failures in CD;(4) in combination therapy with Anti-TNF agents in CD;(5) decreasing antibody formation to Anti-TNF therapy in CD;(6) management of fistulizing disease in CD; and(7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients.

Frequent Itemset Mining of User’s Multi-Attribute under Local Differential Privacy

Frequent itemset mining is an essential problem in data mining and plays a key role in many data mining applications.However,users’personal privacy will be leaked in the mining process.In recent years,application of local differential privacy protection models to mine frequent itemsets is a relatively reliable and secure protection method.Local differential privacy means that users first perturb the original data and then send these data to the aggregator,preventing the aggregator from revealing the user’s private information.We propose a novel framework that implements frequent itemset mining under local differential privacy and is applicable to user’s multi-attribute.The main technique has bitmap encoding for converting the user’s original data into a binary string.It also includes how to choose the best perturbation algorithm for varying user attributes,and uses the frequent pattern tree(FP-tree)algorithm to mine frequent itemsets.Finally,we incorporate the threshold random response(TRR)algorithm in the framework and compare it with the existing algorithms,and demonstrate that the TRR algorithm has higher accuracy for mining frequent itemsets.

User’s Relevance of PIR System Based on Cloud Models

A new method to evaluate fuzzily user＇s relevance on the basis of cloud models has been proposed. All factors of personalized information retrieval system are taken into account in this method. So using this method for personalized information retrieval （PIR） system can efficiently judge multi-value relevance, such as quite relevant, comparatively relevant, commonly relevant, basically relevant and completely non-relevant, and realize a kind of transform of qualitative concepts and quantity and improve accuracy of relevance judgements in PIR system. Experimental data showed that the method is practical and valid. Evaluation results are more accurate and approach to the fact better.

Repositioning of clinically approved drug Bazi Bushen capsule for treatment of Alzheimer′s disease using network pharma⁃cology approach and in vitro experimental validation

OBJECTIVE To explore the new indications and key mechanism of Bazi Bushen capsule(BZBS)by network pharmacology and in vitro experiment.METHODS The potential tar⁃get profiles of the components of BZBS were pre⁃dicted.Subsequently,new indications for BZBS were predicted by disease ontology(DO)enrich⁃ment analysis and initially validated by GO and KEGG pathway enrichment analysis.Further⁃more,the therapeutic target of BZBS acting on AD signaling pathway were identified by intersec⁃tion analysis.Two Alzheimer′s disease(AD)cell models,BV-2 and SH-SY5Y,were used to pre⁃liminarily verify the anti-AD efficacy and mecha⁃nism of BZBS in vitro.RESULTS In total,1499 non-repeated ingredients were obtained from 16 herbs in BZBS formula,and 1320 BZBS targets with high confidence were predicted.Disease enrichment results strongly suggested that BZBS formula has the potential to be used in the treat⁃ment of AD.In vitro experiments showed that BZ⁃BS could significantly reduce the release of TNF-αand IL-6 and the expression of COX-2 and PSEN1 in Aβ25-35-induced BV-2 cells.BZBS reduced the apoptosis rate of Aβ25-35 induced SH-SY5Y cells,significantly increased mitochon⁃drial membrane potential,reduced the expres⁃sion of Caspase3 active fragment and PSEN1,and increased the expression of IDE.CONCLU⁃SIONS BZBS formula has a potential use in the treatment of AD,which is achieved through regu⁃lation of ERK1/2,NF-κB signaling pathways,and GSK-3β/β-catenin signaling pathway.Further⁃more,the network pharmacology technology is a feasible drug repurposing strategy to reposition new clinical use of approved TCM and explore the mechanism of action.The study lays a foun⁃dation for the subsequent in-depth study of BZBS in the treatment of AD and provides a basis for its application in the clinical treatment of AD.

Multi-action-based approach for constructing knowledge map

To alleviate the information overload in the product design process,this work proposes a multiaction-based method for constructing knowledge map. Since the relationships of knowledge are implicit in the collected user activities,the method calculates the similarity according to the collected user activities.Three concepts,including knowledge,action and user,are explained first. Based on this,the similarity calculation method is illustrated in detail. The dependencies of actions and relations of the user are considered in the calculation method. Further,the approach of applying the constructed knowledge map to alleviate information overload is proposed. At last,the proposed method is validated by a knowledge search and result comparison experiment.

Forestry Action Program——On China's 21st Century Agenda

Environment and development are important issues of common concern to societies of the contemporary world. They have a direct bearing on the destiny of mankind, as well as the future of the world. Their influence extends to every country, every people and every individual in this world. Forests are the key and bond to carry out the integration of environment and development. It has become a consensus in international society. Forestry shoulders two missions: optimization of the environment and promotion

Mach’s Principle, Action at a Distance and Cosmology

Hoyle and Narlikar (HN) in the 1960’s [1] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003400310031003900330036003000340034000000 -[3] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003400310031003900330036003000340037000000 developed a theory of gravitation which was completely Machian and used both retarded and advanced waves to communicate gravitational influence between particles. The advanced waves, which travel backward in time, are difficult to visualize and although they are mathematically allowed by relativistic wave equations, they never really caught on. The HN theory reduced to Einstein’s theory of gravity in the smooth fluid approximation and a transformation into the rest frame of the fluid. Hawking [4] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003400310031003900330036003000350030000000 in 1965 pointed out a possible flaw in the theory. This involved integrating out into the distant future to account for all the advanced waves which might influence the mass of a particle here and now. Hawking used infinity as his upper time limit and showed the integral was divergent. We point out that since the universe is known to be expanding, and accelerating, the upper limit in the advanced wave time integral should not be infinite but is bounded by the Cosmic Event Horizon. This event horizon He represents a barrier between future events that can be observed and those which cannot. We show that the advanced wave integral is finite when He/C, is used as the upper limit of the advanced wave integral. Hawking’s objection is no longer valid and the HN theory becomes a working theory once again.

基于S曲线和分子对接技术对不同香气物质相互作用研究

通过S曲线法测定了9种天然产物中的香气物质的识别阈值,并将这9种香气物质按食品中常见的5种香韵(烤香、木香、甜香、酸香和果香香韵)进行分类,研究香气二元混合物之间的相互作用研究,香韵结构两两组合共得到32组混合物,通过双向协同研究,共计64组数据,不同香韵的香气物质之间呈现的相互作用大部分是掩盖效果和协同效果,小部分呈现出加成作用。利用分子对接技术对4组香气物质(5-甲基糠醛、丁酸、愈创木酚和丙酸)与嗅觉受体OR1D2进行研究,结果显示,香气化合物可以通过氢键和疏水键与嗅觉受体OR1D2上的氨基酸残基发生相互作用,从而激活嗅觉受体,以实现香味的感知。香气化合物之间会通过竞争活性位点来使某种气味被感知到的强度减弱,而有些香气化合物之间可能会相互协作与受体之间的活性位点结合,从而表现出协同作用。

Method of Consistency Judgment for App Software’s User Comments

With the popularity of mobile intelligent terminal, user comments of App software is viewed as one of the research interests of social computing. Faced with the massive App software, most users usually view the other users’ comments and marks to selecting the desired App software. Due to the freedom and randomness of the network comments, the inconsistence between the user’s comment and mark makes it difficult to choose App software. This paper presents a method by analyzing the relationships among user’s comment information, the user’s mark and App software information. Firstly, the consistency between user’s comment information and App software information is judged. Then, through analyzing the grammar relationships among the feature-words, adverbs and the feature-sentiment-words in App software’s feature-sentimentword- pairs, the user’s emotional tendency about App software is quantified quantified combining with the dictionary and the network sentiment words. After calculating the user’s comprehensive score of App software, the consistency of App software’s user comment is judged by comparing this score and the user’s mark. Finally, the experimental results show that the method is effective.

China's Action Plan on IPR Protection 2006

China’s terrific trade growth is often getting a lot of flake from its international peers for one of the many alleged reasons that China, more often than not, infringes intellectual property right (IPR),’copyright theft’ as a far-fetched simile puts it. But China’s efforts to crack down on infringements are also applauded worldwide; the source from The Ministry of Commerce provides the following ’Action Plan 2006’ to fight IPR violation.

A Contribution to the DLF-Theory: On Singularities of the SU(2,2)-Action in U(1,1)

Segal’s chronometric theory is based on a space-time D, which might be viewed as a Lie group with a causal structure defined by an invariant Lorentzian form on the Lie algebra u(2). Similarly, the space-time F is realized as the Lie group with a causal structure defined by an invariant Lorentzian form on u(1,1). Two Lie groups G, GF are introduced as representations of SU(2,2): they are related via conjugation by a certain matrix Win Gl(4). The linear-fractional action of G on D is well-known to be global, conformal, and it plays a crucial role in the analysis on space-time bundles carried out by Paneitz and Segal in the 1980’s. This analysis was based on the parallelizing group U(2). In the paper, singularities’ general (“geometric”) description of the linear-fractional conformal GF-action on F is given and specific examples are presented. The results call for the analysis of space-time bundles based on U(1,1) as the parallelizing group. Certain key stages of such an analysis are suggested.