Spatial modulation(SM) is a class of novel multiple-input multiple-output(MIMO) techniques toward future wireless communications,which activates only one transmit antenna in each time slot,so as to reduce the number o...Spatial modulation(SM) is a class of novel multiple-input multiple-output(MIMO) techniques toward future wireless communications,which activates only one transmit antenna in each time slot,so as to reduce the number of RF chains for saving the implement cost.Meanwhile,considering its application in 5G systems with multiple users,the detection of multi-user spatial modulation has drawn greater attention.In this paper,a pair of efficient detectors are proposed for multi-user spatial modulation.Specially,a threshold-aided approximate message passing(T-AMP) detector is proposed with the purpose of reducing the computational complexity of traditional structured approximate message passing(Str-AMP) detector.In addition,a novel probability sorting aided approximate message passing detector,called probability-ranking-aided AMP detector(P-AMP),is also proposed with the purpose of improving the performance.Simulation results show that the proposed T-AMP detector is able to achieve similar performance as traditional StrAMP with lower complexity,while the proposed P-AMP detector exhibits a better symbol error rate(SER) performance with similar complexity.展开更多
We introduce and investigate the concept of s-injective modules and strongly s-injective modules. New characterizations of SI-rings, GV-rings and pseudo-Frobenius rings are given in terms of s-injectivity of their mod...We introduce and investigate the concept of s-injective modules and strongly s-injective modules. New characterizations of SI-rings, GV-rings and pseudo-Frobenius rings are given in terms of s-injectivity of their modules.展开更多
We characterize V modules by relative (quasi )continuity of left R modules in this paper. It is shown that a left R module M is a V module if and only if every finitely cogenerated left R ...We characterize V modules by relative (quasi )continuity of left R modules in this paper. It is shown that a left R module M is a V module if and only if every finitely cogenerated left R module in σ[M] is S ( quasi )continuous if and only if every left R module in σ[M] is S continuous, where S is the set of all simple left R modules. We also show that a left R module M is a locally noetherian V module if and only if every semisimple left R module (in σ[M]) is M injective if and only if every essential extension in σ[M] of every semisimple left R module in σ[M] is S ? 2 (quasi )continuous, where S ? 2 is the set of all semisimple left R modules.展开更多
In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the con...In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the concepts of(R,S)-bi-Γ-submodules,quasi-Γ-submodules and regular Γ-modules.Meanwhile,some illustrative examples are given to show the rationality of the definitions introduced in this paper.Second,several new kinds of generalized fuzzy soft Γ-submodules are proposed,and related properties and mutual relationships are also investigated.Third,we discover some intrinsic connections between the generalized fuzzy soft Γ-submodules presented in this paper and crisp Γ-submodules,and describe the relationships between regular Γ-modules and the generalized fuzzy soft Γ-submodules presented in this paper.展开更多
Higher order statistical features have been recently proved to be very efficient in the classification of wideband communications and radar signals with great accuracy. On the other hand, the denoising properties of t...Higher order statistical features have been recently proved to be very efficient in the classification of wideband communications and radar signals with great accuracy. On the other hand, the denoising properties of the wavelet transform make WT an efficient signal processing tool in noisy environments. A novel technique for the classification of multi-user chirp modulation signals is presented in this paper. A combination of the higher order moments and cumulants of the wavelet coefficients as well as the peaks of the bispectrum and its bi-frequencies are proposed as effective features. Different types of artificial intelligence based classifiers and clustering techniques are used to identify the chirp signals of the different users. In particular, neural networks (NN), maximum likelihood (ML), k-nearest neighbor (KNN) and support vector machine (SVMs) classifiers as well as fuzzy c-means (FCM) and fuzzy k-means (FKM) clustering techniques are tested. The Simulation results show that the proposed technique is able to efficiently classify the different chirp signals in additive white Gaussian noise (AWGN) channels with high accuracy. It is shown that the NN classifier outperforms other classifiers. Also, the simulations prove that the classification based on features extracted from wavelet transform results in more accurate results than that using features directly extracted from the chirp signals, especially at low values of signal-to-noise ratios.展开更多
The paper presents a design method that ensures the ingenuity of the product form as well as the whole and exact expression of user’s needs. The key idea is to establish an automatic design system which can transform...The paper presents a design method that ensures the ingenuity of the product form as well as the whole and exact expression of user’s needs. The key idea is to establish an automatic design system which can transform the user’s language needs into the product features in real-time. A rifle was taken as a research instance and soldiers were chosen as evaluation customers. The theory of fuzzy set and semantic difference are adopted to evaluate the relationship between user’s needs and product features as well as their alternatives. FAHP (fuzzy analytic hierarchy process) is utilized to judge the user’s satisfactory forms. This method can also be applied to other product form designs.展开更多
Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bo...Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios:(1) steroid dependant Crohn's disease(CD);(2) maintenance of remission in steroid free CD;(3) azathioprine failures in CD;(4) in combination therapy with Anti-TNF agents in CD;(5) decreasing antibody formation to Anti-TNF therapy in CD;(6) management of fistulizing disease in CD; and(7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients.展开更多
Frequent itemset mining is an essential problem in data mining and plays a key role in many data mining applications.However,users’personal privacy will be leaked in the mining process.In recent years,application of ...Frequent itemset mining is an essential problem in data mining and plays a key role in many data mining applications.However,users’personal privacy will be leaked in the mining process.In recent years,application of local differential privacy protection models to mine frequent itemsets is a relatively reliable and secure protection method.Local differential privacy means that users first perturb the original data and then send these data to the aggregator,preventing the aggregator from revealing the user’s private information.We propose a novel framework that implements frequent itemset mining under local differential privacy and is applicable to user’s multi-attribute.The main technique has bitmap encoding for converting the user’s original data into a binary string.It also includes how to choose the best perturbation algorithm for varying user attributes,and uses the frequent pattern tree(FP-tree)algorithm to mine frequent itemsets.Finally,we incorporate the threshold random response(TRR)algorithm in the framework and compare it with the existing algorithms,and demonstrate that the TRR algorithm has higher accuracy for mining frequent itemsets.展开更多
A new method to evaluate fuzzily user's relevance on the basis of cloud models has been proposed. All factors of personalized information retrieval system are taken into account in this method. So using this method f...A new method to evaluate fuzzily user's relevance on the basis of cloud models has been proposed. All factors of personalized information retrieval system are taken into account in this method. So using this method for personalized information retrieval (PIR) system can efficiently judge multi-value relevance, such as quite relevant, comparatively relevant, commonly relevant, basically relevant and completely non-relevant, and realize a kind of transform of qualitative concepts and quantity and improve accuracy of relevance judgements in PIR system. Experimental data showed that the method is practical and valid. Evaluation results are more accurate and approach to the fact better.展开更多
For telecommunication operators, how to improve the utilization of bandwidth resources is always a problem which worthy of study, nowadays, this issue has become more and more important, since the traffic load burstin...For telecommunication operators, how to improve the utilization of bandwidth resources is always a problem which worthy of study, nowadays, this issue has become more and more important, since the traffic load bursting in the mobile Internet. So the key to solving this problem is that we need to find a kind of traffic model to predict the traffic load that users need. According to the predicted traffic load to allocate bandwidth to each base station dynamically.But the traffic consumption behavior of a single base station is random, it is difficult to predict[ 1 ]. For this reason, we based on reality that, when the user moves, it may get traffic load from different base stations, therefore, there will have some kind of relationship between those base stations.We use this relationship to establish a kind of Spatial Collaborative Network.consequently, we make use of stability algorithm to divided those base station cluster into different communities, According to the traffic load usage rules which these communities indicated to us, we get a traffic model.At the same time, we studied bow to use this traffic model in the future networks to dynamically allocate bandwidth resources, then we propose a new kind of EPS architecture based on SDN, on this platform, we can deploy our strategy through it's programmable interface.Finally, we designed an experiment to test the performance of our dynamic strategy, and the result shows that our method enables bandwidth utilization has been greatly improved.展开更多
2.488 Gb/s optical fiber transmission experiment using a domestic Ti.LiNbO<sub>3</sub> externalmodulator was demonstrated for the first time in China.A receiver sensitivity of -30.3dBmwas obtained at a BER...2.488 Gb/s optical fiber transmission experiment using a domestic Ti.LiNbO<sub>3</sub> externalmodulator was demonstrated for the first time in China.A receiver sensitivity of -30.3dBmwas obtained at a BER of 10<sup>-10</sup>after transmission through 50.7 km conventional single modefiber.展开更多
Instead of avoiding occurrence of chaos in motor drives, chaos is positively utilized in this paper. A new chaotic pulse width modulation (PWM) scheme is proposed and implemented for AC motors, which functions to si...Instead of avoiding occurrence of chaos in motor drives, chaos is positively utilized in this paper. A new chaotic pulse width modulation (PWM) scheme is proposed and implemented for AC motors, which functions to significantly suppress harmonic peaks and hence acoustic noise. The key is to employ the Chua's circuit for generating a desired chaotic sequence. By using a practical induction motor, computer simulation and experimental results verify that the chaotic PWM has advantages of harmonic peak suppression and simple hardware implementation over the conventional PWM and random PWM.展开更多
A 32 Gb/s monolithically integrated electroabsorption modulated laser is fabricated by selective area growth technology. The threshold current of the device is below 13mA. The output power exceeds 10mW at 0V bias when...A 32 Gb/s monolithically integrated electroabsorption modulated laser is fabricated by selective area growth technology. The threshold current of the device is below 13mA. The output power exceeds 10mW at 0V bias when the injection current of the distributed feedback laser is 100mA at 25℃. The side mode suppression ratio is over 50 dB. A 32Gb/s eye diagram is measured with a 3.SVpp nonreturn-to-zero pseudorandom modulation signal at -2.3 V bias. A clearly opening eyediagram with a dynamic extinction ratio of 8.01 dB is obtained.展开更多
针对跌倒检测任务中复杂信息干扰和数据集缺乏导致模型精度不高的问题,设计一种高精度跌倒检测算法,降低模型参数的同时保持各种场景下的鲁棒性。该算法基于YOLOv5s改进,在骨干网络中使用Ghost module和解耦全连接注意力,以较低计算开...针对跌倒检测任务中复杂信息干扰和数据集缺乏导致模型精度不高的问题,设计一种高精度跌倒检测算法,降低模型参数的同时保持各种场景下的鲁棒性。该算法基于YOLOv5s改进,在骨干网络中使用Ghost module和解耦全连接注意力,以较低计算开销提升模型在光线变化、遮挡等干扰环境下的性能。在颈部层使用自适应感受野和空间通道混合注意力,提升神经元对不同尺度特征的适应性,应对人体形变、视角变化等干扰。引入EIoU损失函数,加速收敛提升训练精度。在公开数据集Le2i Fall Detection Dataset和UR Fall Detection上,精确率、召回率、mAP0.5和mAP(0.5:0.95)相比YOLOv5s分别提高4.0%,4.2%,2.9%和4.3%,参数量降低38.6%。该算法在多种应用场景下都保持较高检测精度,参数量较低,满足实际应用场景部署要求。展开更多
Despite the advances in combinatorial or synthetic chemis- try and bioinformatics, recent literature has demonstrated the relevance of nature and biomass as a source of new molecules to treat different pathologies, i....Despite the advances in combinatorial or synthetic chemis- try and bioinformatics, recent literature has demonstrated the relevance of nature and biomass as a source of new molecules to treat different pathologies, i.e., bioactive com- pounds obtained from Ecteinascidia turbinate to treat some types of cancer or rapamycin from Streptomyces hygroscop- icus to prevent organ rejection after transplant. This trend will continue simply due to the fact that Mother Nature has been synthesizing molecules for millions of years. In our lab- oratory, we have characterized several compounds obtained from natural sources and that possess important neuronal effects,展开更多
Infantile Blount's disease is a condition that causes genu varum and internal tibial torsion. Treatment options include observation, orthotics, corrective osteotomy, elevation of the medial tibial plateau, resecti...Infantile Blount's disease is a condition that causes genu varum and internal tibial torsion. Treatment options include observation, orthotics, corrective osteotomy, elevation of the medial tibial plateau, resection of a physeal bar, lateral hemi-epiphysiodesis, and guided growth of the proximal tibial physis. Each of these treatment options has its disadvantages. Treating the coronal deformity alone(genu varum) will result in persistence of the internal tibial torsion(the axial deformity). In this report, we describe the combination of lateral growth modulation and distal tibial external rotation osteotomy to correct all the elements of the disease. This has not been described before for treatment of Blount's disease. Both coronal and axial deformities were corrected in this patient. We propose this combination(rather than the lateral growth modulation alone) as the method of treatment for early stages of Blount's disease as it corrects both elements of the disease and in the same time avoids the complications of proximal tibial osteotomy.展开更多
基金The financial support is gratefully acknowledged by the National Science Foundation of China under Grant numbers 61471090the Open Research Fund of National Mobile Communications Research Laboratory,Southeast University(No.2015D09)+1 种基金the Foundation Project of Science and Technology on Electronic Information Control Laboratory under Grant JS17041403811(201606071370-004001)the Foundation Project of National Key Lab.of Sci.and Tech.on Comm.under Grant 6142102010702
文摘Spatial modulation(SM) is a class of novel multiple-input multiple-output(MIMO) techniques toward future wireless communications,which activates only one transmit antenna in each time slot,so as to reduce the number of RF chains for saving the implement cost.Meanwhile,considering its application in 5G systems with multiple users,the detection of multi-user spatial modulation has drawn greater attention.In this paper,a pair of efficient detectors are proposed for multi-user spatial modulation.Specially,a threshold-aided approximate message passing(T-AMP) detector is proposed with the purpose of reducing the computational complexity of traditional structured approximate message passing(Str-AMP) detector.In addition,a novel probability sorting aided approximate message passing detector,called probability-ranking-aided AMP detector(P-AMP),is also proposed with the purpose of improving the performance.Simulation results show that the proposed T-AMP detector is able to achieve similar performance as traditional StrAMP with lower complexity,while the proposed P-AMP detector exhibits a better symbol error rate(SER) performance with similar complexity.
文摘We introduce and investigate the concept of s-injective modules and strongly s-injective modules. New characterizations of SI-rings, GV-rings and pseudo-Frobenius rings are given in terms of s-injectivity of their modules.
文摘We characterize V modules by relative (quasi )continuity of left R modules in this paper. It is shown that a left R module M is a V module if and only if every finitely cogenerated left R module in σ[M] is S ( quasi )continuous if and only if every left R module in σ[M] is S continuous, where S is the set of all simple left R modules. We also show that a left R module M is a locally noetherian V module if and only if every semisimple left R module (in σ[M]) is M injective if and only if every essential extension in σ[M] of every semisimple left R module in σ[M] is S ? 2 (quasi )continuous, where S ? 2 is the set of all semisimple left R modules.
基金Supported by the National Natural Science Foundation of China (61175055)the Innovation Term of Higher Education of Hubei Province,China (T201109)+1 种基金the Natural Science Foundation of Hubei Province (2012FFB01101)the Natural Science Foundation of Education Committee of Hubei Province (D20131903)
文摘In this paper,we focus on combining the theories of fuzzy soft sets with Γ-modules,and establishing a new framework for fuzzy soft Γ-submodules.The main contributions of the paper are 3-fold.First,we present the concepts of(R,S)-bi-Γ-submodules,quasi-Γ-submodules and regular Γ-modules.Meanwhile,some illustrative examples are given to show the rationality of the definitions introduced in this paper.Second,several new kinds of generalized fuzzy soft Γ-submodules are proposed,and related properties and mutual relationships are also investigated.Third,we discover some intrinsic connections between the generalized fuzzy soft Γ-submodules presented in this paper and crisp Γ-submodules,and describe the relationships between regular Γ-modules and the generalized fuzzy soft Γ-submodules presented in this paper.
文摘Higher order statistical features have been recently proved to be very efficient in the classification of wideband communications and radar signals with great accuracy. On the other hand, the denoising properties of the wavelet transform make WT an efficient signal processing tool in noisy environments. A novel technique for the classification of multi-user chirp modulation signals is presented in this paper. A combination of the higher order moments and cumulants of the wavelet coefficients as well as the peaks of the bispectrum and its bi-frequencies are proposed as effective features. Different types of artificial intelligence based classifiers and clustering techniques are used to identify the chirp signals of the different users. In particular, neural networks (NN), maximum likelihood (ML), k-nearest neighbor (KNN) and support vector machine (SVMs) classifiers as well as fuzzy c-means (FCM) and fuzzy k-means (FKM) clustering techniques are tested. The Simulation results show that the proposed technique is able to efficiently classify the different chirp signals in additive white Gaussian noise (AWGN) channels with high accuracy. It is shown that the NN classifier outperforms other classifiers. Also, the simulations prove that the classification based on features extracted from wavelet transform results in more accurate results than that using features directly extracted from the chirp signals, especially at low values of signal-to-noise ratios.
文摘The paper presents a design method that ensures the ingenuity of the product form as well as the whole and exact expression of user’s needs. The key idea is to establish an automatic design system which can transform the user’s language needs into the product features in real-time. A rifle was taken as a research instance and soldiers were chosen as evaluation customers. The theory of fuzzy set and semantic difference are adopted to evaluate the relationship between user’s needs and product features as well as their alternatives. FAHP (fuzzy analytic hierarchy process) is utilized to judge the user’s satisfactory forms. This method can also be applied to other product form designs.
文摘Methotrexate has been used an immunomodulator in many autoimmune diseases,including inflammatory bowel disease. However,many physicians are unfamiliar or uncomfortable with its use in the management of inflammatory bowel disease. We summarize the data for use of methotrexate in common clinical scenarios:(1) steroid dependant Crohn's disease(CD);(2) maintenance of remission in steroid free CD;(3) azathioprine failures in CD;(4) in combination therapy with Anti-TNF agents in CD;(5) decreasing antibody formation to Anti-TNF therapy in CD;(6) management of fistulizing disease in CD; and(7) as well as induction and maintenance of remission in ulcerative colitis. An easy to use algorithm is provided for the busy clinician to access and safely prescribe methotrexate for their inflammatory bowel disease patients.
基金This paper is supported by the Inner Mongolia Natural Science Foundation(Grant Number:2018MS06026,Sponsored Authors:Liu,H.and Ma,X.,Sponsors’Websites:http://kjt.nmg.gov.cn/)the Science and Technology Program of Inner Mongolia Autonomous Region(Grant Number:2019GG116,Sponsored Authors:Liu,H.and Ma,X.,Sponsors’Websites:http://kjt.nmg.gov.cn/).
文摘Frequent itemset mining is an essential problem in data mining and plays a key role in many data mining applications.However,users’personal privacy will be leaked in the mining process.In recent years,application of local differential privacy protection models to mine frequent itemsets is a relatively reliable and secure protection method.Local differential privacy means that users first perturb the original data and then send these data to the aggregator,preventing the aggregator from revealing the user’s private information.We propose a novel framework that implements frequent itemset mining under local differential privacy and is applicable to user’s multi-attribute.The main technique has bitmap encoding for converting the user’s original data into a binary string.It also includes how to choose the best perturbation algorithm for varying user attributes,and uses the frequent pattern tree(FP-tree)algorithm to mine frequent itemsets.Finally,we incorporate the threshold random response(TRR)algorithm in the framework and compare it with the existing algorithms,and demonstrate that the TRR algorithm has higher accuracy for mining frequent itemsets.
文摘A new method to evaluate fuzzily user's relevance on the basis of cloud models has been proposed. All factors of personalized information retrieval system are taken into account in this method. So using this method for personalized information retrieval (PIR) system can efficiently judge multi-value relevance, such as quite relevant, comparatively relevant, commonly relevant, basically relevant and completely non-relevant, and realize a kind of transform of qualitative concepts and quantity and improve accuracy of relevance judgements in PIR system. Experimental data showed that the method is practical and valid. Evaluation results are more accurate and approach to the fact better.
基金part of the National Natural Science Foundation of China(NSFC)under Grant No.61371126the Independent Research Program of Central Universities under Grant No.2042014kf0256+2 种基金the National High Technology Research and Development Program of China(863 Program)under Grant No.2014AA01A707the National Key Basic Research Program of China(973 Program)under Grant No.2011CB707106Applied Basic Research Programs of Wuhan under Grant No.2014010101010026
文摘For telecommunication operators, how to improve the utilization of bandwidth resources is always a problem which worthy of study, nowadays, this issue has become more and more important, since the traffic load bursting in the mobile Internet. So the key to solving this problem is that we need to find a kind of traffic model to predict the traffic load that users need. According to the predicted traffic load to allocate bandwidth to each base station dynamically.But the traffic consumption behavior of a single base station is random, it is difficult to predict[ 1 ]. For this reason, we based on reality that, when the user moves, it may get traffic load from different base stations, therefore, there will have some kind of relationship between those base stations.We use this relationship to establish a kind of Spatial Collaborative Network.consequently, we make use of stability algorithm to divided those base station cluster into different communities, According to the traffic load usage rules which these communities indicated to us, we get a traffic model.At the same time, we studied bow to use this traffic model in the future networks to dynamically allocate bandwidth resources, then we propose a new kind of EPS architecture based on SDN, on this platform, we can deploy our strategy through it's programmable interface.Finally, we designed an experiment to test the performance of our dynamic strategy, and the result shows that our method enables bandwidth utilization has been greatly improved.
基金the High Technology Research and Development Programme of China.
文摘2.488 Gb/s optical fiber transmission experiment using a domestic Ti.LiNbO<sub>3</sub> externalmodulator was demonstrated for the first time in China.A receiver sensitivity of -30.3dBmwas obtained at a BER of 10<sup>-10</sup>after transmission through 50.7 km conventional single modefiber.
基金Project supported by the Shanghai Leading Academic Discipline Project (Grant No.T0103)
文摘Instead of avoiding occurrence of chaos in motor drives, chaos is positively utilized in this paper. A new chaotic pulse width modulation (PWM) scheme is proposed and implemented for AC motors, which functions to significantly suppress harmonic peaks and hence acoustic noise. The key is to employ the Chua's circuit for generating a desired chaotic sequence. By using a practical induction motor, computer simulation and experimental results verify that the chaotic PWM has advantages of harmonic peak suppression and simple hardware implementation over the conventional PWM and random PWM.
基金Supported by the National High-Technology Research and Development Program of China under Grant Nos 2011AA010303and 2012AA012203the National Basic Research Program of China under Grant No 2011CB301702the National Natural Science Foundation of China under Grant Nos 61321063 and 6132010601
文摘A 32 Gb/s monolithically integrated electroabsorption modulated laser is fabricated by selective area growth technology. The threshold current of the device is below 13mA. The output power exceeds 10mW at 0V bias when the injection current of the distributed feedback laser is 100mA at 25℃. The side mode suppression ratio is over 50 dB. A 32Gb/s eye diagram is measured with a 3.SVpp nonreturn-to-zero pseudorandom modulation signal at -2.3 V bias. A clearly opening eyediagram with a dynamic extinction ratio of 8.01 dB is obtained.
文摘针对跌倒检测任务中复杂信息干扰和数据集缺乏导致模型精度不高的问题,设计一种高精度跌倒检测算法,降低模型参数的同时保持各种场景下的鲁棒性。该算法基于YOLOv5s改进,在骨干网络中使用Ghost module和解耦全连接注意力,以较低计算开销提升模型在光线变化、遮挡等干扰环境下的性能。在颈部层使用自适应感受野和空间通道混合注意力,提升神经元对不同尺度特征的适应性,应对人体形变、视角变化等干扰。引入EIoU损失函数,加速收敛提升训练精度。在公开数据集Le2i Fall Detection Dataset和UR Fall Detection上,精确率、召回率、mAP0.5和mAP(0.5:0.95)相比YOLOv5s分别提高4.0%,4.2%,2.9%和4.3%,参数量降低38.6%。该算法在多种应用场景下都保持较高检测精度,参数量较低,满足实际应用场景部署要求。
文摘Despite the advances in combinatorial or synthetic chemis- try and bioinformatics, recent literature has demonstrated the relevance of nature and biomass as a source of new molecules to treat different pathologies, i.e., bioactive com- pounds obtained from Ecteinascidia turbinate to treat some types of cancer or rapamycin from Streptomyces hygroscop- icus to prevent organ rejection after transplant. This trend will continue simply due to the fact that Mother Nature has been synthesizing molecules for millions of years. In our lab- oratory, we have characterized several compounds obtained from natural sources and that possess important neuronal effects,
文摘Infantile Blount's disease is a condition that causes genu varum and internal tibial torsion. Treatment options include observation, orthotics, corrective osteotomy, elevation of the medial tibial plateau, resection of a physeal bar, lateral hemi-epiphysiodesis, and guided growth of the proximal tibial physis. Each of these treatment options has its disadvantages. Treating the coronal deformity alone(genu varum) will result in persistence of the internal tibial torsion(the axial deformity). In this report, we describe the combination of lateral growth modulation and distal tibial external rotation osteotomy to correct all the elements of the disease. This has not been described before for treatment of Blount's disease. Both coronal and axial deformities were corrected in this patient. We propose this combination(rather than the lateral growth modulation alone) as the method of treatment for early stages of Blount's disease as it corrects both elements of the disease and in the same time avoids the complications of proximal tibial osteotomy.