Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment options.Besides genetic mutations,epigenetic dysregulatio...Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment options.Besides genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target.Mechanisms beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under trails.Combinations of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa patients.Recent studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic therapies.Epigenetics thus promises to generate a significant amount of new knowledge of biological and medical importance.Our review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to breakthroughs.We aim to highlight the possibilities that exist and the potential therapeutic interventions.展开更多
针对已有的层流信道模型不能直接应用于存在目标的复杂层流信道的问题,提出一种基于模型驱动的信道建模方法.研究了存在目标的层流扩散信道的系统模型,在无目标平流模型的基础上加入参数,考虑层流和目标对接收分子的影响.结合仿真结果,...针对已有的层流信道模型不能直接应用于存在目标的复杂层流信道的问题,提出一种基于模型驱动的信道建模方法.研究了存在目标的层流扩散信道的系统模型,在无目标平流模型的基础上加入参数,考虑层流和目标对接收分子的影响.结合仿真结果,将有目标的复杂层流信道近似为两个稳定的层流信道,建立有目标的点源-接收机层流扩散信道模型.结合神经网络使用Levenberg-Marquardt算法对信道模型参数进行学习和预测,同时提出基于数据和模型驱动结合(combination of data and model driven, CDMD)的检测方法对目标进行检测.结果表明:通过公式数据与仿真数据对比验证了其信道模型的准确性,所有数据的相关系数为0.999 15,该神经网络模型具有可行性;使用神经网络二分类算法验证提出的目标检测方法,检测准确率达到98.8%时,提出的CDMD检测方法所需数据量约为基于数据检测方法的1/6.展开更多
Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an ob...Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon tumors.Here,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the colon.In order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification technique.The average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic environment.In vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer cells.Meanwhile,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.展开更多
Electromagnetic pulses(EMPs)produced by the interaction of a TW femtosecond laser with solid targets at the Compact Laser Plasma Accelerator(CLAPA)are measured and interpreted.The statistical results confirm that the ...Electromagnetic pulses(EMPs)produced by the interaction of a TW femtosecond laser with solid targets at the Compact Laser Plasma Accelerator(CLAPA)are measured and interpreted.The statistical results confirm that the intensities of the EMPs are closely related to both target material and thickness.The signal of the titanium target is more abundant than that of the copper target with the same thickness,and the intensity of EMP is positively correlated with the target thickness for aluminium foil.With the boosted EMP radiations,the energy of accelerated protons is also simultaneously enhanced.In addition,EMPs emitted from the front of the target exceed those from the rear,which are also pertinent to the specific target position.The resonant waveforms in the target chamber are analyzed using the fast Fourier transform,and the local resonance and the attenuation lead to changes of the frequency spectra of EMPs with variation of detecting positions,which is well supported by the modeling results.The findings are beneficial to gaining insight into the mechanism of EMP propagation in a typical target chamber and providing more information for EMP shielding design.展开更多
文摘Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment options.Besides genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target.Mechanisms beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under trails.Combinations of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa patients.Recent studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic therapies.Epigenetics thus promises to generate a significant amount of new knowledge of biological and medical importance.Our review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to breakthroughs.We aim to highlight the possibilities that exist and the potential therapeutic interventions.
文摘针对已有的层流信道模型不能直接应用于存在目标的复杂层流信道的问题,提出一种基于模型驱动的信道建模方法.研究了存在目标的层流扩散信道的系统模型,在无目标平流模型的基础上加入参数,考虑层流和目标对接收分子的影响.结合仿真结果,将有目标的复杂层流信道近似为两个稳定的层流信道,建立有目标的点源-接收机层流扩散信道模型.结合神经网络使用Levenberg-Marquardt算法对信道模型参数进行学习和预测,同时提出基于数据和模型驱动结合(combination of data and model driven, CDMD)的检测方法对目标进行检测.结果表明:通过公式数据与仿真数据对比验证了其信道模型的准确性,所有数据的相关系数为0.999 15,该神经网络模型具有可行性;使用神经网络二分类算法验证提出的目标检测方法,检测准确率达到98.8%时,提出的CDMD检测方法所需数据量约为基于数据检测方法的1/6.
基金supported by the National Key R&D Program of China(grant No.2019YFB1309703).
文摘Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent characteristics.However,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon tumors.Here,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the colon.In order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification technique.The average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic environment.In vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer cells.Meanwhile,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.
基金supported by the National Natural Science Foundation of China(Grant Nos.11975037 and 11921006)the National Grand Instrument Project of China(Grant Nos.2019YFF01014400 and 2019YFF01014404)。
文摘Electromagnetic pulses(EMPs)produced by the interaction of a TW femtosecond laser with solid targets at the Compact Laser Plasma Accelerator(CLAPA)are measured and interpreted.The statistical results confirm that the intensities of the EMPs are closely related to both target material and thickness.The signal of the titanium target is more abundant than that of the copper target with the same thickness,and the intensity of EMP is positively correlated with the target thickness for aluminium foil.With the boosted EMP radiations,the energy of accelerated protons is also simultaneously enhanced.In addition,EMPs emitted from the front of the target exceed those from the rear,which are also pertinent to the specific target position.The resonant waveforms in the target chamber are analyzed using the fast Fourier transform,and the local resonance and the attenuation lead to changes of the frequency spectra of EMPs with variation of detecting positions,which is well supported by the modeling results.The findings are beneficial to gaining insight into the mechanism of EMP propagation in a typical target chamber and providing more information for EMP shielding design.
