Treatment of fat-poor renal angiomyolipoma with ectopic blood supply by fluorescent laparoscopy:A case report and review of literature

BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in treatment methods.Fat-poor renal angiomyolipoma is a relatively rare type of in renal angiomyolipoma.Its fat imaging features are not obvious,and it is easily misdiagnosed as renal cell carcinoma.CASE SUMMARY We report the case of a 41-year-old man who complained of osphyalgia.Subsequent abdominal computed tomography scans revealed that a heterogeneous mass was seen in the lower pole of the right kidney,with the size of about 53 mm×47 mm.And showed two right renal arteries,with the mass supplied by an ectopic vessel from the abdominal aorta.Fluorescent laparoscopic blockade of the right renal heterotopic artery and partial nephrectomy was performed.Based on histological and immunohistochemical findings,the tumor was diagnosed as fatpoor renal angiomyolipoma.CONCLUSION The use of fluorescent laparoscopy can effectively help intraoperative management,and the fluorescence pattern provided by intravenous indocyanine green can help suggest the final diagnosis,effectively guide the surgical decisionmaking,and avoid preoperative imaging diagnosis leading to nephrectomy for benign renal tumors,through fluorescent navigation of tumor supply vessel precise block,minimize the loss of renal function.

The Observation of Blood-Uterus,-Oviduct and-Fimbriae Lumen Barriers Under Transmission Electron Microscope

The author has observed the epithelium and basement membrane of uterus, oviduct and fimbriae in mice under the TEM by oral administration of AgNo3 tracer. The results showed that there was obvious deposit of argentum granules outside the basement membrane of mucosal epithelium of the uterus, oviduct and fimbriae as well as outside the basement membrane of uterine glands. And there was dilatation fully filled with high electron-dense argentum granules at the intercellular space just beneath the tight junction between the mucosal epithelial cells of uterus, oviduet, fimbriae. All these finding suggest that the uterus, oviduct and fimbriae serve as barriers to the heavy metal argentum ions.

The origin of blood supply for cavernous hemangioma of the liver

OBJECTIVE: To investigate the origin of blood supply to cavernous hemangioma of the liver (CHL). METHODS: To observe the relation of cavernous hemangioma of the liver to the hepatic artery and portal vein, we performed serial selective hepatic arteriography in 22 patients. Five patients after ligation of the right hepatic arteries underwent portography and liver staining by in jection of methylene blue into the portal veins and 2 patients had hepatic specimens resected, which were made into a model cast by filling the hepatic veins (yellow) and portal venous branches (blue) with methyl methacrylate after vascular lavage. RESULTS: Serial selective hepatic arteriography showed that hepatic arteries and hemangioma were displayed simultaneously, and that hemangioma was supplied by one to numerous arterial branches. In the portal phase of portography, contrast medium failed to enter the tumor and the intrahepatic branches of the portal vein were pushed aside by the tumor; in the liver parenchymal phase, however, the tumor appeared to be a low-density area. Hepatic arteriography and portography revealed that the fistula between the artery and portal vein may not be existed. The liver stained with methylene blue showed that the normal hepatic parenchyma could be stained with deep blue; in contrast, the tumor was not stained at all. The casting specimens showed that the eroded tumor left a round vacant area because of its total shedding, and no blue stained branches of the portal vein extended into the tumor. CONCLUSION: Blood supply of CHL may originate from the hepatic artery.

Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy

Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type Ⅷb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction.

Source of blood supply of liver cavernous hemangioma and sclerosis and embolization treatment

AIM To investigate the source of blood supply of carvenous hemangioma of liver (CHL) and provide a feasibile treatment for CHL via hepatic artery. METHODS Ⅰ. Origin of blood supply of CHL: portovenography, hepatic arteriography and portal vein staining were performed in 5 patients. Two casts of hepatic blood vessels from resected specimen were observed. Ⅱ. Clinical data: Among 75 patients (30 males, 45 females, aged 25～57 years with a mean of 37 4). 56 were of solitary type (44 on the right lobe, 12 on the left with 4 having intraparenchymatoma) and 19 were of multiple type (9 on the right, 2 the left, 8 whole liver). Twenty two patients were treated by sclerosis, 50 by embolization via hepatic artery and 3 were excised. RESULTS In 5 cases with portography, the contrast medium did not enter the tumor, the tumor appeared as low denty area and the intrahepatic branches of portal vein were pushed aside. In 5 cases with portal vein staining, the normal liver parenchyma was stained deep blue, and the tumor was not stained. The tumor area appeared as a round vacant cavity in 2 specimen casts. In 72 patients treated with sclerosis a or embolization via hepatic artery or through interventional method, the tumors diminished by 10%～30% in diameter and no tumors grew larger. CONCLUSION The blood supply of CHL originates from the hepatic artery. Tumors treated with sclerosis and emblization decreased in size or got fiberized.

Applied anatomical study of the vascularized ulnar nerve and its blood supply for cubital tunnel syndrome at the elbow region

Cubital tunnel syndrome is often accompanied by paresthesia in ulnar nerve sites and hand muscle atrophy. When muscle weakness occurs, or after failure of more conservative treatments, anterior transposition is used. In the present study, the ulnar nerve and its blood vessels were examined in the elbows of 18 adult cadavers, and the external diameter of the nutrient vessels of the ulnar nerve at the point of origin, the distances between the origin of the vessels and the medial epicondyle of the humerus, and the length of the vessels accompanying the ulnar nerve in the superior ulnar collateral artery, the inferior ulnar collateral artery, and the posterior ulnar recurrent artery were measured. Anterior transposition of the vascularized ulnar nerve was per- formed to treat cubital tunnel syndrome. The most appropriate distance that the vascularized ulnar nerve can be moved to the subcutaneous tissue under tension-free conditions was 1.8 ± 0.6 cm （1.1-2.5 cm）, which can be used as a reference value during the treatment of cubital tunnel syndrome with anterior transposition of the vascularized ulnar nerve.

INVESTIGATION OF BLOOD SUPPLY OF BRONCHOGENIC CARCINOMA DERIVING FROM PULMONARY ARTERY

Microfil perfusion technique was used to investigate the blood supply of bronchogenic carcinoma deriving from pulmonary artery on 20 fresh specimens of lung cancer, including 11 squamous carcinoma, 6adenocarcinoma, 1 alveolar cell carcinoma and 2undifferentiated carcinoma cases. The results showed that the appearance and quantity of pulmonary blood supply of bronchogenic carcinoma depended on and changed with the site, activity,growth mode as well as the local condition of tumor nodules; pulmonary artery supplied blood to the Periphery of the tumor and its iunermost part as well; vessels from pulmonary artery in tumor nodules were generally less in number than those in the surrounding normal lung tissues around. The results suggested that the tumor blood supply from pulmonary artery should he evaluated comprehensively and dynamically; during interventional chemotherapy via pulmonary artery, patients should bc selected carefully and the catheter for infusion placed in suitable position so as to gain the best therapeutic effect.

基于“任主胞宫”理论探讨针灸治疗薄型子宫内膜不孕症临床疗效

目的:探究基于“任主胞宫”理论针灸治疗薄型子宫内膜不孕症患者临床疗效。方法:选取薄型子宫内膜不孕症患者80例,根据患者意愿纳入对照组(40例)与观察组(40例)。对照组常规服用拜耳戊酸雌二醇片治疗,观察组在对照组基础上采用基于“任主胞宫”理论针灸治疗,评估治疗后两组子宫内膜厚度、A型子宫内膜形态占比、子宫内膜血流微循环[子宫内膜下血流搏动指数(PI)与阻力指数(RI)]、雌激素含量[黄体期雌激素(E2)、孕酮(P)和促卵泡生成素(FSH)、黄体生成素(LH)等性激素]及1年内妊娠情况。结果:治疗后观察组子宫内膜厚度高于对照组(P<0.05);治疗后观察组A型子宫内膜形态比例高于对照组(P<0.05);两组治疗前PI与RI比较无统计学差异(P>0.05),治疗后观察组PI与RI水平低于对照组(P<0.05);治疗后观察组E2、P与LH水平高于对照组,而FSH水平低于对照组(P<0.05);观察组一年内妊娠率50.00%,对照组为25.00%,观察组明显高于对照组(P<0.05)。结论:基于“任主胞宫”理论针灸可提升薄型子宫内膜不孕症患者的子宫内膜厚度,促进子宫内膜生长,并可改善患者子宫内膜内血流微循环及生殖相关激素水平,提高1年内妊娠率,可优化临床疗效。

质量管理在血站采供血工作中的应用

目的 分析在血站采供血工作中质量管理的应用价值。方法 选取2021年7月—2022年7月在济宁市中心血站献血的70名献血者和11名护理工作人员,均实施质量管理,纳入研究组;另选择2020年5月—2021年5月在血站献血的70名献血者和11名护理工作人员,实施常规管理,纳入对照组。对比和分析工作管理效果。结果 研究组工作管理质量(设备维修保养、责任心、消毒工作质量、环境质量)各项评分高于对照组(P<0.05);研究组献血者总满意度为97.14%,高于对照组的81.43%(P<0.05);研究组一次穿刺成功率、采血质量达标率、健康教育覆盖率分别为92.86%、98.57%、100%,高于对照组的72.86%、85.71%、90.00%,研究组工作差错率为2.86%,低于对照组的17.14%(P<0.05)。结论 在血站采供血工作中质量管理应用价值较高,在工作管理质量、献血者满意度、一次穿刺成功率、采血质量达标率、工作差错率、健康教育覆盖率方面优势明显。

子宫假性动脉瘤误诊分析

目的 探讨子宫假性动脉瘤(uterine artery pseudoaneurysm, UAP)超声特征并分析误诊原因。方法 回顾性选取2016年1月至2023年4月首都医科大学附属北京妇产医院UAP患者35例,收集其超声图像及临床资料,分析其误诊原因。结果 UAP灰阶超声呈肌层或同时累及宫腔及肌层的含有液性无回声区团块状病变,彩色多普勒超声可见一条或多条载瘤动脉血流射入假腔,频谱多普勒超声呈高速低阻血流;部分可伴发动静脉瘘(uterine arteriovenous fistula,UAVF),表现为与子宫静脉同方向的粗大血流,频谱呈与心动周期一致的搏动性频谱。UAP误诊率为71.4%(25/35),被误诊的疾病包括与滋养细胞相关疾病的富血供征象(12例)、UAVF(9例)、滋养细胞疾病(3例)、胚物残留(1例)。结论减少UAP误诊首先需提高对该病的认识,超声检查过程中要注意调节仪器的条件设置以获得更佳图像帮助诊断。

2021—2023年江西省采供血机构血液安全调研情况分析

目的调查分析江西省各采供血机构贯彻落实法律法规情况和工作开展情况,持续提升血液安全水平,保障血液和血液制品质量安全。方法采取听取汇报、查阅资料、实地查看等方式对2021—2023年江西省12家血站、16家单采血浆站开展血液安全调研。结果通过调研,了解了本省各采供血机构工作中的亮点特色,同时也发现了本省采供血机构在人员、机器、物料、方法、环境方面存在的问题,3年的调研中,血站累计发现问题111次,单采血浆站累计发现问题157次。结论根据调研结果,让本省各采供血机构明确改进的方向,也为卫生行政管理部门制定政策提供依据,提高采供血服务水平和血液质量安全监督工作效率。

我国采供血机构双轨用工的问题与对策研究

目的 探析采供血机构双轨用工的问题,为优化人力资源管理提供对策建议。方法 运用专用调查表,对全国229家采供血机构进行调研,统计编制与非编制人员的数量、流动量等信息,并使用T检验进行差异性分析。结果 全国采供血机构普遍存在编制配比变动迟滞、人员新进量存在差异、自因型人员流失量差异明显、薪酬管理体系复杂且多样化的问题。结论 加强对双轨用工所带来的管理复杂性的认识,规划人员编制标准的动态机制,创新编制内外人员管理,优化人员配置结构。

CT平扫与CTPA在肺栓塞邻近肺组织血供变化中的诊断价值对比

目的:对比分析CT平扫与CT肺动脉血管成像(CTPA)在肺栓塞邻近肺组织血供变化中的诊断价值。方法:回顾性分析120例急性肺栓塞患者,其中主肺动脉栓塞(主肺动脉栓塞组)、左右肺动脉干栓塞(左右肺动脉干栓塞组)、叶间动脉栓塞(叶间动脉栓塞组)各40例。3组均行肺部CT平扫及CTPA。3组CT值与CTPA血流参数行Pearson相关性分析。3组CT值行logistic回归分析。采用ROC曲线分析各组CT值对肺栓塞邻近肺组织血供变化的诊断效能。结果:3组的CT值与肺毛细血管嵌压(PCWP)、肺动脉舒张压(PAPd)、肺动脉收缩压(PAPs)均呈正相关(均P<0.05)。多因素logistic回归分析显示,PCWP、PAPd、PAPs是影响各组CT值的独立危险因素(均P<0.05)。主肺动脉栓塞组平扫CT值诊断肺组织血供变化的敏感度为82.12%、特异度为81.31%、AUC为0.735,左右肺动脉干栓塞组分别为83.10%、82.10%、0.741,叶间动脉栓塞组分别为80.01%、82.00%、0.723。结论:CT平扫可准确反映肺栓塞邻近肺组织血供变化,可作为临床诊断肺栓塞的间接征象。

不同针灸介入时机对大脑中动脉供血区急性脑梗死神经功能预后的影响

目的观察不同针灸介入时机对大脑中动脉供血区急性脑梗死神经功能预后的影响。方法回顾性选取2020年1月—2022年8月收治的116例大脑中动脉供血区急性脑梗死患者的临床资料进行分析,根据针灸介入时机分为两组。两组均进行静脉溶栓及常规药物治疗,观察组61例患者于发病72 h内给予针灸治疗,对照组55例患者于发病2周时给予针灸治疗。检测两组不同时间点侧支循环代偿情况、脑损伤标志物的水平,评估两组不同时间点简易精神状态检查(Mini-mental state examination,MMSE)评分、神经功能评分、Barthel指数(Barthel index,BI)评分、肢体运动功能评分、中医症状评分的差异,统计两组疗效。结果治疗前,两组侧支循环代偿情况比较,差异无统计学意义(P>0.05)。治疗4周和随访时,两组患侧大脑前动脉平均血流速度与对侧大脑中动脉平均血流速度的比值(Ratio of the average flow ve⁃locity of the affected anterior cerebral artery to the average flow velocity of the contralateral middle cerebral artery,iVACA/cVM⁃CA)较治疗前升高,观察组同时间点较对照组更高(P<0.05);两组患侧大脑后动脉平均血流速度与对侧大脑中动脉平均血流速度的比值(Ratio of the average flow velocity of the affected posterior cerebral artery to the average flow velocity of the contralateral middle cerebral artery,iVPCA/cVMCA)与治疗前比较,差异无统计学意义(P>0.05)。治疗前,两组脑损伤标志物比较,差异无统计学意义(P>0.05)。治疗4周和随访时,两组脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF)较治疗前升高,观察组同时间点较对照组更高(P<0.05);两组钙结合蛋白β(Calcium binding proteinβ,S100β)、神经胶质纤维酸性蛋白(Glial fibrillary acid protein,GFAP)较治疗前下降,观察组同时间点较对照组更低(P<0.05)。治疗前,两组Fugl-Meyer评分、中医症状评分等相关评分比较,差异无统计学意义(P>0.05)。治疗4周和随访时,两组MMSE评分、BI评分及上肢和下肢Fugl-Meyer评分较治疗前升高,观察组同时间点较对照组更高(P<0.05);两组美国国立卫生院神经功能缺损(National institutes of health stroke scale,NIHSS)评分、中医症状评分较治疗前下降,观察组同时间点较对照组更低(P<0.05)。观察组总有效率为88.52%(54/61)高于对照组的72.73%(40/55),差异有统计学意义(P<0.05)。结论发病72h内采用针灸治疗可改善大脑中动脉供血区急性脑梗死脑损伤标志物的表达,改善脑血流,促进神经功能的恢复,有利于疾病的康复。

不确定环境下采血点定位-资源配置集成决策的鲁棒优化

为提高血液采集量、缓解血液短缺现状,研究不确定环境下两类采血点定位-资源配置集成决策优化问题。首先,考虑区域人流量、献血活跃度等因素对采血点权重的影响,基于广义最大覆盖模型,建立以覆盖权重最大为目标的采血点定位-资源配置集成决策模型。在此基础上,采用鲁棒优化技术处理可用献血车、人员和设备等参数的不确定性,建立相应的鲁棒优化模型。针对模型特点,设计改进的灰狼优化算法对模型进行求解。数值结果表明,改进的灰狼优化算法优于传统灰狼优化算法与粒子群算法。

妊娠期肝内胆汁瘀积症患者脐动脉血流参数与胎儿宫内窘迫关系

目的:探讨妊娠期肝内胆汁瘀积症(ICP)脐动脉血流参数与胎儿宫内窘迫的关系。方法:收集2018年3月-2021年3月于本院治疗的妊娠期肝内胆汁瘀积症患者101例临床资料为病例组,产前检查健康孕妇85例临床资料为对照组,以是否发生胎儿宫内窘迫将病例组分为宫内窘迫组和非宫内窘迫组,分析各组脐动脉血流参数水平及与胎儿宫内窘迫发生的相关性。结果:病例组脐动脉血流参数S/D(4.23±0.35)、RI(1.66±0.32)及PI(1.05±0.15)水平均高于对照组(3.61±0.25、1.01±0.21、0.74±0.23),胎儿宫内窘迫组高于无胎儿宫内窘迫组;相关性分析,脐动脉血流参数S/D、RI及PI与胎儿宫内窘迫发生呈正相关(均P<0.05)。结论:妊娠期肝内胆汁瘀积症患者脐动脉血流参数异常,且与发生胎儿宫内窘迫正相关,为临床病情控制有临床指导意义。

山东省血站献血服务、成分制备及血液供应过程质量监测指标体系的应用

目的建立有效的献血服务、成分制备及血液供应过程质量指标监测体系,客观地评价血液采集、制备和供应过程的质量控制水平,促进血站采供血过程的持续优化和标准化管理。方法建立覆盖采供血全过程的献血服务、成分制备、血液检测、血液供应和质量控制的质量监测指标体系,向山东省17家血站发放《采供血过程质量监测指标统计表》,明确指标定义和计算公式,收集各血站2022年1—12月质量监测指标数据,利用SPSS25.0软件对其中的献血服务(10个)、成分制备(7个)和血液供应(4个)3个方面21个质量监测指标数据进行统计学分析,并比较了不同规模血站质量监测指标的差异。结果17家血站献血服务过程质量监测指标平均值分别为:定期献血者比例44.66%(2233/5000)、献血不良反应发生率0.22%(11/50)、非标量全血采集率0.46%(23/5000)、HBsAg初筛漏检率0.052%(13/25000)、血液采集一针率99.42%(4971/5000)、双份单采血小板采集率86.49%(173/200)、400 mL全血采集率66.50%(133/200)、献血者满意度99.25%(397/400)、带旁路留样系统全血采集袋使用率82.68%(2067/2500)、血液采集职业暴露发生数1例;定期献血者比例和400 mL全血采集率具有较强的正相关(P<0.05);大型血站双份单采血小板采集率、献血不良反应发生率和非标量全血采集率显著低于中、小型血站(P<0.05)。17家血站成分制备过程质量监测指标平均值分别为:血液成分制备血袋破损率0.03%(3/10000)、乳糜血报废率3.05%(61/2000)、溶血报废率0.13%(13/10000)、贴签错误发生数0.06件、血液导管渗漏数8袋、血液穿刺/接驳渗漏数2.76袋、耗材不合格数0.59件;大型血站溶血报废率显著低于中型和小型血站(P<0.05)、大型和中型血站乳糜血报废率显著低于小型血站(P<0.05)。17家血站血液供应过程质量监测指标平均值分别为:血液制剂过期报废率0.023%(23/100000)、血液制剂储存发放破损率0.009%(9/100000)、退血报废率0.106%(53/50000)、用血医院服务满意度99.16%(2479/2500)。不同血站之间血液制剂储存发放破损率与血液成分制备血袋破损率差异具有统计学意义(P<0.05)。在大、中和小型血站之间定期献血者比例、献血不良反应发生率、非标量全血采集率、400 mL全血采集率、双份单采血小板采集率,血液成分制备血袋破损率、乳糜血报废率、溶血报废率、血液制剂过期报废率、血液制剂储存发放破损率和退血报废率的差异具有统计学意义(P均<0.05)。结论山东省血站献血服务、成分制备及血液供应过程质量监测指标体系的建立具有较好的适用性、可行性和有效性,能够客观评价血站采供血过程质量管理水平,推进全省血液管理同质化和标准化发展,为今后开展血站综合评价奠定基础。

山东省血站血液质量监测指标体系的构建

目的构建山东省血站血液质量监测指标体系,以期持续提升血液质量和标准化管理。方法通过文献、标准等检索,结合采供血实际工作,以采供血业务过程关键控制点为导向,拟定血液质量监测指标体系。经2轮德尔菲法专家征询和论证,运用主观加权和层次分析法分析各指标权重,又经6个月的试行,完成对指标内容的修订和完善。结果构建了覆盖采供血全过程的血液质量监测指标体系,包括一级指标5项,分别为献血服务、成分制备、血液检测、血液供应和质量控制;二级指标72项,包含指标含义、计算公式等。2轮专家征询意见和2轮论证会议,修订指标17项,并通过主观加权和层次分析法获得指标权重,经试行的局部微调,形成了血液质量监测指标体系。结论首次构建覆盖采供血业务全过程的血液质量监测指标体系,可有效评价血站质量管理水平,为打造山东省血液质量管理“一盘棋”发展模式、提升标准化管理水平奠定基础。

名中医丛慧芳从“正虚邪恋”论治“寒地”盆腔炎性疾病后遗症经验

总结丛慧芳教授治疗盆腔炎性疾病后遗症的临床经验。丛慧芳教授基于女性胞宫的生理独特性,认为胞宫为至阴之地以及地处北方的地域性,再结合疾病迁延难愈的特性,总结正虚邪恋是此病的关键病机,病位虽在胞宫,病机为冲任受损,但与五脏相因,切不可一味攻伐祛湿清热,认为“虚”和“瘀”是导致本病发生和经久不愈的关键因素。此时瘀血同时作为病理产物和继发病因,机体无力自主,缠绵痛苦势所必然。由此在治疗时以扶正祛邪为其根本治疗思路,唯清热除湿恐难取效,亦非独驱邪攻瘕以复其能,故丛慧芳教授在此基础上采取温散祛瘀之法,使正气匡扶,邪气可散,余症自瘥。

新冠肺炎疫情对国内25家地级市中心血站全血制备成分血的供应影响分析

目的分析2017—2022年国内25家地市级中心血站全血制备的成分血供应情况是否受到新冠肺炎疫情的影响。方法采用回顾性研究方法,收集2017—2022年国内25家中心血站红细胞成分血、冰冻血浆、冷沉淀凝血因子、病原体灭活冰冻血浆、调剂红细胞成分血和冰冻血浆的发放数据,根据新冠疫情发生时间(2019年底),将发放数据分为两组,2017年、2018年、2019年为非新冠疫情组(简称非疫情组),2020年、2021年、2022年为新冠疫情组(简称疫情组)。结果2017—2022年,红细胞成分血发放量呈波动增长,2022年>2021年>2019年>2020年>2018年>2017年,2020年较2019年下降19724.12 U,呈负增长(–1.43%),与中心血站显著相关(P<0.05);冰冻血浆发放量呈逐年递增,2022年>2021年>2020年>2019年>2018年>2017年,与中心血站显著相关(P<0.05);冷沉淀凝血因子发放量基本呈逐年递增,2021年>2022年>2020年>2019年>2018年>2017年,2022年较2021年下降6303.72 U,呈负增长(–1.54%),与中心血站显著相关(P<0.05)。2020—2022年,病原体灭活冰冻血浆发放量呈波动增长;年度同比增长率2021年呈负增长,2022年呈正增长;调剂红细胞成分血发放量呈逐年递减,年度同比增长率呈负增长;调剂冰冻血浆发放量呈逐年递减,年度同比增长率呈负增长。结论国内25家中心血站全血制备成分血的供应情况地区差异大,受新冠疫情的影响程度亦不同,总体上对2020年的供应能力影响最显著,血液调剂是新冠疫情期间保证血液供应的措施之一。