Novel Application of Vacuum Sealing Drainage with Continuous Irrigation of Potassium Permanganate for Managing Infective Wounds of Gas Gangrene

Summary： Traumatic gas gangrene is a fatal infection mainly caused by Clostridium perfringens. It is a challenge to manage gas gangrene in open wounds and control infection after debridement or amputa- tion. The aim of the present study was to use vacuum sealing drainage （VSD） with continuous irrigation of potassium permanganate to manage infective wounds of gas gangrene and observe its clinical effi- cacy. A total of 48 patients with open traumatic gas gangrene infection were included in this study. Am- putations were done for 27 patients, and limb salvage procedures were performed for the others. After amputation or aggressive debridement, the VSD system, including polyvinyl alcohol （PVA） foam dress- ing and polyurethane （PU） film, with continuous irrigation of 1：5000 potassium permanganate solutions, was applied to the wounds. During the follow-up, all the patients healed without recurrence within 8-18 months. There were four complications. Cardiac arrest during amputation surgery occurred in one pa- tient who suffered from severe septic shock. Emergent resuscitation was performed and the patient re- turned to stable condition. One patient suffered from mixed infection of Staphylococcal aureus, and a second-stage debridement was performed. One patient suffered from severe pain of the limb after the debridement. Exploratory operation was done and the possible reason was trauma of a local peripheral nerve. Three cases of crush syndrome had dialysis treatment for concomitant renal failure. In conclusion, VSD can convert open wound to closed wound, and evacuate necrotic tissues. Furthermore, potassium permanganate solutions help eliminate anaerobic microenviroument and achieve good therapeutic effect on gas gangrene and mixed infection. VSD with continuous irrigation of potassium permanganate is a novel, simple and feasible alternative for severe traumatic open wounds with gas gangrene infection.

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Background:Vacuum sealing drainage(VSD)and epidermal growth factor(EGF)both play an important role in the treatment of wounds.This study aims to explore the effects of the combination of VSD and EGF on wound healing and the optimal concentration and time of EGF.Methods:We tested the proliferation and migration capacity of HaCaT and L929 cells at different EGF concentrations(0,1,5,10,and 100ng/ml)and different EGF action times(2,10,and 30min).A full-thickness skin defect model was established using male,30-week-old Bama pigs.The experiment included groups as follows:routine dressing change after covering with sterile auxiliary material(Control),continuous negative pressure drainage of the wound(VSD),continuous negative pressure drainage of the wound and injection of EGF 10min followed by removal by continuous lavage(V+E 10min),and continuous negative pressure drainage of the wound and injection of EGF 30min followed by removal by continuous lavage(V+E 30min).The wound healing rate,histological repair effect and collagen deposition were compared among the four groups.Results:An EGF concentration of 10ng/ml and an action time of 10min had optimal effects on the proliferation and migration capacities of HaCaT and L929 cells.The drug dispersion effect was better than drug infusion after bolus injection effect,and the contact surface was wider.Compared with other groups,the V+E 10min group promoted wound healing to the greatest extent and obtained the best histological score.Conclusions:A recombinant human epidermal growth factor(rhEGF)concentration of 10 ng/ml can promote the proliferation and migration of epithelial cells and fibroblasts to the greatest extent in vitro.VSD combined with rhEGF kept in place for 10min and then washed,can promote wound healing better than the other treatments in vitro.

Salvage of vascular graft infections via vacuum sealing drainage and rectus femoris muscle flap transposition: A case report

BACKGROUND The management of vascular graft infections continues to be a significant challenge in a clinical situation.The aim of this report is to illustrate the novel vacuum sealing drainage(VSD)technique and rectus femoris muscle flap transposition for vascular graft infections,and to evaluate the prospective of future testing of this surgical procedure.CASE SUMMARY We report the case of a 32-year-old male patient,who presented a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure.Using the VSD and muscle flap transposition,the groin wound and vascular graft infection were finally treated successfully.CONCLUSION Our case report highlights that VSD technique and rectus femoris muscle flap transposition could be considered in patients presenting with a severe infected groin wound with biological vascular graft Acinetobacter baumannii infection resulting in extensive graft exposure,especially in consideration of treatable conditions.

Effect of vacuum sealing drainage combined with biological dressings on the angiogenesis and inflammatory response after diabetic foot ulcer wound grafting

Objective: To study the effect of vacuum sealing drainage combined with biological dressings on the angiogenesis and inflammatory response after diabetic foot ulcer wound grafting. Methods: Patients with diabetic foot who were treated in Sichuan Provincial People's Hospital between May 2014 and February 2017 were selected and randomly divided into vacuum drainage group and normal control group who received vacuum sealing drainage combined with biological dressings as well as conventional debridement and dressing change to deal with the wound respectively. Before treatment as well as 1 d, 3 d and 5 d after treatment, the wound tissue was collected to determine the expression of angiogenesis molecules, angiogenesis signaling pathway molecules and inflammatory response molecules. Results: 1 d, 3 d and 5 d after treatment, VEGF, VEGFR, CD105, MMP9, PI3K, AKT, cyclinD1, p38MAPK and NF-kB protein expression in wound tissue of vacuum drainage group were significantly higher than those of normal control group while COX-2, iNOS, TNF-α and IL-6 mRNA expression were significantly lower than those of normal control group. Conclusion: Vacuum sealing drainage combined with biological dressings promotes the angiogenesis and inhibits the inflammatory response after diabetic foot ulcer wound grafting.

Assessment of the trauma degree and bone metabolism after external fixation combined with vacuum sealing drainage treatment of open tibiofibula fracture

Objective: To evaluate the effect of external fixation combined with vacuum sealing drainage on the trauma degree and bone metabolism in patients with open tibiofibula fracture. Methods:A total of 116 patients with open tibiofibula fracture who received surgical treatment in Luzhou People's Hospital between February 2015 and January 2017 were divided into control group (n=58) and study group (n=58) by random number table. Control group received debridement + external fixation, and study group received debridement + external fixation +vacuum sealing drainage. The differences in the levels of trauma indexes and bone metabolism indexes were compared between the two groups before and after treatment. Results: Before surgery, there was no statistically significant difference in serum levels of trauma indexes and bone metabolism indexes between the two groups. 1 week after surgery, serum acute phase protein Tf level of study group was higher than that of control group whereas CER, Hp and CRP levels were lower than those of control group;stress indexes NE and Cor levels were lower than those of control group;bone metabolism indexes P1NP, BGP and BALP levels were higher than those of control group whereas β-CTX level was lower than that of control group. Conclusion: External fixation combined with vacuum sealing drainage can effectively reduce fracture trauma and promote fracture end healing in patients with open tibiofibula fracture.

Effect of vacuum sealing drainage combined with intermittent insulin flushing on expression of inflammatory factors and apoptosis factors in diabetic lower limb ulcer wound

Objective: To discuss the effect of vacuum sealing drainage combined with intermittent insulin flushing on the expression of inflammatory factors and apoptosis factors in diabetic lower limb ulcer wound. Methods: A total of 48 patients with diabetic lower limb ulcer who were treated in the Endocrine Department of the hospital between January 2016 and January 2017 were divided into the control group and research group by random number table, 24 cases in each group. Control group received vacuum sealing drainage, and research group received vacuum sealing drainage combined with intermittent insulin flushing. The differences in the expression of inflammatory factors and apoptosis genes in the wound exudate were compared between the two groups before and after treatment. Results: Before treatment, the differences in the inflammatory factor contents and apoptsis gene expression in wound exudate were not statistically significant between the two groups of patients. After treatment, inflammatory factors IL-6, IL-1β, TNF-α, CRP, VCAM-1 and FGF2 contents in wound exudate of research group were lower than those of control group;apoptosis gene Bcl-2 mRNA expression in wound exudate of research group was higher than that of control group while Bax, p53 and Fas mRNA expression were lower than those of control group. Conclusions: Vacuum sealing drainage combined with intermittent insulin flushing can effectively reduce the local inflammatory response and promote the granulation cell proliferation in wound of patients with diabetic lower limb ulcer.

Application of vacuum sealing drainage in skin graft of calf pedicle island flap donor-site

Objective: To explore the clinical effect of vacuum sealing drainage on free dermatoplasty in the donor-site of calf pedicled island flap. Method: From January 2016 to January 2018, a total of 70 patients undergoing reconstruction of skin and soft tissue defects in ankles and legs with calf pedicle island flap in Foshan Traditional Chinese Medicine Hospital were selected into our research. Selected patients were divided into VSD group and pressure dressing group according to the order of surgery. The VSD group was treated with free skin grafting and vacuum sealing drainage after separation of donor-site flap. The pressure dressing group was treated with free skin grafting and traditional pressure dressing technology after the separation of donor-site flap. Visual acuity simulation scores (VAS) were observed and recorded on the 1st, 7th, and 14th day after surgery. The unpacking time, skin graft healing time, skin graft survival rate, infection rate and incidence of subcutaneous hematoma were compared between the two groups. Results: The VAS scores on the 7th and 14th day after surgery in the VSD group were lower than those in the pressure dressing group. The unpacking time and skin graft healing time of the VSD group were shorter than those of the pressure dressing group. The survival rate of skin graft in VSD group was higher than that in the pressure dressing group. The infection rate and the incidence of subcutaneous hematoma in the VSD group were lower than those in the pressure dressing group. Conclusion: Vacuum sealing drainage is beneficial to promote the healing of free skin grafts in the donor site of the calf pedicle island flap, relieve pain, reduce adverse reactions, safe and effective, and worthy of clinical promotion.

Effect of Ilizarov external fixation combined with negative pressure sealing drainage and antibiotics in the treatment of infective tibial nonunion

Objective:Observation on the effect of Ilizarov external fixation combined with vacuum pressure sealing drainage and antibiotics in the treatment of infective tibial nonunion.Methods:79 patients with tibial infective nonunion who were treated in our hospital from August 2016 to August 2018 were divided into two groups according to random number table,with 39 patients in the control group treated with Ilizarov external fixation technology and 40 patients in the study group treated with vacuum pressure sealing drainage and antibiotics on the basis of the control group.Bone healing time and daily walking were recorded.Rasmussen score,serum intercellular adhesion molecule-1(ICAM-1)and IL-6 levels,lower limb Fugl-Meyer motor function score and lower limb BI index score were compared at different time.Results:The daily walking condition of the study group was significantly better than that of the control group(P<0.05),and the healing time of bone was significantly shorter than that of the control group(P<0.05);the Rasmussen score of the study group was higher than that of the control group at 1 month,6 months and 12 months after treatment(P<0.05);the levels of serum ICAM-1 and IL-6 in the two groups after treatment were lower than those before treatment(P<0.05),and the levels of serum ICAM-1 and IL-6 in the study group were lower than those in the control group after treatment(P<0.05).The lower limb Fugl-Meyer motor function score and lower limb BI index score of the two groups after treatment were higher than those before treatment(P<0.05),and the lower limb Fugl-Meyer motor function score and lower limb BI index score of the study group after treatment were higher than those of the control group(P<0.05).Conclusions:Ilizarov external fixation combined with vacuum pressure sealing drainage and antibiotics can promote the bone healing of patients with infective tibial nonunion,significantly improving their daily walking condition,alleviating inflammation,and recovering the knee joint function and lower limb function well.

真空预压-PVD排水板加固吹填土地基试验及数值模拟研究

对虎门港地区某施工现场典型吹填土开展了室内土工试验、真空预压-PVD排水板加固吹填土的室内单井模型试验,通过试验测量模型筒内的孔隙水压力、土体沉降量、排水板不同位置的真空度大小和试验排水量,并在模型试验结束后取模型筒内不同位置的土样进行直剪试验和含水率测定,对真空预压-PVD排水板加固土体效果和排水板淤堵问题进行了分析,并用Abaqus软件建立了相应的二维有限元模型,分析改变膜下真空度和改变排水板插入深度等因素对地基固结效果的影响。研究发现,土体的抗剪强度随着深度的增加而逐渐降低,土样的顶部沉降量最大,逐渐减少至中部以下土样的沉降仅有轻微差异,受淤堵层的影响,排水表现出在排水开始时排水量迅速增加,达最大值后逐渐减小,最后趋于稳定的现象;而随着膜下真空度的增大和排水板打设深度的增加,地基固结效果越好。

新型改良负压引流瓶在体液引流患者中的应用

目的研制一种新型改良一次性可调速螺纹接口负压引流瓶(简称新型改良负压引流瓶),并探讨其应用效果。方法选取2023年2月至8月在本院CCU持续体液引流的27例患者为研究对象。采用简单随机法将患者随机分为对照组12例(置管期间共更换负压引流瓶76次),试验组15例(置管期间共更换新型改良负压引流瓶83次)。对照组患者采用引流管外接负压引流瓶,试验组采用引流管外接新型改良负压引流瓶,比较两组患者在置管引流期间渗液/漏液/脱管发生率,每次更换引流瓶耗时、耗材费用的差异;比较两组护患对两种引流方法的满意度。结果两组患者均完成研究。试验组患者渗液/漏液/脱管发生率与每次更换引流瓶耗时、耗材费用均低于对照组,两组比较,差异具有统计学意义(均P<0.05);试验组护患满意度均高于对照组,两组比较,差异具有统计学意义(均P<0.001)。结论新型改良负压引流瓶能弥补传统负压引流瓶不足,降低患者引流期间渗液/漏液/脱管发生率,而且更换的费用与耗时更少,受到护患的欢迎。

四妙勇安汤负压滴灌治疗湿热内蕴型糖尿病足伴严重下肢缺血患者的临床观察

目的观察四妙勇安汤负压滴灌治疗湿热内蕴型糖尿病足伴严重下肢缺血患者的临床疗效。方法选取2021年6月—2023年10月期间邢台医学高等专科学校附属二院收治的糖尿病足(Diabetic foot,DF)伴严重下肢缺血(Critial limb ischemia,CLI)患者60例,采用随机数表法分为对照组和观察组,每组各30例,术前WIFI分级评估,进行相应的血管腔内治疗,血运重建成功后,分别行坏疽趾或趾列开放性切除或溃疡清创术,其中对照组术后采用负压封闭引流(VSD)进行治疗,观察组术后采用四妙勇安汤负压滴灌治疗,1周后拆除VSD敷料查看创面情况,创面内组织细菌培养阴性后,行创面修复,直至创面愈合,分别检测治疗1、2周后血清C反应蛋白(C-reactive protein,CRP)、降钙素原(Procalcitonin,PCT),治疗2周后创面细菌转阴率;检测治疗2周后经皮氧分压(Transcutaneous oxygen pressure,T_(C)PO_(2))及踝肱指数(Ankle-brachialindex,ABI)、创面愈合时间及不良反应。结果治疗后观察组总有效率90.00%(27/30)明显高于对照组80.00%(24/30),差异有统计学意义(P<0.05)。治疗后两组患者CRP、PCT水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组CRP、PCT水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组创面细菌转阴率90%(27/30)明显高于对照组70%(21/30),差异有统计学意义(P<0.05)。治疗后两组患者T_(C)PO_(2)水平均较治疗前升高,差异有统计学意义(P<0.05);且观察组T_(C)PO_(2)水平明显高于对照组,差异有统计学意义(P<0.05),观察组ABI指数与对照组比较,治疗前后差异无统计学意义(P>0.05)。治疗后观察组创面愈合时间(28.63±5.30)d明显优于对照组(40.87±5.14)d,差异有统计学意义(P<0.05)。治疗期间,两组患者均无过敏、肿胀、感染加重等不良反应发生。结论四妙勇安汤负压滴灌治疗糖尿病足伴严重下肢缺血腔内治疗术后湿热内蕴型可有效控制感染,改善局部微循环,缩短创面愈合时间,具有临床应用及推广价值。

归因分析理论下护理流程再造对骨折负压封闭引流术术后患者的恢复影响

目的 分析归因分析理论下护理流程再造对骨折负压封闭引流术(VSD)术后患者恢复的影响。方法 选取我院2022年2月至2023年3月收治的82例骨折VSD术后患者,随机分为参照组和试验组,每组各41例,参照组采用一般性护理干预,试验组采用归因分析理论下护理流程再造模式,对比两组骨折VSD术后患者二期植皮天数、创面缩小面积、平均骨折愈合时间、住院时间和并发症发生率及两组疼痛评分、焦虑评分改善情况。结果 试验组二期植皮天数、平均骨折愈合时间、住院时间明显短于参照组(P <0.05),创面缩小面积明显大于参照组(P <0.05);试验组骨折患者疼痛评分、焦虑评分改善情况明显优于参照组(P <0.05),并发症发生率低于参照组(P <0.05)。结论 归因分析理论下护理流程再造对骨折VSD术后患者恢复具有良好的应用效果,更有利于缩短患者恢复时间,改善患者疼痛程度和焦虑心理,减少并发症发生。

自体富血小板血浆联合负压封闭引流对糖尿病足溃疡患者创面愈合情况的影响

目的探究自体富血小板血浆联合负压封闭引流对糖尿病足溃疡患者创面愈合情况的影响。方法选取2018年1月至2020年12月大连大学附属中山医院收治的100例Wagner 2~4级糖尿病足溃疡患者作为研究对象,使用抽签法分为对照组与研究组,每组50例。对照组采用常规方案治疗,研究组采用自体富血小板血浆联合负压封闭引流治疗。比较两组临床疗效、瘙痒评分、疼痛评分[数字评分法(NRS)]、肉芽组织血管生成因子[碱性成纤维细胞生长因子(bFCF)、表皮生长因子(EGF)、血管内皮生长因子(VEGF)]水平、临床指标、血糖指标[空腹血糖(FPG)、糖化血红蛋白Alc(HbAlc)、餐后2 h血糖(2 h PBG)]、胰岛素水平[空腹胰岛素(FIns)、稳态模型评估-胰岛素抵抗指数(HOMA-IR)]。结果研究组治疗总有效率为98.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,两组瘙痒评分、NRS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组bFCF、EGF、VEGF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组创面愈合时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组FPG、HbAlc、2 h PBG、HOMA-IR水平均低于治疗前,FIns水平均高于治疗前,且研究组FPG、HbAlc、2 h PBG、HOMA-IR水平均低于对照组,FIns高于对照组,差异有统计学意义(P<0.05)。结论自体富血小板血浆联合负压封闭引流治疗糖尿病足溃疡效果显著,可促进患者创面愈合,改善患者临床症状,值得临床推广应用。

负压封闭引流技术在Ⅲ级暴露犬咬伤创面处理中的应用

目的 探讨负压封闭引流技术(VSD)在Ⅲ级暴露犬咬伤创面的治疗效果。方法 选取2020年1月至2023年12月在郑州大学第五附属医院接受治疗的90例Ⅲ级暴露犬咬伤创面患者,以随机数字表法分为研究组(n=45)与对照组(n=45),研究组采用常规清创结合VSD治疗,对照组采用常规清创、换药治疗,对两组临床相关指标、疼痛程度、各时间段C反应蛋白(CRP)、并发症发生率进行比较。结果 研究组换药次数较对照组少,二期缝合、肿胀消退、创面愈合及住院时间短,差异有统计学意义(P <0.05);研究组换药时疼痛评分较对照组低,差异有统计学意义(P <0.05);两组治疗前、治疗后1 d CRP水平比较差异无统计学意义(P> 0.05),治疗后2 d两组CRP水平均达到最高值,治疗后2~5 d研究组CRP水平低于对照组,差异有统计学意义(P <0.05);随访6个月,研究组并发症发生率(8.89%)低于对照组(24.44%),差异有统计学意义(P <0.05)。结论 Ⅲ级暴露犬咬伤创面应用常规清创结合VSD进行治疗,能够缩短创面愈合时间,减轻患者疼痛,降低创面感染等并发症发生率。

慢性难治性创口清创减张缝合VSD综合治疗方案临床分析

目的:分析27例通过清创减张缝合封闭式负压引流技术(VSD)综合治疗方案在解决慢性难治性创口术后愈合不良问题中应用的疗效。方法:回顾性分析27例2019年12月-2023年11月我院骨科应用VSD综合治疗方案治疗慢性难治性创口的临床资料,记录患者创面不愈合时间、VSD次数、愈合时间、血红蛋白含量、白蛋白含量,评估VSD综合治疗方案在治疗慢性难治性创口术后愈合不良问题中的作用。结果:共27例不同原因导致大面积或复杂创面不愈合的病人,在经过平均2.1次VSD引流术后采用多层减张缝合闭合创面。在入我科行VSD综合治疗后,创面愈合时间5-56(平均23.2)天,术后随访2-36月,伤口均愈合良好,无复发。结论:清创减张缝合VSD综合治疗方案在治疗慢性难治性创口术后愈合不良问题中有着良好的疗效。

负压封闭吸引对结核术后难愈性创面中相关因子表达及预后的研究

目的探讨应用负压封闭引流(VSD)治疗结核术后出现难愈性创面的患者,研究其相关因子的表达及预后。方法选取2016年1月-2022年5月我院胸外科结核术后出现伤口愈合不良的患者76例,按数字表格法分为观察组和对照组,每组38例,观察组接受VSD治疗,对照组接受外科换药治疗,在治疗前和治疗后第7天用ELISA法测定血清中TNF-α、IL-4、IL-8、IL-10的含量和伤口肉芽组织中TGF-β1、VEGF、HIF-1α的含量及伤口愈合拆线时间。结果比较两组治疗前TNF-α、IL-4、IL-8、IL-10及TGF-β1、VEGF、HIF-1α水平,差异无统计学意义(P>0.05)。治疗后第7天检测,TNF-α、IL-8较治疗前均降低,其中观察组较对照组降低更明显(P<0.05);IL-4、IL-10较治疗前均升高,其中观察组较对照组升高更明显(P<0.05);TGF-β1、VEGF较治疗前均升高,其中观察组较对照组升高更明显(P<0.05);HIF-1α较治疗前均降低,其中观察组较对照组降低更明显(P<0.05)。观察组愈合拆线时间较对照组明显缩短,差异有统计学意义(P<0.05)。结论应用VSD治疗结核术后出现的难愈性创面,可以减轻炎症反应,促进增殖、修复,加速创面愈合。

复合皮移植联合VSD修复碾压伤致肘关节外露

目的:探讨复合皮移植联合负压封闭引流(Vacuum sealing drainage,VSD)在碾压伤伴关节外露创面修复中的临床应用效果及可行性。方法:2020年12月,笔者科室收治1例因左上肢车祸伤致皮肤坏死伴肿胀1 d的患者,入院时查体左上肢肿胀,左前臂、肘部可见约15.0 cm×20.0 cm皮肤坏死,左手感觉功能减退,桡动脉尚可触及,急诊手术探查见肘关节外露、脱位,肱三头肌自肱骨大范围撕脱,尺神经外露、移位,肘关节、尺骨外露范围约3.0 cm×5.0 cm。根据患者病史、临床表现、左上肢X线片及手术探查体征诊断左上肢碾压伤,肘关节外露。应用复合皮移植两步法联合VSD覆盖创面,自体中厚皮片移植修复皮肤缺损。结果:患者左上肢皮肤缺损处愈合良好,术后4个月复查,肘关节屈曲、伸直、旋转功能均恢复良好。结论:对于此例肘关节、骨外露创面,应用复合皮移植后可覆盖骨外露创面,大大降低了手术难度及患者的痛苦,为以后相对小面积骨外露创面的修复提供了新思路。

负压封闭引流在颌面颈部间隙感染致下行性坏死性纵隔炎治疗中的应用效果评价

目的:探讨负压封闭引流(vacuum sealing drainage,VSD)在颌面颈部间隙感染致下行性坏死性纵隔炎(descending necrotizing mediastinitis,DNM)中的临床应用效果。方法:回顾2014年7月—2023年7月就诊于新疆医科大学附属口腔医院采用负压封闭引流术治疗的53例DNM患者的临床资料,对治疗效果进行总结分析。采用SPSS 26.0软件包对数据进行统计分析。结果:53例患者中,3例放弃治疗,1例死亡,其余患者均治愈出院。平均住院天数(25.3±13.75)d,VSD平均放置时间(16.15±8.22)d,ICU平均监护时间(12.02±11.56)d,平均更换VSD次数(1.57±1.32)次。患有糖尿病患者与血糖正常患者的住院天数、ICU监护时间、VSD使用时长、抗生素使用天数、住院总费用,入院时中性粒细胞数与淋巴细胞数比值(N/L值)、白介素6(IL-6)及D-二聚体(D-D)值均有显著差异。结论:负压封闭引流术在颌面颈部间隙感染致下行性纵隔炎的治疗中创伤小,能促进炎症吸收,减轻患者病程中换药的痛苦,对于感染至前下纵隔及全纵隔的病例,联合胸腔闭式引流或纵隔切开引流,效果肯定,具有一定的临床应用价值。

脐带间充质干细胞移植联合负压封闭引流技术治疗糖尿病足溃疡的疗效观察

目的 观察脐带间充质干细胞移植(UCMSCs)联合负压封闭引流技术(VSD)治疗糖尿病足溃疡(DFU)的疗效。方法纳入2020年5月至2022年5月邯郸市中心医院收治的86例DFU病人,根据随机数字表法分为引流组(43例)和联合组(43例)。其中引流组给予VSD,联合组给予UCMSCs联合VSD。比较两组创面愈合时间及创面愈合率,足部相关指标[足背动脉血管内径、血流速度、踝肱指数(ABI)],周围血管恢复情况[密歇根神经体征评分(MNSI)、CT血管造影(CTA)检查],炎症指标[C反应蛋白(CRP)、白细胞(WBC)、中性粒细胞百分比(NEU%)],肾功能(尿酸、肌酐)及临床疗效。结果 联合组创面愈合率[(68.42±6.95)%比(52.78±5.35)%]明显高于引流组(P<0.05),创面愈合时间[(27.34±2.76)d比(31.46±3.25)d]明显低于引流组(P<0.05);引流组和联合组治疗后足背动脉血管内径[(1.95±0.21)mm比(1.86±0.17)mm,(2.10±0.35)mm比(1.82±0.15)mm]、ABI(0.87±0.26比0.61±0.15,0.75±0.21比0.64±0.17)均明显升高(P<0.05),且与引流组比较,联合组明显升高(P<0.05);与治疗前比较,引流组和联合组治疗后足背动脉血流速度[(47.35±4.75)cm/s比(52.75±5.32)cm/s,(41.78±4.27)cm/s比(52.14±5.26)cm/s]、MNSI评分(4.68±0.51比5.74±0.61,4.12±0.42比5.89±0.65)、CRP[(35.78±3.62)mg/L比(41.78±4.25)mg/L,(29.36±3.02)mg/L比(2.14±4.31)mg/L]、WBC[(7.58±0.79)×10^(9)/L比(9.45±1.06)×10^(9)/L,(6.42±0.67)×10^(9)/L比(9.12±1.01)×10^(9)/L]、NEU%[(64.31±6.53)%比(69.72±7.02)%,(58.14±5.86)%比(70.54±7.11)%]水平均明显降低(P<0.05),且与引流组比较,联合组明显降低(P<0.05);联合组总有效率(95.35%)明显高于引流组(72.09%),联合组临床疗效优于引流组(Z=2.09,P<0.05)。结论UCMSCs联合VSD治疗DFU可有效减轻炎症反应,改善临床症状,促进创面恢复,效果较好。

负压封闭引流联合威伐光治疗难愈性创面的临床效果观察

目的:观察负压封闭引流(VSD)联合威伐光(wIRA)治疗难愈性创面的临床效果。方法:选取2020年1月—2023年1月遂宁市中心医院收治的64例难愈性创面患者,按住院顺序排列,分为试验组和对照组,每组32例。试验组清创术后实施VSD+wIRA治疗,对照组清创术后实施换药治疗。观察两组肉芽生长速度、创面愈合速度、治疗时间以及临床换药次数。结果:试验组治疗第7天创面肉芽生长情况评分高于对照组,差异有统计学意义(P<0.05);试验组行Ⅱ期手术闭合创面的时间短于对照组,差异有统计学意义(P<0.05);试验组行Ⅱ期手术术前1d创面肉芽组织生长情况评分低于对照组,差异有统计学意义(P<0.05);试验组换药次数少于对照组,差异有统计学意义(P<0.05)。结论:VSD技术联合wIRA治疗难愈性创面的疗效确切,能缩短病程,是一种较理想的治疗方式。