Application of Nursing Cooperation Path in Operating Room and Analysis of Complication Rate During Laparoscopic Hysterectomy

Objective:To explore the clinical benefits achieved by implementing the operating room nursing cooperation path for patients undergoing laparoscopic hysterectomy.Methods:64 laparoscopic hysterectomy cases were divided into groups according to the order of admission.The control group received routine perioperative care.The observation group implemented the nursing cooperation path in the operating room on the same basis as the control group.The two groups’physiological responses,stimulus indicators,anxiety,and complication rates were compared.Results:The heart rate,blood pressure 0.5 hours after surgery,anxiety scores 1 day before and 3 days after surgery,and the total number of complications in the observation group were all lower than those in the control group(P<0.05).Conclusion:The development of a nursing cooperation path in the operating room can help patients undergoing laparoscopic hysterectomy reduce heart rate,blood pressure,stress responses,and the risk of complications,and is worthy of promotion.

Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report

BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare.Polycythemia is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and obesity.Here we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated polycythemia.CASE SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous uterus.She suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several months.Laboratory analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of polycythemia.Arterial blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 mmHg.Abdominal computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 cm.To reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic hysterectomy.The uterus weighed 5400 g and the histology confirmed a diagnosis of leiomyoma.We did not find increased erythropoietin levels in the supernatant of the myomatous uterine tissue.There were no complications.On postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,respectively.Arterial blood gas analysis after surgery showed a pO2 of 144.7 mmHg.These results suggested the diagnosis of myomatous erythrocytosis syndrome.The patient was discharged on the second postoperative day in very good condition with no symptoms.CONCLUSION We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and obesity.Multiple VTE risk factors warranted a laparoscopic approach.

Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies： a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China

Background： To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy （LH） compared with abdominal hysterectomy （AH） in case of benign gynecological disease. Methods： A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies （3,539 LH vs.1,356 AH） between 2007 and 2013 was involved. Operative time （OT）, estimated blood loss （EBL）, intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed. Results： The EBL （174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively）, passing flatus （38.7±14.1 vs. 48.1±13.2 hours）, days with indwelling catheter （1.5±0.6 vs. 2.2±0.8 days）, use of analgesics （6.5% vs. 73.1%）, intra-operative complication rate （2.4% vs. 4.1%）, post-operative complication rate （2.3 % vs. 5.7%）, post-operative constipation （12.1% vs. 24.6%）, mild and serious stress urinary incontinence （SUI） post-operative （P〈0.001; P=0.014）, and proportion of Female Sexual Functioning Index （FSFI） total score 〈26.55 post-operative （P〈0.001） of the LH group were significantly less than those of AH group. There were no significant differences in OT （106.5±34.5 vs. 106.2±40.3 min） between the two groups. Conclusions： LH is a safe and efficient operation for improving patients＇ long-term quality of life （QoL）, and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus.

Total laparoscopic hysterectomy after liver transplantation

BACKGROUND: The number of females who undergo liver transplantation is growing and sometimes gynecologic operations are needed to control gynecologic diseases after liver transplantation. METHOD: Total laparoscopic hysterectomy was performed in 2 patients who had undergone liver transplantation, one for adenomyosis and the other for hysteromyoma. RESULTS: It was safe to create a pneumoperitoneum through the umbilical skinfold even though mild adhesion in the pelvic cavity occurred in one patient. The operative times were 95 and 90 minutes, with blood loss of about 100 and 60 ml, respectively. Oral intake, flatus passage, and ambulation recovered within a day, after the operation. No significant changes in liver function were observed except complication of diarrhea caused by Candida albicans in one patient. CONCLUSIONS: The result of the two patients suggest that total laparoscopic hysterectomy is a safe and effective surgical approach for patients who have undergone liver transplantation.

Primarily Outcome of Laparoscopic Hysterectomy for Early-Stage Malignant Gynecological Cancer of Unselected Cases in Five Years

Objective: To investigate the feasibility and safety of laparoscopic hysterectomy (LH) in early-stage malignant gynecological cancer. Methods: Data from patients who underwent surgical management for early-stage gynecological cancer between 2009 and 2014 were retrospectively reviewed. Each woman gave her informed consent to be included into the study, which was previously approved by the local ethics committee and Institutional Review Board. Inclusion Criteria: All patients presented with stage I or II disease, and underwent comprehensive staging surgery consisting of hysterectomy or radical hysterectomy, with or without bilateral salpingo-oophorectomy, with or without para-aortic lymphadenectomy, with or without omentectomy, and peritoneal cytology. Results: 345 patients who underwent laparoscopic surgery (201 cervical cancer cases, 110 endometrial cancer cases and 34 ovarian cancer cases) were identified. Surgery for none of the patients was converted from laparoscopy to laparotomy. The median patient age for early-stage of gynecological cancer was 48 years (range, 29 - 71 years). 87 (25.22%) of whom were elderly (>60 years);98 (28.41%) were obese (>30 kg/m2);164 (62.96%) were postmenopausal;103 (29.86%) had undergone previous abdominal surgery;96 (25%) had a history of medical disease. The median operative time and estimated blood loss were 3.5 hours (range, 2.5 - 5.5 hour) and 80 mL (20 - 200 mL), respectively. Intra-operative and postoperative complications occurred in 6 (1.74%) and 34 (9.86%). None of the patients occurred death. The interval to bowel movement and indwelling catheter were 3 days (range, 1 - 5 days) and 7 days (range, 5 - 11 days). The median postoperative hospital stay was 10 days (range, 6 - 18 days). The mean operating time and hospital days for cervical cancer was shorter;the estimated blood loss was lower;and the peri-operative complications were lower in the second stage (July 2012-May 2014) than in the first three years (May 2009-June 2012) in our department

Novel technique of extracorporeal intrauterine morcellation after total laparoscopic hysterectomy: Three emblematic case reports

BACKGROUND In the presence of a large uterus,total laparoscopic hysterectomy(TLH),always requires morcellation to allow removal of the tissues from the abdominal cavity.However,uncontained morcellation has been scrutinized because of the possible spread of occult leiomyosarcoma.Therefore,in-bag extracorporeal morcellation has been developed.However,tissue containment and extraction are extremely challenging,especially when considering the increasing uterine size to be removed through minimally invasive surgery.CASE SUMMARY Herein,we describe a novel technique for extracorporeal intrauterine morcellation using the uterus outermost layer as a bag to achieve tissue extraction of very large uteri with suspected occult leiomyosarcoma after TLH.The study enrolled patients who were planned for TLH for large uteri(weight>500 g).TLH was performed following the procedure reported in our previous studies.The novel technique has been described step-by-step in a video,which representatively describes the preoperative imaging and morcellation procedure of three very large uteri weighing 1500 g,1700 g,and 3700 g,respectively.The procedures were performed without any complications.The patients had an uneventful postoperative course,and in all cases,the pathology was benign leiomyoma.CONCLUSION Extracorporeal intrauterine morcellation using the uterus outmost layer as a bag was found to be a feasible technique that allows a careful diagnosis and safe removal of suspected occult malignancies.The technique herein presented may be adopted in surgical practice,by adding it to the other available techniques of contained morcellation.It may represent a valid and feasible alternative,especially useful in cases of very large uteri exceeding the capacity of specimen retrieval bags.

Intraoperative systemic vascular resistance is associated with postoperative nausea and vomiting after laparoscopic hysterectomy

BACKGROUND The incidence of postoperative nausea and vomiting(PONV)in patients undergoing laparoscopic hysterectomy is very high compared with other surgeries,even when many prophylactic measures have been taken.However,the pathogenesis of PONV is multifactorial.Female sex,a history of motion sickness or PONV,nonsmokers,and perioperative opioid use are the most closely related factors.Among the multiple risk factors,suboptimal gastrointestinal(GI)perfusion may be attributed to some cases of PONV,and increased systemic vascular resistance(SVR)may lead to GI ischemia.The hypothesis of this research was that SVR is related to PONV.AIM To investigate the relationship between SVR and PONV in patients undergoing laparoscopic hysterectomy.METHODS A total of 228 patients who underwent elective laparoscopic hysterectomy were included in this prospective observational study.SVR was monitored using a noninvasive hemodynamic monitoring system.Four indices of SVR,the baseline,mean,area under the curve(AUC),and weighted AUC,were used for analysis.The incidence and severity of nausea and vomiting were evaluated while patients were awake and throughout the intervals from 0 to 2 h,2 to 6 h,and 6 to 24 h starting upon arrival at the post-anesthesia care unit.The associations between various SVR indices and PONV were investigated by logistic regression.P<0.05 was considered statistically significant.RESULTS The incidence of PONV in the study was 56.14%(128/228),and PONV tended to appear within 6 h after surgery.Five variables were significant in univariate analyses,however,only SVR mean[odds ratio(OR)=1.015,95%CI:1.005-1.109,P=0.047]and duration of surgery(OR=1.316,95%CI:1.003-2.030,P=0.012)were associated with PONV after logistic regression analysis.Furthermore,patients with high SVR mean were more likely to suffer from PONV after laparoscopic hysterectomy.On average,patients who developed PONV needed more time to tolerate diet and demonstrated poorer sleep quality on the first night after surgery.CONCLUSION In this study,PONV was a common complication after laparoscopic hysterectomy.SVR was associated with PONV,and high SVR mean was associated with a significantly increased risk of PONV.

Induction of total laparoscopic hysterectomy adopted the marionette technique in peri-menopausal and post-menopausal CIN3 patients

Objective:When performing cervical conization in post-menopausal cervical intraepithelial neoplasia 3(CIN3)patients,the positive rate of endocervical cone margin and the incidence of postoperative cervical stenosis increase.This study summarized a 4-year experience of total laparoscopic hysterectomy as a treatment option for peri-menopausal and post-menopausal CIN3 patients at a single institution.Furthermore,it shared the refinement strategies used during the surgery.Methods:This study retrospectively analyzed the medical records of CIN3 patient aged45 years and who underwent open or laparoscopic hysterectomy at our institution from January 1,2017 to December 31,2020.Totally,30 CIN3 patients were enrolled and divided into abdominal hysterectomy group and laparoscopic hysterectomy based on surgery method,with 5 patients and 25 patients respectively.Results:Compared to the abdominal hysterectomy group,the perioperative blood loss(20 mL vs.220 mL,p=0.004)was less and the duration of in-hospital stay(7 d vs.11 d,p<0.001)were significantly shorter in the laparoscopic hysterectomy group.However,no significant differences in age at hysterectomy(53 y vs.77 y,p=0.054)and operative time(154.4±27.8 min vs.161.0±62.4 min,p=0.826)were observed between them.Diagnostic conization was performed in advance for 12 patients,and among them,10(83.3%)patients had positive endocervical cone margin.Postoperative intestinal obstructionwas noted in one abdominal hysterectomy patient,no other complications were observed in the remaining patients.Conclusion:Compared to conization,hysterectomy is more invasive;however,it is an acceptable treatment option for peri-menopausal and post-menopausal CIN3 patients.In such cases,opting for total laparoscopic hysterectomy adopted the marionette technique might be preferable because the procedure is less invasive.

Single port laparoscopic hysterectomy: Feasibility and safety

Objective: To evaluate the feasibility and safety of single-port laparoscopic hysterectomy comparing with multi-port laparoscopic hysterectomy in treatment of benign uterine diseases. Methods: Data were collected retrospectively by review of the medical records of 252 patients who underwent multi-port or single-port laparoscopic surgery for treatment of benign gynecologic diseases. Laparoscopy assisted vaginal hysterectomy (LAVH) was performed for single-port surgery and LAVH and total laparoscopic hysterectomy (TLH) were performed for multi-port surgery. Demographic variables were collected and analyzed by independent t-test and Pearson Chi-Square test. The primary outcome was analyzed by independent t-test and Fisher’s Exact test. Results: A longer operative time was observed in the multi-port surgery group compared with that of the single-port group (p < 0.05). No difference with respect to change of Hemoglobin between the preoperative level and that of the postoperative first day, the number of days from the operation to discharge, uterine weight, and the rate of laparotomy conversion and complications were observed between the two groups. Conclusion: Single-port laparoscopic hysterectomy for treatment of benign uterine diseases is a safe and feasible method.

Total Laparoscopic Hysterectomy for Diagnosis and Treatment of Cervical Cystic Lesions: A Case Series

Objective: Cervical cystic lesions are often observed in gynecological clinical practice. Many are caused by benign diseases such as lobular endocervical glandular hyperplasia (LEGH), and it is important to differentiate these lesions from those due to malignant diseases such as minimal deviation adenocarcinoma (MDA). In cases in which fertility preservation is not a concern, the final pathology is often confirmed by hysterectomy. To investigate the feasibility and safety of laparoscopic surgery for cervical cystic lesions, we retrospectively examined cases in which total laparoscopic hysterectomy (TLH) was performed for diagnosis and treatment. Methods: The subjects were 28 women who underwent TLH from April 2012 to March 2017 at Keio University Hospital. The pre- and post-operative courses of these patients were examined. Results: The average age was 49.4 (range 39 - 65) years and the mean body mass index was 21.7 (16.8 - 30.5) kg/m2. The average operation time was 159 (101 - 314) min and the average bleeding volume was 106.8 (0 - 600) g. There were no severe perioperative complications. The average hospital stay was 8.4 (7 - 14) days. In postoperative pathological diagnosis, 13 cases had benign diseases such as Nabot cysts, there were 14 cases of LEGH, and one patient was diagnosed with MDA. In the MDA case, additional bilateral salpingo-oophorectomy and pelvic lymph node dissection were performed at a later date. No metastasis was observed in these excised specimens. Conclusions: Our results suggest that TLH for cervical cystic lesions can be performed safely. However, it is important to consider the TLH indication before surgery based on the possibility of malignant disease.

Factors associated with surgical-site infection after total laparoscopic hysterectomy

Objective:In recent years,minimally invasive surgery has been emphasized in gynecological surgery,and total laparoscopic hysterectomy has been increasingly reported.In this retrospective single-center study,the main objective was to identify risk factors for the development of surgical-site infection(SSI)after total laparoscopic hysterectomy.The secondary objective was to investigate the efficacy of transvaginal drainage as a treatment for SSI.Methods:This retrospective study investigated 377 patients who underwent total laparoscopic hysterectomy in the Department of Obstetrics and Gynecology at the Saitama Medical Center,Saitama Medical University,Japan between January 1,2015 and December 31,2019.Patients were divided into the SSI group and non-SSI group based on whether they suffered from SSI.The data of preoperative,intraoperative,and postoperative risk factors for SSI were collected and analyzed.Results:Of the 377 patients who underwent total laparoscopic hysterectomy,21 patients were in the SSI group and 356 patients were in the non-SSI group.After the comparison between the two groups and the multivariate analysis,only the C-reactive protein level on postoperative day 3(OR¼1.556,95%CI:1.233 e1.964,p<0.001)showed a significant correlation with SSI.The receiver operating characteristic curve revealed that the C-reactive protein level>7.6 mg/dL on postoperative day 3 could detect the SSI onset early.In the SSI group,the hospital stay was longer for patients with transvaginal drainage than for patients without(17.40±3.21 d vs.10.90±2.39 d,p¼0.0027).However,none required reoperation.Conclusions:Patients with a high postoperative C-reactive protein level may be experiencing SSI,and ultrasonography and other imaging procedures should be performed immediately.If a vaginal abscess is confirmed on imaging,transvaginal drainage should be performed early,which may prevent reoperation.

Usefulness of Detailed Analysis with Operative Procedure of Total Laparoscopic Hysterectomy (TLH) Done a Single Surgeon, to Master the Surgical Technique of TLH and Gain Higher Proficiency

Objective: To analyze the relationship between the numbers of cases experienced and the operation time for a single surgeon aiming to master the TLH surgical technique. Material and Methods: Retrospective data analysis of women who underwent TLH for benign diseases between April, 2014 and March, 2016 was conducted by a single surgeon in a single hospital (Showa University of Fujigaoka Hospital). We divided the main procedures of the TLH operation into five sections, and measured the time required for each section. These cases were divided into three groups, group 1, 2, and 3. Results: There were 54 cases of TLH over two years for a single surgeon, and 21 cases that included essential operative procedures were divided into three groups of seven cases each. The average duration of the surgery (min.) was 178.3 ± 48.2 in the group 1, 128.3 ± 15.6 in the group 2, and 111.3 ± 15.9 in the group 3. A significant reduction in the required time was observed between group 1, 2, and 3 groups. As the number of cases increased, the operation time became statistically significantly shorter for every section except B and D. The skill growth rate was different at each section. Conclusion: For a single surgeon, as the number of surgical cases increased, we recognized the increased skill with the procedure in every section and the rate of skill growth differed for different sections. The difference of growth rate for each section implied that the number of operative cases required for a surgeon in each section was different.

Vaginal hysterectomy or laparoscopic assisted vaginal hysterectomy for enlarged myomatous uterus:a randomized clinical trial

Objective:To compare the intraoperative condition and short-term outcomes of vaginal hysterectomy(VH) and laparoscopic assisted vaginal hysterectomy(LAVH) for enlarged myomatous uterus. Methods:Fifty patients from Peking Union Medical College Hospital(PUMCH) were randomly assigned to two treatment groups:VH(n= 23) and LAVH(n= 27).All procedures were performed by a single senior surgeon to maintain homogeneity. Results:The baseline characteristics of the two groups were comparable.The operative time for LAVH was significantly longer than for VH(76.7±23.2 vs.57.6±23.5 min,P<0.05),and LAVH costs more money than VH(6,923.07±622.96 vs.5,974.46±1,408.08 RMB,P<0.05).Major complications,uterine weight and the length of hospital stay were comparable between VH and LAVH group.One case of VH was converted to LAVH due to adhesion. Conclusions:Compared with LAVH,VH is a time- and cost-saving operative technique for enlarged myomatous uterus.VH should be the primary method for uterine removal,but LAVH may have advantages when adhesion is present.

Effects of dexmedetomidine on inflammatory response and oxidative stress in laparoscopic hysterectomy patients

Objective: To investigate the effect of dexmedetomidine on inflammatory response and oxidative stress in patients with laparoscopic total hysterectomy. Methods: Ninety patients with laparoscopic hysterectomy under general anesthesia were selected in our hospital from January 2015 to December 2016, and randomly divided into control group and observation group, Each group of 45 cases. The observation group was given dexmedetomidine, intravenous pump injection, The control group was given the same amount of saline in the same manner, followed by anesthesia induction. The hemodynamics, inflammatory factors and oxidative stress were monitored before anesthesia (T0), 30 min after the end of pneumoperitoneum (T1), after operation (T2) and at the end of 24 h (T3). Results: Compared with T0, T1, T2 and T3, the observation group of patients with MAP and HR levels were no significant difference;T3, the control group MAP and HR levels were not significantly different;T1 and T2, MAP and HR levels in the control group were significantly increased, And significantly higher than the observation group;Compared with T0, the levels of CRP, TNF-α and IL-1β in patients were significantly increased in T1, T2 and T3, but the levels of CRP, TNF-α and IL-1β in the observation group were significantly lower than those in the control group;Compared with T0, both groups of patients with H2O2 and MDA levels were significantly increased, TAS levels were significantly reduced, the difference was statistically significant, However, the levels of H2O2 and MDA in the observation group were significantly lower than those in the control group, the level of TAS was significantly higher than the control group. Conclusion:Laparoscopic hysterectomy increases the inflammatory response and oxidative stress in patients, while the use of dexmedetomidine can maintain hemodynamic stability in a certain extent, reduce the inflammatory response and reduce oxidative stress injury;it is worth of further clinical application.

Port-Site Metastasis after Laparoscopic Surgery with Rapid Second Recurrence in Early Stage Endometrial Carcinoma: A Case Report and Review of the Literature

Introduction: Port site metastases have been reported with laparoscopic surgery. The mechanism of action is unknown. Theories include tumor tracking, spillage, pneumoperitoneum, and immune factors. Methods: We report on a case of aggressive port site metastases and intra-abdominal recurrence after an uncomplicated laparoscopic hysterectomy for a grade 2, minimally invasive endometrioid adenocarcinoma of the uterus. The world literature on port site metastases in gynecological cancer is reviewed. Results: Port site metastases have two distinct presentations. In the first pattern, the metastases are isolated to the laparoscopic port sites. In the second pattern, port site metastases are associated with widespread intra-abdominal recurrence. Conclusion: Port site metastases are rare but occur with laparoscopic surgery. Meticulous attention to surgical technique including the use of specimen bags to isolate tissue and prevent spillage should be performed. Data registries should be instituted to track the incidence and outcomes of port site metastases.

腹腔镜下子宫切除术与经腹子宫切除术治疗子宫肌瘤患者的疗效对比

目的探讨腹腔镜下子宫切除术与经腹子宫切除术治疗子宫肌瘤患者的疗效。方法80例子宫肌瘤患者,采用随机数字表法分为开腹组和腔镜组,每组40例。开腹组采用经腹子宫切除术完成疾病治疗,腔镜组采用腹腔镜下子宫切除术完成疾病治疗。对比两组的治疗效果、手术相关指标及并发症发生率。结果腔镜组子宫肌瘤患者治疗总有效率95.00%相较于开腹组的70.00%显著提升(P<0.05)。腔镜组子宫肌瘤患者术中出血量(60.25±5.23)ml相较于开腹组(160.19±3.11)ml显著减少,手术时间(90.25±2.25)min、术后拆线时间(5.22±1.36)d、住院时间(7.65±0.28)d、术后肛门排气时间(30.25±2.25)h相较于开腹组的(120.36±5.26)min、(7.25±1.49)d、(9.29±1.33)d、(45.69±5.29)h显著缩短(P<0.05)。腔镜组子宫肌瘤患者并发症总发生率7.50%相较于开腹组的25.00%显著降低(P<0.05)。结论经腹子宫切除术以及腹腔镜下子宫切除术治疗子宫肌瘤均获得广泛应用,同前者比较,后者的治疗优势明显,可显著提升子宫肌瘤患者总体预后。

腹腔镜辅助阴式子宫切除术联合双侧髂耻韧带悬吊术治疗老年子宫脱垂患者的临床效果分析

目的分析腹腔镜辅助阴式子宫切除术联合双侧髂耻韧带悬吊术治疗老年子宫脱垂患者的临床效果。方法选取2020年9月至2022年9月安徽医科大学附属安庆第一人民医院治疗的76例老年子宫脱垂患者作为研究对象,采用随机数字表法分为观察组和对照组,各38例。分别采用腹腔镜辅助阴式子宫切除术联合阴道前后壁修补术、腹腔镜辅助阴式子宫切除术联合双侧髂耻韧带悬吊术治疗。比较两组围手术期指标、手术疗效、手术前后盆腔器官脱垂定量分期法(POP-Q)各指示点位置、性功能及阴道穹隆脱垂情况。结果观察组手术时间、术中出血量、术后肛门排气时间、留置导尿管时间均短于或少于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05);两组术后3个月POP-Q各指示点位置及女性性功能量表(FSFI)评分均较术前改善(P<0.05),且观察组优于对照组(P<0.05);观察组术后6个月内阴道穹隆脱垂发生率低于对照组(P<0.05)。结论腹腔镜辅助阴式子宫切除术联合双侧髂耻韧带悬吊术治疗老年子宫脱垂疗效确切,创伤小,术后恢复快。

举宫杯指引下腹腔镜全子宫切除术的临床应用

目的:探索举宫杯指引的腹腔镜全子宫切除术方法在妇科临床应用可行性。方法:回顾性分析2020年10月-2021年10月本院65例腹腔镜全子宫切除术患者临床资料,观察组30例为举宫杯指引的腹腔镜全子宫切除术患者,常规组为35例常规腹腔镜全子宫切除术患者,比较分析两组手术时间、术中出血量、手术并发症、肛门排气时间、术后住院时间及术后阴道伤口残端愈合情况。结果:观察组手术时间(65.7±5.4min)、术中出血量(26.8±10.0 ml)、肛门排气时间(11.2±2.2h)、术后住院中位时间[5.0(5.0,5.0)d]均低于常规组(86.0±7.1min、57.0±8.5ml、17.9±2.1h)[5.0(5.0,6.0)d](均P<0.05);观察组未出现膀胱、输尿管损伤及阴道残端感染,常规组分别出现1例输尿管损伤、1例膀胱损伤和2例阴道残端感染。两组术中并发症、术后随访阴道残端感染率无差异(P>0.05)。结论:举宫杯指引的腹腔镜全子宫切除术手术时间短、术后恢复快、安全可靠,初步证实该方法在妇科临床应用的可行性。

甲磺酸瑞马唑仑麻醉对腹腔镜子宫切除术患者炎症应激反应和认知功能的影响

目的:探究甲磺酸瑞马唑仑麻醉对腹腔镜子宫切除术患者炎症应激反应和认知功能的影响。方法:纳入2021年8月-2023年1月本院收治拟行腹腔镜子宫切除术患者85例,信封法随机分为瑞马唑仑组(n=46例,甲磺酸瑞马唑仑麻醉)和丙泊酚组(n=39例,丙泊酚麻醉)。比较两组术前未麻醉时(T0)、麻醉后5 min(T1)、气管插管后10 min(T2)、拔管后即刻(T3)和手术结束前5 min时(T4)的血流动力学指标[心率(HR)、收缩压(SBP)和舒张压(DBP)],术前1 h和术后12 h炎症应激指标[白介素(IL-6)、C蛋白反应(CRP)、肿瘤坏死因子(TNF-α)、去甲肾上腺素(NE)水平],认知能力[蒙特利尔认知评估(MoCA)分数、简明精神状态(MMSE)评分]以及术后不良发生率。结果:瑞马唑仑组HR水平在T3(86.6±7.4次/min)、T4(78.6±6.2次/min)均低于丙泊酚组(94.1±7.0次/min、82.6±6.9次/min),SBP水平T3时(132.9±7.1mmHg)高于丙泊酚组(128.5±6.8mmHg),DBP在T3、T4时(78.6±6.8mmHg、80.3±8.3mmHg)高于丙泊酚组(85.6±6.0mmHg、85.7±8.8mmHg)(均P<0.05)。瑞马唑仑组术后12 h,IL-6、CRP、TNF-α和NE水平(92.87±13.75ng/L、15.61±2.99mg/L、7.42±1.96ng/ml、74.14±11.96ng/L)均低于丙泊酚组(121.81±13.99ng/L、18.79±3.67mg/L、8.76±2.17ng/ml、82.57±15.53ng/L),术后3 d MoCA(29.85±1.66分)和MMSE(29.46±1.11分)均高于丙泊酚组(28.92±1.36分、28.62±1.06分),不良反应发生率(19.6%)低于丙泊酚组(41.0%)(均P<0.05)。结论:腹腔镜子宫切除术应用甲磺酸瑞马唑仑麻醉对患者有稳定血流动力学、改善炎症应激负荷、保护认知的功效。

艾司氯胺酮切皮前用药对腹腔镜全子宫切除术后患者抑郁情绪与睡眠质量的影响

目的:探讨腹腔镜全子宫切除术(LTH)切皮前艾司氯胺酮用药镇痛效果。方法:选取2021年2月-2023年5月本院LTH患者110例,随机数字表法分为2组各55例。均择期行全麻下LTH治疗,观察组于切皮前予以艾司氯胺酮0.3 mg/kg静脉注射、对照组同时间点予以同剂量生理盐水注射。统计两组各时间点17项汉密尔顿抑郁量表(HAMD-17)、数字评定量表(NRS)以及匹兹堡睡眠质量指数(PSQI)评分,比较两组血清神经递质[多巴胺(DA)、肾上腺素(E)、去甲肾上腺素(NE)]水平,统计不良反应。结果:观察组剔除术中转开腹1例、个人因素退出1例,纳入53例;对照组剔除数据不全1例,纳入54例。观察组术后4 h、12 h、24 h、48 h静息时NRS评分(2.27±0.36分、2.53±0.41分、2.40±0.30分、2.12±0.32分)均低于对照组(2.62±0.40分、3.08±0.46分、2.85±0.38分、2.52±0.42分),术后2 d和5 d HAMD-17评分(13.24±2.16分、10.16±2.42分)、PSQI评分(12.46±1.84分、9.35±1.75分)均低于对照组(15.07±2.33分、11.59±2.51分、13.85±2.13分、10.08±1.92分),术后5 d观察组血清NE(129.45±17.25ng/L)、E(33.46±5.42ng/L)及DA(7.37±0.86μg/L)水平均高于对照组(113.62±13.48ng/L、30.72±4.15ng/L、7.03±0.72μg/L)(均P<0.05)。观察组不良反应总发生率(17.0%)与对照组(14.8%)无差异(P>0.05)。结论:艾司氯胺酮切皮前用药可减轻LTH患者术后疼痛,调节神经递质表达水平,改善抑郁、睡眠状态,且未增加不良反应。