Improved stereoselective syntheses of the targeted compounds （＋）-valiolamine 1 and （＋）-valienamine 2 starting from naturally abundant （–）-shikimic acid are described. A common key intermediate compound 7 was ...Improved stereoselective syntheses of the targeted compounds （＋）-valiolamine 1 and （＋）-valienamine 2 starting from naturally abundant （–）-shikimic acid are described. A common key intermediate compound 7 was first synthesized from （–）-shikimic acid in 9 steps. The compound 7 was then converted to （＋）-valiolamine 1 in 3 steps, and was also converted to （＋）-valienamine 2 in 4 steps. In summary, （＋）-valiolamine 1 and （＋）-valienamine 2 were synthesized from （–）-shikimic acid in 12 （or 13） steps in 40% and 39% overall yields, respectively.展开更多
With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Feng Yan(冯雁),collaborating with Prof.Bai LinQuan(白林泉)at the S...With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Feng Yan(冯雁),collaborating with Prof.Bai LinQuan(白林泉)at the State Key Laboratory of Microbial Metabolism,School of Life Science&Biotechnology,Shanghai Jiao Tong University,recently reported"De novo biosynthesis ofβ-valienamine in engi-展开更多
基金We thank the National Natural Science Foundation of China （No. 20972048） for the financial support of this work.
文摘Improved stereoselective syntheses of the targeted compounds （＋）-valiolamine 1 and （＋）-valienamine 2 starting from naturally abundant （–）-shikimic acid are described. A common key intermediate compound 7 was first synthesized from （–）-shikimic acid in 9 steps. The compound 7 was then converted to （＋）-valiolamine 1 in 3 steps, and was also converted to （＋）-valienamine 2 in 4 steps. In summary, （＋）-valiolamine 1 and （＋）-valienamine 2 were synthesized from （–）-shikimic acid in 12 （or 13） steps in 40% and 39% overall yields, respectively.
文摘With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Feng Yan(冯雁),collaborating with Prof.Bai LinQuan(白林泉)at the State Key Laboratory of Microbial Metabolism,School of Life Science&Biotechnology,Shanghai Jiao Tong University,recently reported"De novo biosynthesis ofβ-valienamine in engi-
