Estimation of Return Level for Maximum Daily and Hourly Precipitation in Nagano Prefecture, Japan, Using the Extreme Value Theory

The weather in Nagano Prefecture, Japan, can be roughly classified into four types according to principal component analysis and k-means clustering. We predicted the extreme values of the maximum daily and hourly precipitation in Nagano Prefecture using the extreme value theory. For the maximum daily precipitation, the vales of ξ in Matsumoto, Karuizawa, Sugadaira, and Saku were positive;therefore, it has no upper bound and tends to take large values. Therefore, it is dangerous and caution is required. The values of ξ in Nagano, Kisofukushima, and Minamishinano were determined to be zero, therefore, there was no upper limit, the probability of obtaining a large value was low, and caution was required. We predicted the maximum return levels for return periods of 10, 20, 50, and 100 years along with respective 95% confidence intervals in Nagano, Matsumoto, Karuizawa, Sugadaira, Saku, Kisofukushima, and Minamishinano. In Matsumoto, the 100-year return level was 182 mm, with a 95% CI [129, 236]. In Minamishinano, the 100-year return level was 285 mm, with a 95% CI [173, 398]. The 100-year return levels for the maximum daily rainfall were 285, 271, and 271 mm in Minamishinano, Saku, and Karuizawa, respectively, where the changes in the daily maximum rainfall were larger than those at other points. Because these values are large, caution is required during heavy rainfall. The 100-year return levels for the maximum daily and hourly precipitation were similar in Karuizawa and Saku. In Sugadaira, the 100-year return level for a maximum hourly rainfall of 107.2 mm was larger than the maximum daily rainfall. Hence, it is necessary to be careful about short-term rainfall events.

THE NONLINEAR BOUNDARY VALUE PROBLEM FOR k HOLOMORPHIC FUNCTIONS IN C^(2)

k holomorphic functions are a type of generation of holomorphic functions.In this paper,a nonlinear boundary value problem for k holomorphic functions is primarily discussed on generalized polycylinders in C^(2).The existence of the solution for the problem is studied in detail with the help of the boundary properties of Cauchy type singular integral operators with a k holomorphic kernel.Furthermore,the integral representation for the solution is obtained.

Pearl S. Buck’s Values of “Cultural Convergence” and Their Application

The typical features of internal and external integration of cultures as revealed by the conception of“cultural convergence”provide a new perspective on the study of cultural exchanges and mutual learning.In the context of“a global community of shared future for humankind”,this paper adopts the novel idea of“cultural convergence”to probe the growth of Pearl S.Buck’s cultural values and the specific contents and representation of Pearl S.Buck’s conception of“cultural convergence”,highlighting the application of Pearl S.Buck’s values to cultural education,growth and success,family education,cultural exchanges,humanistic practices,etc.Feasible suggestions and countermeasures are put forward to better promote the cultural exchanges and mutual learning as well as the convergence of different cultures.

基于数据流的K-S变化检测的动态多目标规划算法

为了更加准确地判断环境是否发生变化并快速追踪动态多目标规划问题(dynamicmulti-objectiveoptimization problem,DMOP)当前时刻的Pareto前沿,提出了一种基于数据流的Kolmogorov-Smirnov(K-S)变化检测的动态多目标规划(DSK-SDMOP)算法。该算法以NSGA-Ⅱ为基础,通过数据流建立2个时刻的检验窗口,再利用K-S检验基于数据流的Pareto最优前沿是否发生变化,检测2个窗口的数据是否服从同一分布来判断环境是否发生变化,并就环境变化的剧烈程度实行相应的应答机制,以提高对环境的适应程度。利用基于数据流的K-S检测方法,对环境变化不会过于敏感,而且不用提前假设对应目标值的分布,易于操作。通过5个动态多目标规划标准测试函数对该算法进行测试,并和现有的2种算法进行对比分析,结果表明该算法处理动态多目标规划问题具有良好的性能。

Prognostic Value of Semi-Quantitative 18F-FDG PET/CT Parameters in Hodgkin’s Lymphoma

Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography(18F-FDG PET/CT)imaging in Hodgkin’s lymphoma patients.Methods:A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good(125 cases)and poor(23 cases)prognosis groups.The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters;the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma;receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients.Results:Mean SUVmax,MTV,and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26±2.38,12.46±3.14 cm3,and 76.83±18.56 g,respectively.Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters(P<0.05).The semi-quantitative parameters were not correlated with age and gender(P>0.05)but positively correlated with Ann Arbor stage and clinical classification(P<0.05).These parameters in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of SUVmax,MTV,and TLG in predicting the poor prognosis group was 0.881,0.875,and 0.838,with cut-off values of 7.264,12.898 cm3,and 74.580g,as well as specificity of 88.8%,84.0%,and 78.4%,and sensitivity of 87.0%,87.0%,and 78.3%,respectively;the AUC of the combined prediction was 0.986,with a specificity of 97.6%and sensitivity of 86.3%.Conclusion:The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.

KLF4通过mTOR/P70S6K途径激活细胞自噬减轻高糖诱导的足细胞损伤

目的:分析Krüppel样转录因子4(KLF4)对高糖诱导的足细胞损伤的影响及相关分子机制。方法:体外培养MPC5细胞,将MPC5细胞分为对照组(Control组)、高糖组(HG组)、高糖+空载质粒对照组(HG+NC组)、高糖+KLF4过表达组(HG+KLF4组)。采用qRT-PCR法检测细胞中KLF4 mRNA表达水平,CCK-8法测定细胞增殖活性,流式细胞术检测细胞凋亡,Western blot法检测细胞中相关蛋白表达水平。结果:与Control组比较,HG组MPC5细胞中KLF4 mRNA和蛋白表达量降低,细胞增殖活性降低,细胞凋亡率升高,细胞中突触足蛋白(synaptopodin)、足蛋白(podocin)、肾蛋白(nephrin)、微管相关蛋白轻链3-Ⅱ(LC3-Ⅱ)、Beclin1蛋白表达量降低,P62蛋白表达量、磷酸化哺乳动物雷帕霉素靶蛋白(p-mTOR)/mTOR和磷酸化核糖体40S小亚基S6蛋白激酶(p-P70S6K)/P70S6K比值升高;差异均有统计学意义(P<0.05)。与HG组比较,HG+KLF4组MPC5细胞中KLF4 mRNA和蛋白表达量升高,细胞增殖活性升高,细胞凋亡率降低,细胞中synaptopodin、podocin、nephrin、LC3-Ⅱ、Beclin1蛋白表达量升高,P62蛋白表达量、p-mTOR/mTOR和p-P70S6K/P70S6K比值降低,差异均有统计学意义(P<0.05)。结论:KLF4通过激活足细胞自噬减轻高糖诱导的足细胞损伤,其作用机制可能与调控mTOR/P70S6K信号通路有关。

K-S变换及其电网超谐波时频分析应用

依据FFT→优化窗→IFFT思路,突破线性时频变换的窗函数积分性能桎梏,实现高性能优化窗函数的线性时频变换应用,建立新型时频变换算法——K-S变换.对信号x(t)的FFT频谱向量进行频移处理后,与该频移点下Kaiser优化窗的频谱向量进行Hadamard乘积,再将乘积结果进行FFT逆变换(IFFT),构造出K-S变换复时频矩阵,由此获得x(t)的时间-频率-幅值、时间-频率-相位三维信息;给出逆变换的数学推导与局部性质、线性性质和变分辨率特性;0~150 kHz电网的稳态与时变超谐波信号仿真实验表明,K-S变换的时域、频域分辨能力均优于流行的短时傅里叶变换、S变换,具有优良的变分辨率性能;0~40 kHz超谐波信号的实测证明,基于K-S变换的超谐波电压幅值测量绝对误差均小于0.032 3 V.

基于交通拥堵信息的高速公路拥堵路段ACK-Means聚类

为了充分利用实际高速公路路段交通拥堵信息,更合理地聚类交通拥堵的内在规律和特征变化,提出自适应确定聚类中心C和类别K值(adaptive center and K-means value,ACK-Means)的聚类算法,进行高速公路拥堵路段聚类。ACK-Means算法借助簇类密度、簇类间距以及簇类强度,同时又考虑到数据样本的偶然性,对离群点进行合理分配,ACK-Means算法可实现自适应确定聚类中心C和类别K值。基于实际交通拥堵信息构建数据集,Python编程实现高速公路拥堵路段ACK-Means聚类,巧妙解决了高速公路拥堵路段聚类数目K和聚类中心C设定问题。聚类结果表明,ACK-Means算法实现高速公路拥堵路段无监督聚类,聚类结果完全基于实际的高速公路交通拥堵信息,具有更高的实用性。

非瑟酮调节LKB1-AMPK-mTOR-p70S6K通路改善大鼠少弱精子症

目的研究非瑟酮对少弱精子大鼠的睾丸及精子保护作用,并探究其机制。方法构建大鼠少弱精子模型,将大鼠随机分为空白组、模型组、非瑟酮低、中、高剂量治疗组、LKB1激动剂组,每组各10只。ELISA法检测各组卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinising hormone,LH)、睾酮(testosterone,T)、雌二醇(estradiol,E2)、催乳素(prolactin,PRL)水平;流式细胞术检测精子细胞凋亡;HE染色检测大鼠睾丸组织损伤;透射电镜检测精子细胞超微结构;qRT-PCR和Western blot检测LKB1、AMPK、mTOR、p70S6K mRNA和蛋白表达。结果与空白组相比,模型组和LKB1激动剂组FSH、LH、PRL、T等激素水平明显降低,精子细胞出现凋亡,睾丸损伤严重,LKB1、p-AMPK/AMPK表达明显上调,mTOR、p-p70S6K/p70S6K表达下调(P<0.05);与模型组相比,不同剂量的非瑟酮治疗后,精子细胞凋亡数明显减少,FSH、LH、PRL、T等激素水平明显上升,LKB1、p-AMPK/AMPK明显下调,mTOR、p-p70S6K/p70S6K明显上调(P<0.05)。结论非瑟酮可有效治疗少弱精症大鼠,其作用机制可能与LKB1-AMPK-mTOR-p70S6K信号通路有关。

基于SVD-K-means算法的软扩频信号伪码序列盲估计

针对通信中软扩频信号伪码序列盲估计困难的问题,提出一种奇异值分解(singular value decomposition,SVD)和K-means聚类相结合的方法。该方法先对接收信号按照一倍伪码周期进行不重叠分段构造数据矩阵。其次对数据矩阵和相似性矩阵分别进行SVD完成对伪码序列集合规模数的估计、数据降噪、粗分类以及初始聚类中心的选取。最后通过K-means算法优化分类结果,得到伪码序列的估计值。该算法在聚类之前事先确定聚类数目,大大减少了迭代次数。同时实验结果表明,该算法在信息码元分组小于5 bit,信噪比大于-10 dB时可以准确估计出软扩频信号的伪码序列,性能较同类算法有所提升。

基于主成分分析和深度森林算法的S700K转辙机故障诊断

针对目前转辙机故障诊断准确性不高、效率低等问题,提出了一种基于主成分分析(PCA)和深度森林(gcForest)算法的故障诊断方法。对于S700K转辙机11种故障模式下的电流、功率曲线,采用主成分分析进行电流特征值特征简约,然后使用嵌入简约特征值的改进深度森林模型提高数据处理能力,增强模型内在特征代表性。结果表明,改进深度森林模型故障诊断准确率为97.62%,验证了该方法的有效性和优越性。

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease.The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

胡桃醌通过Akt/mTOR/p70S6K通路调控肺癌细胞A549自噬的研究

目的:研究胡桃醌通过Akt/mTOR/p70S6K通路调控肺癌细胞A549自噬,发挥其抗肺癌作用的机制。方法:MTT法检测胡桃醌对A549细胞存活率的影响。透射电镜和细胞自噬染色检测试剂盒(MDC)观察胡桃醌诱导A549细胞自噬。蛋白免疫印迹法检测自噬标志蛋白Beclin-1、LC3Ⅱ和LC3I蛋白和自噬经典通路Akt/mTOR/p70S6K相关蛋白的表达水平。RT-PCR法检测A549细胞中Beclin-1和LC3ⅡmRNA表达水平。结果:MTT结果表明胡桃醌抑制A549细胞增殖,IC 50=10μmol/L;透射电镜和MDC实验发现胡桃醌可以诱导A549细胞产生自噬;与对照组相比,胡桃醌可以显著增加Beclin-1蛋白表达水平、LC3Ⅱ/LC3I比值和Beclin-1、LC3ⅡmRNA表达水平(P<0.05,P<0.01);胡桃醌干预后,与对照组相比,Akt、mTOR和p70S6K蛋白的表达水平基本不变,但Akt、mTOR和p70S6K磷酸化蛋白的表达水平显著降低(P<0.05,P<0.01)。结论:胡桃醌可能通过Akt/mTOR/p70S6K通路调控肺癌细胞A549自噬。

S对铸造高温合金K417G凝固行为的影响

在1340~1230℃采用等温凝固实验,研究了w[S]分别为0.0001%、0.0018%和0.0037%对K417G合金凝固特性的影响。结果表明,S降低合金的固相线温度,扩大固液两相区,当w[S]从0.0001%增加到0.0037%时,合金的固相线温度由1255℃降低至1245℃。在凝固过程中S元素偏析于液相,并在终凝区析出Y相,且S促进Al、Cr元素在固液界面处的富集。在相同等温温度下,S元素对MC碳化物和γ+γ’共晶的析出温度与形貌无明显影响,但S含量的增加促使MC碳化物、γ+γ’共晶和Y相数量的增加,且Y相的析出温度从1230℃提升至1240℃。

K8S融媒体云平台设计研究

媒体融合发展是互联网时代下的必然趋势,给各种新媒体兴起带来了更大的竞争压力,也迫使传统媒体进行转型升级,而建立功能完善、性能良好的融媒体云平台对于媒体行业高质量发展有着重要价值。Kubernetes(简称“K8S”)技术在融媒体云平台建设中具有技术优势,可应用场景多,能够满足媒体行业内容制作、发布、管理以及资源调度、用户管理等各方面需求,为用户提供全方位、综合性的一站式服务。对K8S融媒体云平台设计进行分析,探讨其建设目标、系统架构、设计要求等要点,并开展应用部署,以期为融媒体云平台的建设提供参考。

中西医结合治疗Kümmell’s病研究进展

Kümmell’s病最早被德国医生Herman Kümmell在1895年发现并提出,结合此病的病理表现及影像特征,此后相关研究者又将其称为创伤后椎体迟发性骨坏死、骨质疏松性椎体压缩骨折延迟愈合或不愈合、椎体内真空裂隙、椎体内假关节和迟发性椎体塌陷等[1]。随着人口老龄化加剧及医学影像技术的进步,Kümmell’s病的确诊率正逐年上升。

基于K-means聚类算法的烘烤烟叶图像分割研究

目前我国烟叶烘烤过程主要依赖人工监测,存在主观性、模糊性和高成本等问题,使用机器视觉方法对烘烤过程烟叶质量变化进行实时监测与判断的研究逐渐增多,实时监测需建立在高效且准确的烘烤烟叶图像分割之上,因此烘烤烟叶图像分割的研究变得尤其重要。提出了基于K-means聚类算法的烘烤烟叶图像分割方法,首先读取图像并将RGB转换为CYMK颜色空间,然后提取CYMK颜色空间下的K通道灰度化图像,再对此单通道图像进行聚类,根据聚类中心确定图像分割阈值,最后利用图像处理方法对图像进行分割。研究比较了K-means、模糊C均值聚类(FCM)和高斯混合聚类(GMM)3种聚类方法,结果表明K-means算法的像素准确率为97.8%、交并比为96.43%、Dice系数为98.2%,均优于其他2种方法。K-means算法能够更好地提取烤烟的烟叶轮廓,去除冗余信息,使得分割结果更清晰。

药物抑制率联合K值、年龄与GCS评分对钝性重型颅脑损伤预后的评估价值

目的探讨药物[血小板花生四烯酸(AA)、血小板二磷酸腺苷(ADP)]抑制率联合血凝块形成时间(K值)、年龄与格拉斯哥昏迷量表(GCS)评分对钝性重型颅脑损伤(TBI)患者预后的评估价值。方法选择2021年1月至2022年12月该院收治的未使用抗血小板药物治疗的急诊钝性重型TBI患者184例,根据患者28 d病情好转情况分为预后良好组、预后不良组,比较两组患者一般资料。采集两组患者静脉血,均行TEG检查并比较两组患者凝血反应时间(R值)、血凝块形式时间(K值)、血凝块形成的最大幅度(MA值)、血凝块形成速率(α角)、血凝块力学强度(G值)、AA抑制率、ADP抑制率。采用多因素Logistic回归分析影响钝性重型TBI患者预后的因素。采用受试者工作特征(ROC)曲线分析药物抑制率联合K值、年龄、GCS评分对钝性重型TBI患者预后的评估价值。结果预后良好组138例,预后不良组46例。预后不良组患者年龄≥45岁、头部AIS评分5~6分、入院后插管比例、K值、AA抑制率、ADP抑制率明显高于预后良好组,R值、α角、MA值、G值、GCS评分明显低于预后良好组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,年龄≥45岁,K值、AA抑制率、ADP抑制率升高为钝性重型TBI患者预后不良的危险因素(P<0.05),GCS评分升高为钝性重型TBI患者预后不良的保护因素(P<0.05)。ROC曲线分析发现,AA抑制率、ADP抑制率、年龄、K值及GCS评分联合检测对钝性重型TBI预后的评估价值较高。结论AA抑制率和ADP抑制率升高、GCS评分降低、K值升高可作为预警指标,辅助评估钝性重型TBI患者的预后情况。

基于改进SOM+K-means算法的客户价值研究

为提高多特征参数聚类相似度,针对多特征参数相关性和分布不等问题,提出一种改进的聚类算法,并以此算法研究RFM客户价值模型。此改进算法,通过矩阵旋转和压缩变换以及协方差矩阵处理,构造一种聚类相似度目标的距离函数,以此距离函数结合SOM算法和K-means算法各自优点,设计改进SOM+K-means组合聚类算法。应用该算法创建RFM客户价值模型,并实验验证。通过轮廓系数法评估,该算法聚类的轮廓系数相比原K-means和SOM算法聚类的轮廓系数,分别提高约0.129和0.126。该聚类算法提高了RFM客户价值聚类效果,为客户价值研究提供了一种新的聚类方法。

Emotional Value Care to Promote Emotional Communication Between Teachers and Students Under the New Era of Education Mode

With the development of the times and the progress of the society,the ancient education mode can no longer meet the requirements of the times.The concept of educating people must keep pace with the times.The way teachers and students get along is no longer like in ancient times,where teachers teach students to listen.In the new era,it is necessary to build a new model of interaction between teachers and students.If educators pay attention and come to understand students’psychology,listen to students’aspirations,tend to students’emotions,grow in love for education,and treat students from their hearts,they would be able to win the favor of students.Paying attention to students’emotional value can promote emotional communication between teachers and students.It is possible to adapt to the requirements of the new era for the construction of morality and ethics among teachers by caring for students’emotional value.