BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations ...BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.展开更多
As one of the most important part of weapon system of systems(WSoS),quantitative evaluation of reconnaissance satellite system(RSS)is indispensable during its construction and application.Aiming at the problem of nonl...As one of the most important part of weapon system of systems(WSoS),quantitative evaluation of reconnaissance satellite system(RSS)is indispensable during its construction and application.Aiming at the problem of nonlinear effectiveness evaluation under small sample conditions,we propose an evaluation method based on support vector regression(SVR)to effectively address the defects of traditional methods.Considering the performance of SVR is influenced by the penalty factor,kernel type,and other parameters deeply,the improved grey wolf optimizer(IGWO)is employed for parameter optimization.In the proposed IGWO algorithm,the opposition-based learning strategy is adopted to increase the probability of avoiding the local optima,the mutation operator is used to escape from premature convergence and differential convergence factors are applied to increase the rate of convergence.Numerical experiments of 14 test functions validate the applicability of IGWO algorithm dealing with global optimization.The index system and evaluation method are constructed based on the characteristics of RSS.To validate the proposed IGWO-SVR evaluation method,eight benchmark data sets and combat simulation are employed to estimate the evaluation accuracy,convergence performance and computational complexity.According to the experimental results,the proposed method outperforms several prediction based evaluation methods,verifies the superiority and effectiveness in RSS operational effectiveness evaluation.展开更多
Adaptive fractional polynomial modeling of general correlated outcomes is formulated to address nonlinearity in means, variances/dispersions, and correlations. Means and variances/dispersions are modeled using general...Adaptive fractional polynomial modeling of general correlated outcomes is formulated to address nonlinearity in means, variances/dispersions, and correlations. Means and variances/dispersions are modeled using generalized linear models in fixed effects/coefficients. Correlations are modeled using random effects/coefficients. Nonlinearity is addressed using power transforms of primary (untransformed) predictors. Parameter estimation is based on extended linear mixed modeling generalizing both generalized estimating equations and linear mixed modeling. Models are evaluated using likelihood cross-validation (LCV) scores and are generated adaptively using a heuristic search controlled by LCV scores. Cases covered include linear, Poisson, logistic, exponential, and discrete regression of correlated continuous, count/rate, dichotomous, positive continuous, and discrete numeric outcomes treated as normally, Poisson, Bernoulli, exponentially, and discrete numerically distributed, respectively. Example analyses are also generated for these five cases to compare adaptive random effects/coefficients modeling of correlated outcomes to previously developed adaptive modeling based on directly specified covariance structures. Adaptive random effects/coefficients modeling substantially outperforms direct covariance modeling in the linear, exponential, and discrete regression example analyses. It generates equivalent results in the logistic regression example analyses and it is substantially outperformed in the Poisson regression case. Random effects/coefficients modeling of correlated outcomes can provide substantial improvements in model selection compared to directly specified covariance modeling. However, directly specified covariance modeling can generate competitive or substantially better results in some cases while usually requiring less computation time.展开更多
The desired economics of hard rock surface mining is mainly determined by the parameters of process design which minimize the overall cost per tonne of the rock mined in drilling, blasting, handling and primary crushi...The desired economics of hard rock surface mining is mainly determined by the parameters of process design which minimize the overall cost per tonne of the rock mined in drilling, blasting, handling and primary crushing in given rockmass conditions. The most effective parameters of process design could be established based on the regression models of the cumulative influence of rockmass and mine design parameters on the overall cost per tonne of the rock drilled, blasted, handled and crushed. These models could be developed from the huge data accumulated worldwide on the costs per tonne of hard rock surface mining in drilling, blasting, handling and primary crushing vs the parameters of rockmass and mine design. This paper only dwelt on the development of regression models for oversize generation, blasthole productivity and blasting cost for iron ore surface mines, whose data is available. The SPSS standard statistical correlation – regression analysis software was used in the analysis. Interpretation of the models generated shows that the individual effects of the determinant rockmass and blast design parameters on oversize generation, blasthole productivity and blasting cost are all in compliance with the findings of other researchers and the theory of explosive rock fragmentation and could be used for the estimation of oversize generation, blasthole productivity and blasting cost in rockmass and blast design conditions similar to those of the iron ore surface mines examined in this study. However, the regression models obtained here could not be used alone for the optimization of blast design because most of the determinant parameters also have conflicting effect on the other processes of drilling, handling and primary crushing the blasted rock. Also, the quality and content of the regression models could be enhanced further by increasing the content of rockmass and blast design parameters and the volume of data considered in the regression analysis.展开更多
The angular acceleration due to the spin effect increases the burning rate of solid propellant and changes the motor performance by increasing the operating pressure and decreasing the burning time. So it is important...The angular acceleration due to the spin effect increases the burning rate of solid propellant and changes the motor performance by increasing the operating pressure and decreasing the burning time. So it is important to know the grain regression taken place in the solid propellant rocket motor in the acceleration field. This study represents the grain regression analysis of two-dimensional axis-symmetric star grain configuration of the solid propellant rocket motor with spin induced acceleration effect and pressure effect on burn rate using geometrical and numerical analysis. While the rocket is spinning, the burn rates on each point of the propellant surface are different with its radial distance, acceleration vector angle and surface slope. With the different burn rates on the propellant surface, we analyze the propellant surface perimeter and port area, and these results are compared with those of constant burn rate and burn rate affected by the chamber pressure.展开更多
Meta regression analysis method was applied to study 23 papers about the effect of Chinese labor reallocation on the economic growth. The results showed that both the method of the World Bank (1996) or M.Syrquin(1986)...Meta regression analysis method was applied to study 23 papers about the effect of Chinese labor reallocation on the economic growth. The results showed that both the method of the World Bank (1996) or M.Syrquin(1986) had little impact on the results, while the calculation of the stock of physical capital had a positive impact on the results. The result by using panel data study was bigger than results obtained in the time series data. The time span had little influences on the results. Therefore, it was necessary to measure the exact stock of physical capital in China, so as to evaluate the Chinese labor reallocation展开更多
In order to find out the factors which influence community participation in tourism,several effect factors are summed up through the investigation of the local residents and the analysis of the logistic regression of ...In order to find out the factors which influence community participation in tourism,several effect factors are summed up through the investigation of the local residents and the analysis of the logistic regression of the data gained from Xingwen world Geopark.Results indicated there are several main influencing factors of community participation such as the comparative benefit of tourist industry,participant residents' subjective wishes,preference consciousness of working opportunity obtainment in the tourist enterprise and participant skills.Based on above investigation data and field travel,the paper put forward several methods about how to enhance the residents' participant degree:increasing the comparative benefit of tourist industry,enhancing the attraction of tourism for boosting participant wishes,improving the preference consciousness on obtaining working opportunity in tourism industry and cultivating residents' participant skills through training.展开更多
基金National Natural Science Foundation of China,No.72101236China Postdoctoral Science Foundation,No.2022M722900+1 种基金Collaborative Innovation Project of Zhengzhou City,No.XTCX2023006Nursing Team Project of the First Affiliated Hospital of Zhengzhou University,No.HLKY2023005.
文摘BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.
基金the National Defense Science and Technology Key Laboratory Fund of China(XM2020XT1023).
文摘As one of the most important part of weapon system of systems(WSoS),quantitative evaluation of reconnaissance satellite system(RSS)is indispensable during its construction and application.Aiming at the problem of nonlinear effectiveness evaluation under small sample conditions,we propose an evaluation method based on support vector regression(SVR)to effectively address the defects of traditional methods.Considering the performance of SVR is influenced by the penalty factor,kernel type,and other parameters deeply,the improved grey wolf optimizer(IGWO)is employed for parameter optimization.In the proposed IGWO algorithm,the opposition-based learning strategy is adopted to increase the probability of avoiding the local optima,the mutation operator is used to escape from premature convergence and differential convergence factors are applied to increase the rate of convergence.Numerical experiments of 14 test functions validate the applicability of IGWO algorithm dealing with global optimization.The index system and evaluation method are constructed based on the characteristics of RSS.To validate the proposed IGWO-SVR evaluation method,eight benchmark data sets and combat simulation are employed to estimate the evaluation accuracy,convergence performance and computational complexity.According to the experimental results,the proposed method outperforms several prediction based evaluation methods,verifies the superiority and effectiveness in RSS operational effectiveness evaluation.
文摘Adaptive fractional polynomial modeling of general correlated outcomes is formulated to address nonlinearity in means, variances/dispersions, and correlations. Means and variances/dispersions are modeled using generalized linear models in fixed effects/coefficients. Correlations are modeled using random effects/coefficients. Nonlinearity is addressed using power transforms of primary (untransformed) predictors. Parameter estimation is based on extended linear mixed modeling generalizing both generalized estimating equations and linear mixed modeling. Models are evaluated using likelihood cross-validation (LCV) scores and are generated adaptively using a heuristic search controlled by LCV scores. Cases covered include linear, Poisson, logistic, exponential, and discrete regression of correlated continuous, count/rate, dichotomous, positive continuous, and discrete numeric outcomes treated as normally, Poisson, Bernoulli, exponentially, and discrete numerically distributed, respectively. Example analyses are also generated for these five cases to compare adaptive random effects/coefficients modeling of correlated outcomes to previously developed adaptive modeling based on directly specified covariance structures. Adaptive random effects/coefficients modeling substantially outperforms direct covariance modeling in the linear, exponential, and discrete regression example analyses. It generates equivalent results in the logistic regression example analyses and it is substantially outperformed in the Poisson regression case. Random effects/coefficients modeling of correlated outcomes can provide substantial improvements in model selection compared to directly specified covariance modeling. However, directly specified covariance modeling can generate competitive or substantially better results in some cases while usually requiring less computation time.
文摘The desired economics of hard rock surface mining is mainly determined by the parameters of process design which minimize the overall cost per tonne of the rock mined in drilling, blasting, handling and primary crushing in given rockmass conditions. The most effective parameters of process design could be established based on the regression models of the cumulative influence of rockmass and mine design parameters on the overall cost per tonne of the rock drilled, blasted, handled and crushed. These models could be developed from the huge data accumulated worldwide on the costs per tonne of hard rock surface mining in drilling, blasting, handling and primary crushing vs the parameters of rockmass and mine design. This paper only dwelt on the development of regression models for oversize generation, blasthole productivity and blasting cost for iron ore surface mines, whose data is available. The SPSS standard statistical correlation – regression analysis software was used in the analysis. Interpretation of the models generated shows that the individual effects of the determinant rockmass and blast design parameters on oversize generation, blasthole productivity and blasting cost are all in compliance with the findings of other researchers and the theory of explosive rock fragmentation and could be used for the estimation of oversize generation, blasthole productivity and blasting cost in rockmass and blast design conditions similar to those of the iron ore surface mines examined in this study. However, the regression models obtained here could not be used alone for the optimization of blast design because most of the determinant parameters also have conflicting effect on the other processes of drilling, handling and primary crushing the blasted rock. Also, the quality and content of the regression models could be enhanced further by increasing the content of rockmass and blast design parameters and the volume of data considered in the regression analysis.
文摘The angular acceleration due to the spin effect increases the burning rate of solid propellant and changes the motor performance by increasing the operating pressure and decreasing the burning time. So it is important to know the grain regression taken place in the solid propellant rocket motor in the acceleration field. This study represents the grain regression analysis of two-dimensional axis-symmetric star grain configuration of the solid propellant rocket motor with spin induced acceleration effect and pressure effect on burn rate using geometrical and numerical analysis. While the rocket is spinning, the burn rates on each point of the propellant surface are different with its radial distance, acceleration vector angle and surface slope. With the different burn rates on the propellant surface, we analyze the propellant surface perimeter and port area, and these results are compared with those of constant burn rate and burn rate affected by the chamber pressure.
基金Supported by Sichuan Rural Development Center(CR1226):Combined Subjects of Social and Scientific Research of Sichuan Agricultural University
文摘Meta regression analysis method was applied to study 23 papers about the effect of Chinese labor reallocation on the economic growth. The results showed that both the method of the World Bank (1996) or M.Syrquin(1986) had little impact on the results, while the calculation of the stock of physical capital had a positive impact on the results. The result by using panel data study was bigger than results obtained in the time series data. The time span had little influences on the results. Therefore, it was necessary to measure the exact stock of physical capital in China, so as to evaluate the Chinese labor reallocation
文摘In order to find out the factors which influence community participation in tourism,several effect factors are summed up through the investigation of the local residents and the analysis of the logistic regression of the data gained from Xingwen world Geopark.Results indicated there are several main influencing factors of community participation such as the comparative benefit of tourist industry,participant residents' subjective wishes,preference consciousness of working opportunity obtainment in the tourist enterprise and participant skills.Based on above investigation data and field travel,the paper put forward several methods about how to enhance the residents' participant degree:increasing the comparative benefit of tourist industry,enhancing the attraction of tourism for boosting participant wishes,improving the preference consciousness on obtaining working opportunity in tourism industry and cultivating residents' participant skills through training.
