Vascularization of acellular nerves has been shown to contribute to nerve bridging.In this study,we used a 10-mm sciatic nerve defect model in rats to determine whether cartilage oligomeric matrix protein enhances the...Vascularization of acellular nerves has been shown to contribute to nerve bridging.In this study,we used a 10-mm sciatic nerve defect model in rats to determine whether cartilage oligomeric matrix protein enhances the vascularization of injured acellular nerves.The rat nerve defects were treated with acellular nerve grafting（control group） alone or acellular nerve grafting combined with intraperitoneal injection of cartilage oligomeric matrix protein（experimental group）.As shown through two-dimensional imaging,the vessels began to invade into the acellular nerve graft from both anastomotic ends at day 7 post-operation,and gradually covered the entire graft at day 21.The vascular density,vascular area,and the velocity of revascularization in the experimental group were all higher than those in the control group.These results indicate that cartilage oligomeric matrix protein enhances the vascularization of acellular nerves.展开更多
BACKGROUND Epithelioid hemangioendothelioma(EHE)is an uncommon low-grade aggressive vascular tumor.It can occur in almost all locations,but is rarely encountered in bone.CASE SUMMARY We report a 23-year-old man who pr...BACKGROUND Epithelioid hemangioendothelioma(EHE)is an uncommon low-grade aggressive vascular tumor.It can occur in almost all locations,but is rarely encountered in bone.CASE SUMMARY We report a 23-year-old man who presented with left hip pain with no obvious cause.X-ray revealed bone destruction in the left femoral neck with sclerosis at the edges of the lesions.Magnetic resonance imaging(MRI)showed bone destruction in the medullary cavity of the left femoral head and neck.18Fdeoxyglucose-positron emission tomography/computed tomography(PET/CT)imaging showed bone destruction in the left ischium,acetabulum,and left femoral head neck,accompanied by increased radioactive uptake;the maximum standard uptake value was 4.2.Histopathologic examination revealed spindleshaped mesenchymal tissue hyperplasia with scattered epithelioid cells.The patient underwent left femoral head replacement surgery.No signs of recurrence were observed as of the 18-mo follow-up.CONCLUSION The definitive diagnosis of femoral EHE can be established aided by the MRI and PET/CT findings.展开更多
基金supported by the Specialized Research Fund for Science and Technology Plan of Guangdong Province in China,No.201313060300007the National High-Technology Research and Development Program of China(863 Program),No.2012AA020507+2 种基金the National Basic Research Program of China(973 Program),No.2014CB542201the Doctoral Program of Higher Education of China,No.20120171120075Doctoral Start-up Project of the Natural Science Foundation of Guangdong Province in China,No.S201204006336 and 1045100890100590
文摘Vascularization of acellular nerves has been shown to contribute to nerve bridging.In this study,we used a 10-mm sciatic nerve defect model in rats to determine whether cartilage oligomeric matrix protein enhances the vascularization of injured acellular nerves.The rat nerve defects were treated with acellular nerve grafting（control group） alone or acellular nerve grafting combined with intraperitoneal injection of cartilage oligomeric matrix protein（experimental group）.As shown through two-dimensional imaging,the vessels began to invade into the acellular nerve graft from both anastomotic ends at day 7 post-operation,and gradually covered the entire graft at day 21.The vascular density,vascular area,and the velocity of revascularization in the experimental group were all higher than those in the control group.These results indicate that cartilage oligomeric matrix protein enhances the vascularization of acellular nerves.
文摘BACKGROUND Epithelioid hemangioendothelioma(EHE)is an uncommon low-grade aggressive vascular tumor.It can occur in almost all locations,but is rarely encountered in bone.CASE SUMMARY We report a 23-year-old man who presented with left hip pain with no obvious cause.X-ray revealed bone destruction in the left femoral neck with sclerosis at the edges of the lesions.Magnetic resonance imaging(MRI)showed bone destruction in the medullary cavity of the left femoral head and neck.18Fdeoxyglucose-positron emission tomography/computed tomography(PET/CT)imaging showed bone destruction in the left ischium,acetabulum,and left femoral head neck,accompanied by increased radioactive uptake;the maximum standard uptake value was 4.2.Histopathologic examination revealed spindleshaped mesenchymal tissue hyperplasia with scattered epithelioid cells.The patient underwent left femoral head replacement surgery.No signs of recurrence were observed as of the 18-mo follow-up.CONCLUSION The definitive diagnosis of femoral EHE can be established aided by the MRI and PET/CT findings.
