Stem cells are undifferentiated cells which have the unique potential to self-renew and to supply, via intermediate stages of transit amplifying cells （TACs）, differentiated cells. With- in the stem cell niches not ...Stem cells are undifferentiated cells which have the unique potential to self-renew and to supply, via intermediate stages of transit amplifying cells （TACs）, differentiated cells. With- in the stem cell niches not only heterologous cells, but also differentiated progeny of stem cells provide regulation to the stem cells parents. Stem cells can differentiate in various cell types during tissue maintenance or repair.展开更多
Background: The exact incidence of vascular injuries in Nigeria as a country especially south-east zone of Nigeria is unknown on account of under reporting and uncoordinated management of victims. Aim: To determine th...Background: The exact incidence of vascular injuries in Nigeria as a country especially south-east zone of Nigeria is unknown on account of under reporting and uncoordinated management of victims. Aim: To determine the pattern and outcome of common civilian vascular injuries managed in a teaching hospital in the south-east zone of Nigeria. Method: This is a retrospective study from January, 2007 to December, 2013. All case records of common civilian vascular injuries presenting at the accident center and those referred to the clinics as well as operation register and data banks of managing surgeons, were retrieved and analysed. Results: The age range of 12 - 75 years was rec-orded for the 26 patients. In this spectrum, age range of 21 - 30 years (19.2%) was the highest while the age range, 61 - 70 years (0%) was the lowest. One female (3.9%) and twenty five males (96.1%) were recorded, giving a female to male ratio of 1:25. In the upper extremity, brachial artery 6 (23.1%) was the most involved vessel while in the lower extremity, the most involved was the femoral artery 9 (34.6%). The patterns of presentation were isolated bleeding 10 (38%), arterivenous fistula 1 (3.5%) and pseudoaneurysm 8 (30%). 23 (88%) had good outcome. Conclusion: The incidence is about 4 cases per year. 23 (88%) had good outcome. The shortcoming of lattending physicians was because they were not conversant with hard and soft signs of vascular injuries with attendant limb loss and death of one of the victims. This short coming can be averted by training and retraining of doctors.展开更多
Atypical fibroxanthoma(AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be eas...Atypical fibroxanthoma(AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be easily misdiagnosed and undertreated by many clinicians who encounter them. Dermoscopy represents a valuable tool for easily assessing skin lesions, even though histological examination is required for final diagnosis. We report a case of a cheek lesion with dermoscopic "blue amber pattern", easily recognisable and not observed in others skin tumours, which could represent an additional feature useful in differentiating this tumour from other skin neoplasms.展开更多
AIM：To describe the prevalence and changes in treatment patterns of ranibizumab and photodynamic therapy（PDT） among retinal disease patients who attended the Ophthalmology Clinic in the tertiary care Hospital Selay...AIM：To describe the prevalence and changes in treatment patterns of ranibizumab and photodynamic therapy（PDT） among retinal disease patients who attended the Ophthalmology Clinic in the tertiary care Hospital Selayang from 2010 to 2014.METHODS：Study subjects were recruited retrospectively using the Electronic Medical Record（EMR） database software in Hospital Selayang.Demographic data,medical history,diagnostic procedure,treatments and diagnosis of patients were recorded.RESULTS：The five-year analysis included 821 patients with a mean age of 65.9±11.73 y.Overall,there were a highernumber of males（63.1%） and a higher number of Chinese（47.4%） patients.Among the 821 patients,62.9% received ranibizumab injection followed by 19.2% PDT therapy and 17.9% had ranibizumab combined with PDT therapy.Age-related macular degeneration（AMD） and polypoidal choroidal vasculopathy（PCV） were the most common retinal eye diseases reported,recording prevalence of 25.0% and 45.6%,respectively.The trend in ranibizumab treatment was reported to increase while PDT showed a decrease in trend from year 2010 to 2014.In terms of treatment,following multiple logistic regression,AMD was associated with the subjects being more likely to have received ranibizumab monotherapy（P〈0.001） while PCV was associated with more likely to have received PDT（P〈0.001） and PDT combined with ranibizumab therapy（P〈0.001）.CONCLUSION：The tertiary care setting in Malaysia is consistent with management of patients from other countries whereby ranibizumab is the most common treatment given to patients with AMD,while PCV patients most commonly receive PDT and ranibizumab combined with PDT therapy.展开更多
目的观察电针联合芪参还五胶囊治疗痰瘀互结型血管性痴呆的临床疗效,并观察其对患者认知功能和脑血流动力学指标的影响。方法将96例痰瘀互结型血管性痴呆患者以信封法随机分为3组(A组、B组和C组),每组32例。A组予口服胞磷胆碱胶囊,B组在...目的观察电针联合芪参还五胶囊治疗痰瘀互结型血管性痴呆的临床疗效,并观察其对患者认知功能和脑血流动力学指标的影响。方法将96例痰瘀互结型血管性痴呆患者以信封法随机分为3组(A组、B组和C组),每组32例。A组予口服胞磷胆碱胶囊,B组在A组治疗基础上予口服芪参还五胶囊,C组在B组治疗基础上另予电针治疗。比较3组的临床疗效和不良反应发生情况,观察3组治疗前后简易精神状态检查量表(mini mental state examination,MMSE)评分、日常生活能力(activity of daily living,ADL)评分、脑血流动力学指标(大脑中动脉收缩期峰值速度和舒张期峰值速度)以及血清脑损伤指标[中枢神经特异性蛋白β(central nervous system specific proteinβ,S-100β)和神经元特异性烯醇化酶(neuron-specific enolase,NSE)]的变化。结果C组总有效率为93.8%,高于B组的75.0%与A组的50.0%(P<0.05);B组总有效率高于A组(P<0.05)。治疗后,3组MMSE和ADL评分、大脑中动脉收缩期峰值速度和舒张期峰值速度以及血清S100β和NSE水平组间比较,差异均具有统计学意义(P<0.05);C组MMSE和ADL评分、大脑中动脉收缩期峰值速度和舒张期峰值速度以及血清S100β和NSE水平均优于A组和B组(P<0.05);时间与组间存在交互作用(P<0.05)。结论在口服胞磷胆碱胶囊基础上,电针联合芪参还五胶囊治疗痰瘀互结型血管性痴呆的临床疗效优于单纯口服药物,可提高患者认知功能及日常生活能力,改善大脑中动脉血流动力学指标以及血清脑损伤指标的水平。展开更多
文摘Stem cells are undifferentiated cells which have the unique potential to self-renew and to supply, via intermediate stages of transit amplifying cells （TACs）, differentiated cells. With- in the stem cell niches not only heterologous cells, but also differentiated progeny of stem cells provide regulation to the stem cells parents. Stem cells can differentiate in various cell types during tissue maintenance or repair.
文摘Background: The exact incidence of vascular injuries in Nigeria as a country especially south-east zone of Nigeria is unknown on account of under reporting and uncoordinated management of victims. Aim: To determine the pattern and outcome of common civilian vascular injuries managed in a teaching hospital in the south-east zone of Nigeria. Method: This is a retrospective study from January, 2007 to December, 2013. All case records of common civilian vascular injuries presenting at the accident center and those referred to the clinics as well as operation register and data banks of managing surgeons, were retrieved and analysed. Results: The age range of 12 - 75 years was rec-orded for the 26 patients. In this spectrum, age range of 21 - 30 years (19.2%) was the highest while the age range, 61 - 70 years (0%) was the lowest. One female (3.9%) and twenty five males (96.1%) were recorded, giving a female to male ratio of 1:25. In the upper extremity, brachial artery 6 (23.1%) was the most involved vessel while in the lower extremity, the most involved was the femoral artery 9 (34.6%). The patterns of presentation were isolated bleeding 10 (38%), arterivenous fistula 1 (3.5%) and pseudoaneurysm 8 (30%). 23 (88%) had good outcome. Conclusion: The incidence is about 4 cases per year. 23 (88%) had good outcome. The shortcoming of lattending physicians was because they were not conversant with hard and soft signs of vascular injuries with attendant limb loss and death of one of the victims. This short coming can be averted by training and retraining of doctors.
文摘Atypical fibroxanthoma(AFX) is a spindle cell neoplasm with low metastatic potential but high tendency to recur after surgery. Because of the rarity of this lesion and its aspecific clinical features, AFX could be easily misdiagnosed and undertreated by many clinicians who encounter them. Dermoscopy represents a valuable tool for easily assessing skin lesions, even though histological examination is required for final diagnosis. We report a case of a cheek lesion with dermoscopic "blue amber pattern", easily recognisable and not observed in others skin tumours, which could represent an additional feature useful in differentiating this tumour from other skin neoplasms.
基金Supported by Putra Grant from Universiti Putra Malaysia(No.9409800No.9432700)
文摘AIM：To describe the prevalence and changes in treatment patterns of ranibizumab and photodynamic therapy（PDT） among retinal disease patients who attended the Ophthalmology Clinic in the tertiary care Hospital Selayang from 2010 to 2014.METHODS：Study subjects were recruited retrospectively using the Electronic Medical Record（EMR） database software in Hospital Selayang.Demographic data,medical history,diagnostic procedure,treatments and diagnosis of patients were recorded.RESULTS：The five-year analysis included 821 patients with a mean age of 65.9±11.73 y.Overall,there were a highernumber of males（63.1%） and a higher number of Chinese（47.4%） patients.Among the 821 patients,62.9% received ranibizumab injection followed by 19.2% PDT therapy and 17.9% had ranibizumab combined with PDT therapy.Age-related macular degeneration（AMD） and polypoidal choroidal vasculopathy（PCV） were the most common retinal eye diseases reported,recording prevalence of 25.0% and 45.6%,respectively.The trend in ranibizumab treatment was reported to increase while PDT showed a decrease in trend from year 2010 to 2014.In terms of treatment,following multiple logistic regression,AMD was associated with the subjects being more likely to have received ranibizumab monotherapy（P〈0.001） while PCV was associated with more likely to have received PDT（P〈0.001） and PDT combined with ranibizumab therapy（P〈0.001）.CONCLUSION：The tertiary care setting in Malaysia is consistent with management of patients from other countries whereby ranibizumab is the most common treatment given to patients with AMD,while PCV patients most commonly receive PDT and ranibizumab combined with PDT therapy.
文摘目的观察电针联合芪参还五胶囊治疗痰瘀互结型血管性痴呆的临床疗效,并观察其对患者认知功能和脑血流动力学指标的影响。方法将96例痰瘀互结型血管性痴呆患者以信封法随机分为3组(A组、B组和C组),每组32例。A组予口服胞磷胆碱胶囊,B组在A组治疗基础上予口服芪参还五胶囊,C组在B组治疗基础上另予电针治疗。比较3组的临床疗效和不良反应发生情况,观察3组治疗前后简易精神状态检查量表(mini mental state examination,MMSE)评分、日常生活能力(activity of daily living,ADL)评分、脑血流动力学指标(大脑中动脉收缩期峰值速度和舒张期峰值速度)以及血清脑损伤指标[中枢神经特异性蛋白β(central nervous system specific proteinβ,S-100β)和神经元特异性烯醇化酶(neuron-specific enolase,NSE)]的变化。结果C组总有效率为93.8%,高于B组的75.0%与A组的50.0%(P<0.05);B组总有效率高于A组(P<0.05)。治疗后,3组MMSE和ADL评分、大脑中动脉收缩期峰值速度和舒张期峰值速度以及血清S100β和NSE水平组间比较,差异均具有统计学意义(P<0.05);C组MMSE和ADL评分、大脑中动脉收缩期峰值速度和舒张期峰值速度以及血清S100β和NSE水平均优于A组和B组(P<0.05);时间与组间存在交互作用(P<0.05)。结论在口服胞磷胆碱胶囊基础上,电针联合芪参还五胶囊治疗痰瘀互结型血管性痴呆的临床疗效优于单纯口服药物,可提高患者认知功能及日常生活能力,改善大脑中动脉血流动力学指标以及血清脑损伤指标的水平。
文摘目的:探讨芪参还五胶囊对血管性痴呆(vascular dementia,VD)痰瘀互结型患者认知功能及血清标志物的影响。方法:将痰瘀互结型VD患者80例应用计算机随机数字发生器分为对照组和观察组各40例。对照组应用吡拉西坦片治疗,观察组采用芪参还五胶囊治疗,两组患者均连续服药6周。观察治疗前后两组患者中医证候积分、认知功能[简易智力状态检查量表(Mini-mental state examination,MMSE)]与日常生活能力量表(ability of daily life,ADL)评分、血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、超敏C反应蛋白(high-sensitive C-reactive protein,hs-CRP)、脑源性神经营养因子(brain derived neurotrophic factor,BDNF)、乙酰胆碱(acetylcholine,Ach)、乙酰胆碱酯酶(acetylcholinesterase,AChE)、胆碱乙酰转移酶(choline acetyltransferase,ChAT)水平变化情况及临床疗效。分析血清指标变化与认知功能变化的相关性。结果:治疗后两组患者智能减退、神情呆钝、形盛体胖、呕吐痰涎、唇甲青紫及肌肤甲错症状均较治疗前减轻,观察组效果优于对照组(P<0.05)。总有效率观察组为90%,高于对照组的60%(P<0.05)。治疗后两组患者MMSE、ADL评分均升高(P<0.05),观察组高于对照组(P<0.05);血清NSE、hs-CRP及AchE水平均降低(P<0.05),观察组低于对照组(P<0.05);BDNF及Ach、ChAT水平均升高(P<0.05),观察组高于对照组(P<0.05)。Pearson相关系数分析显示MMSE、ADL评分均与血清Ach、ChAT、BDNF呈正相关,与血清AchE、NSE及hs-CRP呈负相关,且差异具有统计学意义(P<0.05)。结论:芪参还五胶囊能改善VD患者临床症状,调节血清NSE、hs-CRP、BDNF与胆碱能神经递质水平,提高认知功能和日常生活功能,效果优于吡拉西坦片。
