Background： Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations ...Background： Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee veuom allergy, Methods： Retrospective review of honeybee venom allergy versus nonallergy patients presenled v,ith positive honeybee venom （iI） sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups. Patient residence and exposure types were analyzed. The slgE/T-IgE among allergy and control groups was compared, Results： Gender ratio male：female was 32：22： median age was 39 years （31. 50）. 48% （26/54） of patients live in urban areas. 52% （28/54） in rural areas. Based on bee sting reactions, patients were divided into common localized reactions （32/54）. large localized reactions （7/54）, and systemic reactions （15/54）, In the systemic reaction group, patients presented as Type Ⅱ （6/15）, Type Ⅲ （6/15）. There is significant difference （P 〈 0,001 ） between the three groups in regards to exposure types. In the systemic reaction group. 8.7% （13/15） of patients are beekeepers. A significant difference （P 〈 0.001 ） was observed between allergic and control groups based on slgE/T-lgE results. As well as significant difference observed between the systemic reaction group to the other two reaction groups in regards to slgE/T-IgE results. Six systemic reaction patients presented with large localized reactions before onset of system symptoms 1 month to 1year of being stung. Conclusions： Occupational exposure is the most common cause in honeybee venom allergy induced systemic reactions. The use of sIgE/T-IgE results is a useful diagnostic parameter in determining honeybee venom allergy,展开更多
BACKGROUND Many ant species can harm humans;however,only a few cause life-threatening allergic reactions.Normally,reactions caused by ants occur in patients who come into contact with ant venom.Venom contains various ...BACKGROUND Many ant species can harm humans;however,only a few cause life-threatening allergic reactions.Normally,reactions caused by ants occur in patients who come into contact with ant venom.Venom contains various biologically active peptides and protein components,of which acids and alkaloids tend to cause anaphylaxis.Ant venom can cause both immediate and delayed reactions.The main histopathological changes observed in ant hypersensitivity are eosinophil recruitment and Th2 cytokine production.CASE SUMMARY A 70-year-old man was bitten by a large number of ants when he was in a drunken stupor and was hospitalized at a local hospital.Five days later,because of severe symptoms,the patient was transferred to our hospital for treatment.Numerous pustules were observed interspersed throughout the body,with itching and pain reported.He had experienced fever,vomiting,hematochezia,mania,soliloquy,sleep disturbances,and elevated levels of myocardial enzymes since the onset of illness.The patient had a history of hypertension for more than 1 year,and his blood pressure was within the normal range after hypotensive drug treatment.He had no other relevant medical history.Based on the clinical history of an ant bite and its clinical manifestations,the patient was diagnosed with an ant venom allergy.The patient was treated with 60 mg methylprednisolone for 2 d,40 mg methylprednisolone for 3 d,and 20 mg methylprednisolone for 2 d.Oral antihistamines and diazepam were administered for 12 d and 8 d,respectively.Cold compresses were used to treat the swelling during the process.After 12 d of treatment,most pustules became crusts,whereas some had faded away.No symptoms of pain,itching,or psychological disturbances were reported during the follow-up visits within 6 mo.CONCLUSION This case report emphasizes the dangers of ant stings.展开更多
文摘Background： Venom allergy is significantly underestimated in China. Venom-specific IgE may not provide accurate clinical reactions. Our conducted retrospective analysis observes alternative diagnostic considerations in assessing confirmation and severity of honeybee veuom allergy, Methods： Retrospective review of honeybee venom allergy versus nonallergy patients presenled v,ith positive honeybee venom （iI） sIgE results. According to clinically observed reactions caused by a honeybee sting, patients were divided into three groups. Patient residence and exposure types were analyzed. The slgE/T-IgE among allergy and control groups was compared, Results： Gender ratio male：female was 32：22： median age was 39 years （31. 50）. 48% （26/54） of patients live in urban areas. 52% （28/54） in rural areas. Based on bee sting reactions, patients were divided into common localized reactions （32/54）. large localized reactions （7/54）, and systemic reactions （15/54）, In the systemic reaction group, patients presented as Type Ⅱ （6/15）, Type Ⅲ （6/15）. There is significant difference （P 〈 0,001 ） between the three groups in regards to exposure types. In the systemic reaction group. 8.7% （13/15） of patients are beekeepers. A significant difference （P 〈 0.001 ） was observed between allergic and control groups based on slgE/T-lgE results. As well as significant difference observed between the systemic reaction group to the other two reaction groups in regards to slgE/T-IgE results. Six systemic reaction patients presented with large localized reactions before onset of system symptoms 1 month to 1year of being stung. Conclusions： Occupational exposure is the most common cause in honeybee venom allergy induced systemic reactions. The use of sIgE/T-IgE results is a useful diagnostic parameter in determining honeybee venom allergy,
文摘BACKGROUND Many ant species can harm humans;however,only a few cause life-threatening allergic reactions.Normally,reactions caused by ants occur in patients who come into contact with ant venom.Venom contains various biologically active peptides and protein components,of which acids and alkaloids tend to cause anaphylaxis.Ant venom can cause both immediate and delayed reactions.The main histopathological changes observed in ant hypersensitivity are eosinophil recruitment and Th2 cytokine production.CASE SUMMARY A 70-year-old man was bitten by a large number of ants when he was in a drunken stupor and was hospitalized at a local hospital.Five days later,because of severe symptoms,the patient was transferred to our hospital for treatment.Numerous pustules were observed interspersed throughout the body,with itching and pain reported.He had experienced fever,vomiting,hematochezia,mania,soliloquy,sleep disturbances,and elevated levels of myocardial enzymes since the onset of illness.The patient had a history of hypertension for more than 1 year,and his blood pressure was within the normal range after hypotensive drug treatment.He had no other relevant medical history.Based on the clinical history of an ant bite and its clinical manifestations,the patient was diagnosed with an ant venom allergy.The patient was treated with 60 mg methylprednisolone for 2 d,40 mg methylprednisolone for 3 d,and 20 mg methylprednisolone for 2 d.Oral antihistamines and diazepam were administered for 12 d and 8 d,respectively.Cold compresses were used to treat the swelling during the process.After 12 d of treatment,most pustules became crusts,whereas some had faded away.No symptoms of pain,itching,or psychological disturbances were reported during the follow-up visits within 6 mo.CONCLUSION This case report emphasizes the dangers of ant stings.
