Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm such as asthma and chronic obstructive pulmonary disease (COPD). It is mostly taken through an inhaler device. The compa...Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm such as asthma and chronic obstructive pulmonary disease (COPD). It is mostly taken through an inhaler device. The comparative toxicity assessment between two salbutamol sulfate preparations containing hydrofluoroalkane (HFA) metered dose inhalers with 100 μg per puff was evaluated in selected patients with asthma and COPD after prescribing. An open label, non-randomized, non-interventional observational study was designed. A large cohort of patients with asthma or related respiratory disorder of the general population from Dhaka and Chittagong of Bangladesh were recruited and treated with prescribed generic preparation Azmasol inhaler and brand preparation Ventolin Evohaler. Total 508 patients with asthma and minor obstructive airway disease were selected by the general medical practitioners in Bangladesh those who visited out patient consultation center in hospitals and physicians’ chambers and reported any adverse side effects of inhaled medications. There were no significant differences between the metered dose generic preparation Azmasol inhaler and Ventolon Evohaler among the patients treated with the medicines in asthma and related respiratory diseases in terms of adverse effects like immune system problem,dizziness,tremor,headache,nervousness,diarrhea,nausea,vomiting,heartburn,palpitation,skin rash,hypertension and taste feeling. It is concluded that Azmasol Inhaler, the generic salbutamol sulphate metered dose preparation containing HFA was as safe as the Ventolin Evohaler,a salbutamol sulfate brand preparation containing HFA when given to the patients in primary care after their physicians’ visits. Both the preparations have shown the similar safety profiles after regular use.展开更多
Objective:To investigate the effects of Pulmicort Respules,Ventolin combined with methylprednisolone in the adjuvant treatment of bronchiolitis in children.Methods:A total of 100 children with bronchiolitis in our hos...Objective:To investigate the effects of Pulmicort Respules,Ventolin combined with methylprednisolone in the adjuvant treatment of bronchiolitis in children.Methods:A total of 100 children with bronchiolitis in our hospital from March 2018 to March 2020 were selected and divided into 2 groups with 50 cases in each group by using random number table.Both groups received conventional treatment.Based on this,the control group was given Pulmicort Respules and Ventolin,and the observation group was given methylprednisolone in combination with the conventional regimens on the basis of the control group treatment,the course of treatment was 5 days.The levels of inflammatory factors[tumor necrosis factor-a(TNF-a),interleukin 6(IL-6)]and the time to symptom disappearance before and after treatment were compared and analyzed between the two groups.Results:After treatment,the levels of serum TNF-a and IL-6 in the two groups decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the disappearance of pulmonary moist rales,lung wheezing,cough and wheezing in the observation group were all earlier than the control group,the difference was statistically significant(P<0.05).Conclusion:Pulmicort Respules,Ventolin combined with methylprednisolone is effective in adjuvant treatment of bronchiolitis in children,which can reduce inflammation and promote the recovery of children.展开更多
文摘Salbutamol is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm such as asthma and chronic obstructive pulmonary disease (COPD). It is mostly taken through an inhaler device. The comparative toxicity assessment between two salbutamol sulfate preparations containing hydrofluoroalkane (HFA) metered dose inhalers with 100 μg per puff was evaluated in selected patients with asthma and COPD after prescribing. An open label, non-randomized, non-interventional observational study was designed. A large cohort of patients with asthma or related respiratory disorder of the general population from Dhaka and Chittagong of Bangladesh were recruited and treated with prescribed generic preparation Azmasol inhaler and brand preparation Ventolin Evohaler. Total 508 patients with asthma and minor obstructive airway disease were selected by the general medical practitioners in Bangladesh those who visited out patient consultation center in hospitals and physicians’ chambers and reported any adverse side effects of inhaled medications. There were no significant differences between the metered dose generic preparation Azmasol inhaler and Ventolon Evohaler among the patients treated with the medicines in asthma and related respiratory diseases in terms of adverse effects like immune system problem,dizziness,tremor,headache,nervousness,diarrhea,nausea,vomiting,heartburn,palpitation,skin rash,hypertension and taste feeling. It is concluded that Azmasol Inhaler, the generic salbutamol sulphate metered dose preparation containing HFA was as safe as the Ventolin Evohaler,a salbutamol sulfate brand preparation containing HFA when given to the patients in primary care after their physicians’ visits. Both the preparations have shown the similar safety profiles after regular use.
文摘Objective:To investigate the effects of Pulmicort Respules,Ventolin combined with methylprednisolone in the adjuvant treatment of bronchiolitis in children.Methods:A total of 100 children with bronchiolitis in our hospital from March 2018 to March 2020 were selected and divided into 2 groups with 50 cases in each group by using random number table.Both groups received conventional treatment.Based on this,the control group was given Pulmicort Respules and Ventolin,and the observation group was given methylprednisolone in combination with the conventional regimens on the basis of the control group treatment,the course of treatment was 5 days.The levels of inflammatory factors[tumor necrosis factor-a(TNF-a),interleukin 6(IL-6)]and the time to symptom disappearance before and after treatment were compared and analyzed between the two groups.Results:After treatment,the levels of serum TNF-a and IL-6 in the two groups decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the disappearance of pulmonary moist rales,lung wheezing,cough and wheezing in the observation group were all earlier than the control group,the difference was statistically significant(P<0.05).Conclusion:Pulmicort Respules,Ventolin combined with methylprednisolone is effective in adjuvant treatment of bronchiolitis in children,which can reduce inflammation and promote the recovery of children.
