Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction...Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.展开更多
Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and ...Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease,and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion,including trauma and major surgery.Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease.A variety of tests have been developed to assess intestinal epithelial cell damage,intestinal tight junction status and consequences of intestinal barrier integrity loss,i.e.increased intestinal permeability.This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function.展开更多
【目的】探讨P波离散度对高血压左心室肥厚患者心房颤动的临床价值。【方法】对本院自2010年4月至2013年3月收治的204例高血压左心室肥厚患者，根据患者的病理特征，将104例伴有心房颤动患者作为观察组，100例无心房颤动患者作为对照组...【目的】探讨P波离散度对高血压左心室肥厚患者心房颤动的临床价值。【方法】对本院自2010年4月至2013年3月收治的204例高血压左心室肥厚患者，根据患者的病理特征，将104例伴有心房颤动患者作为观察组，100例无心房颤动患者作为对照组，测量两组患者最大P波时限（Pmax ）、最小P波时限（Pmin）、P波离散度（P波离散度＝Pmax -Pmin），比较两组心电图和彩色脉冲多普勒超声心动检查指标左心室质量指数（LVMI）的差异性。【结果】观察组与对照组的P波离散度分别为（45．3±10．8）m s、（30．7±11．0）m s ，两组相比较差异有显著性（ P ＜0．05），观察组Pmax值明显高于对照组 Pmax值，两组相比较差异有显著性（ P ＜0．05）；观察组LVMI值为（152．4±14．9）g/m2，与对照组（101．1±9．2）g/m2比较，差异有显著性（ P ＜0．05）。【结论】P波离散度、Pmax是高血压左心室肥厚患者心房颤动的预测因子，其可为高血压左心室肥厚患者心房颤动的临床诊断提供关键的价值参考。展开更多
目的探讨厄贝沙坦联合缺血后适应对2型糖尿病大鼠缺血再灌注损伤早期心肌纤维化及心室重构的影响及机制。方法选取SD大鼠40只,建立2型糖尿病大鼠模型,随机分为4组(n=10):1假手术组;2缺血再灌注对照组(对照组);3缺血后适应组(Post组);4...目的探讨厄贝沙坦联合缺血后适应对2型糖尿病大鼠缺血再灌注损伤早期心肌纤维化及心室重构的影响及机制。方法选取SD大鼠40只,建立2型糖尿病大鼠模型,随机分为4组(n=10):1假手术组;2缺血再灌注对照组(对照组);3缺血后适应组(Post组);4厄贝沙坦后处理+缺血后适应组(Eba+Post组)。检测各组大鼠血清肌钙蛋白c Tn T以及心肌酶CK-MB、血清AT1受体自身抗体及心肌AT1R m RNA的表达;HE染色和电镜测定大鼠心肌间质纤维化及心肌炎性水平,以及各组大鼠心重指数和心肌胶原蛋白含量。结果 Post组CK-MB和c Tn T水平均低于对照组(均P<0.05),Eba+Post组CK-MB和c Tn T水平低于Post组,P<0.05;Post组及Eba+Post组抗AT1R受体阳性率分别为30%(3/10)和20%(2/10),明显低于对照组50%(5/10),P<0.05;Post组、Eba+Post组大鼠治疗后AT1R m RNA的表达明显减少,均明显低于对照组,P<0.05,与Post组相比,Eba+Post组AT1R m RNA的表达显著减少,P<0.05;HE染色切片及电镜检查显示,Post组、Eba+Post组心肌超微结构的改善明显,Eba+Post组心肌炎症及心肌纤维化的改善效果更为明显;对照组、Post组及Eba+Post组心重指数及心肌胶原蛋白含量较假手术组升高,治疗组上述指标均显著下降,Eba+Post组心重指数及心肌胶原蛋白含量较Post组降低,P<0.05。结论在高血糖大鼠心肌缺血再灌注条件下,ARB药物后处理对心肌缺血后适应有协同保护作用,其机制可能与调节AngⅡ、AT1R的水平有关,可改善早期心肌纤维化,减轻早期心室重构。展开更多
文摘Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.
文摘Over the past decades evidence has been accumulating that intestinal barrier integrity loss plays a key role in the development and perpetuation of a variety of disease states including inflammatory bowel disease and celiac disease,and is a key player in the onset of sepsis and multiple organ failure in situations of intestinal hypoperfusion,including trauma and major surgery.Insight into gut barrier integrity and function loss is important to improve our knowledge on disease etiology and pathophysiology and contributes to early detection and/or secondary prevention of disease.A variety of tests have been developed to assess intestinal epithelial cell damage,intestinal tight junction status and consequences of intestinal barrier integrity loss,i.e.increased intestinal permeability.This review discusses currently available methods for evaluating loss of human intestinal barrier integrity and function.
文摘【目的】探讨P波离散度对高血压左心室肥厚患者心房颤动的临床价值。【方法】对本院自2010年4月至2013年3月收治的204例高血压左心室肥厚患者，根据患者的病理特征，将104例伴有心房颤动患者作为观察组，100例无心房颤动患者作为对照组，测量两组患者最大P波时限（Pmax ）、最小P波时限（Pmin）、P波离散度（P波离散度＝Pmax -Pmin），比较两组心电图和彩色脉冲多普勒超声心动检查指标左心室质量指数（LVMI）的差异性。【结果】观察组与对照组的P波离散度分别为（45．3±10．8）m s、（30．7±11．0）m s ，两组相比较差异有显著性（ P ＜0．05），观察组Pmax值明显高于对照组 Pmax值，两组相比较差异有显著性（ P ＜0．05）；观察组LVMI值为（152．4±14．9）g/m2，与对照组（101．1±9．2）g/m2比较，差异有显著性（ P ＜0．05）。【结论】P波离散度、Pmax是高血压左心室肥厚患者心房颤动的预测因子，其可为高血压左心室肥厚患者心房颤动的临床诊断提供关键的价值参考。
文摘目的探讨厄贝沙坦联合缺血后适应对2型糖尿病大鼠缺血再灌注损伤早期心肌纤维化及心室重构的影响及机制。方法选取SD大鼠40只,建立2型糖尿病大鼠模型,随机分为4组(n=10):1假手术组;2缺血再灌注对照组(对照组);3缺血后适应组(Post组);4厄贝沙坦后处理+缺血后适应组(Eba+Post组)。检测各组大鼠血清肌钙蛋白c Tn T以及心肌酶CK-MB、血清AT1受体自身抗体及心肌AT1R m RNA的表达;HE染色和电镜测定大鼠心肌间质纤维化及心肌炎性水平,以及各组大鼠心重指数和心肌胶原蛋白含量。结果 Post组CK-MB和c Tn T水平均低于对照组(均P<0.05),Eba+Post组CK-MB和c Tn T水平低于Post组,P<0.05;Post组及Eba+Post组抗AT1R受体阳性率分别为30%(3/10)和20%(2/10),明显低于对照组50%(5/10),P<0.05;Post组、Eba+Post组大鼠治疗后AT1R m RNA的表达明显减少,均明显低于对照组,P<0.05,与Post组相比,Eba+Post组AT1R m RNA的表达显著减少,P<0.05;HE染色切片及电镜检查显示,Post组、Eba+Post组心肌超微结构的改善明显,Eba+Post组心肌炎症及心肌纤维化的改善效果更为明显;对照组、Post组及Eba+Post组心重指数及心肌胶原蛋白含量较假手术组升高,治疗组上述指标均显著下降,Eba+Post组心重指数及心肌胶原蛋白含量较Post组降低,P<0.05。结论在高血糖大鼠心肌缺血再灌注条件下,ARB药物后处理对心肌缺血后适应有协同保护作用,其机制可能与调节AngⅡ、AT1R的水平有关,可改善早期心肌纤维化,减轻早期心室重构。
