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On the calibration and verification of Voronoi-based discontinuous deformation analysis for modeling rock fracture 被引量:2
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作者 Kaiyu Zhang Feng Liu +3 位作者 Kaiwen Xia Ying Xu Peng Dong Changyi Yu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第8期2025-2038,共14页
Since its introduction,discontinuous deformation analysis(DDA)has been widely used in different areas of rock mechanics.By dividing large blocks into subblocks and introducing artificial joints,DDA can be applied to r... Since its introduction,discontinuous deformation analysis(DDA)has been widely used in different areas of rock mechanics.By dividing large blocks into subblocks and introducing artificial joints,DDA can be applied to rock fracture simulation.However,parameter calibration,a fundamental issue in discontinuum methods,has not received enough attention in DDA.In this study,the parameter calibration of DDA for intact rock is carefully studied.To this end,a subblock DDA with Voronoi tessellation is presented first.Then,a modified contact constitutive law is introduced,in which the tensile and shear meso-strengths are modified to be independent of the bond lengths.This improvement can prevent the unjustified preferential failure of short edges.A method for imposing confining pressure is also introduced.Thereafter,sensitivity analysis is performed to investigate the influence of the calculated parameters and meso-parameters on the mechanical properties of modeled rock.Based on the sensitivity analysis,a unified calibration procedure is suggested for both cases with and without confining pressure.Finally,the calibration procedure is applied to two examples,including a biaxial compression test.The results show that the proposed Voronoi-based DDA can simulate rock fracture with and without confining pressure very well after careful parameter calibration. 展开更多
关键词 Discontinuous deformation analysis(DDA) Voronoi tessellation Parameter calibration Confining pressure Rock fracture
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Non-crossing Quantile Regression Neural Network as a Calibration Tool for Ensemble Weather Forecasts 被引量:1
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作者 Mengmeng SONG Dazhi YANG +7 位作者 Sebastian LERCH Xiang'ao XIA Gokhan Mert YAGLI Jamie M.BRIGHT Yanbo SHEN Bai LIU Xingli LIU Martin Janos MAYER 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第7期1417-1437,共21页
Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,under-dispersed.As such,forecast calibration tools have become popular.Among those tools,quantil... Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,under-dispersed.As such,forecast calibration tools have become popular.Among those tools,quantile regression(QR)is highly competitive in terms of both flexibility and predictive performance.Nevertheless,a long-standing problem of QR is quantile crossing,which greatly limits the interpretability of QR-calibrated forecasts.On this point,this study proposes a non-crossing quantile regression neural network(NCQRNN),for calibrating ensemble NWP forecasts into a set of reliable quantile forecasts without crossing.The overarching design principle of NCQRNN is to add on top of the conventional QRNN structure another hidden layer,which imposes a non-decreasing mapping between the combined output from nodes of the last hidden layer to the nodes of the output layer,through a triangular weight matrix with positive entries.The empirical part of the work considers a solar irradiance case study,in which four years of ensemble irradiance forecasts at seven locations,issued by the European Centre for Medium-Range Weather Forecasts,are calibrated via NCQRNN,as well as via an eclectic mix of benchmarking models,ranging from the naïve climatology to the state-of-the-art deep-learning and other non-crossing models.Formal and stringent forecast verification suggests that the forecasts post-processed via NCQRNN attain the maximum sharpness subject to calibration,amongst all competitors.Furthermore,the proposed conception to resolve quantile crossing is remarkably simple yet general,and thus has broad applicability as it can be integrated with many shallow-and deep-learning-based neural networks. 展开更多
关键词 ensemble weather forecasting forecast calibration non-crossing quantile regression neural network CORP reliability diagram POST-PROCESSING
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Refinement modeling and verification of secure operating systems for communication in digital twins
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作者 Zhenjiang Qian Gaofei Sun +1 位作者 Xiaoshuang Xing Gaurav Dhiman 《Digital Communications and Networks》 SCIE CSCD 2024年第2期304-314,共11页
In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the d... In traditional digital twin communication system testing,we can apply test cases as completely as possible in order to ensure the correctness of the system implementation,and even then,there is no guarantee that the digital twin communication system implementation is completely correct.Formal verification is currently recognized as a method to ensure the correctness of software system for communication in digital twins because it uses rigorous mathematical methods to verify the correctness of systems for communication in digital twins and can effectively help system designers determine whether the system is designed and implemented correctly.In this paper,we use the interactive theorem proving tool Isabelle/HOL to construct the formal model of the X86 architecture,and to model the related assembly instructions.The verification result shows that the system states obtained after the operations of relevant assembly instructions is consistent with the expected states,indicating that the system meets the design expectations. 展开更多
关键词 Theorem proving Isabelle/HOL Formal verification System modeling Correctness verification
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Semantic Consistency and Correctness Verification of Digital Traffic Rules
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作者 Lei Wan Changjun Wang +3 位作者 Daxin Luo Hang Liu Sha Ma Weichao Hu 《Engineering》 SCIE EI CAS CSCD 2024年第2期47-62,共16页
The consensus of the automotive industry and traffic management authorities is that autonomous vehicles must follow the same traffic laws as human drivers.Using formal or digital methods,natural language traffic rules... The consensus of the automotive industry and traffic management authorities is that autonomous vehicles must follow the same traffic laws as human drivers.Using formal or digital methods,natural language traffic rules can be translated into machine language and used by autonomous vehicles.In this paper,a translation flow is designed.Beyond the translation,a deeper examination is required,because the semantics of natural languages are rich and complex,and frequently contain hidden assumptions.The issue of how to ensure that digital rules are accurate and consistent with the original intent of the traffic rules they represent is both significant and unresolved.In response,we propose a method of formal verification that combines equivalence verification with model checking.Reasonable and reassuring digital traffic rules can be obtained by utilizing the proposed traffic rule digitization flow and verification method.In addition,we offer a number of simulation applications that employ digital traffic rules to assess vehicle violations.The experimental findings indicate that our digital rules utilizing metric temporal logic(MTL)can be easily incorporated into simulation platforms and autonomous driving systems(ADS). 展开更多
关键词 Autonomous driving Traffic rules DIGITIZATION FORMALIZATION verification
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A real-time calibration method based on time-to-digital converter for accelerator timing system
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作者 Qi-Hao Duan Liang Ge +2 位作者 Yan-Hao Jia Jie-Yu Zhu Wei Zhang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期127-140,共14页
The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed ov... The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed over a certain range of 2 km,involving over a hundred devices.The white rabbit,a technology-enhancing Gigabit Ethernet,has shown the capability of scheduling distributed timing devices but still faces the challenge of obtaining real-time synchronization calibration param-eters with high precision.This study presents a calibration system based on a time-to-digital converter implemented on an ARM-based System-on-Chip(SoC).The system consists of four multi-sample delay lines,a bubble-proof encoder,an edge controller for managing data from different channels,and a highly effective calibration module that benefits from the SoC architecture.The performance was evaluated with an average RMS precision of 5.51 ps by measuring the time intervals from 0 to 24,000 ps with 120,000 data for every test.The design presented in this study refines the calibration precision of the HIAF timing system.This eliminates the errors caused by manual calibration without efficiency loss and provides data support for fault diagnosis.It can also be easily tailored or ported to other devices for specific applications and provides more space for developing timing systems for particle accelerators,such as white rabbits on HIAF. 展开更多
关键词 HIAF White rabbit calibration system Time-to-digital converter(TDC)
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The First Verification Test of Space-Ground Collaborative Intelligence via Cloud-Native Satellites
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作者 Wang Shangguang Zhang Qiyang +2 位作者 Xing Ruolin Qi Fei Xu Mengwei 《China Communications》 SCIE CSCD 2024年第4期208-217,共10页
Recent advancements in satellite technologies and the declining cost of access to space have led to the emergence of large satellite constellations in Low Earth Orbit(LEO).However,these constellations often rely on be... Recent advancements in satellite technologies and the declining cost of access to space have led to the emergence of large satellite constellations in Low Earth Orbit(LEO).However,these constellations often rely on bent-pipe architecture,resulting in high communication costs.Existing onboard inference architectures suffer from limitations in terms of low accuracy and inflexibility in the deployment and management of in-orbit applications.To address these challenges,we propose a cloud-native-based satellite design specifically tailored for Earth Observation tasks,enabling diverse computing paradigms.In this work,we present a case study of a satellite-ground collaborative inference system deployed in the Tiansuan constellation,demonstrating a remarkable 50%accuracy improvement and a substantial 90%data reduction.Our work sheds light on in-orbit energy,where in-orbit computing accounts for 17%of the total onboard energy consumption.Our approach represents a significant advancement of cloud-native satellite,aiming to enhance the accuracy of in-orbit computing while simultaneously reducing communication cost. 展开更多
关键词 cloud-native satellite orbital edge computing satellite inference verification test
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A linkable signature scheme supporting batch verification for privacy protection in crowd-sensing
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作者 Xu Li Gwanggil Jeon +1 位作者 Wenshuo Wang Jindong Zhao 《Digital Communications and Networks》 SCIE CSCD 2024年第3期645-654,共10页
The maturity of 5G technology has enabled crowd-sensing services to collect multimedia data over wireless network,so it has promoted the applications of crowd-sensing services in different fields,but also brings more ... The maturity of 5G technology has enabled crowd-sensing services to collect multimedia data over wireless network,so it has promoted the applications of crowd-sensing services in different fields,but also brings more privacy security challenges,the most commom which is privacy leakage.As a privacy protection technology combining data integrity check and identity anonymity,ring signature is widely used in the field of privacy protection.However,introducing signature technology leads to additional signature verification overhead.In the scenario of crowd-sensing,the existing signature schemes have low efficiency in multi-signature verification.Therefore,it is necessary to design an efficient multi-signature verification scheme while ensuring security.In this paper,a batch-verifiable signature scheme is proposed based on the crowd-sensing background,which supports the sensing platform to verify the uploaded multiple signature data efficiently,so as to overcoming the defects of the traditional signature scheme in multi-signature verification.In our proposal,a method for linking homologous data was presented,which was valuable for incentive mechanism and data analysis.Simulation results showed that the proposed scheme has good performance in terms of security and efficiency in crowd-sensing applications with a large number of users and data. 展开更多
关键词 5G network Crowd-sensing Privacy protection Ring signature Batch verification
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Dynamic Signature Verification Using Pattern Recognition
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作者 Emmanuel Nwabueze Ekwonwune Duroha Austin Ekekwe +1 位作者 Chinyere Iheakachi Ubochi Henry Chinedu Oleribe 《Journal of Software Engineering and Applications》 2024年第5期214-227,共14页
Dynamic signature is a biometric modality that recognizes an individual’s anatomic and behavioural characteristics when signing their name. The rampant case of signature falsification (Identity Theft) was the key mot... Dynamic signature is a biometric modality that recognizes an individual’s anatomic and behavioural characteristics when signing their name. The rampant case of signature falsification (Identity Theft) was the key motivating factor for embarking on this study. This study was necessitated by the damages and dangers posed by signature forgery coupled with the intractable nature of the problem. The aim and objectives of this study is to design a proactive and responsive system that could compare two signature samples and detect the correct signature against the forged one. Dynamic Signature verification is an important biometric technique that aims to detect whether a given signature is genuine or forged. In this research work, Convolutional Neural Networks (CNNsor ConvNet) which is a class of deep, feed forward artificial neural networks that has successfully been applied to analysing visual imagery was used to train the model. The signature images are stored in a file directory structure which the Keras Python library can work with. Then the CNN was implemented in python using the Keras with the TensorFlow backend to learn the patterns associated with the signature. The result showed that for the same CNNs-based network experimental result of average accuracy, the larger the training dataset, the higher the test accuracy. However, when the training dataset are insufficient, better results can be obtained. The paper concluded that by training datasets using CNNs network, 98% accuracy in the result was recorded, in the experimental part, the model achieved a high degree of accuracy in the classification of the biometric parameters used. 展开更多
关键词 verification SECURITY BIOMETRICS SIGNATURE AUTHENTICATION Model Pattern Recognition Dynamic
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Wavelength calibration and spectral analysis of vacuum ultraviolet spectroscopy in EAST
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作者 计华健 张洪明 +6 位作者 吕波 Cheonho BAE 何梁 林子超 尹相辉 沈永才 戴舒宇 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第8期37-43,共7页
A vacuum ultraviolet(VUV)spectroscopy with a focal length of 1 m has been engineered specifically for observing edge impurity emissions in Experimental Advanced Superconducting Tokamak(EAST).In this study,wavelength c... A vacuum ultraviolet(VUV)spectroscopy with a focal length of 1 m has been engineered specifically for observing edge impurity emissions in Experimental Advanced Superconducting Tokamak(EAST).In this study,wavelength calibration for the VUV spectroscopy is achieved utilizing a zinc lamp.The grating angle and charge-coupled device(CCD)position are carefully calibrated for different wavelength positions.The wavelength calibration of the VUV spectroscopy is crucial for improving the accuracy of impurity spectral data,and is required to identify more impurity spectral lines for impurity transport research.Impurity spectra of EAST plasmas have also been obtained in the wavelength range of 50–300 nm with relatively high spectral resolution.It is found that the impurity emissions in the edge region are still dominated by low-Z impurities,such as carbon,oxygen,and nitrogen,albeit with the application of fulltungsten divertors on the EAST tokamak. 展开更多
关键词 vacuum ultraviolet spectroscopy wavelength calibration impurity spectra
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A Novel High-Efficiency Transaction Verification Scheme for Blockchain Systems
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作者 Jingyu Zhang Pian Zhou +3 位作者 Jin Wang Osama Alfarraj Saurabh Singh Min Zhu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期1613-1633,共21页
Blockchain can realize the reliable storage of a large amount of data that is chronologically related and verifiable within the system.This technology has been widely used and has developed rapidly in big data systems... Blockchain can realize the reliable storage of a large amount of data that is chronologically related and verifiable within the system.This technology has been widely used and has developed rapidly in big data systems across various fields.An increasing number of users are participating in application systems that use blockchain as their underlying architecture.As the number of transactions and the capital involved in blockchain grow,ensuring information security becomes imperative.Addressing the verification of transactional information security and privacy has emerged as a critical challenge.Blockchain-based verification methods can effectively eliminate the need for centralized third-party organizations.However,the efficiency of nodes in storing and verifying blockchain data faces unprecedented challenges.To address this issue,this paper introduces an efficient verification scheme for transaction security.Initially,it presents a node evaluation module to estimate the activity level of user nodes participating in transactions,accompanied by a probabilistic analysis for all transactions.Subsequently,this paper optimizes the conventional transaction organization form,introduces a heterogeneous Merkle tree storage structure,and designs algorithms for constructing these heterogeneous trees.Theoretical analyses and simulation experiments conclusively demonstrate the superior performance of this scheme.When verifying the same number of transactions,the heterogeneous Merkle tree transmits less data and is more efficient than traditional methods.The findings indicate that the heterogeneous Merkle tree structure is suitable for various blockchain applications,including the Internet of Things.This scheme can markedly enhance the efficiency of information verification and bolster the security of distributed systems. 展开更多
关键词 Blockchain architecture transaction verification information security heterogeneous Merkle tree distributed systems
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A Weakly-Supervised Crowd Density Estimation Method Based on Two-Stage Linear Feature Calibration
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作者 Yong-Chao Li Rui-Sheng Jia +1 位作者 Ying-Xiang Hu Hong-Mei Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期965-981,共17页
In a crowd density estimation dataset,the annotation of crowd locations is an extremely laborious task,and they are not taken into the evaluation metrics.In this paper,we aim to reduce the annotation cost of crowd dat... In a crowd density estimation dataset,the annotation of crowd locations is an extremely laborious task,and they are not taken into the evaluation metrics.In this paper,we aim to reduce the annotation cost of crowd datasets,and propose a crowd density estimation method based on weakly-supervised learning,in the absence of crowd position supervision information,which directly reduces the number of crowds by using the number of pedestrians in the image as the supervised information.For this purpose,we design a new training method,which exploits the correlation between global and local image features by incremental learning to train the network.Specifically,we design a parent-child network(PC-Net)focusing on the global and local image respectively,and propose a linear feature calibration structure to train the PC-Net simultaneously,and the child network learns feature transfer factors and feature bias weights,and uses the transfer factors and bias weights to linearly feature calibrate the features extracted from the Parent network,to improve the convergence of the network by using local features hidden in the crowd images.In addition,we use the pyramid vision transformer as the backbone of the PC-Net to extract crowd features at different levels,and design a global-local feature loss function(L2).We combine it with a crowd counting loss(LC)to enhance the sensitivity of the network to crowd features during the training process,which effectively improves the accuracy of crowd density estimation.The experimental results show that the PC-Net significantly reduces the gap between fullysupervised and weakly-supervised crowd density estimation,and outperforms the comparison methods on five datasets of Shanghai Tech Part A,ShanghaiTech Part B,UCF_CC_50,UCF_QNRF and JHU-CROWD++. 展开更多
关键词 Crowd density estimation linear feature calibration vision transformer weakly-supervision learning
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Ghost Module Based Residual Mixture of Self-Attention and Convolution for Online Signature Verification
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作者 Fangjun Luan Xuewen Mu Shuai Yuan 《Computers, Materials & Continua》 SCIE EI 2024年第4期695-712,共18页
Online Signature Verification (OSV), as a personal identification technology, is widely used in various industries.However, it faces challenges, such as incomplete feature extraction, low accuracy, and computational h... Online Signature Verification (OSV), as a personal identification technology, is widely used in various industries.However, it faces challenges, such as incomplete feature extraction, low accuracy, and computational heaviness. Toaddress these issues, we propose a novel approach for online signature verification, using a one-dimensionalGhost-ACmix Residual Network (1D-ACGRNet), which is a Ghost-ACmix Residual Network that combines convolutionwith a self-attention mechanism and performs improvement by using Ghost method. The Ghost-ACmix Residualstructure is introduced to leverage both self-attention and convolution mechanisms for capturing global featureinformation and extracting local information, effectively complementing whole and local signature features andmitigating the problem of insufficient feature extraction. Then, the Ghost-based Convolution and Self-Attention(ACG) block is proposed to simplify the common parts between convolution and self-attention using the Ghostmodule and employ feature transformation to obtain intermediate features, thus reducing computational costs.Additionally, feature selection is performed using the random forestmethod, and the data is dimensionally reducedusing Principal Component Analysis (PCA). Finally, tests are implemented on the MCYT-100 datasets and theSVC-2004 Task2 datasets, and the equal error rates (EERs) for small-sample training using five genuine andforged signatures are 3.07% and 4.17%, respectively. The EERs for training with ten genuine and forged signaturesare 0.91% and 2.12% on the respective datasets. The experimental results illustrate that the proposed approacheffectively enhances the accuracy of online signature verification. 展开更多
关键词 Online signature verification feature selection ACG block ghost-ACmix residual structure
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A new calibration method for radon detector in seismic systems
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作者 Hongwei Ren Yaowei Liu 《Earthquake Science》 2024年第5期445-458,共14页
Radon observation is an important measurement item of seismic precursor network observation.The radon detector calibration is a key technical link for ensuring radon observation accuracy.At present,the radon detector ... Radon observation is an important measurement item of seismic precursor network observation.The radon detector calibration is a key technical link for ensuring radon observation accuracy.At present,the radon detector calibration in seismic systems in China is faced with a series of bottleneck problems,such as aging and scrap,acquisition difficulties,high supervision costs,and transportation limitations of radon sources.As a result,a large number of radon detectors cannot be accurately calibrated regularly,seriously affecting the accuracy and reliability of radon observation data in China.To solve this problem,a new calibration method for radon detectors was established.The advantage of this method is that the dangerous radioactive substance,i.e.,the radon source,can be avoided,but only“standard instruments”and water samples with certain dissolved radon concentrations can be used to realize radon detector calibration.This method avoids the risk of radioactive leakage and solves the current widespread difficulties and bottleneck of radon detector calibration in seismic systems in China.The comparison experiment with the traditional calibration method shows that the error of the calibration coefficient obtained by the new method is less than 5%compared with that by the traditional method,which meets the requirements of seismic observation systems,confirming the reliability of the new method.This new method can completely replace the traditional calibration method of using a radon source in seismic systems. 展开更多
关键词 radon detector calibration “standard instrument” scintillation chamber radon source
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Kinematic calibration under the expectation maximization framework for exoskeletal inertial motion capture system
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作者 QIN Weiwei GUO Wenxin +2 位作者 HU Chen LIU Gang SONG Tainian 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期769-779,共11页
This study presents a kinematic calibration method for exoskeletal inertial motion capture (EI-MoCap) system with considering the random colored noise such as gyroscopic drift.In this method, the geometric parameters ... This study presents a kinematic calibration method for exoskeletal inertial motion capture (EI-MoCap) system with considering the random colored noise such as gyroscopic drift.In this method, the geometric parameters are calibrated by the traditional calibration method at first. Then, in order to calibrate the parameters affected by the random colored noise, the expectation maximization (EM) algorithm is introduced. Through the use of geometric parameters calibrated by the traditional calibration method, the iterations under the EM framework are decreased and the efficiency of the proposed method on embedded system is improved. The performance of the proposed kinematic calibration method is compared to the traditional calibration method. Furthermore, the feasibility of the proposed method is verified on the EI-MoCap system. The simulation and experiment demonstrate that the motion capture precision is significantly improved by 16.79%and 7.16%respectively in comparison to the traditional calibration method. 展开更多
关键词 human motion capture kinematic calibration EXOSKELETON gyroscopic drift expectation maximization(EM)
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Calibration of CO and CO2 Monitors Used in Periodic Inspection of Vehicles at Fixed Stations for Environmental Control
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作者 Adel Bassuoni Shehata Abdulrahman Rashed Al Askar +2 位作者 Najjy Hamad Al Yami Abdullah Suleiman Al Owaysi Sultan K. Alharbi 《Green and Sustainable Chemistry》 2024年第2期29-41,共13页
Global efforts for environmental cleanliness through the control of gaseous emissions from vehicles are gaining momentum and attracting increasing attention. Calibration plays a crucial role in these efforts by ensuri... Global efforts for environmental cleanliness through the control of gaseous emissions from vehicles are gaining momentum and attracting increasing attention. Calibration plays a crucial role in these efforts by ensuring the quantitative assessment of emissions for informed decisions on environmental treatments. This paper describes a method for the calibration of CO/CO<sub>2</sub> monitors used for periodic inspections of vehicles in cites. The calibration was performed in the selected ranges: 900 - 12,000 µmol/mol for CO and 2000 - 20,000 µmol/mol for CO<sub>2</sub>. The traceability of the measurement results to the SI units was ensured by using certified reference materials from CO/N<sub>2</sub> and CO<sub>2</sub>/N<sub>2</sub> primary gas mixtures. The method performance was evaluated by assessing its linearity, accuracy, precision, bias, and uncertainty of the calibration results. The calibration data exhibited a strong linear trend with R² values close to 1, indicating an excellent fit between the measured values and the calibration lines. Precision, expressed as relative standard deviation (%RSD), ranged from 0.48 to 4.56% for CO and from 0.97 to 3.53% for CO<sub>2</sub>, staying well below the 5% threshold for reporting results at a 95% confidence level. Accuracy measured as percent recovery, was consistently high (≥ 99.1%) for CO and ranged from 84.90% to 101.54% across the calibration range for CO<sub>2</sub>. In addition, the method exhibited minimal bias for both CO and CO<sub>2</sub> calibrations and thus provided a reliable and accurate approach for calibrating CO/CO<sub>2</sub> monitors used in vehicle inspections. Thus, it ensures the effectiveness of exhaust emission control for better environment. 展开更多
关键词 MONITORS Periodic Inspection CO/CO2 calibration LINEARITY Precision Accuracy
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Efficacy of Juanbi capsule on ameliorating knee osteoarthritis:a network pharmacology and experimental verification-based study
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作者 Wen-Bo Huang Shu-Ya Qin +3 位作者 Jun-Bo Zou Xun Li Wu-Lin Kang Pu-Wei Yuan 《Traditional Medicine Research》 2024年第6期19-30,共12页
Background:The purpose of the study was to investigate the active ingredients and potential biochemical mechanisms of Juanbi capsule in knee osteoarthritis based on network pharmacology,molecular docking and animal ex... Background:The purpose of the study was to investigate the active ingredients and potential biochemical mechanisms of Juanbi capsule in knee osteoarthritis based on network pharmacology,molecular docking and animal experiments.Methods:Chemical components for each drug in the Juanbi capsule were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,while the target proteins for knee osteoarthritis were retrieved from the Drugbank,GeneCards,and OMIM databases.The study compared information on knee osteoarthritis and the targets of drugs to identify common elements.The data was imported into the STRING platform to generate a protein-protein interaction network diagram.Subsequently,a“component-target”network diagram was created using the screened drug components and target information with Cytoscape software.Common targets were imported into Metascape for GO function and KEGG pathway enrichment analysis.AutoDockTools was utilized to predict the molecular docking of the primary chemical components and core targets.Ultimately,the key targets were validated through animal experiments.Results:Juanbi capsule ameliorated Knee osteoarthritis mainly by affecting tumor necrosis factor,interleukin1β,MMP9,PTGS2,VEGFA,TP53,and other cytokines through quercetin,kaempferol,andβ-sitosterol.The drug also influenced the AGE-RAGE,interleukin-17,tumor necrosis factor,Relaxin,and NF-κB signaling pathways.The network pharmacology analysis results were further validated in animal experiments.The results indicated that Juanbi capsule could decrease the levels of tumor necrosis factor-αand interleukin-1βin the serum and synovial fluid of knee osteoarthritis rats and also down-regulate the expression levels of MMP9 and PTGS2 proteins in the articular cartilage.Conclusion:Juanbi capsule may improve the knee bone microstructure and reduce the expression of inflammatory factors of knee osteoarthritis via multiple targets and multiple signaling pathways. 展开更多
关键词 OSTEOARTHRITIS INFLAMMATION MMP9/PTGS2 network pharmacology Juanbi capsule experimental verification
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Parameter calibration of the tensile-shear interactive damage constitutive model for sandstone failure
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作者 Yun Shu Zheming Zhu +4 位作者 Meng Wang Weiting Gao Fei Wang Duanying Wan Yuntao Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1153-1174,共22页
The tensile-shear interactive damage(TSID)model is a novel and powerful constitutive model for rock-like materials.This study proposes a methodology to calibrate the TSID model parameters to simulate sandstone.The bas... The tensile-shear interactive damage(TSID)model is a novel and powerful constitutive model for rock-like materials.This study proposes a methodology to calibrate the TSID model parameters to simulate sandstone.The basic parameters of sandstone are determined through a series of static and dynamic tests,including uniaxial compression,Brazilian disc,triaxial compression under varying confining pressures,hydrostatic compression,and dynamic compression and tensile tests with a split Hopkinson pressure bar.Based on the sandstone test results from this study and previous research,a step-by-step procedure for parameter calibration is outlined,which accounts for the categories of the strength surface,equation of state(EOS),strain rate effect,and damage.The calibrated parameters are verified through numerical tests that correspond to the experimental loading conditions.Consistency between numerical results and experimental data indicates the precision and reliability of the calibrated parameters.The methodology presented in this study is scientifically sound,straightforward,and essential for improving the TSID model.Furthermore,it has the potential to contribute to other rock constitutive models,particularly new user-defined models. 展开更多
关键词 Damage constitutive model Parameter calibration Rock modeling SANDSTONE Dynamic impact load Tensile-shear interactive damage(TSID)model
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Global Calibration Method for Monocular Multi-View System Using Rotational Dual-Target
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作者 Kun He Hongwei He 《Open Journal of Applied Sciences》 2024年第5期1192-1203,共12页
To make the problems of existing high requirements of calibration tools, complex global calibration process addressed for monocular multi-view visual measurement system during measurement, in the paper, a global calib... To make the problems of existing high requirements of calibration tools, complex global calibration process addressed for monocular multi-view visual measurement system during measurement, in the paper, a global calibration method is proposed for the geometric properties of rotational correlation motion and the absolute orientation of the field of view without over lap. Firstly, a dual-camera system is constructed for photographing and collecting the rotating image sequence of two flat targets rigidly connected by a long rod at different positions, and based on the known parameters, such as, target feature image, world coordinates, camera internal parameters and so on, then the global PnP optimization method is used to solve the rotation axis and the reference point at different positions;Then, the absolute orientation matrix is constructed based on the parameters of rotation axis, reference point and connecting rod length obtained by this method. In the end, the singular value decomposition method is used to find the optimal rotation matrix, and then get the translation matrix. It’s shown based on simulation and actual tests that in comparison with the existing methods, the maximum attitude and pose errors is 0.0083˚ and 0.3657 mm, respectively, which improves the accuracy by 27.8% and 24.4%, respectively. The calibration device in this paper is simple, and there are no parallel, vertical and coplanar requirements between multiple rotating positions. At the same time, in view of the calibration accuracy, the accuracy requirements of most application scenarios can be met. 展开更多
关键词 Machine Vision Accurate Demarcating Global calibration Absolute Orientation
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Verification and Application Evaluation of Intelligent Audit Rules for The UN9000 Urine Analysis System
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作者 Hualin He Ling Zhang +8 位作者 Weiwei Shi Rui Wang Chuanxin Dai Jun Li Zheng Wang Li Zuo Qunchao Wang Ning Li Jianmin Li 《Journal of Clinical and Nursing Research》 2024年第3期238-246,共9页
Objective:To apply and verify the application of intelligent audit rules for urine analysis by Cui et al.Method:A total of 1139 urine samples of hospitalized patients in Tai’an Central Hospital from September 2021 to... Objective:To apply and verify the application of intelligent audit rules for urine analysis by Cui et al.Method:A total of 1139 urine samples of hospitalized patients in Tai’an Central Hospital from September 2021 to November 2021 were randomly selected,and all samples were manually microscopic examined after the detection of the UN9000 urine analysis line.The intelligent audit rules(including the microscopic review rules and manual verification rules)were validated based on the manual microscopic examination and manual audit,and the rules were adjusted to apply to our laboratory.The laboratory turnaround time(TAT)before and after the application of intelligent audit rules was compared.Result:The microscopic review rate of intelligent rules was 25.63%(292/1139),the true positive rate,false positive rate,true negative rate,and false negative rate were 27.66%(315/1139),6.49%(74/1139),62.34%(710/1139)and 3.51%(40/1139),respectively.The approval consistency rate of manual verification rules was 84.92%(727/856),the approval inconsistency rate was 0%(0/856),the interception consistency rate was 12.61%(108/856),and the interception inconsistency rate was 0%(0/856).Conclusion:The intelligence audit rules for urine analysis by Cui et al.have good clinical applicability in our laboratory. 展开更多
关键词 URINALYSIS Manual verification rules Intelligent verification TAT
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Verification and recalibration of HY-2A microwave radiometer brightness temperature 被引量:2
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作者 ZHAO Yili LI Huimin +1 位作者 CHEN Chuntao ZHU Jianhua 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2019年第3期968-981,共14页
HY-2A is the first one of the Chinese HY-2 ocean satellite series carrying a microwave radiometer(RM)to measure sea surface temperature,sea surface wind speed,atmospheric water vapor,cloud liquid water content,and rai... HY-2A is the first one of the Chinese HY-2 ocean satellite series carrying a microwave radiometer(RM)to measure sea surface temperature,sea surface wind speed,atmospheric water vapor,cloud liquid water content,and rain rate.We verified the RM level 1B brightness temperature(T B)to retrieve environmental parameters.In the verification,TB that simulated using the ocean-atmosphere radiative transfer model(RTM)was used as a reference.The total bias and total standard deviation(SD)of the RM level 1B TB,with reference to the RTM simulation,ranged-20.6-4.38 K and 0.7-2.93 K,respectively.We found that both the total bias and the total SD depend on the frequency and polarization,although the values for ascending and descending passes are different.In addition,substantial seasonal variation of the bias was found at all channels.The verification results indicate the RM has some problems regarding calibration,e.g.,correction of antenna spillover and antenna physical emission,especially for the 18.7-GHz channel.Based on error analyses,a statistical recalibration algorithm was designed and recalibration was performed for the RM level 1B TB.Validation of the recalibrated TB indicated that the quality of the recalibrated RM level 1B TB was improved significantly.The bias of the recalibrated T B at all channels was reduced to<0.4 K,seasonal variation was almost eradicated,and SD was diminished(i.e.,the SD of the 18.7-GHz channel was reduced by more than 0.5K). 展开更多
关键词 HY-2A MICROWAVE RADIOMETER BRIGHTNESS temperature(TB) verification calibration
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