Based on the key function of version management in PDM system, this paper discusses the function and the realization of version management and the transitions of version states with a workflow. A directed aeyclic grap...Based on the key function of version management in PDM system, this paper discusses the function and the realization of version management and the transitions of version states with a workflow. A directed aeyclic graph is used to describe a version model. Three storage modes of the directed acyelic graph version model in the database, the bumping block and the PDM working memory are presented and the conversion principle of these three modes is given. The study indicates that building a dynamic product structure configuration model based on versions is the key to resolve the problem. Thus a version model of single product object is built. Then the version management model in product structure configuration is built and the application of version management of PDM syster is presented as a case.展开更多
Software projects are becoming larger and more complicated. Managing those projects is based on several software development methodologies. One of those methodologies is software version control, which is used in the ...Software projects are becoming larger and more complicated. Managing those projects is based on several software development methodologies. One of those methodologies is software version control, which is used in the majority of worldwide software projects. Although existing version control systems provide sufficient functionality in many situations, they are lacking in terms of semantics and structure for source code. It is commonly believed that improving software version control can contribute substantially to the development of software. We present a solution that considers a structural model for matching source code that can be used in version control.展开更多
A version of a product consists of the product structure tree and the versions of all its components. The model includes two sets of data: attributes and documents describing each component. The paper discusses the v...A version of a product consists of the product structure tree and the versions of all its components. The model includes two sets of data: attributes and documents describing each component. The paper discusses the version change relations between a sub-node component and a up-node component in a product structure tree, analyzes the version control system for a static reference and that for a dynamic reference and proposes a product structure model in support of dynamic reference, which is easy to use and contains a complete set of information providing an essential way of data organization for the PDM system.展开更多
By comparing China's import of major imported agriculture textile material( cotton and wool),the characteristics of import are concluded. On this basis,a restricted version of source differentiated almost ideal de...By comparing China's import of major imported agriculture textile material( cotton and wool),the characteristics of import are concluded. On this basis,a restricted version of source differentiated almost ideal demand system( RSDAIDS) is used to estimate the income and price elasticity of major imported agriculture textile material from the major sources based on the data from 1992 to 2015. The results are shown as follows.( 1) Although the dependency on imported cotton is lower than wool, the fluctuation of cotton import is much more drastic; China's demand for cotton is relatively price elastic with higher expenditure elasticity compared with wool; besides,the existence of complementarity is proved between imported cotton and wool.( 2) According to the import elasticity of cotton,demand for cotton imported from India shows priority over cotton from other sources; demand for cotton imported from America is the most price-sensitive one; substitution among cotton from different sources is weak.( 3) According to the import elasticity of wool,wool imported from Uruguay has bright market prospects. In addition,wool imported from Australia has irreplaceable advantage than that from New Zealand.展开更多
Contents1. Diagnosis and dynamic assessment of persistent/recurrent and metastatic differentiated thyroid cancer (prmDTC)1.1 Basic principles of diagnosis1.2 Diagnostic methods1.3 Ongoing assessment of response to the...Contents1. Diagnosis and dynamic assessment of persistent/recurrent and metastatic differentiated thyroid cancer (prmDTC)1.1 Basic principles of diagnosis1.2 Diagnostic methods1.3 Ongoing assessment of response to therapy2. Multidisciplinary treatment of prmDTC2.1 Basic principles of treatment2.2 Surgical management2.2.1 Preoperative clinical assessment2.2.2 Principles of surgical treatment for prmDTC.展开更多
Objective: Response Evaluation Criteria in Solid Tumors (RECIST) guideline version 1.0 (RECIST 1.0) was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized mea...Objective: Response Evaluation Criteria in Solid Tumors (RECIST) guideline version 1.0 (RECIST 1.0) was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure. With a number of issues being raised on RECIST 1.0, however, a revised RECIST guideline version 1.1 (RECIST 1.1) was proposed by the RECIST Working Group in 2009. This study was conducted to compare CT tumor response based on RECIST 1.1 vs. RECIST 1.0 in patients with advanced gastric cancer (AGC). Methods: We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010. These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using the κ statistic. Results: The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0 (P〈0.0001). However, there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0 0(κ=0.844). The overall response rates (ORRs) according to RECIST 1.0 and RECIST 1.1 were 32.7% (20/61) and 34.5% (20/58), respectively. One patient with partial response (PR) based on RECIST 1.0 was reclassified as stable disease (SD) by RECIST 1.1. Of two patients with SD by RECIST 1.0, one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1. Conclusions: RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC.展开更多
Contents1. Overview2. Risk factors of prostate cancer2.1 Age and genetic factors2.2 Exogenous factors3. Pathological classification and grading system4. Diagnostic evaluation4.1 Monitoring and screening for population...Contents1. Overview2. Risk factors of prostate cancer2.1 Age and genetic factors2.2 Exogenous factors3. Pathological classification and grading system4. Diagnostic evaluation4.1 Monitoring and screening for population with high-risk prostate cancer4.2 Genetic testing4.3 Digital rectal examination (DRE)4.4 Magnetic resonance examination4.5 Bone scan examination.展开更多
Background: Laparoscopic hepatectomy has many advantages over open surgery, including minimiza- tion of local injury, reduced systemic reactions, and faster postoperative recovery. The aim of this "Consensus" is to...Background: Laparoscopic hepatectomy has many advantages over open surgery, including minimiza- tion of local injury, reduced systemic reactions, and faster postoperative recovery. The aim of this "Consensus" is to provide guidance and reference to surgeons who perform, or are interested in per- forming laparoscopic liver surgeries. Methods: The National Hepatic Surgery Group of the Society of Surgery, a professional society of the Chinese Medical Association, gathered 60 expert hepatic surgeons in Wuhan, China in December 2012, and an "Expert Consensus on Laparoseopic Hepatectomy" was developed. Results: The types of hepatectomy, indications and contraindications, preoperative preparation, anes- thesia, patient position, insuffiation pressure, port position, control of hepatic inflow and outflow, indi- cations for conversion to open surgery, and surgical devices and equipment are reviewed. Techniques and procedures of various laparoscopic hepatectomies are also discussed.展开更多
AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract surgery.METHODS: Patients underwent cataract s...AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract surgery.METHODS: Patients underwent cataract surgery in Shanghai General Hospital, Shanghai Jiao Tong University, who fit the inclusion criteria were recruited. Two CLVQOLs were administered, including a preoperative CLVQOL and a CLVQOL at the end of the 3 mo follow-up period, and were completed using face-to-face interviews or phone interviews conducted by trained investigators. The minimal clinically important difference(MCID) was calculated using an anchor-based method and a distribution method. In addition, the responsiveness of the questionnaire was measured.RESULTS: A total of 155 residents were enrolled. The average visual acuity(VA) preoperatively was 0.08(SD=0.05), and it increased to 0.47(SD=0.28) at the end of followup. Statistically significant positive changes in the CLVQOL scores indicated significant improvement of vision related quality of life after cataract surgery. With the larger value between the two results as the final value, the MCID values of the CLVQOL(scores of the four scales as well as the total score) were 8.94, 2.61, 4.34, 3.10 and 17.63, respectively. The CLVQOL has both good internal and external responsiveness.CONCLUSION: CLVQOL scores are appropriate instruments for obtaining clinically important changes after cataract surgery. This study is an effective exploration for establishingcataract surgery efficacy standards, which helps clinical and scientific research workers in ophthalmology to gain a more in-depth understanding when using CLVQOL.展开更多
Professionalism is crucial in all professions and is particularly important in the medical field.Measuring students' perceptions of professionalism can help to form education targeting the enhancement of professio...Professionalism is crucial in all professions and is particularly important in the medical field.Measuring students' perceptions of professionalism can help to form education targeting the enhancement of professionalism.This study aimed to validate an effective assessment tool for the measurement of medical students5 perceptions of medical professionalism in China's Mainland.The cross-sectional survey was conducted in three medical colleges in Guangdong,China.Of the 2103 eligible medical students,1976 responded,and 1856 questionnaires were deemed valid.Students from clinical medicine in these three medical colleges were randomly selected by cluster sampling.First,a Simplified Chinese Version questionnaire to measure Student's Perception of Medical Professionalism (SCV-SPMP) was constructed.Second,questionnaires from 1856 students majoring in clinical medicine at three medical colleges were included in the analysis.Third,exploratory factor analysis,Cronbach's alpha,item-subscale correlation,and confirmatory factor analysis were conducted to test the validity and reliability of the SCV-SPMP.Nine items were eliminated following exploratory factor analysis,and four subscales were extracted from the analysis.All internal consistency reliability exceeded the minimum standard.The overall Cronbach's alpha was 0.94,and four subscales' alphas were 0.82 (Accountability and excellence),0.81 (Duty),0.89 (Honor and integrity),and 0.85 (Practice habits and respect for others),respectively.The model fit was good.The convergent validity and discriminant validity were acceptable.The modified SCVSPMP was found to be a valid and reliable tool to capture the main features of Chinese students' perceptions of medical professionalism in four dimensions,and it provides a quantitative method for the measurement of the students' perceptions in China's Mainland..展开更多
A dynamic Web application, which can help the departments of enterprise to collaborate with each other conveniently, is proposed. Several popular design solutions are introduced at first. Then, dynamic Web system is c...A dynamic Web application, which can help the departments of enterprise to collaborate with each other conveniently, is proposed. Several popular design solutions are introduced at first. Then, dynamic Web system is chosen for developing the file access and control system. Finally, the paper gives the detailed process of the design and implementation of the system, which includes some key problems such as solutions of document management and system security. Additionally, the limitations of the system as well as the suggestions of further improvement are also explained.展开更多
A novel dynamic batch selective sampling algorithm based on version space analysis is presented. In the traditional batch selective sampling, example selection is entirely determined by the existing unreliable classif...A novel dynamic batch selective sampling algorithm based on version space analysis is presented. In the traditional batch selective sampling, example selection is entirely determined by the existing unreliable classification boundary; meanwhile, within a batch, examples labeled previously fail to provide instructive information for the selection of the rest. As a result, using the examples selected in batch mode for model refinement will jeopardize the classification performance. Based on the duality between feature space and parameter space under the SVM active learning fi:amework, dynamic batch selective sampling is proposed to address the problem. We select a batch of examples dynamically, using the examples labeled previously as guidance for further selection. In this way, the selection of feedback examples is determined by both the existing classification model and the examples labeled previously. Encouraging experimental results demonstrate the effectiveness of the proposed algorithm.展开更多
Waxy maize is a specialty maize that produces mainly amylopectin starch with special food or industrial values. The objective of this study was to overcome the limitations of wx mutant allele acquisition and breeding ...Waxy maize is a specialty maize that produces mainly amylopectin starch with special food or industrial values. The objective of this study was to overcome the limitations of wx mutant allele acquisition and breeding efficiency by conversion of parental lines from normal to waxy maize. The intended mutation activity was achieved by in vivo CRISPR/Cas9 machinery involving desired-target mutation of the Wx locus in the ZC01 background,abbreviated as ZC01-DTM^(wx). Triple selection was applied to segregants to obtain high genome background recovery with transgene-free wx mutations. The targeted mutation was identified, yielding six types of mutations among progeny crossed with ZC01-DTM^(wx).The amylopectin contents of the endosperm starch in mutant lines and hybrids averaged94.9%, while those of the wild-type controls were significantly(P < 0.01) lower, with an average of 76.9%. Double selection in transgene-free lines was applied using the Bar strip test and Cas9 PCR screening. The genome background recovery ratios of the lines were determined using genome-wide SNP data. That of lines used as male parents was as high as98.19% and that of lines used as female parents was as high as 86.78%. Conversion hybrids and both parental lines showed agronomic performance similar to that of their wild-type counterparts. This study provides a practical example of the efficient extension of CRISPR/Cas9 targeted mutation to industrial hybrids for transformation of a recalcitrant species.展开更多
This paper deals with the exact detection analysis of the Ordered-Statistic(OS) processor along with OS Greatest Of(OSGO) and OS Smallest Of(OSSO) modified versions, for M postdetection integrated pulses when the oper...This paper deals with the exact detection analysis of the Ordered-Statistic(OS) processor along with OS Greatest Of(OSGO) and OS Smallest Of(OSSO) modified versions, for M postdetection integrated pulses when the operating environment is nonhomogeneous. Analytical results are presented in multiple-target case as well as in regions of clutter power transitions. The primary and the secondary interfering targets are assumed to be fluctuating in accordance with the SWII target fluctuation model. As the number of noncoherently integrated pulses increases,lower threshold values and consequently better detection performances are obtained in both homogeneous and multiple target background models. However, the false alarm rate performance of OSSO-CFAR(Constant False Alarm Rate) scheme at clutter edges is worsen with increasing the postdetection integrated pulses. As predicted, the OSGO-CFAR detector accommodates the presence of spurious targets in the reference window, given that their number is within its allowable range in each local window, and controls the rate of false alarm when the contents of the reference cells have clutter boundaries.展开更多
The publishing conference of the Chinese version of National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (hereinafter referred to as NCCN Guidelines) and the inaugural peer reviewe...The publishing conference of the Chinese version of National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (hereinafter referred to as NCCN Guidelines) and the inaugural peer reviewer meeting of NCCN Clinical Practice Guidelines in Oncology: Digestive System Cancers (hereinafter referred to as NCCN Guidelines on Digestive System Cancers) were held in People's Medical Publishing House in January 28^th, 2016 (Figure 1).展开更多
基金the Scientific Technology Development Project of Heilongjiang(Grant No.WH05A01 and GB05A103)Scientific Technology Development Project of Harbin
文摘Based on the key function of version management in PDM system, this paper discusses the function and the realization of version management and the transitions of version states with a workflow. A directed aeyclic graph is used to describe a version model. Three storage modes of the directed acyelic graph version model in the database, the bumping block and the PDM working memory are presented and the conversion principle of these three modes is given. The study indicates that building a dynamic product structure configuration model based on versions is the key to resolve the problem. Thus a version model of single product object is built. Then the version management model in product structure configuration is built and the application of version management of PDM syster is presented as a case.
文摘Software projects are becoming larger and more complicated. Managing those projects is based on several software development methodologies. One of those methodologies is software version control, which is used in the majority of worldwide software projects. Although existing version control systems provide sufficient functionality in many situations, they are lacking in terms of semantics and structure for source code. It is commonly believed that improving software version control can contribute substantially to the development of software. We present a solution that considers a structural model for matching source code that can be used in version control.
基金Supported by the Fundamental Fujian Nature Science (A0440006) and Xiamen Science & Technology Project (3502Z20055028)
文摘A version of a product consists of the product structure tree and the versions of all its components. The model includes two sets of data: attributes and documents describing each component. The paper discusses the version change relations between a sub-node component and a up-node component in a product structure tree, analyzes the version control system for a static reference and that for a dynamic reference and proposes a product structure model in support of dynamic reference, which is easy to use and contains a complete set of information providing an essential way of data organization for the PDM system.
基金Industrial Research of National Wool and Csahmere Industry Technology System,China(No.CARS-40-20)
文摘By comparing China's import of major imported agriculture textile material( cotton and wool),the characteristics of import are concluded. On this basis,a restricted version of source differentiated almost ideal demand system( RSDAIDS) is used to estimate the income and price elasticity of major imported agriculture textile material from the major sources based on the data from 1992 to 2015. The results are shown as follows.( 1) Although the dependency on imported cotton is lower than wool, the fluctuation of cotton import is much more drastic; China's demand for cotton is relatively price elastic with higher expenditure elasticity compared with wool; besides,the existence of complementarity is proved between imported cotton and wool.( 2) According to the import elasticity of cotton,demand for cotton imported from India shows priority over cotton from other sources; demand for cotton imported from America is the most price-sensitive one; substitution among cotton from different sources is weak.( 3) According to the import elasticity of wool,wool imported from Uruguay has bright market prospects. In addition,wool imported from Australia has irreplaceable advantage than that from New Zealand.
文摘Contents1. Diagnosis and dynamic assessment of persistent/recurrent and metastatic differentiated thyroid cancer (prmDTC)1.1 Basic principles of diagnosis1.2 Diagnostic methods1.3 Ongoing assessment of response to therapy2. Multidisciplinary treatment of prmDTC2.1 Basic principles of treatment2.2 Surgical management2.2.1 Preoperative clinical assessment2.2.2 Principles of surgical treatment for prmDTC.
文摘Objective: Response Evaluation Criteria in Solid Tumors (RECIST) guideline version 1.0 (RECIST 1.0) was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure. With a number of issues being raised on RECIST 1.0, however, a revised RECIST guideline version 1.1 (RECIST 1.1) was proposed by the RECIST Working Group in 2009. This study was conducted to compare CT tumor response based on RECIST 1.1 vs. RECIST 1.0 in patients with advanced gastric cancer (AGC). Methods: We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010. These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using the κ statistic. Results: The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0 (P〈0.0001). However, there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0 0(κ=0.844). The overall response rates (ORRs) according to RECIST 1.0 and RECIST 1.1 were 32.7% (20/61) and 34.5% (20/58), respectively. One patient with partial response (PR) based on RECIST 1.0 was reclassified as stable disease (SD) by RECIST 1.1. Of two patients with SD by RECIST 1.0, one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1. Conclusions: RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC.
文摘Contents1. Overview2. Risk factors of prostate cancer2.1 Age and genetic factors2.2 Exogenous factors3. Pathological classification and grading system4. Diagnostic evaluation4.1 Monitoring and screening for population with high-risk prostate cancer4.2 Genetic testing4.3 Digital rectal examination (DRE)4.4 Magnetic resonance examination4.5 Bone scan examination.
文摘Background: Laparoscopic hepatectomy has many advantages over open surgery, including minimiza- tion of local injury, reduced systemic reactions, and faster postoperative recovery. The aim of this "Consensus" is to provide guidance and reference to surgeons who perform, or are interested in per- forming laparoscopic liver surgeries. Methods: The National Hepatic Surgery Group of the Society of Surgery, a professional society of the Chinese Medical Association, gathered 60 expert hepatic surgeons in Wuhan, China in December 2012, and an "Expert Consensus on Laparoseopic Hepatectomy" was developed. Results: The types of hepatectomy, indications and contraindications, preoperative preparation, anes- thesia, patient position, insuffiation pressure, port position, control of hepatic inflow and outflow, indi- cations for conversion to open surgery, and surgical devices and equipment are reviewed. Techniques and procedures of various laparoscopic hepatectomies are also discussed.
文摘AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract surgery.METHODS: Patients underwent cataract surgery in Shanghai General Hospital, Shanghai Jiao Tong University, who fit the inclusion criteria were recruited. Two CLVQOLs were administered, including a preoperative CLVQOL and a CLVQOL at the end of the 3 mo follow-up period, and were completed using face-to-face interviews or phone interviews conducted by trained investigators. The minimal clinically important difference(MCID) was calculated using an anchor-based method and a distribution method. In addition, the responsiveness of the questionnaire was measured.RESULTS: A total of 155 residents were enrolled. The average visual acuity(VA) preoperatively was 0.08(SD=0.05), and it increased to 0.47(SD=0.28) at the end of followup. Statistically significant positive changes in the CLVQOL scores indicated significant improvement of vision related quality of life after cataract surgery. With the larger value between the two results as the final value, the MCID values of the CLVQOL(scores of the four scales as well as the total score) were 8.94, 2.61, 4.34, 3.10 and 17.63, respectively. The CLVQOL has both good internal and external responsiveness.CONCLUSION: CLVQOL scores are appropriate instruments for obtaining clinically important changes after cataract surgery. This study is an effective exploration for establishingcataract surgery efficacy standards, which helps clinical and scientific research workers in ophthalmology to gain a more in-depth understanding when using CLVQOL.
文摘Professionalism is crucial in all professions and is particularly important in the medical field.Measuring students' perceptions of professionalism can help to form education targeting the enhancement of professionalism.This study aimed to validate an effective assessment tool for the measurement of medical students5 perceptions of medical professionalism in China's Mainland.The cross-sectional survey was conducted in three medical colleges in Guangdong,China.Of the 2103 eligible medical students,1976 responded,and 1856 questionnaires were deemed valid.Students from clinical medicine in these three medical colleges were randomly selected by cluster sampling.First,a Simplified Chinese Version questionnaire to measure Student's Perception of Medical Professionalism (SCV-SPMP) was constructed.Second,questionnaires from 1856 students majoring in clinical medicine at three medical colleges were included in the analysis.Third,exploratory factor analysis,Cronbach's alpha,item-subscale correlation,and confirmatory factor analysis were conducted to test the validity and reliability of the SCV-SPMP.Nine items were eliminated following exploratory factor analysis,and four subscales were extracted from the analysis.All internal consistency reliability exceeded the minimum standard.The overall Cronbach's alpha was 0.94,and four subscales' alphas were 0.82 (Accountability and excellence),0.81 (Duty),0.89 (Honor and integrity),and 0.85 (Practice habits and respect for others),respectively.The model fit was good.The convergent validity and discriminant validity were acceptable.The modified SCVSPMP was found to be a valid and reliable tool to capture the main features of Chinese students' perceptions of medical professionalism in four dimensions,and it provides a quantitative method for the measurement of the students' perceptions in China's Mainland..
基金Supported by the National Natural Science Foun-dation of China (60503036)
文摘A dynamic Web application, which can help the departments of enterprise to collaborate with each other conveniently, is proposed. Several popular design solutions are introduced at first. Then, dynamic Web system is chosen for developing the file access and control system. Finally, the paper gives the detailed process of the design and implementation of the system, which includes some key problems such as solutions of document management and system security. Additionally, the limitations of the system as well as the suggestions of further improvement are also explained.
文摘A novel dynamic batch selective sampling algorithm based on version space analysis is presented. In the traditional batch selective sampling, example selection is entirely determined by the existing unreliable classification boundary; meanwhile, within a batch, examples labeled previously fail to provide instructive information for the selection of the rest. As a result, using the examples selected in batch mode for model refinement will jeopardize the classification performance. Based on the duality between feature space and parameter space under the SVM active learning fi:amework, dynamic batch selective sampling is proposed to address the problem. We select a batch of examples dynamically, using the examples labeled previously as guidance for further selection. In this way, the selection of feedback examples is determined by both the existing classification model and the examples labeled previously. Encouraging experimental results demonstrate the effectiveness of the proposed algorithm.
基金supported the National Transgenic Science and Technology Program(2019ZX08010-003)the National Natural Science Foundation of China(31771808)+3 种基金the National Key Research and Development Program of China(2016YFD0101803)the Key Area Research and Development Program of Guangdong Province(2018B020202008)Beijing Municipal Science and Technology Commission(D171100007717001)National Engineering Laboratory for Crop Molecular Breeding。
文摘Waxy maize is a specialty maize that produces mainly amylopectin starch with special food or industrial values. The objective of this study was to overcome the limitations of wx mutant allele acquisition and breeding efficiency by conversion of parental lines from normal to waxy maize. The intended mutation activity was achieved by in vivo CRISPR/Cas9 machinery involving desired-target mutation of the Wx locus in the ZC01 background,abbreviated as ZC01-DTM^(wx). Triple selection was applied to segregants to obtain high genome background recovery with transgene-free wx mutations. The targeted mutation was identified, yielding six types of mutations among progeny crossed with ZC01-DTM^(wx).The amylopectin contents of the endosperm starch in mutant lines and hybrids averaged94.9%, while those of the wild-type controls were significantly(P < 0.01) lower, with an average of 76.9%. Double selection in transgene-free lines was applied using the Bar strip test and Cas9 PCR screening. The genome background recovery ratios of the lines were determined using genome-wide SNP data. That of lines used as male parents was as high as98.19% and that of lines used as female parents was as high as 86.78%. Conversion hybrids and both parental lines showed agronomic performance similar to that of their wild-type counterparts. This study provides a practical example of the efficient extension of CRISPR/Cas9 targeted mutation to industrial hybrids for transformation of a recalcitrant species.
文摘This paper deals with the exact detection analysis of the Ordered-Statistic(OS) processor along with OS Greatest Of(OSGO) and OS Smallest Of(OSSO) modified versions, for M postdetection integrated pulses when the operating environment is nonhomogeneous. Analytical results are presented in multiple-target case as well as in regions of clutter power transitions. The primary and the secondary interfering targets are assumed to be fluctuating in accordance with the SWII target fluctuation model. As the number of noncoherently integrated pulses increases,lower threshold values and consequently better detection performances are obtained in both homogeneous and multiple target background models. However, the false alarm rate performance of OSSO-CFAR(Constant False Alarm Rate) scheme at clutter edges is worsen with increasing the postdetection integrated pulses. As predicted, the OSGO-CFAR detector accommodates the presence of spurious targets in the reference window, given that their number is within its allowable range in each local window, and controls the rate of false alarm when the contents of the reference cells have clutter boundaries.
文摘The publishing conference of the Chinese version of National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (hereinafter referred to as NCCN Guidelines) and the inaugural peer reviewer meeting of NCCN Clinical Practice Guidelines in Oncology: Digestive System Cancers (hereinafter referred to as NCCN Guidelines on Digestive System Cancers) were held in People's Medical Publishing House in January 28^th, 2016 (Figure 1).