In this paper, we present a magnetocardiogram （MCG） simulation study using the boundary element method （BEM） and based on the virtual heart model and the realistic human volume conductor model. The different contr...In this paper, we present a magnetocardiogram （MCG） simulation study using the boundary element method （BEM） and based on the virtual heart model and the realistic human volume conductor model. The different contributions of cardiac equivalent source models and volume conductor models to the MCG are deeply and comprehensively investigated. The single dipole source model, the multiple dipoles source model and the equivalent double layer （EDL） source model are analysed and compared with the cardiac equivalent source models. Meanwhile, the effect of the volume conductor model on the MCG combined with these cardiac equivalent sources is investigated. The simulation results demonstrate that the cardiac electrophysiological information will be partly missed when only the single dipole source is taken, while the EDL source is a good option for MCG simulation and the effect of the volume conductor is smallest for the EDL source. Therefore, the EDL source is suitable for the study of MCG forward and inverse problems, and more attention should be paid to it in future MCG studies.展开更多
基金supported by the State Key Development Program for Basic Research of China (Grant Nos. 2007CB512100 and2006CB601007)the National Natural Science Foundation of China (Grant No. 10674006)+2 种基金the National High Technology Research and Development Program of China (Grant No. 2007AA03Z238)China Postdoctoral Science Foundation (Grant No. 20090461376)the Fundamental Research Funds for the Central Universities (Grant No. KYJD09001)
文摘In this paper, we present a magnetocardiogram （MCG） simulation study using the boundary element method （BEM） and based on the virtual heart model and the realistic human volume conductor model. The different contributions of cardiac equivalent source models and volume conductor models to the MCG are deeply and comprehensively investigated. The single dipole source model, the multiple dipoles source model and the equivalent double layer （EDL） source model are analysed and compared with the cardiac equivalent source models. Meanwhile, the effect of the volume conductor model on the MCG combined with these cardiac equivalent sources is investigated. The simulation results demonstrate that the cardiac electrophysiological information will be partly missed when only the single dipole source is taken, while the EDL source is a good option for MCG simulation and the effect of the volume conductor is smallest for the EDL source. Therefore, the EDL source is suitable for the study of MCG forward and inverse problems, and more attention should be paid to it in future MCG studies.
文摘目的:研究稳定型冠心病合并H型高血压患者血管内超声虚拟组织学冠脉斑块特征。方法 52例稳定型冠心病且合并高血压患者,依据血浆同型半胱氨酸(Hcy)水平分为合并H型高血压组、合并非H型高血压组。所有患者行冠脉造影检查确诊,计算3支血管病变比例及Gensini评分;对冠脉靶病变进行血管内超声检查及虚拟组织学分析,研究两组血管重构及斑块病变特征。结果与合并非H型高血压组比较,合并H型高血压组冠脉3支血管病变比例增高(57.14%vs 41.67%)、Gensini评分增高(30.82±7.18 vs 26.35±4.27),差异有统计学意义(P<0.05);合并H型高血压组血管重构指数、正性重构比例、斑块脂质坏死组织面积、纤维脂质组织面积较合并非H型高血压组升高(P<0.05),斑块钙化组织面积、纤维组织面积两组比较差异无统计学意义(P>0.05)。相关分析显示血浆Hcy水平与3支血管病变比例、Gensini评分、血管重构指数、正性重构比例、脂质坏死组织面积、纤维脂质组织面积存在正相关关系。结论稳定型冠心病合并H型高血压患者,其高血浆Hcy水平不但影响冠脉病变的范围和严重程度,还可能进一步加重血管重塑及斑块组分的差异,造成斑块不稳定趋势。
