Light-Activated Virtual Sensor Array with Machine Learning for Non-Invasive Diagnosis of Coronary Heart Disease

Early non-invasive diagnosis of coronary heart disease(CHD)is critical.However,it is challenging to achieve accurate CHD diagnosis via detecting breath.In this work,heterostructured complexes of black phosphorus(BP)and two-dimensional carbide and nitride(MXene)with high gas sensitivity and photo responsiveness were formulated using a self-assembly strategy.A light-activated virtual sensor array(LAVSA)based on BP/Ti_(3)C_(2)Tx was prepared under photomodulation and further assembled into an instant gas sensing platform(IGSP).In addition,a machine learning(ML)algorithm was introduced to help the IGSP detect and recognize the signals of breath samples to diagnose CHD.Due to the synergistic effect of BP and Ti_(3)C_(2)Tx as well as photo excitation,the synthesized heterostructured complexes exhibited higher performance than pristine Ti_(3)C_(2)Tx,with a response value 26%higher than that of pristine Ti_(3)C_(2)Tx.In addition,with the help of a pattern recognition algorithm,LAVSA successfully detected and identified 15 odor molecules affiliated with alcohols,ketones,aldehydes,esters,and acids.Meanwhile,with the assistance of ML,the IGSP achieved 69.2%accuracy in detecting the breath odor of 45 volunteers from healthy people and CHD patients.In conclusion,an immediate,low-cost,and accurate prototype was designed and fabricated for the noninvasive diagnosis of CHD,which provided a generalized solution for diagnosing other diseases and other more complex application scenarios.

PULSE CUMULATING METHOD FOR MULTI-TARGETS' JOINT AZIMUTH-ELEVATION FREQUENCY-DELAY ESTIMATION

The Directions of Arrivals （DOAs）, speeds and distances of targets are all required for array signal processing. Based on the periodic phase shift of coherent pulse sequence waveform, a new estimation of multi-targets＇ 2-Dimentional （2-D） DOA angle, Doppler frequency shift and relative time-delay is proposed. Based on a virtual sensor array constructed by pulse cumulating, the estinaations of azimuth, elevation, Doppler frequency shift and time-delay can be obtained simultaneously, and the least number of pulses could be two. This method is computationally efficient even in heavier noised environment, and all estimations are automatically paired in calculation process with no used to any plane sensor array and deal with many spectrum searching. Further more, this algorithm can be targets at the same time only by few sensors. The targets number that can deal with simultaneously is several times to the sensor number, which is the upper limit for normal algorithms such as ESPRIT and MUSIC. These characteristics would be very useful, especially, for aerial systems. Simulations demonstrate the capabilities of this method efficiently.