The Epstein-Barr virus membrane antigen was constructed and inserted into vaccinia virus, Tian-tan strain in order to study the effect of this virus on EB infection and tumorogenesis. The EBV-derived membrane antigen ...The Epstein-Barr virus membrane antigen was constructed and inserted into vaccinia virus, Tian-tan strain in order to study the effect of this virus on EB infection and tumorogenesis. The EBV-derived membrane antigen was expressed under the control of a 7.5 K promoter of vaccinia virus. The antibody against the membrane antigen of EB virus was produced on rabbits vaccinated with recombinant vaccinia virus.展开更多
A considerable number of viruses’structures have been discovered and more are expected to be identified.Different viruses’symmetries can be observed at the nanoscale level.The mechanical models of some viruses reali...A considerable number of viruses’structures have been discovered and more are expected to be identified.Different viruses’symmetries can be observed at the nanoscale level.The mechanical models of some viruses realised by scientists are described in this paper,none of which has taken into consideration the internal deformation of subsystems. The authors’models for some viruses’elements are introduced,with rigid and flexible links,which reproduce the movements of viruses including internal deformations of the subunits.展开更多
In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and ...In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and 2）, along with four known sesquiterpene derivatives （3-6）. Structural elucidation of I and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1-6 were also evaluated for their anti-tobacco mosaic virus （anti-TMV） activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.展开更多
文摘The Epstein-Barr virus membrane antigen was constructed and inserted into vaccinia virus, Tian-tan strain in order to study the effect of this virus on EB infection and tumorogenesis. The EBV-derived membrane antigen was expressed under the control of a 7.5 K promoter of vaccinia virus. The antibody against the membrane antigen of EB virus was produced on rabbits vaccinated with recombinant vaccinia virus.
文摘A considerable number of viruses’structures have been discovered and more are expected to be identified.Different viruses’symmetries can be observed at the nanoscale level.The mechanical models of some viruses realised by scientists are described in this paper,none of which has taken into consideration the internal deformation of subsystems. The authors’models for some viruses’elements are introduced,with rigid and flexible links,which reproduce the movements of viruses including internal deformations of the subunits.
基金supported by the National Natural Science Foundation of China (Nos. 31360081 and 31400303)the Basic Research Foundation of Yunnan Province (Nos. 2014FB163 and 2014FD078)the Product Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (No. 2014CP01)
文摘In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and 2）, along with four known sesquiterpene derivatives （3-6）. Structural elucidation of I and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1-6 were also evaluated for their anti-tobacco mosaic virus （anti-TMV） activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.
