A numerical model is developed for describing the transport of virus in a fracture-matrix coupled system with fracture-skin. An advective dispersive virus transport equation, including first- order sorption and inacti...A numerical model is developed for describing the transport of virus in a fracture-matrix coupled system with fracture-skin. An advective dispersive virus transport equation, including first- order sorption and inactivation constant is used for simulating the movement of viruses. Implicit finite-difference numerical technique is used to solve the coupled non-linear governing equations for the triple continuum model consisting of fracture, fracture-skin and the rock-matrix. A varying grid is adopted at the fracture and fracture-skin interface to capture the mass transfer. Sensitivity analysis was performed to investigate the effect of various properties of the fracture-skin as well as viruses on the virus concentration in the fractured formation with fracture-skin. Simulation results suggest that the virus concentration in the fracture decreases with increment in the fracture-skin porosity, fracture-skin diffu- sion coefficient, mass transfer coefficient, inactivation constant and sorption distribution coefficient, and with reduction in the fracture aperture.展开更多
Rabies virus （RABV） of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its...Rabies virus （RABV） of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its arrival into the central nervous system （CNS）, for which it uses the cellular transport machinery. Neurons are irregular cells with a specialized anatomy, and often extend lengthy axons that may span over a meter long. In infected organisms, RABV virions enter the neuron periphery at the area of a bite and must overcome great distances in order to reach the peripheral neuron＇s cell body and from there,展开更多
文摘A numerical model is developed for describing the transport of virus in a fracture-matrix coupled system with fracture-skin. An advective dispersive virus transport equation, including first- order sorption and inactivation constant is used for simulating the movement of viruses. Implicit finite-difference numerical technique is used to solve the coupled non-linear governing equations for the triple continuum model consisting of fracture, fracture-skin and the rock-matrix. A varying grid is adopted at the fracture and fracture-skin interface to capture the mass transfer. Sensitivity analysis was performed to investigate the effect of various properties of the fracture-skin as well as viruses on the virus concentration in the fractured formation with fracture-skin. Simulation results suggest that the virus concentration in the fracture decreases with increment in the fracture-skin porosity, fracture-skin diffu- sion coefficient, mass transfer coefficient, inactivation constant and sorption distribution coefficient, and with reduction in the fracture aperture.
基金supported by the German Israeli Foundation for Scientific Research and Development(GIF)grant G-1107-73.1/2010 to EP and SFThe European Research Council(ERC)grant 309377 and Israel Science Foundation ISF grant 614/11 to EP
文摘Rabies virus （RABV） of the rhabdoviridae family is a prototype neurotropic virus that causes a fatal disease, and is still a major risk mostly in developing countries. A key step in the RABV infection process is its arrival into the central nervous system （CNS）, for which it uses the cellular transport machinery. Neurons are irregular cells with a specialized anatomy, and often extend lengthy axons that may span over a meter long. In infected organisms, RABV virions enter the neuron periphery at the area of a bite and must overcome great distances in order to reach the peripheral neuron＇s cell body and from there,
