Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 pat...Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 patients with type 2 diabetes mellitus(T2DM)and 32 normal controls(NC)were selected from our hospital.Patients with diabetes were divided into a non-DR group(T2DM)(n=69)and a nonproliferative diabetic retinopathy Group(DR)(n=71)after dilated fundus photography and fundus fluorescein angiography.rs2110385/AluⅠgenotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and the differences in the detection rates of different genotypes in the above populations were compared.Results:1)The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups(P<0.05).2)The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups(80.3,69.6,50.0,86.6,79,65.6,P<0.05).3)There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group(P<0.01).Conclusion:Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR.The G allele of the rs2110385 polymorphic site may be related to the risk of DR.展开更多
目的探讨妊娠期糖尿病(GDM)患者脐血血清Visfatin(VF)水平变化及其意义。方法选择GDM孕妇(GDM组)43例、正常糖耐量孕妇(对照组)36例,记录体质量、身高,计算BMI。采集产时脐静脉血3~5 m L,采用电化学发光法测定空腹胰岛素(Fins),ELISE法...目的探讨妊娠期糖尿病(GDM)患者脐血血清Visfatin(VF)水平变化及其意义。方法选择GDM孕妇(GDM组)43例、正常糖耐量孕妇(对照组)36例,记录体质量、身高,计算BMI。采集产时脐静脉血3~5 m L,采用电化学发光法测定空腹胰岛素(Fins),ELISE法测定血清VF水平。结果 GDM组BMI、脐血血清VF水平均高于对照组(P均<0.05)。相关分析发现,VF水平与BMI及血清Fins水平均呈正相关(r分别为0.468、0.524,P均<0.05)。结论 GDM患者脐血血清VF水平升高,在GDM发病中发挥重要作用。展开更多
V isfatin是腹部内脏脂肪组织高表达的一种生物活性小分子,能够调控腹部脂肪细胞的分化和成脂作用,并能与胰岛素受体结合,调节胰岛素敏感性。V isfatin的发现及其类胰岛素生物活性,引发人们对体内糖脂代谢平衡、脂肪细胞分化与增殖的重...V isfatin是腹部内脏脂肪组织高表达的一种生物活性小分子,能够调控腹部脂肪细胞的分化和成脂作用,并能与胰岛素受体结合,调节胰岛素敏感性。V isfatin的发现及其类胰岛素生物活性,引发人们对体内糖脂代谢平衡、脂肪细胞分化与增殖的重新认识。展开更多
基金Xi’an Science and Technology Bureau Fund(23YXYJ0103)Shaanxi Provincial Science and Technology Department Fund(S2022-YF-YBSF-0939).
文摘Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 patients with type 2 diabetes mellitus(T2DM)and 32 normal controls(NC)were selected from our hospital.Patients with diabetes were divided into a non-DR group(T2DM)(n=69)and a nonproliferative diabetic retinopathy Group(DR)(n=71)after dilated fundus photography and fundus fluorescein angiography.rs2110385/AluⅠgenotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and the differences in the detection rates of different genotypes in the above populations were compared.Results:1)The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups(P<0.05).2)The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups(80.3,69.6,50.0,86.6,79,65.6,P<0.05).3)There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group(P<0.01).Conclusion:Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR.The G allele of the rs2110385 polymorphic site may be related to the risk of DR.
文摘目的探讨妊娠期糖尿病(GDM)患者脐血血清Visfatin(VF)水平变化及其意义。方法选择GDM孕妇(GDM组)43例、正常糖耐量孕妇(对照组)36例,记录体质量、身高,计算BMI。采集产时脐静脉血3~5 m L,采用电化学发光法测定空腹胰岛素(Fins),ELISE法测定血清VF水平。结果 GDM组BMI、脐血血清VF水平均高于对照组(P均<0.05)。相关分析发现,VF水平与BMI及血清Fins水平均呈正相关(r分别为0.468、0.524,P均<0.05)。结论 GDM患者脐血血清VF水平升高,在GDM发病中发挥重要作用。
