Traditional reduction coupling reactions of two bromides typically rely on transition metal catalysis.Here,we introduce the development of a visible-light catalytic direct reduction coupling reaction betweenα-CF_(3)-...Traditional reduction coupling reactions of two bromides typically rely on transition metal catalysis.Here,we introduce the development of a visible-light catalytic direct reduction coupling reaction betweenα-CF_(3)-alkyl bromides and alkynyl bromides to access valuable organic frameworks.Our research confirms the excellent compatibility of this reaction with various functional groups,which could be used to modify the substrate with biologically active molecular fragments.Mechanistic investigations,including control experiments,fluorescence quenching studies,and light-switching experiments,have provided insights into the reaction mechanism.This study paves the way for the application of visible-light catalysis in diverse synthetic transformations,offering a sustainable and efficient approach to organic synthesis.展开更多
基金support was from Tianjin University(2024XJD-0062)the National Natural Science Foundation of China(No.22371203).
文摘Traditional reduction coupling reactions of two bromides typically rely on transition metal catalysis.Here,we introduce the development of a visible-light catalytic direct reduction coupling reaction betweenα-CF_(3)-alkyl bromides and alkynyl bromides to access valuable organic frameworks.Our research confirms the excellent compatibility of this reaction with various functional groups,which could be used to modify the substrate with biologically active molecular fragments.Mechanistic investigations,including control experiments,fluorescence quenching studies,and light-switching experiments,have provided insights into the reaction mechanism.This study paves the way for the application of visible-light catalysis in diverse synthetic transformations,offering a sustainable and efficient approach to organic synthesis.
